Bernhard Schieffer

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Role of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors, angiotensin-converting enzyme inhibitors, cyclooxygenase-2 inhibitors, and aspirin in anti-inflammatory and immunomodulatory treatment of cardiovascular diseases
    Bernhard Schieffer
    Department of Cardiology and Angiology, Medizinische Hochschule, Hannover, Germany
    Am J Cardiol 91:12H-18H. 2003
  2. ncbi request reprint Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease
    Bernhard Schieffer
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    J Am Coll Cardiol 44:362-8. 2004
  3. ncbi request reprint Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction
    Carola Doerries
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Hannover, Germany
    Circ Res 100:894-903. 2007
  4. doi request reprint Toll-like receptor 2/6 agonist macrophage-activating lipopeptide-2 promotes reendothelialization and inhibits neointima formation after vascular injury
    Karsten Grote
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Arterioscler Thromb Vasc Biol 33:2097-104. 2013
  5. ncbi request reprint Combined effects of HMG-CoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis
    Christina Grothusen
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Atherosclerosis 182:57-69. 2005
  6. doi request reprint Chemokine receptor 7 knockout attenuates atherosclerotic plaque development
    Maren Luchtefeld
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Circulation 122:1621-8. 2010
  7. ncbi request reprint Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation
    Maren Luchtefeld
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Atherosclerosis 194:62-70. 2007
  8. ncbi request reprint Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation
    Karsten Grote
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Cardiovasc Res 71:596-605. 2006
  9. doi request reprint Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration
    Karsten Grote
    Department of Cardiology and Angiology, Hannover Medical School, 30165, Hannover, Germany
    Blood 115:2543-52. 2010
  10. ncbi request reprint Angiotensin II induces MMP-2 in a p47phox-dependent manner
    Maren Luchtefeld
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    Biochem Biophys Res Commun 328:183-8. 2005

Detail Information

Publications56

  1. ncbi request reprint Role of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors, angiotensin-converting enzyme inhibitors, cyclooxygenase-2 inhibitors, and aspirin in anti-inflammatory and immunomodulatory treatment of cardiovascular diseases
    Bernhard Schieffer
    Department of Cardiology and Angiology, Medizinische Hochschule, Hannover, Germany
    Am J Cardiol 91:12H-18H. 2003
    ..This article reviews the potential immunomodulatory potencies of aspirin, COX-2 inhibitors, statins, and ACE inhibitors as established pharmacotherapy in patients with coronary artery disease...
  2. ncbi request reprint Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease
    Bernhard Schieffer
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    J Am Coll Cardiol 44:362-8. 2004
    ..We evaluated whether renin-angiotensin system (RAS) blockade attenuates cardiovascular events...
  3. ncbi request reprint Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction
    Carola Doerries
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Hannover, Germany
    Circ Res 100:894-903. 2007
    ..The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI...
  4. doi request reprint Toll-like receptor 2/6 agonist macrophage-activating lipopeptide-2 promotes reendothelialization and inhibits neointima formation after vascular injury
    Karsten Grote
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Arterioscler Thromb Vasc Biol 33:2097-104. 2013
    ..We here investigated the therapeutic potential of the toll-like receptor 2/6 agonist macrophage-activating lipopeptide (MALP)-2 on reendothelialization and neointima formation in a murine model of vascular injury...
  5. ncbi request reprint Combined effects of HMG-CoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis
    Christina Grothusen
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Atherosclerosis 182:57-69. 2005
    ....
  6. doi request reprint Chemokine receptor 7 knockout attenuates atherosclerotic plaque development
    Maren Luchtefeld
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Circulation 122:1621-8. 2010
    ..Thus, we investigated the influence of a systemic CCR7 deficiency on atherogenesis in atherosclerosis-prone low-density lipoprotein receptor (ldlr) knockout mice...
  7. ncbi request reprint Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation
    Maren Luchtefeld
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Atherosclerosis 194:62-70. 2007
    ..Theses findings represent a novel anti-atherosclerotic mechanism and imply that AT1-receptor blockade elicits anti-atherosclerotic potencies even in the absence of plasma cholesterol reduction...
  8. ncbi request reprint Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation
    Karsten Grote
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Cardiovasc Res 71:596-605. 2006
    ..Here, we investigated the role of p47phox in blood pressure control, endothelium-dependent relaxation, cardiac hypertrophy, RAS activation, and renal oxidative stress under resting conditions...
  9. doi request reprint Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration
    Karsten Grote
    Department of Cardiology and Angiology, Hannover Medical School, 30165, Hannover, Germany
    Blood 115:2543-52. 2010
    ..This might represent a general mechanism to enhance or restore blood flow and recruit immune cells for pathogen defense and tissue regeneration...
  10. ncbi request reprint Angiotensin II induces MMP-2 in a p47phox-dependent manner
    Maren Luchtefeld
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    Biochem Biophys Res Commun 328:183-8. 2005
    ..MMP-2 protein expression and gelatinolytic activity are increased in atherosclerotic arteries. Thus, activation of the renin-angiotensin system may contribute to plaque destabilization via ROS-dependent induction of MMP-2...
  11. doi request reprint Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phox-dependent manner
    Gustavo Salguero
    Department of Cardiology and Angiology, Germany
    J Hypertens 26:257-68. 2008
    ..Since bone marrow derived endothelial progenitor cells (EPCs) contribute to vascular remodeling and repair, we investigated whether renovascular hypertension stimulates EPC mobilization in a NAD(P)H oxidase-dependent manner...
  12. doi request reprint Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation
    Gustavo Salguero
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Hypertension 54:1035-42. 2009
    ..01). These results imply a critical role for the gp130-dependent systemic acute phase response for vascular inflammation and SMC migration, as well as proliferation, and, subsequently, for vascular remodeling...
  13. ncbi request reprint Impact of a combined treatment of angiotensin II type 1 receptor blockade and 3-hydroxy-3-methyl-glutaryl-CoA-reductase inhibition on secretory phospholipase A2-type IIA and low density lipoprotein oxidation in patients with coronary artery disease
    Dimitar Divchev
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 29:1956-65. 2008
    ....
  14. ncbi request reprint Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis
    Bernhard Schieffer
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Circulation 110:3493-500. 2004
    ..Mediators of inflammation, ie, interleukin (IL)-6, are elevated in patients with acute coronary syndromes and may contribute to the exacerbation of atherosclerosis...
  15. pmc Angiopoietin-2 in adults with congenital heart disease and heart failure
    Alexander Lukasz
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e66861. 2013
    ..Their role in ACHD has not been studied...
  16. ncbi request reprint Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179
    Christine Krämer
    Department of Cardiology, Medizinische Hochschule Hannover, Germany
    Circ Res 90:770-6. 2002
    ..Serum levels of EXP3179 are detectable in patients in concentrations that exhibit antiinflammatory and antiaggregatory properties in vitro...
  17. pmc Asymmetrical dimethylarginine--more sensitive than NT-proBNP to diagnose heart failure in adults with congenital heart disease
    Oktay Tutarel
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e33795. 2012
    ..Asymmetrical dimethylarginine (ADMA) correlates with disease severity and independently predicts adverse clinical events in heart failure of non-congenital origin. Its role in ACHD has not been investigated...
  18. pmc Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
    Maren Luchtefeld
    Abteilung fur Kardiologie und Angiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Exp Med 204:1935-44. 2007
    ..Thus, the acute phase reaction should be considered an important target for future drug development in the management of CAD...
  19. doi request reprint Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose
    Christian Templin
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    J Mol Cell Cardiol 45:394-403. 2008
    ..Ex vivo expanded HPCs improve cardiac function and remodeling post MI in a cell number- and beta-catenin-dependent manner...
  20. pmc Role of suppressor of cytokine signaling-1 in murine atherosclerosis
    Christina Grothusen
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e51608. 2012
    ..Its role in atherogenesis, however has not been elucidated so far...
  21. ncbi request reprint Stretch-inducible expression of the angiogenic factor CCN1 in vascular smooth muscle cells is mediated by Egr-1
    Karsten Grote
    Department of Cardiology and Angiology, Medical School of Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 279:55675-81. 2004
    ....
  22. doi request reprint Transcatheter closure of patent foramen ovale (PFO) in patients with paradoxical embolism: procedural and follow-up results after implantation of the Amplatzer®-occluder device
    Dieter Fischer
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany
    J Interv Cardiol 24:85-91. 2011
    ..The aim of the present study was to evaluate the follow-up results after implantation of the Amplatzer® occluder in patients with PFO using a consistent anticoagulation regimen...
  23. ncbi request reprint Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice
    Kumaravelu Jagavelu
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 01, 30625 Hannover, Germany
    Circ Res 101:1104-12. 2007
    ..Therefore, MK2 might represent an attractive novel target for the treatment of atherosclerotic cardiovascular disease...
  24. doi request reprint Interleukin-1 assembles a proangiogenic signaling module consisting of caveolin-1, tumor necrosis factor receptor-associated factor 6, p38-mitogen-activated protein kinase (MAPK), and MAPK-activated protein kinase 2 in endothelial cells
    Joanna Jagielska
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Arterioscler Thromb Vasc Biol 32:1280-8. 2012
    ..However, signaling pathways mediating IL-1β-induced proangiogenic processes in endothelial cells (ECs) have barely been elucidated yet. Therefore, the present study investigated IL-1β-induced proangiogenic signaling in ECs...
  25. ncbi request reprint 5-Lipoxygenase is involved in the angiotensin II-induced NAD(P)H-oxidase activation
    Maren Luchtefeld
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Germany
    Biochem Biophys Res Commun 308:668-72. 2003
    ..In conclusion, the present study demonstrates that ANG II enhances LTB(4)-formation in an 5-LOX dependent manner. LTB(4) activates the vascular type NAD(P)H-oxidase, leading to an increase in IL-6 transcripts...
  26. ncbi request reprint Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction
    Martin Fuchs
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    FASEB J 17:2118-20. 2003
    ....
  27. pmc Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study
    Jörg Eberhard
    Department of Prosthetic Dentistry and Biomaterials Science, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e55265. 2013
    ..We here investigated whether experimental gingivitis enhances systemic markers of inflammation which are also known as surrogate markers of atherosclerotic plaque development...
  28. doi request reprint Safety and efficiency of chronic ACE inhibition in symptomatic heart failure patients with a systemic right ventricle
    Oktay Tutarel
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Int J Cardiol 154:14-6. 2012
    ..Therefore, we investigated the effects of ACE inhibition in these patients on heart failure symptoms, echocardiographic diameters, NT-proBNP and exercise capacity...
  29. doi request reprint Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
    Harald Schuett
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Arterioscler Thromb Vasc Biol 32:281-90. 2012
    ..Notably, IL-6 also represents an independent risk factor for coronary artery disease (CAD) in humans and is crucially involved in vascular inflammatory processes...
  30. pmc Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways
    Maren Luchtefeld
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e19427. 2011
    ..In a previous study, we demonstrated the importance of the IL-6-gp130 axis -as a key regulator of inflammatory acute phase signaling in hepatocytes-for the development of atherosclerosis...
  31. ncbi request reprint How much is too much? Interleukin-6 and its signalling in atherosclerosis
    Harald Schuett
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Strasse 1, 30165 Hannover, Germany
    Thromb Haemost 102:215-22. 2009
    ....
  32. ncbi request reprint Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species
    Karsten Grote
    Department of Cardiology and Angiology, Medical School Hannover, Germany
    Circ Res 92:e80-6. 2003
    ..These results are consistent with the notion that in arterial hypertension, reactive oxygen species are involved in vascular remodeling via MMP activation. The full text of this article is available online at http://www.circresaha.org...
  33. pmc The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?
    Dimitar Divchev
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    Vasc Health Risk Manag 4:597-604. 2008
    ..The role of sPLA(2)-IIA in the perpetuation of atherosclerosis appears to be the missing link between inflammation, activated RAS and lipid peroxidation...
  34. ncbi request reprint EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis
    Christina Grothusen
    Abt fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Arterioscler Thromb Vasc Biol 27:1184-90. 2007
    ..We investigated the impact of EXP3179, an active metabolite of the angiotensin II type 1 (AT1)-receptor antagonist Losartan (LOS) on GPVI-dependent platelet activation...
  35. doi request reprint Transcatheter closure of patent foramen ovale in patients with paradoxical embolism. Procedural and follow-up results after implantation of the Starflex occluder device with conjunctive intensified anticoagulation regimen
    Dieter Fischer
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany
    J Interv Cardiol 21:183-9. 2008
    ..The aim of the present study was to evaluate the short- and long-term results after implantation of the Starflex occluder in patients with PFO using an intensified anticoagulation regimen...
  36. doi request reprint Mechanical stress modulates SOCS-1 expression in human vascular smooth muscle cells
    Marc Dangers
    Hannover Medical School, Hannover, Germany
    J Vasc Res 47:432-40. 2010
    ..The underlying molecular mechanisms are, however, not completely defined...
  37. ncbi request reprint The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration
    Karsten Grote
    Department of Cardiology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Blood 110:877-85. 2007
    ..These data suggest that CCN1 promotes integrin-dependent recruitment of CD34+ progenitor cells to endothelial cells, which may contribute to paracrine effects on angiogenesis and tissue regeneration...
  38. doi request reprint Toll-like receptors in angiogenesis
    Karsten Grote
    Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    ScientificWorldJournal 11:981-91. 2011
    ....
  39. doi request reprint Anomalous intramural course of coronary arteries in congenital heart disease--three case reports and review of the literature
    Carolin Zwadlo
    Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany
    Congenit Heart Dis 7:139-44. 2012
    ..Although rare, both cardiologists and surgeons need to be aware of intramural courses of coronary arteries to prevent accidental trauma to them and thereby, reducing the risk for the patient...
  40. ncbi request reprint Expression of CYR61, an angiogenic immediate early gene, in arteriosclerosis and its regulation by angiotensin II
    Andres Hilfiker
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    Circulation 106:254-60. 2002
    ..To elucidate the role of angiotensin II (Ang II) at a cellular level, we analyzed the Ang II-induced gene expression profile...
  41. doi request reprint [Allopurinol-induced hypersensitivity syndrome resulting in death]
    Sören Laurisch
    Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Med Klin (Munich) 105:262-6. 2010
    ..Considering the increasing prescription rate of allopurinol, the present case report intends to demonstrate the underestimated threat of AHS...
  42. ncbi request reprint JANUS under stress--role of JAK/STAT signaling pathway in vascular diseases
    Karsten Grote
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Vascul Pharmacol 43:357-63. 2005
    ..Based on these observations, we here review the role of the JAK/STAT signaling pathways as critical regulator for cardiovascular disease development, i.e. atherosclerotic plaque progression or the manifestation of arterial hypertension...
  43. doi request reprint Pulmonary valve replacement in chronic pulmonary regurgitation in adults with congenital heart disease: impact of preoperative QRS-duration and NT-proBNP levels on postoperative right ventricular function
    Mechthild Westhoff-Bleck
    Division of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Int J Cardiol 151:303-6. 2011
    ....
  44. doi request reprint Symmetrical dimethylarginine outperforms CKD-EPI and MDRD-derived eGFR for the assessment of renal function in patients with adult congenital heart disease
    Oktay Tutarel
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Kidney Blood Press Res 34:41-5. 2011
    ..Therefore, this study compares different markers and equations for the estimation of renal function in adults with congenital heart disease...
  45. doi request reprint Characterization of the inhibition of hepatitis C virus entry by in vitro-generated and patient-derived oxidized low-density lipoprotein
    Sandra Westhaus
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 57:1716-24. 2013
    ..Conclusion: oxLDL is a potent pangenotype HCV entry inhibitor that maintains its activity in the context of human serum and targets an early step of HCV entry...
  46. ncbi request reprint Emerging role of chemokine receptor 7 in atherosclerosis
    Bernhard Schieffer
    Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany
    Trends Cardiovasc Med 21:211-6. 2011
    ....
  47. ncbi request reprint TNFalpha decreases alphaMHC expression by a NO mediated pathway: role of E-box transcription factors for cardiomyocyte specific gene regulation
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Cardiovasc Res 53:460-9. 2002
    ..It is not clear, however, whether TNFalpha mediated NO release has sustained cardiac effects, by altering expression of cardiomyocyte specific genes such as alpha-myosin heavy chain (alphaMHC)...
  48. ncbi request reprint Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites
    Boris Schmidt
    Clemens Schöpf Institute for Organic Chemistry and Biochemistry, Technische Universitat Darmstadt, Petersenstrasse 22, Germany
    J Med Chem 46:2261-70. 2003
  49. ncbi request reprint Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 94:534-41. 2004
    ..This interaction of the proinflammatory cytokine IL-6 with the renin-angiotensin system may represent an important pathogenetic mechanism in the atherosclerotic process...
  50. ncbi request reprint Identification of a zinc finger homoeodomain enhancer protein after AT(2) receptor stimulation by differential mRNA display
    Monika Stoll
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Arterioscler Thromb Vasc Biol 22:231-7. 2002
    ..In conclusion, Zfhep not only represents a suitable marker for AT(2) receptor activation, but it may also link AT(2) signaling and downstream events involved in the proposed function of the AT(2) receptor in development and regeneration...
  51. ncbi request reprint Acetylsalicylic acid inhibits monocyte adhesion to endothelial cells by an antioxidative mechanism
    Guido Eisele
    Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg Eppendorf, Germany
    J Cardiovasc Pharmacol 43:514-21. 2004
    ..For ASA, the observed inhibition of monocyte adhesion was accomplished with concentrations that can be reached after single oral doses of 500 mg of ASA...
  52. ncbi request reprint Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury
    Denise Hilfiker-Kleiner
    Department of Cardiology, Medical School Hannover, Germany
    Circ Res 95:187-95. 2004
    ....
  53. ncbi request reprint Renin-angiotensin system and atherosclerosis
    Karsten Grote
    Nephrol Dial Transplant 19:770-3. 2004
  54. ncbi request reprint The race for ACE: a simple answer to the controversial puzzle of angiotensin-converting enzyme (ACE) polymorphisms
    Bernhard Schieffer
    J Am Coll Cardiol 41:1962-3. 2003
  55. ncbi request reprint Increased open probability of single cardiac L-type calcium channels in patients with chronic atrial fibrillation. role of phosphatase 2A
    Gunnar Klein
    Department of Cardiovascular Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Cardiovasc Res 59:37-45. 2003
    ..However, it is unclear, whether this current reduction is related to a decrease in channel number or to alterations in channel function. Hence, we performed a single LCC analysis to assess channel gating and function in human AF...
  56. ncbi request reprint Therapeutic effects of angiotensin (AT1) receptor antagonists: potential contribution of mechanisms other than AT1 receptor blockade
    Boris Schmidt
    Institute for Organic Chemistry, Technische Universitat Darmstadt, Darmstadt, Germany
    Am J Cardiovasc Drugs 4:361-8. 2004
    ....