Affiliation: Hannover Medical School
Scheper V, Paasche G, Miller J, Warnecke A, Berkingali N, Lenarz T, et al
. Effects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigs. J Neurosci Res. 2009;87:1389-99 pubmed publisher
..Additionally, animals in the GDNF/ES group showed reduced EABR thresholds. Thus, delayed treatment with GDNF and ES can protect SGC from degeneration and may improve the benefits of cochlear implants. ..
Scheper V, Wolf M, Scholl M, Kadlecova Z, Perrier T, Klok H, et al
. Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules. Nanomedicine (Lond). 2009;4:623-35 pubmed publisher
..Biocompatibility and traceability were demonstrated for HBPL and LNCs. Thus, they comply with the basic requirements for drug carriers for potential application in the inner ear. ..
Scheper V, Leifholz M, von der Leyen H, Keller M, Denkena U, Koch A, et al
. ACEMg-mediated hearing preservation in cochlear implant patients receiving different electrode lengths (PROHEARING): study protocol for a randomized controlled trial. Trials. 2016;17:394 pubmed publisher
..The German Bundesinstitut fÃ¼r Arzneimittel und Medizinprodukte (BfArM) application number 4039192, was registered on 6 December 2013 with protocol amendment version 3.0 from 19 August 2014. EudraCT number: 2012-005002-22 . ..
Schwieger J, Esser K, Lenarz T, Scheper V. Establishment of a long-term spiral ganglion neuron culture with reduced glial cell number: Effects of AraC on cell composition and neurons. J Neurosci Methods. 2016;268:106-16 pubmed publisher
..This treatment allows longer-term cultivation of SGC and provides deeper insight into SGN-glial cell interaction and the attachment of neurites on test-material surfaces. ..
Konerding W, Janssen H, Hubka P, TornÃ¸e J, Mistrik P, Wahlberg L, et al
. Encapsulated cell device approach for combined electrical stimulation and neurotrophic treatment of the deaf cochlea. Hear Res. 2017;350:110-121 pubmed publisher