Research Topics
Genomes and Genes | A SchaeferSummaryAffiliation: Hannover Medical School Country: Germany Publications
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Publications
[Transcatheter valve interventions for heart valve diseases]A Schaefer
Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl Neuberg Strase 1, Hannover, Germany
Internist (Berl) 51:1480-91. 2010..In the last decade, PPVI has evolved as an alternative treatment option with much less morbidity compared to repeated surgery...
Impact of intracoronary bone marrow cell transfer on diastolic function in patients after acute myocardial infarction: results from the BOOST trialArnd Schaefer
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Eur Heart J 27:929-35. 2006..However, the impact of BMC therapy on LV diastolic function in patients after AMI has remained uncertain...- [Surgery or medical therapy for secondary mitral regurgitation?]Arnd Schaefer
Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Herz 34:118-23. 2009.... - Effects of anesthesia on diastolic function in mice assessed by echocardiographyArnd Schaefer
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Echocardiography 22:665-70. 2005..However, the effect on diastolic function has not been investigated yet. The following study was conducted to evaluate the influence of different agents on diastolic left ventricular function in mice... - Evaluation of Tissue Doppler Tei index for global left ventricular function in mice after myocardial infarction: comparison with Pulsed Doppler Tei indexArnd Schaefer
Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
Eur J Echocardiogr 6:367-75. 2005..Thus, the aim of our study was to validate TDI and Pulsed Doppler Tei index and their reproducibility in mice after experimental anterior myocardial infarction (MI)... - Long-term effects of intracoronary bone marrow cell transfer on diastolic function in patients after acute myocardial infarction: 5-year results from the randomized-controlled BOOST trial--an echocardiographic studyArnd Schaefer
Clinic of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
Eur J Echocardiogr 11:165-71. 2010..Therefore, we conducted a 5-year follow-up of the BOOST trial to evaluate a sustained benefit on echocardiographic parameters on diastolic function... - Evaluation of left ventricular diastolic function by pulsed Doppler tissue imaging in miceArnd Schaefer
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
J Am Soc Echocardiogr 16:1144-9. 2003..Recently, Doppler tissue imaging (DTI) was introduced to evaluate diastolic function. The aim of our study was to validate DTI in the evaluation of diastolic function in mice... - Diagnostic accuracy of handheld echocardiography for evaluation of aortic stenosisArnd Schaefer
Clinic for Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Echocardiography 27:481-6. 2010..We conducted this study to evaluate a handheld ultrasound device (HCU) in patients with suspected severe aortic stenosis (AS) in comparison to a standard echocardiography device (SE)... - Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarctionCarola Doerries
Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Hannover, Germany
Circ Res 100:894-903. 2007..The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI... - Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injuryDenise Hilfiker-Kleiner
Department of Cardiology, Medical School Hannover, Germany
Circ Res 95:187-95. 2004.... - Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?Niels Engberding
Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Circulation 110:2175-9. 2004..We therefore studied the effect of long-term treatment with allopurinol, a potent XO inhibitor, on myocardial ROS production and LV remodeling and dysfunction after MI... - Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trialGerd P Meyer
Department of Cardiology, Hannover Medical School, Hannover, Germany
Circulation 113:1287-94. 2006.... - Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilonGunnar Klein
Department of Cardiovascular Medicine, Hannover Medical School, Germany
Circ Res 96:748-55. 2005.... - Physical aspects of scintigraphy-based dosimetry for nuclear medicine therapyL Geworski
Department of Radiation Protection and Medical Physics, Hannover Medical School, Hannover, 30625 Hannover, Germany
Nuklearmedizin 49:85-95. 2010..Procedural recommendations are proposed covering all processes related to data acquisition, data correction and data analysis which finally lead to reliable estimations of organ dose... - Transcatheter closure of patent foramen ovale in patients with paradoxical embolism. Procedural and follow-up results after implantation of the Starflex occluder device with conjunctive intensified anticoagulation regimenDieter Fischer
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany
J Interv Cardiol 21:183-9. 2008..The aim of the present study was to evaluate the short- and long-term results after implantation of the Starflex occluder in patients with PFO using an intensified anticoagulation regimen... - Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarctionDenise Hilfiker-Kleiner
Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
Circulation 122:145-55. 2010..By analyzing cardiomyocyte-specific gp130(Y757F) mutant mice, we investigated the effect of disturbed gp130 signaling after myocardial infarction... - Transcatheter closure of patent foramen ovale (PFO) in patients with paradoxical embolism: procedural and follow-up results after implantation of the Amplatzer®-occluder deviceDieter Fischer
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany
J Interv Cardiol 24:85-91. 2011..The aim of the present study was to evaluate the follow-up results after implantation of the Amplatzer® occluder in patients with PFO using a consistent anticoagulation regimen... - Intracoronary bone marrow cell transfer after myocardial infarction: 5-year follow-up from the randomized-controlled BOOST trialGerd P Meyer
Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Eur Heart J 30:2978-84. 2009..As previously reported, BMC transfer led to an improvement of LVEF by 6.0% at 6 months (P = 0.003) and 2.8% at 18 months (P = 0.27)... - A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathyDenise Hilfiker-Kleiner
Department of Cardiology and Angiology, MHH, 30625 Hannover, Germany
Cell 128:589-600. 2007..Thus, a biologically active derivative of the pregnancy hormone prolactin mediates PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM... - Critical role for p47phox in renin-angiotensin system activation and blood pressure regulationKarsten Grote
Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
Cardiovasc Res 71:596-605. 2006..Here, we investigated the role of p47phox in blood pressure control, endothelium-dependent relaxation, cardiac hypertrophy, RAS activation, and renal oxidative stress under resting conditions... - Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftmentFlorian P Limbourg
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
Eur J Heart Fail 7:722-9. 2005..However, the cell population mediating myocardial recovery and the fate of the transplanted cells are still controversial... - Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthaseUlf Landmesser
Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Circulation 110:1933-9. 2004.... - Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heartDenise Hilfiker-Kleiner
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Circulation 112:1470-7. 2005..In the present study we analyzed the role of JunD in survival, hypertrophy, and angiogenesis in the pressure-overloaded mouse heart after thoracic aortic constriction... - Transthoracic Doppler validation in mammary artery grafts after minimal invasive direct coronary artery bypass operationGerd Peter Meyer
Department of Cardiology Angiology, Hannover Medical School, Germany
J Am Soc Echocardiogr 17:954-61. 2004..This study was performed to validate noninvasive transthoracic Doppler ultrasound (TTD) with simultaneous invasive Doppler guidewire measurements in patients after minimal invasive direct coronary artery bypass operation... - Thrombus formation on an atrial septal defect closure device: a case report and review of the literatureDimitar Divchev
Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Eur J Echocardiogr 8:53-6. 2007..The 6-month follow up by transoesophageal echocardiography (TEE) revealed the floating thrombus located at the left atrial side of the occluder... - Combined aspirin and clopidogrel resistance associated with recurrent coronary stent thrombosisChristian Templin
Department Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Clin Res Cardiol 95:122-6. 2006..We conclude that identification of these patients is required and alternative therapeutic options have to be considered... - Transcoronary delivery of bone marrow cells to the infarcted murine myocardium: feasibility, cellular kinetics, and improvement in cardiac functionChristian Templin
Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
Basic Res Cardiol 101:301-10. 2006..In conclusion, BMCs delivered by transcoronary injection increase capillary density and improve LV function after MI although homing to the ischemic heart is only transient... - Inflammatory, abscess-forming foreign body reaction mimics a thrombus formation on an atrial septal defect closure device: A commented case reportDimitar Divchev
Hannover Medical School, Department of Cardiology and Angiology, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Eur J Echocardiogr 8:298-302. 2007.... - Reduced delayed rectifier K+ current, altered electrophysiology, and increased ventricular vulnerability in MLP-deficient miceAjmal Gardiwal
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
J Card Fail 13:687-93. 2007..In humans, MLP-expression is downregulated both in ischemic and dilative cardiomyopathy. In this study, we investigated the effects of MLP on the electrophysiologic phenotype in vivo and on outward potassium currents... - Mechanism of coronary artery restenosis after stenting for acute myocardial infarctionArnd Schaefer
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany
Am J Cardiol 94:1037-40. 2004..Restenosis after stenting for AMI was primarily caused by stent underexpansion, not by neointima formation... - Incidence and clinical relevance of supraventricular tachyarrhythmias in pulmonary hypertensionJoern Tongers
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Am Heart J 153:127-32. 2007..Supraventricular tachyarrhythmias (SVTs) may compromise cardiac function and threaten prognosis in patients with PH, but the incidence and clinical relevance of SVTs in PH and chronic right ventricular failure have not been evaluated... - Increased open probability of single cardiac L-type calcium channels in patients with chronic atrial fibrillation. role of phosphatase 2AGunnar Klein
Department of Cardiovascular Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Cardiovasc Res 59:37-45. 2003..However, it is unclear, whether this current reduction is related to a decrease in channel number or to alterations in channel function. Hence, we performed a single LCC analysis to assess channel gating and function in human AF... 
Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-discJoerg Heineke
Department of Cardiology, Hanover Medical School, 30625 Hanover, Germany
Proc Natl Acad Sci U S A 102:1655-60. 2005..Our study reveals a link between the stress sensor MLP and the calcineurin-NFAT pathway at the sarcomeric Z-disk in cardiomyocytes and indicates that reduced MLP-calcineurin signaling predisposes to adverse remodeling after MI...