Kerstin Reimers

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B
    Kerstin Reimers
    Klinik für Plastische, Hand und Wiederherstellungschirurgie, Podbielskistrasse 380, D 30659 Hannover, Germany
    Virology 331:260-8. 2005
  2. pmc Bundles of spider silk, braided into sutures, resist basic cyclic tests: potential use for flexor tendon repair
    Kathleen Hennecke
    Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
    PLoS ONE 8:e61100. 2013
  3. ncbi request reprint Identification of the non-specific cytotoxic cell receptor protein 1 (NCCRP1) in regenerating axolotl limbs
    Kerstin Reimers
    Department for Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, 30659 Hannover, Germany
    J Comp Physiol B 176:599-605. 2006
  4. ncbi request reprint Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family
    Kerstin Reimers
    Klinik für Plastische, Hand und Wiederherstellungschirurgie, Medizinische Hochschule Hannover, D 30659 Hannover, Germany
    Int J Mol Med 18:729-34. 2006
  5. ncbi request reprint The Bax Inhibitor-1 (BI-1) family in apoptosis and tumorigenesis
    Kerstin Reimers
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistrabe 380, D 30659 Hannover, Germany
    Curr Mol Med 8:148-56. 2008
  6. pmc The growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
    Kerstin Reimers
    Department for Plastic, Hand, Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, D 30659 Hannover, Germany
    Int J Biol Sci 3:471-6. 2007
  7. pmc Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice
    Stefanie Michael
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e57741. 2013
  8. doi request reprint First investigation of spider silk as a braided microsurgical suture
    Joern W Kuhbier
    Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biomed Mater Res B Appl Biomater 97:381-7. 2011
  9. pmc Cultivation of keratinocytes and fibroblasts in a three-dimensional bovine collagen-elastin matrix (Matriderm®) and application for full thickness wound coverage in vivo
    Jasper Killat
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover D 30659, Germany
    Int J Mol Sci 14:14460-74. 2013
  10. pmc Artificial skin--culturing of different skin cell lines for generating an artificial skin substitute on cross-weaved spider silk fibres
    Hanna Wendt
    Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
    PLoS ONE 6:e21833. 2011

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B
    Kerstin Reimers
    Klinik für Plastische, Hand und Wiederherstellungschirurgie, Podbielskistrasse 380, D 30659 Hannover, Germany
    Virology 331:260-8. 2005
    ..Furthermore, the activation of NF-kappaB depends on the C-terminus of the RSV M2-1 protein, as shown by NF-kappaB-induced gene expression of a reporter gene construct...
  2. pmc Bundles of spider silk, braided into sutures, resist basic cyclic tests: potential use for flexor tendon repair
    Kathleen Hennecke
    Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
    PLoS ONE 8:e61100. 2013
    ..These results suggest that braided spider silk could be suitable for use as sutures in flexor tendon repair, providing similar tensile behaviour and improved fatigue properties compared with conventional suture materials...
  3. ncbi request reprint Identification of the non-specific cytotoxic cell receptor protein 1 (NCCRP1) in regenerating axolotl limbs
    Kerstin Reimers
    Department for Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, 30659 Hannover, Germany
    J Comp Physiol B 176:599-605. 2006
    ..Our findings suggest the existence of NCC in axolotl and a role of the innate immune system in the processes of limb regeneration...
  4. ncbi request reprint Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family
    Kerstin Reimers
    Klinik für Plastische, Hand und Wiederherstellungschirurgie, Medizinische Hochschule Hannover, D 30659 Hannover, Germany
    Int J Mol Med 18:729-34. 2006
    ..Concordantly, it was shown that Bax co-immunoprecipitates with LFG. Our results indicate that LFG belongs to a new cytoprotective family with evolutionarily conserved functions in the prevention of programmed cell death...
  5. ncbi request reprint The Bax Inhibitor-1 (BI-1) family in apoptosis and tumorigenesis
    Kerstin Reimers
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistrabe 380, D 30659 Hannover, Germany
    Curr Mol Med 8:148-56. 2008
    ..The potent cell death suppression makes this protein family an interesting target for the development of new drugs and gene therapeutic approaches for diseases caused by apoptotic dysregulation, such as cancer...
  6. pmc The growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
    Kerstin Reimers
    Department for Plastic, Hand, Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, D 30659 Hannover, Germany
    Int J Biol Sci 3:471-6. 2007
    ..Here we characterise Ghitm in a first analysis regarding its phylogeny, expression in cancer cell lines, and proteomical properties...
  7. pmc Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice
    Stefanie Michael
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e57741. 2013
    ..These findings represent the prerequisite for the creation of a complex tissue like skin, consisting of different cell types in an intricate 3D pattern...
  8. doi request reprint First investigation of spider silk as a braided microsurgical suture
    Joern W Kuhbier
    Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biomed Mater Res B Appl Biomater 97:381-7. 2011
    ..With regards to the mechanical properties, these sutures were superior to nylon sutures. As spider silk displays high biocompatibility in nerve regeneration, its usage in microsurgical nerve repair should be considered...
  9. pmc Cultivation of keratinocytes and fibroblasts in a three-dimensional bovine collagen-elastin matrix (Matriderm®) and application for full thickness wound coverage in vivo
    Jasper Killat
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover D 30659, Germany
    Int J Mol Sci 14:14460-74. 2013
    ..Based on this study, future investigations are planned to examine behaviour of epidermal stem cells injected into a collagen-elastin matrix under the aspects of establishment of stem cell niches and differentiation. ..
  10. pmc Artificial skin--culturing of different skin cell lines for generating an artificial skin substitute on cross-weaved spider silk fibres
    Hanna Wendt
    Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
    PLoS ONE 6:e21833. 2011
    ..Additionally, it should degrade in an appropriate time period without releasing harmful substances, but not exert a pathological immune response. Spider dragline silk from Nephila spp meets these demands to a large extent...
  11. doi request reprint AmbLOXe--an epidermal lipoxygenase of the Mexican axolotl in the context of amphibian regeneration and its impact on human wound closure in vitro
    Bjoern Menger
    Department of Plastic, Hand, and Reconstructive Surgery, Replantation and Burn Center of Lower Saxony, Laboratory of Experimental Plastic Surgery, Hannover Medical School, Hannover, Germany
    Ann Surg 253:410-8. 2011
    ..In this study we identified an amphibian lipoxygenase and evaluated its impact on human cells in an in vitro wound model...
  12. pmc Interactions between spider silk and cells--NIH/3T3 fibroblasts seeded on miniature weaving frames
    Joern W Kuhbier
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    PLoS ONE 5:e12032. 2010
    ..Not only does it own unique mechanical properties, its biocompatibility has been shown already in vivo. In our study, we used native spider dragline silk which is known as the strongest fibre in nature...
  13. ncbi request reprint Biomechanics and biocompatibility of woven spider silk meshes during remodeling in a rodent fascia replacement model
    Franziska Schäfer-Nolte
    From the Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Hannover, Germany Dr Mirastschijski is now with Department of Plastic, Reconstructive and Aesthetic Surgery, Klinikum Bremen Mitte, University of Gottingen, Bremen Germany
    Ann Surg 259:781-92. 2014
    ..The aim of this study was to investigate biomechanical and immunogenic properties of spider silk meshes implanted as fascia replacement in a rat in vivo model...
  14. pmc Induction of osteogenic differentiation of adipose derived stem cells by microstructured nitinol actuator-mediated mechanical stress
    Sarah Straus
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e51264. 2012
    ..By use of an innovative implant design and synthesis via SLM-technique we achieved high rates of vital cells, proper osteogenic differentiation and mechanically loadable NiTi-scaffolds could be achieved...
  15. doi request reprint Skin tissue generation by laser cell printing
    Lothar Koch
    Department of Nanotechnology, Laser Zentrum Hannover e V, Hannover, Germany
    Biotechnol Bioeng 109:1855-63. 2012
    ..These findings are promising for the realisation of 3D in vitro models and tissue substitutes for many applications in tissue engineering...
  16. pmc Adhesion, vitality and osteogenic differentiation capacity of adipose derived stem cells seeded on nitinol nanoparticle coatings
    Sarah Strauss
    Department for Plastic Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e53309. 2013
    ..Nitinol-nanoparticle coatings offer new possibilities in implantology research regarding bioactivation by autologous ASCs, respectively enhancement of surface attraction to cells...
  17. doi request reprint The nonhematopoietic effects of erythropoietin in skin regeneration and repair: from basic research to clinical use
    Heiko Sorg
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, 30625, Hannover, Germany
    Med Res Rev 33:637-64. 2013
    ....
  18. pmc Spider silk constructs enhance axonal regeneration and remyelination in long nerve defects in sheep
    Christine Radtke
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e16990. 2011
    ..We describe the use of nerve constructs consisting of decellularized vein grafts filled with spider silk fibers as a guiding material to bridge a 6.0 cm tibial nerve defect in adult sheep...
  19. doi request reprint Transactivation of lifeguard (LFG) by Akt-/LEF-1 pathway in MCF-7 and MDA-MB 231 human breast cancer cells
    Vesna Bucan
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, 30659, Hannover, Germany
    Apoptosis 15:814-21. 2010
    ..Our results therefore identify LFG as a target of the Akt/LEF-1 pathway in MDA-MB-231 breast tumour cells, a regulation which could play a key role in breast tumour progression...
  20. doi request reprint The anti-apoptotic protein lifeguard is expressed in breast cancer cells and tissues
    Vesna Bucan
    Department of Plastic, Hand and Reconstructive Surgery, Medical School of Hannover, Germany
    Cell Mol Biol Lett 15:296-310. 2010
    ..Moreover, the overexpression of LFG correlated with tumour grade and reduced Fas sensitivity. Our findings support the idea that LFG may have a role in the downregulation of apoptosis in breast cancer cells...
  21. ncbi request reprint Inhibition of apoptosis by expression of antiapoptotic proteins in recombinant human keratinocytes
    Claudia Y U Choi
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, D 30625 Hannover, Germany
    Cell Transplant 16:663-74. 2007
    ..66), Faim (p = 0.42), or LFG (p = 0.44) expressing cells. Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection...
  22. doi request reprint LEF-1 regulates proliferation and MMP-7 transcription in breast cancer cells
    Vesna Bucan
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistraße 380, Hannover, D 30659, Germany
    Genes Cells 17:559-67. 2012
    ..Taken together, our results indicate a pivotal role of LEF-1 in the regulation of proliferation and MMP-7 transcription in breast cancer cells...
  23. doi request reprint The yeast two hybrid system in a screen for proteins interacting with axolotl (Ambystoma mexicanum) Msx1 during early limb regeneration
    Mehtap Abuqarn
    Departmen tof Plastic, Hand and Reconstructive Surgery, Medical School of Hannover, Podbielskistrasse 380, D 30659 Hannover, Germany
    Biochim Biophys Acta 1814:843-9. 2011
    ..It is the first time, that the yeast two hybrid system was adapted to the axolotl animal model and successfully used in a screen for proteins interacting with Msx1 in the context of amphibian limb regeneration...
  24. doi request reprint Apoptosis in extracorporeal preserved inguinal fat flaps of the rat
    Christian Herold
    Department of Plastic, Hand and Reconstructive Surgery, Hanover Medical School, Germany
    Apoptosis 17:400-9. 2012
    ..Based on these findings, further research to modify the apoptotic pathways to ameliorate viability of fat tissue can be performed...
  25. doi request reprint The mouse dorsal skin fold chamber as a means for the analysis of tissue engineered skin
    Stefanie Michael
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    Burns 39:82-8. 2013
    ..Besides epithelialization the mode and extend of neovascularization and contraction of artificial grafts may be studied under standardized conditions...
  26. doi request reprint Applying amphibian limb regeneration to human wound healing: a review
    Bjoern Menger
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
    Ann Plast Surg 65:504-10. 2010
    ....
  27. ncbi request reprint Percutaneous collagen induction therapy: an alternative treatment for burn scars
    Matthias C Aust
    Department for Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl Neubergstr 1, 30625 Hannover, Germany
    Burns 36:836-43. 2010
    ..This study aims to evaluate percutaneous collagen induction (PCI) in post-burn scarring...
  28. ncbi request reprint Isolation, characterization, differentiation, and application of adipose-derived stem cells
    Jörn W Kuhbier
    Department of Plastic, Hand and Reconstructive Surgery, Podbielskistrasse 380, 30659, Hannover, Germany
    Adv Biochem Eng Biotechnol 123:55-105. 2010
    ....
  29. doi request reprint Paracrine loop of keratinocyte proliferation and directed neuritic outgrowth in a neuroepithelial coculture
    Christine Radtke
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    Ann Plast Surg 70:162-7. 2013
    ..These findings support the hypothesis that nerve-skin interactions play a significant role in wound healing...
  30. pmc A differential pressure laminar flow reactor supports osteogenic differentiation and extracellular matrix formation from adipose mesenchymal stem cells in a macroporous ceramic scaffold
    Birgit Weyand
    Laboratory of Experimental Plastic and Reconstructive Surgery, Department of Plastic and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    Biores Open Access 1:145-56. 2012
    ..We postulate that our system is suitable for studying fluid shear stress effects on stem cell proliferation and differentiation toward bone formation in tissue-engineered 3D constructs...
  31. doi request reprint Resection of a large intra-abdominal tumor in the Mexican axolotl: a case report
    Bjoern Menger
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    Vet Surg 39:232-3. 2010
    ..This case report describes the surgical removal of an intra-abdominal tumor from a Mexican axolotl (Ambystoma mexicanum). The animal was admitted with left abdominal swelling that had increased over 4 months...
  32. pmc Intravenous transplantation of mesenchymal stromal cells to enhance peripheral nerve regeneration
    Stella M Matthes
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, 30659 Hannover, Germany
    Biomed Res Int 2013:573169. 2013
    ..The results of study suggest that nerve repair with cell transplantation could lead to greater functional outcome. ..
  33. doi request reprint Attack the tumor counterattack-c-FLIP expression in Jurkat-T-cells protects against apoptosis induced by coculture with SW620 colorectal adenocarcinoma cells
    Andreas E Steiert
    Department of Plastic, Hand, and Reconstructive Surgery, Sarcoma Center Saxony, Germany
    J Surg Res 176:133-40. 2012
    ..To overcome this tumor-cell survival strategy, we examined the hypothesis that the sensitivity of FAS mediated apoptosis of Jurkat-T-cells can be suppressed by FLIP transfection of Jurkat-T-cells...
  34. doi request reprint Transplantation of olfactory ensheathing cells as adjunct cell therapy for peripheral nerve injury
    Christine Radtke
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    Cell Transplant 20:145-52. 2011
    ..In the present review, we summarize recent experimental evidence regarding the regenerative effects of OECs applied to the peripheral nervous system that may be relevant to design novel autologous cell transplantation therapies...
  35. ncbi request reprint Mesenchymal stem cells maintain long-term in vitro stemness during explant culture
    Anna Otte
    1 Biochemistry and Tumor Biology Lab, Gynecology Research Unit, Department of Obstetrics and Gynecology, Medical University Hannover, Hannover, Germany
    Tissue Eng Part C Methods 19:937-48. 2013
    ....
  36. doi request reprint Validation of differential gene expression in muscle engineered from rat groin adipose tissue by quantitative real-time PCR
    Yang An
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Podbielskistr 380, 30659 Hannover, Germany
    Biochem Biophys Res Commun 421:736-42. 2012
    ..The use of β-2-microglobulin, RPL32 and RPL17 as internal standards may improve the accuracy of gene expression studies aimed at muscle tissue engineering under the proposed settings...
  37. pmc Schwann cell metabolic activity in various short-term holding conditions: implications for improved nerve graft viability
    Insa Janssen
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, 30625 Hannover, Germany
    Int J Otolaryngol 2012:742183. 2012
    ..Greater SC viability at the time of surgical nerve grafting could contribute to improved axonal regeneration and remyelination after nerve transplantation, and thus more successful functional recovery...
  38. doi request reprint Percutaneous collagen induction: minimally invasive skin rejuvenation without risk of hyperpigmentation-fact or fiction?
    Mathias C Aust
    Klinik für Plastische, Hand und Wiederherstellungschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
    Plast Reconstr Surg 122:1553-63. 2008
    ..It was recently shown in clinical trials that percutaneous collagen induction therapy is an alternative for safely treating wrinkles and scars and for smoothening the skin without the risk of dyspigmentation...
  39. doi request reprint Laser printing of skin cells and human stem cells
    Lothar Koch
    Department of Nanotechnology, Laser Zentrum Hannover e V, Hannover, Germany
    Tissue Eng Part C Methods 16:847-54. 2010
    ..This study demonstrates LIFT as a suitable technique for unharmed computer-controlled positioning of different cell types and a promising tool for future applications in the ex vivo generation of tissue replacements...
  40. doi request reprint Covalent vectored binding of functional proteins by bifunctional crosslinking at silicone interfaces
    Andreas Steiert
    Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    J Biomed Mater Res A 100:1248-55. 2012
    ..In summary, our crosslinking procedure enables the stable binding of proteins without the loss of biological function. Through this process, silicones could be endowed with new functions which could improve their biocompatibility...
  41. ncbi request reprint Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduit
    Christina Allmeling
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistr 380, D 30659 Hannover, Germany
    J Cell Mol Med 10:770-7. 2006
    ..In conclusion, our results show that artificial nerve grafts can be constructed successfully from spider silk, acellularized veins and SC mixed with matrigel...
  42. ncbi request reprint Influence of transendothelial mechanisms on microcirculation: consequences for reperfusion injury after free flap transfer. Previous, current, and future aspects
    Andreas Jokuszies
    Department of Plastic and Reconstructive Surgery, Medical School Hannover, Germany
    J Reconstr Microsurg 22:513-8. 2006
    ..Finally, future diagnostic and therapeutical aspects are discussed...
  43. ncbi request reprint Burn-induced organ dysfunction: vagus nerve stimulation attenuates organ and serum cytokine levels
    Andreas D Niederbichler
    Department of Plastic, Hand and Reconstructive Surgery, Burn Center, Medizinische Hochschule Hannover, Germany
    Burns 35:783-9. 2009
    ..Burn induces abacterial cytokine generation and we sought to evaluate whether parasympathetic stimulation after experimental burn decreases cardiodepressive mediator generation...
  44. ncbi request reprint FGF3 attached to a phosholipid membrane anchor gains a high transforming capacity. Implications of microdomains for FGF3 cell transformation
    Roman Köhl
    Heinrich Heine Universitat, Medizinische Fakultat, Institut für Hämostaseologie und Transfusionsmedizin, Moorenstrabetae 5, D Düsseldorf, Germany
    J Biol Chem 277:32760-7. 2002
    ....
  45. ncbi request reprint Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2
    Marianne Antoine
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen, Germany
    Biochem Biophys Res Commun 338:1248-55. 2005
    ..Transient co-expression of rpS2 and nuclear FGF3 resulted in a reduced nucleolar localization of the FGF. These findings suggest that the nuclear form of FGF3 inhibits cell proliferation by interfering with ribosomal biogenesis...