S Petri

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra
    Susanne Petri
    Hannover Medical School, Department of Neurology, D 30623 Hannover, Germany
    J Comp Neurol 452:360-6. 2002
  2. pmc Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia
    Hui Sun
    Department of Neurology, Hannover Medical School, Hannover, Germany Center for Systems Neuroscience, Hannover, Germany
    PLoS ONE 8:e72926. 2013
  3. pmc Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS
    Susanne Petri
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Neurol Res Int 2012:878030. 2012
  4. pmc Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options
    Sonja Körner
    Department of Neurology, Hannover Medical School, Carl Neuberg Str, 1, Hannover 30625, Germany
    BMC Neurol 13:84. 2013
  5. doi request reprint Botulinum toxin as preventive treatment for migraine: a randomized double-blind study
    Susanne Petri
    Department of Neurology, Medizinische Hochschule, Hannover, Germany
    Eur Neurol 62:204-11. 2009
  6. ncbi request reprint The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis
    Susanne Petri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York, USA
    J Neurochem 102:991-1000. 2007
  7. ncbi request reprint Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice
    Susanne Petri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA
    J Neurol Sci 251:44-9. 2006
  8. ncbi request reprint GABA(A)-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    J Neurol Sci 250:124-32. 2006
  9. ncbi request reprint Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis
    Susanne Petri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    J Neurochem 98:1141-8. 2006
  10. doi request reprint Preserved expression of fibroblast growth factor (FGF)-2 and FGF receptor 1 in brain and spinal cord of amyotrophic lateral sclerosis patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    Histochem Cell Biol 131:509-19. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra
    Susanne Petri
    Hannover Medical School, Department of Neurology, D 30623 Hannover, Germany
    J Comp Neurol 452:360-6. 2002
    ..This might represent a negative feedback loop between the striatum and the SNc and be a target of pharmacologic interventions in neurodegenerative diseases such as Parkinson's disease...
  2. pmc Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia
    Hui Sun
    Department of Neurology, Hannover Medical School, Hannover, Germany Center for Systems Neuroscience, Hannover, Germany
    PLoS ONE 8:e72926. 2013
    ..Our data demonstrate that MSC modulate motor neuronal and glial response to apoptosis and inflammation. MSC therefore represent an interesting candidate for further preclinical and clinical evaluation in ALS. ..
  3. pmc Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS
    Susanne Petri
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Neurol Res Int 2012:878030. 2012
    ....
  4. pmc Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options
    Sonja Körner
    Department of Neurology, Hannover Medical School, Carl Neuberg Str, 1, Hannover 30625, Germany
    BMC Neurol 13:84. 2013
    ..In this study we investigated possible causes of weight loss in ALS, its impact on mood/quality of life (QOL) and the benefit of high calorie nutritional/other dietary supplements and percutaneous endoscopic gastrostomy (PEG)...
  5. doi request reprint Botulinum toxin as preventive treatment for migraine: a randomized double-blind study
    Susanne Petri
    Department of Neurology, Medizinische Hochschule, Hannover, Germany
    Eur Neurol 62:204-11. 2009
    ..To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines...
  6. ncbi request reprint The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis
    Susanne Petri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York, USA
    J Neurochem 102:991-1000. 2007
    ..In line with previous studies using metal chelators in the G93A animal model, our results suggest that these compounds have neuroprotective capacities in ALS...
  7. ncbi request reprint Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice
    Susanne Petri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA
    J Neurol Sci 251:44-9. 2006
    ..These results indicate that motor neuron apoptosis triggered by Fas is relevant in ALS pathogenesis...
  8. ncbi request reprint GABA(A)-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    J Neurol Sci 250:124-32. 2006
    ..In the occipital and cerebellar cortex, we did not see disease-specific differences of the mRNA expression of the investigated subunits...
  9. ncbi request reprint Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis
    Susanne Petri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    J Neurochem 98:1141-8. 2006
    ..This further enhances the concept that pharmacological modification of oxidative stress is a therapeutic option for the treatment of ALS...
  10. doi request reprint Preserved expression of fibroblast growth factor (FGF)-2 and FGF receptor 1 in brain and spinal cord of amyotrophic lateral sclerosis patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    Histochem Cell Biol 131:509-19. 2009
    ..The distribution of cells expressing FGF-2 and FGFR1 transcripts showed no differences between ALS and controls. Our data suggest that FGF-2 and FGFR1 expression is preserved in the motor system in end stage ALS...
  11. doi request reprint [Motor neuron diseases]
    S Petri
    Klinik für Neurologie OE 7210, Medizinische Hochschule Hannover, Hannover
    Nervenarzt 82:697-706. 2011
    ....
  12. ncbi request reprint The mRNA expression of AMPA type glutamate receptors in the primary motor cortex of patients with amyotrophic lateral sclerosis: an in situ hybridization study
    Susanne Petri
    Department of Neurology, Hannover Medical School, D 30623 Hannover, Germany
    Neurosci Lett 360:170-4. 2004
    ..Using in situ hybridization histochemistry we did not detect any significant differences in the distribution of AMPA receptor mRNA in the motor cortex of ALS patients compared to controls...
  13. ncbi request reprint Distribution of GABAA receptor mRNA in the motor cortex of ALS patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    J Neuropathol Exp Neurol 62:1041-51. 2003
    ..This may indicate specific alterations of the GABAA receptor subunit composition and result in distinct physiological and pharmacological properties of these receptors in ALS patients...
  14. ncbi request reprint The cellular mRNA expression of GABA and glutamate receptors in spinal motor neurons of SOD1 mice
    S Petri
    Department of Neurology, Medizinische Hochschule Hannover, D 30623, Hannover, Germany
    J Neurol Sci 238:25-30. 2005
    ..e. around 140 days) (n=5, respectively). We detected a slight but statistically significant decrease of the AMPA receptor subunits GluR3 and GluR4 only in end stage disease animals...
  15. ncbi request reprint Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis
    Mahmoud Kiaei
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA
    Neurodegener Dis 2:246-54. 2005
    ..Celastrol has been widely used in treating inflammatory diseases in man, and is well tolerated; therefore, it may be a promising therapeutic candidate for the treatment of human ALS...
  16. ncbi request reprint Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis
    Susanne Petri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Neurobiol Dis 22:40-9. 2006
    ....
  17. doi request reprint Prevalence and prognostic impact of comorbidities in amyotrophic lateral sclerosis
    S Körner
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Eur J Neurol 20:647-54. 2013
    ..In this study, we aimed to determine the prevalence of different cardiovascular, metabolic, and neuropsychiatric comorbidities in a large ALS cohort and to evaluate their influence on the disease course...
  18. pmc Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis
    Arie Neymotin
    Department of Neurology, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA
    Exp Neurol 220:191-7. 2009
    ..These data encourage further clinical evaluation of lenalidomide as therapeutic strategy to block or slow disease progression in human ALS patients...
  19. ncbi request reprint Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis
    Mahmoud Kiaei
    Department of Neurology and Neuroscience, Weill Medical College, Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    J Neurosci 26:2467-73. 2006
    ..Both compounds also reduced interleukin (IL)-12p40, IL-1alpha, and IL-1beta and increased IL-RA and TGF-beta1 mRNA. Therefore, both thalidomide and lenalidomide bear promise as therapeutic interventions for the treatment of ALS...
  20. doi request reprint Modulation of synaptic transmission and analysis of neuroprotective effects of valproic Acid and derivates in rat embryonic motoneurons
    D Ragancokova
    Department of Neurology and Clinical Neurophysiology, Hannover Medical School, OE 7210, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Cell Mol Neurobiol 30:891-900. 2010
    ..Patch-clamp experiments revealed an antiexcitotoxic effect of the S-PE-4-yn enantiomer that reduces the frequency of postsynaptic currents and enhances the inhibitory postsynaptic transmission dependent on the co-culture condition...
  21. doi request reprint Anterior cysts of the spine: a difficult differential diagnosis to amyotrophic lateral sclerosis
    S Schmalbach
    Dept of Neurology and Clinical Neurophysiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Neurol 255:1662-9. 2008
    ..This report intends to highlight this rare and difficult differential diagnosis of ALS and underlines the value of the revised El Escorial criteria in conjunction with electrophysiology to asses the certainty of the diagnosis ALS...
  22. ncbi request reprint Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis
    Claas Janssen
    From the Department of Neurology, Hannover Medical School CJ, SS, SB, As, Rd, SP and Center for Systems Neuroscience RD, SP, Hannover, Germany
    J Neuropathol Exp Neurol 69:573-81. 2010
    ..A more precise knowledge of the disease-related expression pattern could lead to the development of more specific pharmacotherapeutic approaches...
  23. ncbi request reprint Histone deacetylation and motor neuron degeneration
    S Schmalbach
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    CNS Neurol Disord Drug Targets 9:279-84. 2010
    ..A major limitation, however, lies in the broad spectrum of action of currently available HDAC inhibitors causing a variety of toxic side effects...
  24. ncbi request reprint Analysis of neuroprotective effects of valproic acid on primary motor neurons in monoculture or co-cultures with astrocytes or Schwann cells
    D Ragancokova
    Department of Neurology and Clinical Neurophysiology, Hannover Medical School, OE 7210, 30625 Hannover, Germany
    Cell Mol Neurobiol 29:1037-43. 2009
    ..The neuroprotective effect of VPA on primary embryonic motor neuron cultures was not proven. A functional interaction between VPA and KA occurred during the first 10 days in culture...
  25. doi request reprint [Amyotrophic lateral sclerosis. Current clinical trials and underlying pathomechanisms]
    K Kollewe
    Neurologische Klinik mit Klinischer Neurophysiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Nervenarzt 79:653-61. 2008
    ..This review summarizes the current state of clinical studies in ALS patients in the context of underlying therapeutic mechanisms...
  26. ncbi request reprint Ligand-gated channels in early mesencephalic neuronal precursors: immunocytochemical and electrophysiological analysis
    F Schlesinger
    Department of Neurology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Eur J Neurosci 19:2371-6. 2004
    ..Summarizing the results, in the present study it was shown for the first time that neuronal embryonic precursors of the rat VM express both functional AMPA-type glutamate and functional GABA(A) receptor channels in vitro...
  27. doi request reprint Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis
    Sonja Körner
    Department of Neurology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Muscle Nerve 43:636-42. 2011
    ..There is ongoing discussion as to whether ALS is primarily a disease of UMNs or LMNs...
  28. doi request reprint Patterns of cortical activity differ in ALS patients with limb and/or bulbar involvement depending on motor tasks
    Katja Kollewe
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Hannover, Germany
    J Neurol 258:804-10. 2011
    ..Thus, two different patterns of cortical activation changes suggesting fundamental differences in the neurodegenerative process and subsequent reorganisation processes exist for limb and bulbar movements...
  29. ncbi request reprint Selective and nonselective benzodiazepine agonists have different effects on motor cortex excitability
    Bahram Mohammadi
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Muscle Nerve 33:778-84. 2006
    ..This selective modulation of the CSP and the LICI points to a specific role of BZ1 receptors in the control of inhibitory neuronal loops within the primary motor cortex...
  30. ncbi request reprint Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS)
    Sarah Knippenberg
    Hannover Medical School, Department of Neurology, Carl Neuberg Str 1, 30625, Hannover, Germany
    Behav Brain Res 213:82-7. 2010
    ..For preclinical testing of novel drug treatments rotarod and footprint analysis for step length therefore seem to be the most effective methods to detect symptom onset and potential treatment induced improvements...
  31. ncbi request reprint Amyotrophic lateral sclerosis (ALS) and mirror movements in a patient with polymicrogyria
    Klaus Krampfl
    Department of Neurology, Medizinische Hochschule, Hannover, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:266-9. 2003
    ..The corpus callosum was completely developed and of normal size. We hypothesize an enrolment of the dysplastic right frontal lobe pathophysiology of the observed mirror movements...
  32. ncbi request reprint Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice
    Maria Damiano
    The Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, USA
    J Neurochem 96:1349-61. 2006
    ..Thus, mitochondrial dysfunction and Ca2+-mediated excitotoxicity are likely to be interconnected mechanisms that contribute to neuronal degeneration in familial amyotrophic lateral sclerosis...
  33. ncbi request reprint Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis
    Mahmoud Kiaei
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    J Neurochem 93:403-11. 2005
    ..These results suggest that cPLA2 plays an important role in supplying arachidonic acid to the COX-2 driven inflammatory pathway in ALS associated with SOD1 mutations...
  34. doi request reprint Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis
    Alexander Sarlette
    Department of Neurology Neuroanatomy, and Institute for Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    J Neuropathol Exp Neurol 67:1055-62. 2008
    ..These results suggest that alterations in this signaling cascade occur in motor neurons in ALS and that they may contribute to chronic motor neuron degeneration...
  35. doi request reprint ALSFRS-R score and its ratio: a useful predictor for ALS-progression
    Katja Kollewe
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Neurol Sci 275:69-73. 2008
    ..We conclude that the ratio of ALSFRS-R score within 100 days is a useful parameter for clinical trials and daily clinical work in a tertiary ALS-clinic...
  36. ncbi request reprint [Cerebellar symptoms in motor neuron diseases. Special form of amyotrophic lateral sclerosis plus syndrome]
    N Schimke
    Neurologische Klinik, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30623 Hannover
    Nervenarzt 73:751-3. 2002
    ..According to the revised El Escorial criteria, the described unusual combination of upper and lower motor neuron signs in association with cerebellar ataxia can be classified as a specific form of ALS-plus syndromes...
  37. doi request reprint Guidelines for preclinical animal research in ALS/MND: A consensus meeting
    Albert C Ludolph
    Department of Neurology, University of Ulm, Germany
    Amyotroph Lateral Scler 11:38-45. 2010
    ..A second international conference to improve the guidelines was held in 2009. These second and improved guidelines are dedicated to the memory of Sean F. Scott...