Detlef Neumann

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation
    Silke Beermann
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e30285. 2012
  2. ncbi request reprint The dual H3/4R antagonist thioperamide does not fully mimic the effects of the 'standard' H4R antagonist JNJ 7777120 in experimental murine asthma
    Detlef Neumann
    Institute of Pharmacology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:983-90. 2013
  3. ncbi request reprint Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation
    Detlef Neumann
    Deptartment of Pharmacology, Hannover Medical School, Hannover, Germany
    J Leukoc Biol 84:807-13. 2008
  4. ncbi request reprint Development of biologicals for the therapy of lupus erythematosus
    Detlef Neumann
    Hannover Medical School, Department for Pharmacology OE5320, 30625 Hannover, Germany
    Expert Rev Vaccines 6:1001-11. 2007
  5. ncbi request reprint The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4
    Detlef Neumann
    Department for Pharmacology, Hannover Medical School, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Biochem Biophys Res Commun 354:1089-94. 2007
  6. ncbi request reprint Injection of IL-12- and IL-18-encoding plasmids ameliorates the autoimmune pathology of MRL/Mp-Tnfrsf6lpr mice: synergistic effect on autoimmune symptoms
    Detlef Neumann
    Department of Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Int Immunol 18:1779-87. 2006
  7. doi request reprint Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma?
    Detlef Neumann
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    Pharmacology 85:217-23. 2010
  8. ncbi request reprint Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
    Christian Kollewe
    Department of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    J Biol Chem 279:5227-36. 2004
  9. doi request reprint Impact of boostering for the strength of asthma parameters and dendritic cell numbers in a C57BL/6 model of allergic airway inflammation
    Christina Hartwig
    Functional and Applied Anatomy, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Exp Toxicol Pathol 60:425-34. 2008
  10. doi request reprint Endogenous IL-18 in experimentally induced asthma affects cytokine serum levels but is irrelevant for clinical symptoms
    Christina Hartwig
    Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Cytokine 42:298-305. 2008

Collaborators

Detail Information

Publications33

  1. pmc Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation
    Silke Beermann
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e30285. 2012
    ..In the present study, we analyzed the effect of combined antagonism at the histamine H(1) and H(4) receptors in a murine asthma model in relation to the timing of their application, i.e. sensitization or provocation...
  2. ncbi request reprint The dual H3/4R antagonist thioperamide does not fully mimic the effects of the 'standard' H4R antagonist JNJ 7777120 in experimental murine asthma
    Detlef Neumann
    Institute of Pharmacology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:983-90. 2013
    ..Thus, whether these effects of JNJ 7777120 are entirely attributable to an antagonistic activity at the murine H4R or whether an agonistic activity is also involved has to be reconsidered. ..
  3. ncbi request reprint Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation
    Detlef Neumann
    Deptartment of Pharmacology, Hannover Medical School, Hannover, Germany
    J Leukoc Biol 84:807-13. 2008
    ..Thereby, it ensures the transient manner of interactions between IRAK-1 and the other signaling molecules. This essential role, however, is not regulated by phosphorylation of T66 itself...
  4. ncbi request reprint Development of biologicals for the therapy of lupus erythematosus
    Detlef Neumann
    Hannover Medical School, Department for Pharmacology OE5320, 30625 Hannover, Germany
    Expert Rev Vaccines 6:1001-11. 2007
    ....
  5. ncbi request reprint The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4
    Detlef Neumann
    Department for Pharmacology, Hannover Medical School, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Biochem Biophys Res Commun 354:1089-94. 2007
    ..Finally, mutation of IRAK-1 at T66 not only allowed stable binding to the signaling adapters, but also enhanced its signaling capacity...
  6. ncbi request reprint Injection of IL-12- and IL-18-encoding plasmids ameliorates the autoimmune pathology of MRL/Mp-Tnfrsf6lpr mice: synergistic effect on autoimmune symptoms
    Detlef Neumann
    Department of Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Int Immunol 18:1779-87. 2006
    ....
  7. doi request reprint Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma?
    Detlef Neumann
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    Pharmacology 85:217-23. 2010
    ..Therefore, the present review critically analyzes available data on the role of the H4 receptor in the murine bronchial asthma model...
  8. ncbi request reprint Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
    Christian Kollewe
    Department of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    J Biol Chem 279:5227-36. 2004
    ..Thus, IRAK-1 regulates its own availability as an adapter molecule by sequential autophosphorylation...
  9. doi request reprint Impact of boostering for the strength of asthma parameters and dendritic cell numbers in a C57BL/6 model of allergic airway inflammation
    Christina Hartwig
    Functional and Applied Anatomy, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Exp Toxicol Pathol 60:425-34. 2008
    ..We aimed to assess the requirement of boostering needed in the BL/6 murine asthma model and its influence on DC populations in lungs and bronchial lymph nodes...
  10. doi request reprint Endogenous IL-18 in experimentally induced asthma affects cytokine serum levels but is irrelevant for clinical symptoms
    Christina Hartwig
    Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Cytokine 42:298-305. 2008
    ..Thus, in contrast to conflicting data in the literature IL-18 did not suppress or enhance the pulmonary allergic immune response in a murine experimental model of asthma...
  11. doi request reprint Evidence for ligand-specific conformations of the histamine H(2)-receptor in human eosinophils and neutrophils
    Till M Reher
    Institute of Pharmacology, Hannover Medical School, D 30625 Hannover, Germany
    Biochem Pharmacol 84:1174-85. 2012
    ..Thus, our data provide evidence for the notion that the concept of ligand-specific receptor conformations can be extended from recombinant systems to native cells...
  12. ncbi request reprint Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation
    Thomas Tschernig
    Department of Functional and Applied Anatomy, Medical School of Hannover, Hannover, Germany
    Exp Toxicol Pathol 58:419-25. 2007
    ..Thus, our findings identify infiltrating leukocytes as a prominent source of anaphylatoxin receptors in inflamed lungs. A direct involvement of parenchymal cells in anaphylatoxin-mediated pulmonary inflammation is unlikely...
  13. pmc Molecular and cellular analysis of human histamine receptor subtypes
    Roland Seifert
    Institute of Pharmacology, Medical School of Hannover, Hannover, Germany
    Trends Pharmacol Sci 34:33-58. 2013
    ..Rather, multiple systems and parameters have to be studied. Although such studies are time-consuming and expensive, ultimately, they will increase drug safety and efficacy...
  14. ncbi request reprint Experimental bronchial asthma - the strength of the species rat
    Thomas Tschernig
    Institute of Functional and Applied Anatomy, Medical School of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Curr Drug Targets 9:466-9. 2008
    ....
  15. doi request reprint Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity
    Roland Seifert
    Institute of Pharmacology, Medical School of Hannover, Hannover, Germany
    Mol Pharmacol 79:631-8. 2011
    ..We discuss future directions to get out of the current dilemma in which there is no "standard" H(4)R antagonist available to the scientific community...
  16. doi request reprint Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c
    Anna Sophie Zimmermann
    Institute of Pharmacology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Inflamm Res 60:1153-9. 2011
    ..However, a systematic quantification of histamine and its metabolite N-methylhistamine in mouse organs has not been reported so far...
  17. ncbi request reprint Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor
    Karl Friedrich Deml
    Department of Pharmacology, School of Pharmacy, University of Regensburg, Regensburg, Germany
    Mol Pharmacol 76:1019-30. 2009
    ....
  18. doi request reprint Histamine via the histamine H₂-receptor reduces α-CD3-induced interferon-γ synthesis in murine CD4+ T cells in an indirect manner
    Marcus Vauth
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    J Interferon Cytokine Res 32:185-90. 2012
    ..Thus, the histamine effect is mediated by a soluble factor, which, however, is neither of the classical anti-inflammatory mediators, interleukin-10, or transforming growth factor-β...
  19. doi request reprint Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations
    Till M Reher
    Institute of Pharmacology, Hannover Medical School, D 30625 Hannover, Germany
    Biochem Pharmacol 84:192-203. 2012
    ..This indicates functional selectivity of H(4)R ligands, thus ligand-specific stabilization of distinct receptor conformations, inducing distinct biological responses...
  20. doi request reprint Commercially available antibodies against human and murine histamine H₄-receptor lack specificity
    Silke Beermann
    Institute of Pharmacology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 385:125-35. 2012
    ..Improved validation of commercially available antibodies prior to release to the market would avoid time-consuming and expensive validation assays by the user...
  21. doi request reprint Lung function and inflammation during murine Pseudomonas aeruginosa airway infection
    Florian Wölbeling
    Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Immunobiology 216:901-8. 2011
    ..Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs...
  22. ncbi request reprint Analysis of histamine receptor knockout mice in models of inflammation
    Detlef Neumann
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    J Pharmacol Exp Ther 348:2-11. 2014
    ..Thus, the published studies highlight the complexity of histamine function in inflammation and the need for much more systematic experimental work...
  23. ncbi request reprint IL-1beta-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1
    Detlef Neumann
    Hannover Medical School, Department of Pharmacology, Hannover, Germany
    Eur J Immunol 32:3689-98. 2002
    ..Possible models of the interaction between IRAK-1 and the PI3-K pathway are discussed...
  24. ncbi request reprint Modulation of behavior by the histaminergic system: lessons from H(1)R-and H(2)R-deficient mice
    Erich H Schneider
    Institute of Pharmacology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany Electronic address
    Neurosci Biobehav Rev 42:252-66. 2014
    ..The behavioral characterization of Hrh1(-/-)- and Hrh2(-/-)-mice is crucial, because many pharmacological agents lack the required selectivity to unequivocally address the functions of a single histamine receptor subtype. ..
  25. ncbi request reprint A CMP-sialic acid transporter cloned from Arabidopsis thaliana
    Hans Bakker
    Zelluläre Chemie, Zentrum Biochemie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Carbohydr Res 343:2148-52. 2008
    ..The isolated gene (At5g41760) is a member of the triose-phosphate/nucleotide sugar transporter gene family. Recombinant expression of the gene in yeast and testing in vitro confirmed its ability to transport CMP-sialic acid...
  26. doi request reprint Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota-host interactions
    Gwen Büchler
    Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 18:943-54. 2012
    ..The aim of this study was to determine the impact of microbiota on this differential colitis susceptibility using a Helicobacter hepaticus infection model...
  27. doi request reprint Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix
    Nina Luecke
    Hannover Medical School, Institute of Toxicology, Carl Neuberg Str 1, 30625 Hannover, Germany
    Rapid Commun Mass Spectrom 24:561-70. 2010
    ..Moreover, it suggests that DKmix-derived conditioned medium might have therapeutic potency by promoting tissue regeneration...
  28. doi request reprint Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor
    Christoph P Czerner
    Institute of Pharmacology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Inflamm Res 63:239-47. 2014
    ..Expression and function of histamine H4-receptor, an immunomodulatory receptor involved in inflammatory diseases, on murine macrophages, which are vital for immunity, were investigated...
  29. doi request reprint Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice
    Marijana Basic
    Institute of Laboratory Animal Science, Hannover Medical School, Hannover, Germany BioDoc, Hannover, Germany Department of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany Institute for Clinical Biochemistry, Hannover Medical School, Hannover, Germany Medical Clinic 1, Friedrich Alexander University Erlangen Nuernberg, Erlangen, Germany Institute of Pharmacology, Hannover Medical School, Hannover, Germany Department of Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany and Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 20:431-43. 2014
    ..In this study, the influence of murine norovirus (MNV) infection on clinical, histopathological, and immunological features of mucosal inflammation in the IL10-deficient (Il10) mouse model of inflammatory bowel disease was examined...
  30. doi request reprint Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation
    Subhashree Mahapatra
    Department for Pediatric Pneumology, Allergology and Neonatology, Medical School Hannover, Hannover, Germany
    PLoS ONE 9:e87296. 2014
    ..They might also be helpful to probe amendable therapeutic interventions such as histamine-receptor antagonism...
  31. pmc IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease
    Paola Bossù
    Laboratory of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    Proc Natl Acad Sci U S A 100:14181-6. 2003
    ..These studies support the concept that IL-18 plays a major role in the pathogenesis of the autoimmune syndrome of lpr mice and that a reduction in IL-18 activity could be a therapeutic strategy in autoimmune diseases...
  32. ncbi request reprint Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in tubular epithelial cells of human, murine and rat kidneys
    Ziba Kiafard
    Department of Cellular and Molecular Immunology, Georg August University Gottingen, Humboldtallee 34, D 37073 Gottingen, Germany
    Immunobiology 212:129-39. 2007
    ..Furthermore, as we demonstrate in the case of anaphylatoxin receptors, cross-reactivities of mAbs may constitute as yet underestimated pitfalls in immunohistochemical antigen detection...
  33. ncbi request reprint The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling
    Jurgen Radons
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, D 93042 Regensburg, Germany
    J Biol Chem 278:49145-53. 2003
    ....