L. Christian Napp


Affiliation: Hannover Medical School
Location: Hannover, Germany
Molecular Cardiology
Notch Signalling
Vascular Regeneration


  1. Napp L, Drexler H. What are the clinical effects of bone marrow cell therapy in patients with severe coronary artery disease?. Nat Clin Pract Cardiovasc Med. 2008;5:362-3 pubmed publisher
  2. Templin C, Grote K, Schledzewski K, Ghadri J, Schnabel S, Napp L, et al. Ex vivo expanded haematopoietic progenitor cells improve dermal wound healing by paracrine mechanisms. Exp Dermatol. 2009;18:445-53 pubmed publisher
    ..These data suggest that immortalized haematopoietic progenitor cells significantly improve dermal wound healing by paracrine effects. ..
  3. Limbourg A, Korff T, Napp L, Schaper W, Drexler H, Limbourg F. Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat Protoc. 2009;4:1737-46 pubmed publisher
    ..The concurrent and specific analysis of postnatal angiogenesis and arteriogenesis in the same animal is a unique feature of the protocol. ..
  4. Laurisch S, Jaedtke M, Demir R, Sorrentino S, Kielstein J, Rennekampff H, et al. [Allopurinol-induced hypersensitivity syndrome resulting in death]. Med Klin (Munich). 2010;105:262-6 pubmed publisher
    ..Considering the increasing prescription rate of allopurinol, the present case report intends to demonstrate the underestimated threat of AHS. ..
  5. Kempf T, Zarbock A, Widera C, Butz S, Stadtmann A, Rossaint J, et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med. 2011;17:581-8 pubmed publisher
    ..Loss of this anti-inflammatory mechanism leads to fatal cardiac rupture after myocardial infarction. ..
  6. Napp L, Augustynik M, Paesler F, Krishnasamy K, Woiterski J, Limbourg A, et al. Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis. Circ Res. 2012;110:530-5 pubmed publisher
    ..Tip cell differentiation is inhibited through lateral Notch signaling between ECs, which is controlled by Notch ligands expressed in vessel sprouts. The contribution of the Notch ligand Delta-like (Dll) 1 herein is unknown...
  7. Napp L, Kühn C, Hoeper M, Vogel Claussen J, Haverich A, Schäfer A, et al. Cannulation strategies for percutaneous extracorporeal membrane oxygenation in adults. Clin Res Cardiol. 2016;105:283-96 pubmed publisher
    ..Prospective controlled trials are urgently needed to generate evidence on safety and efficacy of ECMO support in different clinical settings. ..
  8. Napp L, Kuhn C, Bauersachs J. ECMO in cardiac arrest and cardiogenic shock. Herz. 2017;42:27-44 pubmed publisher
    ..Of all devices, extracorporeal membrane oxygenation (ECMO) is the most widely used. Here we review features and strategical considerations for the use of ECMO in cardiogenic shock and cardiac arrest. ..
  9. Zauner F, Sieweke J, Hohmann S, Duncker D, Riehle C, Napp L, et al. One symptom, two arrhythmias: the rare and the even rarer. BMC Cardiovasc Disord. 2017;17:244 pubmed publisher
    ..This case highlights the diagnostic defiance of rare tachycardia entities and the paramount importance of ECG documentation and analysis of all available tachycardia ECGs. ..

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