M U Martin

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family
    Michael U Martin
    Institute of Pharmacology OE 5320, Hannover Medical School, Germany
    Biochim Biophys Acta 1592:265-80. 2002
  2. ncbi request reprint The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling
    Jurgen Radons
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, D 93042 Regensburg, Germany
    J Biol Chem 278:49145-53. 2003
  3. ncbi request reprint The interleukin-1 receptor complex and interleukin-1 signal transduction
    M U Martin
    Medical School Hannover, Germany
    Eur Cytokine Netw 8:5-17. 1997
  4. ncbi request reprint The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)
    H Wesche
    Department of Molecular Pharmacology, Medical School Hannover, D 30623 Hannover, Germany
    J Biol Chem 272:7727-31. 1997
  5. ncbi request reprint Interleukin-12 upregulates the IL-18Rbeta chain in BALB/c thymocytes
    D Neumann
    Pharmacology OE 5320, Hannover Medical School, D-30623 Hannover, Germany
    J Interferon Cytokine Res 21:635-42. 2001
  6. ncbi request reprint Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide
    Daniela Bosisio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milano, Italy
    Blood 99:3427-31. 2002
  7. ncbi request reprint Identification and characterization of murine IRAK-M
    Olaf Rosati
    Institute of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    Biochem Biophys Res Commun 293:1472-7. 2002
  8. ncbi request reprint Identification and characterization of murine IRAK-2
    Olaf Rosati
    Institute of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    Biochem Biophys Res Commun 297:52-8. 2002
  9. ncbi request reprint IL-1beta-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1
    Detlef Neumann
    Hannover Medical School, Department of Pharmacology, Hannover, Germany
    Eur J Immunol 32:3689-98. 2002
  10. ncbi request reprint Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
    Christian Kollewe
    Department of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    J Biol Chem 279:5227-36. 2004

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family
    Michael U Martin
    Institute of Pharmacology OE 5320, Hannover Medical School, Germany
    Biochim Biophys Acta 1592:265-80. 2002
    ..The creation of pathogen-specific mediator environments by dendritic cells defines whether a cellular or humoral response will be activated in response to the pathogen...
  2. ncbi request reprint The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling
    Jurgen Radons
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, D 93042 Regensburg, Germany
    J Biol Chem 278:49145-53. 2003
    ....
  3. ncbi request reprint The interleukin-1 receptor complex and interleukin-1 signal transduction
    M U Martin
    Medical School Hannover, Germany
    Eur Cytokine Netw 8:5-17. 1997
    ..It is not the aim of this review to extensively summarize IL-1 induced cytosolic kinase cascades and activation of transcription factors...
  4. ncbi request reprint The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)
    H Wesche
    Department of Molecular Pharmacology, Medical School Hannover, D 30623 Hannover, Germany
    J Biol Chem 272:7727-31. 1997
    ....
  5. ncbi request reprint Interleukin-12 upregulates the IL-18Rbeta chain in BALB/c thymocytes
    D Neumann
    Pharmacology OE 5320, Hannover Medical School, D-30623 Hannover, Germany
    J Interferon Cytokine Res 21:635-42. 2001
    ..Thus, the synergistic effects of IL-12 and IL-18 on BALB/c mouse thymocytes resulted from the induction and regulation of the IL-18Rbeta chain and not the IL-18Ralpha chain...
  6. ncbi request reprint Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide
    Daniela Bosisio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milano, Italy
    Blood 99:3427-31. 2002
    ..These results suggest that enhanced TLR4 expression underlies the long-known priming by IFNgamma of mononuclear phagocytes for pathogen recognition and killing as well as its synergism with LPS in macrophage activation...
  7. ncbi request reprint Identification and characterization of murine IRAK-M
    Olaf Rosati
    Institute of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    Biochem Biophys Res Commun 293:1472-7. 2002
    ....
  8. ncbi request reprint Identification and characterization of murine IRAK-2
    Olaf Rosati
    Institute of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    Biochem Biophys Res Commun 297:52-8. 2002
    ....
  9. ncbi request reprint IL-1beta-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1
    Detlef Neumann
    Hannover Medical School, Department of Pharmacology, Hannover, Germany
    Eur J Immunol 32:3689-98. 2002
    ..Possible models of the interaction between IRAK-1 and the PI3-K pathway are discussed...
  10. ncbi request reprint Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
    Christian Kollewe
    Department of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    J Biol Chem 279:5227-36. 2004
    ..Thus, IRAK-1 regulates its own availability as an adapter molecule by sequential autophosphorylation...
  11. ncbi request reprint The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4
    Detlef Neumann
    Department for Pharmacology, Hannover Medical School, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Biochem Biophys Res Commun 354:1089-94. 2007
    ..Finally, mutation of IRAK-1 at T66 not only allowed stable binding to the signaling adapters, but also enhanced its signaling capacity...
  12. doi request reprint Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation
    Detlef Neumann
    Deptartment of Pharmacology, Hannover Medical School, Hannover, Germany
    J Leukoc Biol 84:807-13. 2008
    ..Thereby, it ensures the transient manner of interactions between IRAK-1 and the other signaling molecules. This essential role, however, is not regulated by phosphorylation of T66 itself...