Ulrich Lehmann

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc Quantitative cross-validation and content analysis of the 450k DNA methylation array from Illumina, Inc
    Jessica Roessler
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Str, 1, D 30625, Hannover, Germany
    BMC Res Notes 5:210. 2012
  2. doi request reprint High-resolution quantitative methylation analysis of microRNA genes using Pyrosequencing™
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Methods Mol Biol 878:229-40. 2012
  3. ncbi request reprint Real-time PCR analysis of DNA and RNA extracted from formalin-fixed and paraffin-embedded biopsies
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Methods 25:409-18. 2001
  4. ncbi request reprint Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling
    Ulrich Lehmann
    Institute of Pathology, Institute of Cell and Molecular Pathology, and Department of Visceral and Transplantation Surgery, Medizinische Hochschule Hannover, Hanover, Germany
    Clin Cancer Res 11:3654-60. 2005
  5. ncbi request reprint Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype
    Ulrich Lehmann
    Institute of Pathology, Department of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Cancer Res 62:6634-8. 2002
  6. pmc Identification of differentially expressed microRNAs in human male breast cancer
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Cancer 10:109. 2010
  7. ncbi request reprint Epigenetic defects of hepatocellular carcinoma are already found in non-neoplastic liver cells from patients with hereditary haemochromatosis
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Hum Mol Genet 16:1335-42. 2007
  8. ncbi request reprint Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    J Pathol 214:17-24. 2008
  9. ncbi request reprint Role of epigenetic changes in hematological malignancies
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Ann Hematol 83:137-52. 2004
  10. doi request reprint [DNA methylation. From basic research to routine diagnostics]
    U Lehmann
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Pathologe 31:274-9. 2010

Detail Information

Publications100

  1. pmc Quantitative cross-validation and content analysis of the 450k DNA methylation array from Illumina, Inc
    Jessica Roessler
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Str, 1, D 30625, Hannover, Germany
    BMC Res Notes 5:210. 2012
    ..The β-values for 692 individual CpG sites from 62 different genes were cross-validated using conventional quantitative pyrosequencing...
  2. doi request reprint High-resolution quantitative methylation analysis of microRNA genes using Pyrosequencing™
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Methods Mol Biol 878:229-40. 2012
    ..The strengths and limitations of this approach are discussed throughout the chapter...
  3. ncbi request reprint Real-time PCR analysis of DNA and RNA extracted from formalin-fixed and paraffin-embedded biopsies
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Methods 25:409-18. 2001
    ..We provide a number of protocols to assist in the application of these techniques...
  4. ncbi request reprint Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling
    Ulrich Lehmann
    Institute of Pathology, Institute of Cell and Molecular Pathology, and Department of Visceral and Transplantation Surgery, Medizinische Hochschule Hannover, Hanover, Germany
    Clin Cancer Res 11:3654-60. 2005
    ..A comparative quantitative methylation profiling of hepatocellular carcinoma and the most frequent benign liver tumor, hepatocellular adenoma, was set up for the identification of tumor-specific methylation patterns...
  5. ncbi request reprint Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype
    Ulrich Lehmann
    Institute of Pathology, Department of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Cancer Res 62:6634-8. 2002
    ..We conclude that different histological subtypes of breast cancer may not only differ concerning specific chromosomal abnormalities and DNA mutations but also with regard to epigenetic inactivation patterns...
  6. pmc Identification of differentially expressed microRNAs in human male breast cancer
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Cancer 10:109. 2010
    ..However, nothing is known so far about microRNA expression in male breast cancer, accounting for approximately 1% of all breast cancer cases...
  7. ncbi request reprint Epigenetic defects of hepatocellular carcinoma are already found in non-neoplastic liver cells from patients with hereditary haemochromatosis
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Hum Mol Genet 16:1335-42. 2007
    ..Thus, changes in DNA methylation patterns are an early event preceding morphological alterations of malignant transformation and represent promising targets for early detection...
  8. ncbi request reprint Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    J Pathol 214:17-24. 2008
    ..8). In conclusion, this study demonstrates that various microRNA genes are also affected by epigenetic inactivation due to aberrant hypermethylation and that this is an early and frequent event in breast cancer development...
  9. ncbi request reprint Role of epigenetic changes in hematological malignancies
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Ann Hematol 83:137-52. 2004
    ..In addition, the implications for therapy and prognosis will be discussed...
  10. doi request reprint [DNA methylation. From basic research to routine diagnostics]
    U Lehmann
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Pathologe 31:274-9. 2010
    ..The detection of MGMT gene methylation is a good prognostic and predictive factor for glioblastoma patients. Performing DNA methylation assays for routine diagnostics requires technical as well as theoretical expertise...
  11. doi request reprint MicroRNA-profiling in formalin-fixed paraffin-embedded specimens
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Methods Mol Biol 667:113-25. 2010
    ..In this chapter, the extraction of RNA from FFPE samples and the subsequent microRNA profiling utilizing fluorescence-labeled bead technology from Luminex Inc. is described...
  12. pmc Quantitative assessment of promoter hypermethylation during breast cancer development
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Am J Pathol 160:605-12. 2002
    ....
  13. ncbi request reprint Quantitative molecular analysis of laser-microdissected paraffin-embedded human tissues
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Pathobiology 68:202-8. 2000
    ....
  14. pmc Demonstration of light chain restricted clonal B-lymphoid infiltrates in archival bone marrow trephines by quantitative real-time polymerase chain reaction
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Am J Pathol 159:2023-9. 2001
    ....
  15. ncbi request reprint [Fibroblasts of recipient origin contribute to broncholitis obliterans in human lung transplants]
    Verena Bröcker
    Institut fur Pathologie, Medizinische Hochschule, Hannover
    Verh Dtsch Ges Pathol 90:277-85. 2006
    ..The participation of circulating precursor cells in the development of experimental pulmonary fibrosing lesions in mice has been recently demonstrated...
  16. pmc Down-regulation of the fetal stem cell factor SOX17 by H33342: a mechanism responsible for differential gene expression in breast cancer side population cells
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 285:6412-8. 2010
    ..This has significant implications for the future interpretation of cancer SP cells...
  17. doi request reprint Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Cancer Sci 100:1767-71. 2009
    ..This has significant implications for the use of KAI1 as a clinical marker and the understanding of the metastatic process in human breast cancer...
  18. doi request reprint Oncogenic PIK3CA mutations in lobular breast cancer progression
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Genes Chromosomes Cancer 52:69-80. 2013
    ..Intriguingly, these findings imply that PIK3CA mutations are positively selected for during ILBC progression to local recurrence but not distant metastasis, which may have clinical implications for PI3K inhibitor-based therapy...
  19. doi request reprint Concordant hypermethylation of intergenic microRNA genes in human hepatocellular carcinoma as new diagnostic and prognostic marker
    Sumadi Lukman Anwar
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Int J Cancer 133:660-70. 2013
    ..Concordant hypermethylation of three or more microRNA genes is a highly specific marker for the detection of HCC and for poor prognosis...
  20. doi request reprint Epigenetic inactivation of tumour suppressor gene KLF11 in myelodysplastic syndromes*
    Anna Potapova
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Haematol 84:298-303. 2010
    ..05). In conclusion, epigenetic inactivation and subsequent transcriptional repression of the KLF11 gene is quite frequent in MDS. Patients with an isolated 5q-deletion seem to harbour a distinct epigenetic profile...
  21. ncbi request reprint Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome
    Kai Brakensiek
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Br J Haematol 130:209-17. 2005
    ....
  22. ncbi request reprint Recipient-derived neoangiogenesis of arterioles and lymphatics in quilty lesions of cardiac allografts
    Danny Jonigk
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Transplantation 84:1335-42. 2007
    ..Complex subendocardial infiltrates, known as Quilty lesions, are frequently observed in cardiac allografts. The origin of the different cellular components of Quilty lesions is not known...
  23. ncbi request reprint Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern
    Mathewos Tessema
    Institute of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Int J Oncol 26:499-507. 2005
    ..The data suggest a disturbed regulation of the IGF-2/H19 locus in myeloid leukemias which is not caused by loss of imprinting...
  24. ncbi request reprint Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas
    Tim Ripperger
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Haematologica 92:460-8. 2007
    ..The identification of inactivated tumor suppressor genes contributing to the development of MCL may lead to further elucidation of the biology of this disease and help to identify novel targets for therapy...
  25. doi request reprint Optimized RNA extraction from non-deparaffinized, laser-microdissected material
    Danny Jonigk
    Medizinische Hochschule Hannover, Institute of Pathology, Hannover, Germany
    Methods Mol Biol 755:67-75. 2011
    ..We describe a method of isolating anatomic compartments from non-deparaffinized, formalin-fixed, and paraffin-embedded tissues by laser-assisted microdissection which allows for a highly efficient mRNA retrieval...
  26. doi request reprint KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Int J Cancer 123:2239-46. 2008
    ..Importantly, KAI1 might be reinducible by endocrine therapy with ER-antagonists in patients suffering from ER-positive breast cancer...
  27. doi request reprint MicroRNA profiling using RNA from microdissected immunostained tissue
    Clemens L Bockmeyer
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Methods Mol Biol 755:85-94. 2011
    ..Employing this new methodological approach, we could identify distinct microRNA profiles of luminal and basal breast epithelial cells by real-time PCR-based profiling...
  28. pmc Obliterative airway remodeling: molecular evidence for shared pathways in transplanted and native lungs
    Danny Jonigk
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Am J Pathol 178:599-608. 2011
    ..These distinct expression patterns warrant further investigation as potential markers of impending airway remodeling, especially for prospective longitudinal molecular profiling...
  29. pmc Loss of imprinting and allelic switching at the DLK1-MEG3 locus in human hepatocellular carcinoma
    Sumadi Lukman Anwar
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 7:e49462. 2012
    ..It might also serve in the future as predictive biomarker and for monitoring response to epigenetic therapy...
  30. doi request reprint Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression
    Clemens L Bockmeyer
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    J Heart Lung Transplant 31:764-72. 2012
    ..Specific miRNAs in plexiform vasculopathy of severe pulmonary arterial hypertension (PAH) in humans have not yet been investigated...
  31. pmc Reliable microRNA profiling in routinely processed formalin-fixed paraffin-embedded breast cancer specimens using fluorescence labelled bead technology
    Britta Hasemeier
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    BMC Biotechnol 8:90. 2008
    ..Therefore, the aim of this study was to examine the feasibility of microRNA profiling studies in routinely processed formalin-fixed paraffin-embedded human breast cancer specimens using fluorescence labelled bead technology...
  32. doi request reprint Obliterative airway remodelling in transplanted and non-transplanted lungs
    Danny Jonigk
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Virchows Arch 457:369-80. 2010
    ..BMPs, especially BMP-7, warrant further investigation as possible markers for the aggravation of airway remodelling...
  33. pmc Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment
    Danny Jonigk
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Am J Pathol 179:167-79. 2011
    ..Neoplastic models of angiogenesis seem to be of limited use in further study of plexiform vasculopathy...
  34. doi request reprint Detection of putative cancer stem cells of the side population phenotype in human tumor cell cultures
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Methods Mol Biol 878:201-15. 2012
    ..Here we provide a detailed protocol for the detection of putative cancer stem cells of the SP phenotype in human adherent breast cancer cell cultures...
  35. doi request reprint MicroRNA profiles of healthy basal and luminal mammary epithelial cells are distinct and reflected in different breast cancer subtypes
    Clemens L Bockmeyer
    Institute for Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Breast Cancer Res Treat 130:735-45. 2011
    ..Malignant myoepithelioma seems to exhibit a basal pattern of microRNA expression, whereas the so-called basal-like breast cancer is clearly different and reveals a luminal type pattern...
  36. pmc GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells
    Nils Nickel
    Clinic for Pulmonary Medicine, Hannover Medical School, Hannover, Germany
    Respir Res 12:62. 2011
    ..The aim of the study was to examine the expression and biological roles of GDF-15 in the lung of patients with pulmonary arterial hypertension (PAH)...
  37. ncbi request reprint Quantitative mRNA expression analysis of co-stimulatory molecules in sequential biopsies from heart allografts
    Fatma Akdere
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Transpl Int 18:1197-202. 2005
    ..The present results suggest a simultaneous and long-term therapeutical blockade of more than one costimulatory pathway for the prevention of repetitive T-cell mediated acute rejection episodes after heart transplantation...
  38. pmc Chimerism of metanephric adenoma but not of carcinoma in kidney transplants
    Michael Mengel
    Institut fuer Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Am J Pathol 165:2079-85. 2004
    ..The mixed derivation of metanephric adenomas indicates an incorporation of recipient-derived progenitor cells. This finding suggests that adult stem cells can assume neoplastic phenotypes...
  39. ncbi request reprint Fibroblasts of recipient origin contribute to bronchiolitis obliterans in human lung transplants
    Verena Bröcker
    Institute of Pathology, Department of Pneumology, Medizinische Hochschule Hannover, Hannover, Germany
    Am J Respir Crit Care Med 173:1276-82. 2006
    ..The participation of circulating precursor cells in the development of experimental pulmonary fibrosing lesions in mice has been recently demonstrated...
  40. doi request reprint Histopathological criteria and selection algorithms for BRCA1 genetic testing
    Dorothea Gadzicki
    Institute of Cell and Molecular Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cancer Genet Cytogenet 189:105-11. 2009
    ..001 for G3), ER negativity (P = 0.0075), Ki67 > or = 65% (P = 0.0039), and triple negativity (i.e., ER(-), PR(-), Her2/neu(-)) (P = 0.0019) between tumors of mutation carriers and noncarriers...
  41. ncbi request reprint Absence of p21(CIP 1), p27(KIP 1) and p 57(KIP 2) methylation in MDS and AML
    Kai Brakensiek
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Leuk Res 29:1357-60. 2005
    ..p 57(KIP 2) hypermethylation was found in 4/9 cell lines, but methylation of p21(CIP 1) and p27(KIP 1) was infrequent. All patient samples analysed were methylation-negative for these three genes...
  42. doi request reprint IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Lab Invest 92:1635-47. 2012
    ..From a tumor pathology perspective, IPH-926 also provides the first direct evidence of a p53-related clonal evolutionary pathway in lobular breast cancer progression...
  43. ncbi request reprint Expression profiling of breast cancer cells by differential peptide display
    Harald Tammen
    BioVisioN AG, Hannover, Germany
    Breast Cancer Res Treat 79:83-93. 2003
    ..Comparing cell lines with native tumors, overlapping peptide patterns were found between HMEC and a phylloides tumor (CP) on the one hand and MCF-7 cells and tissue from a invasive ductal carcinoma (DC) on the other hand...
  44. pmc Quantitative intra-individual monitoring of BCR-ABL transcript levels in archival bone marrow trephines of patients with chronic myeloid leukemia
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    J Mol Diagn 5:54-60. 2003
    ..To the best of our knowledge, this is the first study demonstrating the feasibility of large-scale quantitative expression analysis in archival bone marrow trephines for monitoring molecular markers over several years or even decades...
  45. doi request reprint Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    J Pathol 217:620-32. 2009
    ..In summary, IPH-926 significantly extends the biological spectrum of the established breast cancer cell lines and will facilitate functional analyses of genuine human ILBC cells in vitro and in vivo...
  46. ncbi request reprint Quantitative high-resolution CpG island mapping with Pyrosequencing reveals disease-specific methylation patterns of the CDKN2B gene in myelodysplastic syndrome and myeloid leukemia
    Kai Brakensiek
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Clin Chem 53:17-23. 2007
    ..Methylation patterns are often very heterogeneous, however, presenting a serious challenge for the development of methylation assays for diagnostic purposes...
  47. pmc Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution
    Anna Potapova
    Institute of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Biotechnol 11:6. 2011
    ..Therefore, a systematic cross-validation of 454 sequencing and conventional pyrosequencing, both of which offer exact quantification of methylation levels with a single CpG dinucleotide resolution, was performed...
  48. doi request reprint High intrahepatic HHV-6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis
    Sven Pischke
    Department for Gastroenterology, Hannover Medical School, Hannover, Germany
    J Hepatol 56:1063-9. 2012
    ..In liver transplant recipients with graft hepatitis, the relevance of herpesviruses is not well defined...
  49. ncbi request reprint Real-time PCR-based assay for quantitative determination of methylation status
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Methods Mol Biol 287:207-18. 2004
    ..In addition to providing quantitative methylation data, this methodology is suitable for high-throughput analysis...
  50. pmc Decentral gene expression analysis for ER+/Her2- breast cancer: results of a proficiency testing program for the EndoPredict assay
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Virchows Arch 460:251-9. 2012
    ..0. Taken together, the EndoPredict test could be successfully implemented in all seven participating laboratories and is feasible for reliable decentralized assessment of gene expression in luminal breast cancer...
  51. ncbi request reprint Combined laser-assisted microdissection and short tandem repeat analysis for detection of in situ microchimerism after solid organ transplantation
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Methods Mol Biol 293:113-23. 2005
    ....
  52. ncbi request reprint Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell line
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Mol Cell Biochem 306:201-12. 2007
    ..In summary, we established Cal-51 SP cells as a novel in vitro model to study differential gene expression in breast cancer-derived SP and NSP cells...
  53. ncbi request reprint Tubular chimerism occurs regularly in renal allografts and is not correlated to outcome
    Michael Mengel
    Institut fuer Pathologie, Medizinischen Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 15:978-86. 2004
    ..Probably recipient-derived stem cells contribute in a minor fashion to tissue homeostasis, and cell turnover in renal allografts is predominantly enabled by donor cell renewal...
  54. ncbi request reprint LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
    Julia Skokowa
    Department of Pediatric Hematology and Oncology Carl Neuberg Str 1, 30625 Hannover, Germany
    Nat Med 12:1191-7. 2006
    ..These observations indicate that LEF-1 is an instructive factor regulating neutrophilic granulopoiesis whose absence plays a critical role in the defective maturation program of myeloid progenitors in individuals with CN...
  55. ncbi request reprint Up-regulation of DNA methyltransferases DNMT1, 3A, and 3B in myelodysplastic syndrome
    Florian Langer
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 29:325-9. 2005
    ..This elevated mRNA expression most probably contributes to the frequently found aberrant hypermethylation in MDS and might explain the promising clinical response of MDS patients treated with DNMT inhibitors...
  56. pmc Limited value of KAI1/CD82 protein expression as a prognostic marker in human gastric cancer
    Maximilian Knoener
    Institute of Pathology, Hannover Medical School, Germany
    Dis Markers 32:337-42. 2012
    ..However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup...
  57. doi request reprint ABCB1/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells
    Till Krech
    Institute of Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cancer Lett 315:153-60. 2012
    ..IPH-926 provides evidence that ABCB1 can occasionally cause anticancer drug-resistance in breast cancer patients and offers a new tool for the evaluation of compounds to overcome drug-resistance...
  58. pmc Constitutional mismatch repair deficiency and childhood leukemia/lymphoma--report on a novel biallelic MSH6 mutation
    Tim Ripperger
    Institute of Cell and Molecular Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Haematologica 95:841-4. 2010
    ....
  59. pmc Diminished met signaling in podocytes contributes to the development of podocytopenia in transplant glomerulopathy
    Putri A Agustian
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Am J Pathol 178:2007-19. 2011
    ..Decreased antiapoptotic Met signaling in podocytes, probably due to decreased HGF secretion by glomerular epithelial cells, could contribute to podocyte loss and FSGS in TxG...
  60. doi request reprint MicroRNA miR-335 is crucial for the BRCA1 regulatory cascade in breast cancer development
    Holger Heyn
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Int J Cancer 129:2797-806. 2011
    ..Deregulation of the microRNA during breast cancer development and progression may thereby lead to an increased tumorigenic potential by inactivating crucial tumor-suppressive signals...
  61. pmc Frequent and distinct aberrations of DNA methylation patterns in fibrolamellar carcinoma of the liver
    Wolfgang Tränkenschuh
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 5:e13688. 2010
    ..However, very little is known about epigenetic defects in fibrolamellar carcinoma (FLC), a rare variant of hepatocellular carcinoma that displays distinct clinical and morphological features...
  62. ncbi request reprint Laser-assisted microdissection and isolation of DNA and RNA
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Methods Mol Med 120:65-75. 2006
    ....
  63. ncbi request reprint Bone marrow infiltration pattern in B-cell chronic lymphocytic leukemia is related to immunoglobulin heavy-chain variable region mutation status and expression of 70-kd zeta-associated protein (ZAP-70)
    Ulrika Schade
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Hum Pathol 37:1153-61. 2006
    ..The mixed type of infiltration is displayed by mutated as well as unmutated cases with a varying pattern of ZAP-70 expression...
  64. ncbi request reprint [Epigenetic inactivation of microRNA genes in mammary carcinoma]
    U Lehmann
    Institut fur Pathologie, Medizinische Hochschule Hannover, Hannover
    Verh Dtsch Ges Pathol 91:214-20. 2007
    ..This study addresses the question whether microRNA genes are affected by aberrant hypermethylation and subsequent transcriptional repression in human breast cancer...
  65. ncbi request reprint Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML)
    M Tessema
    1Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Street 1, Hannover, Germany
    Leukemia 17:910-8. 2003
    ..We conclude that aberrant gene methylation is a frequent event in CMML that might contribute to the pathogenesis of this MDS/MPD...
  66. ncbi request reprint Reliability of lymphoma classification in bone marrow trephines
    Thomas Buhr
    Institute of Pathology, Hannover Medical University, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Br J Haematol 118:470-6. 2002
    ..e. lymph nodes, extranodal sites) was noted. We conclude from our results that bone marrow trephines are a reliable tool, not only for establishing bone marrow infiltration, but also for the subtyping of lymphomas...
  67. ncbi request reprint Marked intratumoral heterogeneity of c-myc and cyclinD1 but not of c-erbB2 amplification in breast cancer
    Sabine Glockner
    Institute of PathologyMedizinische Hochschule Hannover, Hannover, Germany
    Lab Invest 82:1419-26. 2002
    ..Patterns of heterogeneity can be used to trace the clonal evolution within different compartments of an individual tumor...
  68. pmc Increased chimerism of bronchial and alveolar epithelium in human lung allografts undergoing chronic injury
    Wolfram Kleeberger
    Institute of Pathology, Division of Thoracic and Cardiovascular Surgery, Medizinische Hochschule Hannover, Hannover, Germany
    Am J Pathol 162:1487-94. 2003
    ..The observation of an enhanced integration of recipient cells into chronically damaged epithelial structures suggests that extrapulmonary precursor cells are able to contribute to pulmonary regeneration...
  69. doi request reprint Rapid early HDV RNA decline in the peripheral blood but prolonged intrahepatic hepatitis delta antigen persistence after liver transplantation
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Hepatol 56:115-22. 2012
    ..The aims of this study were to investigate kinetics of HDV RNA and HBsAg early after LTX, to apply the data to a mathematical model and to study long-term persistence of HDV after LTX...
  70. pmc Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration
    Mariam Al-Omari
    Department of Pulmonology, Hannover Medical School, Hannover, Germany
    Mol Med 17:865-74. 2011
    ....
  71. ncbi request reprint Overexpression of delta-like (Dlk) in a subset of myelodysplastic syndrome bone marrow trephines
    Florian Langer
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Leuk Res 28:1081-3. 2004
    ..Therefore, the quantitative detection of dlk mRNA can support the morphological diagnosis of MDS in selected cases...
  72. ncbi request reprint High frequency of epithelial chimerism in liver transplants demonstrated by microdissection and STR-analysis
    Wolfram Kleeberger
    Institutes of Pathology and Legal Medicine, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 35:110-6. 2002
    ....
  73. pmc Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer
    Inke Timmerbeul
    Department of Gastroenterology, Hepatology, and Endocrinology, Institute for Molecular Biology, Department of Hematology and Oncology, Institute for Pathology, Hannover Medical School, D 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 103:14009-14. 2006
    ..These studies may guide the choice of clinical settings in which pharmacologic inhibitors of the Skp2 pathway might be of therapeutic value...
  74. ncbi request reprint MDA-MB-435: the questionable use of a melanoma cell line as a model for human breast cancer is ongoing
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Cancer Biol Ther 6:1355-7. 2007
    ....
  75. pmc Identification of a novel murine pancreatic tumour antigen, which elicits antibody responses in patients with pancreatic carcinoma
    Fei Zhao
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
    Immunology 128:134-40. 2009
    ..Reverse transcriptase-polymerase chain reaction analysis showed Tankyrase-2 expression in human pancreatic tumour. These findings show the relevance of spontaneous murine tumour models for the identification of human tumour antigens...
  76. ncbi request reprint Head injury mechanisms in helmet-protected motorcyclists: prospective multicenter study
    M Richter
    Trauma Department, Hannover, Germany
    J Trauma 51:949-58. 2001
    ....
  77. ncbi request reprint Laser-assisted microdissection and short tandem repeat PCR for the investigation of graft chimerism after solid organ transplantation
    W Kleeberger
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Pathobiology 68:196-201. 2000
    ..The combination of laser-based microdissection and STR-PCR thus provides a powerful tool for the genotyping of even very few cells isolated from routinely processed biopsies after solid organ transplantation...
  78. ncbi request reprint Detection of gene amplification in intraductal and infiltrating breast cancer by laser-assisted microdissection and quantitative real-time PCR
    S Glockner
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Pathobiology 68:173-9. 2000
    ....
  79. ncbi request reprint Positive display of methylated sites: a novel method for the detection of promoter methylation
    R Lilischkis
    Institute of Pathology, Hannover Medical School, Germany
    Diagn Mol Pathol 9:165-71. 2000
    ..The conclusion is that PDM provides a useful tool in determining the degree and pattern of promoter methylation and is suitable to screen large series of tissue samples...
  80. ncbi request reprint Compartment-specific quantitative gene expression analysis after laser microdissection from archival renal allograft biopsies
    E Serinsoz
    Institut fur Pathologie, Medizinischen Hochschule, Hannover, Germany
    Clin Nephrol 63:193-201. 2005
    ....
  81. ncbi request reprint Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype
    P Flemming
    Institut fur Pathologie, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 32:213-7. 2000
    ..The epithelioid subtype may give rise to intrahepatic metastasis...
  82. doi request reprint [Beyond staging, typing and grading. New challenges in breast cancer pathology]
    H H Kreipe
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Pathologe 31:54-9. 2010
    ....
  83. pmc Detection of gene amplification in archival breast cancer specimens by laser-assisted microdissection and quantitative real-time polymerase chain reaction
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Am J Pathol 156:1855-64. 2000
    ....
  84. pmc Bone marrow-derived progenitor cells do not contribute to podocyte turnover in the puromycin aminoglycoside and renal ablation models in rats
    Catherine Meyer-Schwesinger
    Department of Internal Medicine, Nephrology, University Hospital Hamburg Eppendorf, Hannover, Germany
    Am J Pathol 178:494-9. 2011
    ..Further studies will address this discrepancy, which could be explained by species differences or by predominant podocyte regeneration from a parietal epithelial cell niche...
  85. doi request reprint Chemokine receptor CCR7 contributes to a rapid and efficient clearance of lytic murine gamma-herpes virus 68 from the lung, whereas bronchus-associated lymphoid tissue harbors virus during latency
    Jessica R Kocks
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 182:6861-9. 2009
    ..Finally, by microdissecting BALT, we could demonstrate that these ectopic lymphoid structures are a place in the lung where virus resides during latency...
  86. ncbi request reprint Molecular cloning of a functional promoter of the human plakoglobin gene
    E Potter
    Department of Clinical Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Eur J Endocrinol 145:625-33. 2001
    ..Whereas Pg expression is lost in some thyroid tumours and carcinoma cell lines, little information on Pg gene regulation is currently available owing to a lack of promoter studies...
  87. ncbi request reprint Amplification of growth regulatory genes in intraductal breast cancer is associated with higher nuclear grade but not with the progression to invasiveness
    S Glockner
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Lab Invest 81:565-71. 2001
    ....
  88. doi request reprint Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension
    Nils Nickel
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Am J Respir Crit Care Med 178:534-41. 2008
    ..Circulating levels of GDF-15 provide independent prognostic information in patients with acute pulmonary embolism and chronic left-sided heart failure...
  89. doi request reprint Tissue procurement for molecular studies using laser-assisted microdissection
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Methods Mol Biol 506:299-310. 2009
    ....
  90. ncbi request reprint [Promoter hypermethylation during tumor progression: quantitative analysis employing kinetic PCR]
    U Lehmann
    , Medizinische Hochschule Hannover
    Verh Dtsch Ges Pathol 85:264-8. 2001
    ..Quantitative differences detected by this assay will offer new insights into early steps in carcinogenesis and tumour cell heterogeneity...
  91. ncbi request reprint Refined mapping of the human Ets-related gene Elk-1 to Xp11.2-p11.4, distal to the OATL1 region
    M Janz
    Institut fur Molekularbiologie, Hannover, Germany
    Hum Genet 94:442-4. 1994
    ..Elk-1 has been assigned to Xp11.2-p11.4, distal to the OATL1 region...
  92. ncbi request reprint Heterotopic ossifications in patients after severe blunt trauma with and without head trauma: incidence and patterns of distribution
    H C Pape
    Department of Trauma Surgery, Hannover Medical School, Hannover, Germany
    J Orthop Trauma 15:229-37. 2001
    ..Causative factors for the development of heterotopic ossification at initially uninjured joints in long-term ventilated patients with multiple trauma with and without head trauma remain to be elucidated...
  93. pmc Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice
    Anurag Kumar Singh
    Department of Gastroenterology, Hepatology, and Endocrinology, Carl Neuberg Strasse 1, Hannover Medical School, Hannover, Germany
    J Clin Invest 119:540-50. 2009
    ..These data suggest that the NHERF proteins differentially modulate duodenal HCO3- secretion: while NHERF1 is an obligatory linker for beta2-AR stimulation of CFTR, NHERF2 confers inhibitory signals by coupling the LPA receptor to CFTR...
  94. ncbi request reprint Cell cycle and no end
    Mathewos Tessema
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Virchows Arch 444:313-23. 2004
    ..The molecular mechanisms of actual cell division (sister chromatid segregation and cytokinesis) are mentioned only briefly...
  95. doi request reprint Re: Rahner et al. Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome. J Pathol 2008; 214: 10-16
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Pathol 215:97; author reply 98. 2008
  96. ncbi request reprint [Epigenetic changes in breast cancer shown by aberrant promoter methylation]
    U Lehmann
    Institut fur Pathologie, Medizinische Hochschule Hannover
    Zentralbl Gynakol 126:272-4. 2004
    ..The occurrence of specific aberrant methylation patterns is associated with the histological grade and subtype of mammary carcinoma biopsies...
  97. ncbi request reprint [Methylation status of LINE-1 sequences in patients with MDS or secondary AML]
    D Römermann
    Institut fur Pathologie, Medizinische Hochschule Hannover
    Verh Dtsch Ges Pathol 91:338-42. 2007
    ..This study analyzes changes in the degree of global methylationlevel in myelodysplastic syndrome during progression of the disease...
  98. ncbi request reprint High-resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer
    Daniel E Stange
    Division of Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Clin Cancer Res 12:345-52. 2006
    ..They differ with regard to presentation, metastatic spread, and epidemiologic features. To elucidate the genetic basis of these differences, we analyzed copy number imbalances that differentiate the histologic subtypes...
  99. ncbi request reprint Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease
    Andre Lechel
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Germany
    Gastroenterology 132:1465-75. 2007
    ..The function of telomerase during in vivo hepatocarcinogenesis has not been studied in this genetic context...
  100. ncbi request reprint Low level of DAP-kinase DNA methylation in myelodysplastic syndrome
    Kai Brakensiek
    Blood 104:1586-7; author reply 1587-8. 2004