Ulrich Lehmann


Affiliation: Hannover Medical School
Country: Germany


  1. Bartels S, Schipper E, Hasemeier B, Kreipe H, Lehmann U. Hotspot mutations in cancer genes may be missed in routine diagnostics due to neighbouring sequence variants. Exp Mol Pathol. 2018;105:37-40 pubmed publisher
    ..Because many commercially available diagnostic kits rely on the analysis of only one DNA strand they are prone to fail in cases like these. Detailed protocols and quality control measures to prevent corresponding pitfalls are presented. ..
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    Lehmann U, Berg Ribbe I, Wingen L, Brakensiek K, Becker T, Klempnauer J, et al. Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling. Clin Cancer Res. 2005;11:3654-60 pubmed
    ..In hepatocellular carcinoma, the altered methylation patterns accompanying malignant transformation override the age-dependent increase in gene methylation. ..
  3. Lehmann U. Quantitative Validation and Quality Control of Pyrosequencing® Assays. Methods Mol Biol. 2015;1315:39-46 pubmed publisher
  4. Lehmann U. Lobular breast cancer--the most common special subtype or a most special common subtype?. Breast Cancer Res. 2015;17:99 pubmed publisher
    ..Leading experts review the molecular and cellular bases, the model systems, the histopathology and profiling approaches, risk factors, imaging tools and therapeutic options for lobular breast cancer. ..
  5. Anwar S, Lehmann U. MicroRNAs: Emerging Novel Clinical Biomarkers for Hepatocellular Carcinomas. J Clin Med. 2015;4:1631-50 pubmed publisher
    ..This review focuses on potential values, benefits, and limitations of microRNAs as new clinical markers for diagnosis, prognosis, prediction, and therapeutic monitoring in HCC. ..
  6. Lehmann U, Streichert T, Otto B, Albat C, Hasemeier B, Christgen H, et al. Identification of differentially expressed microRNAs in human male breast cancer. BMC Cancer. 2010;10:109 pubmed publisher
    ..Male breast cancer displays several differentially expressed microRNAs. Not all of them are shared with breast cancer biopsies from female patients indicating male breast cancer specific alterations of microRNA expression. ..
  7. Solbach P, Potthoff A, Raatschen H, Soudah B, Lehmann U, Schneider A, et al. Testosterone-receptor positive hepatocellular carcinoma in a 29-year old bodybuilder with a history of anabolic androgenic steroid abuse: a case report. BMC Gastroenterol. 2015;15:60 pubmed publisher
    ..Hepatocellular carcinoma occurring in association with anabolic androgenic steroid abuse should sensitize physicians and especially professional bodybuilders for the harmful use of high doses of steroids. ..
  8. Anwar S, Wulaningsih W, Lehmann U. Transposable Elements in Human Cancer: Causes and Consequences of Deregulation. Int J Mol Sci. 2017;18: pubmed publisher
  9. Mägel L, Bartels S, Lehmann U. Next-Generation Sequencing Analysis of Laser-Microdissected Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue Specimens. Methods Mol Biol. 2018;1723:111-118 pubmed publisher
    ..In this chapter, a detailed protocol is provided for microdissection of human mammary adenomyoepithelioma tissue specimens and subsequent targeted resequencing of a panel of cancer-related genes using IonTorrent/PGM technology. ..

More Information


  1. Anwar S, Lehmann U. Detection of Aberrant DNA Methylation Patterns in the RB1 Gene. Methods Mol Biol. 2018;1726:35-47 pubmed publisher
    ..In this chapter, we provide a detailed protocol for the quantitative analysis of RB1 gene methylation using bisulfite Pyrosequencing®. ..
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    Lehmann U, Hasemeier B, Christgen M, Muller M, Römermann D, Langer F, et al. Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer. J Pathol. 2008;214:17-24 pubmed
    ..8). In conclusion, this study demonstrates that various microRNA genes are also affected by epigenetic inactivation due to aberrant hypermethylation and that this is an early and frequent event in breast cancer development...