Ulf Landmesser

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease
    Ulf Landmesser
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Carl Neuberg Str 130625 Hannover, Germany
    Arterioscler Thromb Vasc Biol 27:943-8. 2007
  2. ncbi Endothelial function and hypertension
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Curr Opin Cardiol 22:316-20. 2007
  3. ncbi Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 110:1933-9. 2004
  4. ncbi Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 106:3073-8. 2002
  5. ncbi Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 111:2356-63. 2005
  6. ncbi The clinical significance of endothelial dysfunction
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Curr Opin Cardiol 20:547-51. 2005
  7. ncbi Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?
    Niels Engberding
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 110:2175-9. 2004
  8. ncbi Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy
    Sajoscha A Sorrentino
    Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 121:110-22. 2010
  9. ncbi Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction
    Carola Doerries
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Hannover, Germany
    Circ Res 100:894-903. 2007
  10. ncbi Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    Sajoscha A Sorrentino
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 116:163-73. 2007

Collaborators

Detail Information

Publications32

  1. ncbi Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease
    Ulf Landmesser
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Carl Neuberg Str 130625 Hannover, Germany
    Arterioscler Thromb Vasc Biol 27:943-8. 2007
    ..Mechanisms, however, leading to endothelial XO activation remain poorly defined. We tested the effect of angiotensin II (Ang II) on endothelial XO and its relevance for endothelial dysfunction in patients with coronary disease...
  2. ncbi Endothelial function and hypertension
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Curr Opin Cardiol 22:316-20. 2007
    ..This paper outlines some notable studies in this dynamic field published recently...
  3. ncbi Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 110:1933-9. 2004
    ....
  4. ncbi Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 106:3073-8. 2002
    ....
  5. ncbi Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 111:2356-63. 2005
    ..We therefore tested the hypothesis that similar reductions in LDL cholesterol with simvastatin and ezetimibe, a novel cholesterol absorption inhibitor, result in different effects on endothelial function...
  6. ncbi The clinical significance of endothelial dysfunction
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Curr Opin Cardiol 20:547-51. 2005
    ....
  7. ncbi Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?
    Niels Engberding
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 110:2175-9. 2004
    ..We therefore studied the effect of long-term treatment with allopurinol, a potent XO inhibitor, on myocardial ROS production and LV remodeling and dysfunction after MI...
  8. ncbi Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy
    Sajoscha A Sorrentino
    Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 121:110-22. 2010
    ..Moreover, in diabetic patients, we examined the impact of extended-release (ER) niacin therapy on the endothelial effects of HDL...
  9. ncbi Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction
    Carola Doerries
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Hannover, Germany
    Circ Res 100:894-903. 2007
    ..The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI...
  10. ncbi Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    Sajoscha A Sorrentino
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 116:163-73. 2007
    ....
  11. ncbi Exercise training improves in vivo endothelial repair capacity of early endothelial progenitor cells in subjects with metabolic syndrome
    Kristina Sonnenschein
    Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Cardiovasc Prev Rehabil 18:406-14. 2011
    ....
  12. ncbi Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose
    Christian Templin
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    J Mol Cell Cardiol 45:394-403. 2008
    ..Ex vivo expanded HPCs improve cardiac function and remodeling post MI in a cell number- and beta-catenin-dependent manner...
  13. ncbi Cytochrome P450 2C9 is involved in flow-dependent vasodilation of peripheral conduit arteries in healthy subjects and in patients with chronic heart failure
    Dieter Fischer
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Heart Fail 9:770-5. 2007
    ..Recently, a cytochrome P450 (CYP) epoxygenase of the 2C family was linked to NO- and prostacyclin-independent relaxation of conduit arteries. We therefore evaluated the contribution of CYP 2C9 to FMD in humans...
  14. ncbi Chronic heart failure: an overview of conventional treatment versus novel approaches
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Nat Clin Pract Cardiovasc Med 2:628-38. 2005
    ..In this review, we discuss current treatment methods and new strategies to improve treatment of CHF...
  15. ncbi Effect of angiotensin II type 1 receptor antagonism on endothelial function: role of bradykinin and nitric oxide
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    J Hypertens Suppl 24:S39-43. 2006
    ..These beneficial effects of ACE inhibition and AT1-receptor blockade are likely to contribute to their effects on cardiovascular events...
  16. ncbi Arrhythmia susceptibility in mice after therapy with beta-catenin-transduced hematopoietic progenitor cells after myocardial ischemia/reperfusion
    Ajmal Gardiwal
    Department of Cardiovascular Medicine, Hannover Medical School, Hannover, Germany
    Cardiology 114:199-207. 2009
    ..In this study, we investigated the cardiac electrophysiological properties of ex vivo expanded HPCs, generated by beta-catenin gene transfer, after transcoronary delivery in a murine model of ischemia/reperfusion (I/R) injury...
  17. ncbi Endothelial function: a critical determinant in atherosclerosis?
    Ulf Landmesser
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Carl Neuberg Str 1, 30625 Hannover, Germany
    Circulation 109:II27-33. 2004
    ..New insights into mechanisms of endothelial dysfunction, such as a better understanding of the regulation of important vascular sources of oxygen radicals, may lead to novel therapeutic strategies with the potential to improve prognosis...
  18. ncbi Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation
    Karsten Grote
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Cardiovasc Res 71:596-605. 2006
    ..Here, we investigated the role of p47phox in blood pressure control, endothelium-dependent relaxation, cardiac hypertrophy, RAS activation, and renal oxidative stress under resting conditions...
  19. ncbi A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, MHH, 30625 Hannover, Germany
    Cell 128:589-600. 2007
    ..Thus, a biologically active derivative of the pregnancy hormone prolactin mediates PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM...
  20. ncbi Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges
    Jörn Tongers
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Eur Heart J 32:1197-206. 2011
    ..In this context, cell priming, bionanotechnology, and tissue engineering are emerging tools and may merge into a combined biological approach of ischaemic tissue repair...
  21. ncbi Allopurinol and endothelial function in heart failure: future or fantasy?
    Ulf Landmesser
    Circulation 106:173-5. 2002
  22. ncbi Extracellular superoxide dismutase and cardiovascular disease
    Tohru Fukai
    Department of Medicine, Division of Cardiology, Emory University, 1639 Pierce Drive, WMB 319, Atlanta, GA 30322, USA
    Cardiovasc Res 55:239-49. 2002
    ..Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases...
  23. ncbi Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome
    Maria Carolina Gongora
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 173:915-26. 2008
    ..Strategies either to prevent SOD3 inactivation or to augment its levels might prove useful in the treatment of acute lung injury...
  24. ncbi Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phox-dependent manner
    Gustavo Salguero
    Department of Cardiology and Angiology, Germany
    J Hypertens 26:257-68. 2008
    ..Since bone marrow derived endothelial progenitor cells (EPCs) contribute to vascular remodeling and repair, we investigated whether renovascular hypertension stimulates EPC mobilization in a NAD(P)H oxidase-dependent manner...
  25. ncbi Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase
    Sergey Dikalov
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Georgia 30322, USA
    J Biol Chem 277:25480-5. 2002
    ..In light of these findings, the studies using geldanamycin as an inhibitor of Hsp90 should be interpreted with caution...
  26. ncbi Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Hypertension 40:511-5. 2002
    ..These results suggest a pivotal role of the NAD(P)H oxidase and its subunit p47(phox) in the vascular oxidant stress and the blood pressure response to angiotensin II in vivo...
  27. ncbi Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation
    Stephan Spiekermann
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, GA, USA
    Circulation 107:1383-9. 2003
    ..Furthermore, the present study suggests that increased xanthine oxidase activity contributes to endothelial dysfunction in patients with CAD and may thereby promote the atherosclerotic process...
  28. ncbi Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
    ..Treatment strategies that increase tetrahydrobiopterin or prevent its oxidation may prove useful in preventing vascular complications of this common disease...
  29. ncbi Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease
    David G Harrison
    Division of Caridology, Emory University, Atlanta, Georgia 30322, USA
    J Renin Angiotensin Aldosterone Syst 4:51-61. 2003
    ..Furthermore, increasing evidence suggest that the NAD(P)H oxidase contributes to human disease, suggesting that it is a potential target for future therapeutic intervention...
  30. ncbi Toward understanding of extracellular superoxide dismutase regulation in atherosclerosis: a novel role of uric acid?
    Ulf Landmesser
    Arterioscler Thromb Vasc Biol 22:1367-8. 2002
  31. ncbi Role of oxidative stress in atherosclerosis
    David Harrison
    Department of Medicine, Division of Cardioogy, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Am J Cardiol 91:7A-11A. 2003
    ..Oxidative stress in humans with coronary artery disease is also exacerbated by a reduction of vascular extracellular superoxide dismutase, normally an important protective enzyme against the superoxide anion...
  32. ncbi Endothelial dysfunction as an early sign of atherosclerosis
    Gianna Giannotti
    Cardiovascular Center, University of Zurich, Switzerland
    Herz 32:568-72. 2007
    ....