Florian Laenger

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint [Differential diagnosis of spindle cell tumors of the breast from biopsy material]
    F Langer
    Institut fur Pathologie, Medizinischen Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 35:26-35. 2014
  2. doi request reprint [Papillary lesions of the breast]
    F Langer
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 35:36-44. 2014
  3. pmc Imatinib-induced liver cirrhosis in a patient with advanced gastrointestinal stroma tumor (GIST)
    Christoph Seidel
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    BMC Cancer 12:186. 2012
  4. pmc TissuePatch™ as a novel synthetic sealant for repair of superficial lung defect: in vitro tests results
    Ruoyu Zhang
    Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Str, 1, Hannover, 30625, Germany
    Ann Surg Innov Res 6:12. 2012
  5. pmc GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells
    Nils Nickel
    Clinic for Pulmonary Medicine, Hannover Medical School, Hannover, Germany
    Respir Res 12:62. 2011
  6. pmc Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis
    Mrigank Srivastava
    Department of Pulmonary Medicine, Laboratory for Experimental Lung Research, Hannover School of Medicine, Hannover, Germany
    Respir Res 9:54. 2008
  7. pmc Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1
    Thomas Rodt
    Department of Radiology, Hannover Medical School, Hannover, Germany
    Respir Res 11:181. 2010
  8. pmc Identification of differentially expressed microRNAs in human male breast cancer
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Cancer 10:109. 2010
  9. doi request reprint [Histopathology of graft-versus-host disease]
    F Langer
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 32:144-51. 2011
  10. ncbi request reprint [Morphological response to therapy of breast carcinoma]
    F Langer
    Institut fur Pathologie, Medizinische Hochschule Hannover
    Pathologe 25:455-60. 2004

Collaborators

Detail Information

Publications31

  1. doi request reprint [Differential diagnosis of spindle cell tumors of the breast from biopsy material]
    F Langer
    Institut fur Pathologie, Medizinischen Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 35:26-35. 2014
    ..In this review five morphological patterns of spindle cell tumors of the breast and the most important representatives in this group are discussed. ..
  2. doi request reprint [Papillary lesions of the breast]
    F Langer
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 35:36-44. 2014
    ..In this review the most useful morphological and immunohistochemical criteria for routine diagnostic practice are presented. ..
  3. pmc Imatinib-induced liver cirrhosis in a patient with advanced gastrointestinal stroma tumor (GIST)
    Christoph Seidel
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    BMC Cancer 12:186. 2012
    ..While the most frequent adverse events (AEs) are blood count alterations, abdominal discomfort and edema, the occurrence of grade 3 or 4 increase of AST or ALT is specified with 2.1% and 2.7% respectively...
  4. pmc TissuePatch™ as a novel synthetic sealant for repair of superficial lung defect: in vitro tests results
    Ruoyu Zhang
    Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Str, 1, Hannover, 30625, Germany
    Ann Surg Innov Res 6:12. 2012
    ..abstract:..
  5. pmc GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells
    Nils Nickel
    Clinic for Pulmonary Medicine, Hannover Medical School, Hannover, Germany
    Respir Res 12:62. 2011
    ..The aim of the study was to examine the expression and biological roles of GDF-15 in the lung of patients with pulmonary arterial hypertension (PAH)...
  6. pmc Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis
    Mrigank Srivastava
    Department of Pulmonary Medicine, Laboratory for Experimental Lung Research, Hannover School of Medicine, Hannover, Germany
    Respir Res 9:54. 2008
    ..We here tested the hypothesis that over-expression of cathepsin K in the lungs of mice is protective in bleomycin-induced pulmonary fibrosis...
  7. pmc Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1
    Thomas Rodt
    Department of Radiology, Hannover Medical School, Hannover, Germany
    Respir Res 11:181. 2010
    ..Its value for assessing progressive lung fibrosis in mice has not been reported so far. Here we examined the importance of in vivo micro-CT as non-invasive tool to assess progression of pulmonary fibrosis in mice over time...
  8. pmc Identification of differentially expressed microRNAs in human male breast cancer
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Cancer 10:109. 2010
    ..However, nothing is known so far about microRNA expression in male breast cancer, accounting for approximately 1% of all breast cancer cases...
  9. doi request reprint [Histopathology of graft-versus-host disease]
    F Langer
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 32:144-51. 2011
    ..This review covers the diagnostic morphological criteria and differential diagnoses of GvHD in the skin, gastrointestinal tract and the liver...
  10. ncbi request reprint [Morphological response to therapy of breast carcinoma]
    F Langer
    Institut fur Pathologie, Medizinische Hochschule Hannover
    Pathologe 25:455-60. 2004
    ..Predictive for the chemosensitivity of tumours are a high nuclear grade, overexpression of Her-2-neu, lack of estrogen receptor expression and lymph node metastases...
  11. ncbi request reprint [The importance of immunohistochemistry for the diagnosis of cholangiocarcinomas]
    F Langer
    Institut fur Pathologie, Medizinische Hochschule, Carl Neuberg Strasse 1, 30625, Hannover
    Pathologe 27:244-50. 2006
    ..Although this pattern allows the separation of CC from most metastatic carcinomas, pancreatic carcinomas show a broad overlap with this expression pattern...
  12. doi request reprint [Immunodeficiency and immunocompromised patients. Opportunistic infection of the lungs]
    F Langer
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 32:411-7. 2011
    ..In this review morphological reaction patterns and their differential diagnoses of the most common bacterial, viral and mycotic infections in the lungs of immunocompromised patients are discussed...
  13. ncbi request reprint [Epigenetic inactivation of microRNA genes in mammary carcinoma]
    U Lehmann
    Institut fur Pathologie, Medizinische Hochschule Hannover, Hannover
    Verh Dtsch Ges Pathol 91:214-20. 2007
    ..This study addresses the question whether microRNA genes are affected by aberrant hypermethylation and subsequent transcriptional repression in human breast cancer...
  14. doi request reprint [Beyond staging, typing and grading. New challenges in breast cancer pathology]
    H H Kreipe
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Pathologe 31:54-9. 2010
    ....
  15. doi request reprint [Diagnostics and treatment of primary bone tumors]
    T Gosling
    Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Hannover
    Chirurg 81:657-78; quiz 679-80. 2010
    ..Several biological as well as alloplastic reconstruction techniques exist. The treatment of primary malignant bone tumors requires a lot of experience and should only be done in specialized centers...
  16. ncbi request reprint [Methylation status of LINE-1 sequences in patients with MDS or secondary AML]
    D Römermann
    Institut fur Pathologie, Medizinische Hochschule Hannover
    Verh Dtsch Ges Pathol 91:338-42. 2007
    ..This study analyzes changes in the degree of global methylationlevel in myelodysplastic syndrome during progression of the disease...
  17. pmc Demonstration of light chain restricted clonal B-lymphoid infiltrates in archival bone marrow trephines by quantitative real-time polymerase chain reaction
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Am J Pathol 159:2023-9. 2001
    ....
  18. ncbi request reprint Detection of gene amplification in intraductal and infiltrating breast cancer by laser-assisted microdissection and quantitative real-time PCR
    S Glockner
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Pathobiology 68:173-9. 2000
    ....
  19. doi request reprint [Tuberculous Otitis media - a rare differential diagnosis in Germany]
    M Teschner
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, Medizinische Hochschule Hannover
    Laryngorhinootologie 87:503-6. 2008
    ....
  20. ncbi request reprint Yersinia infection mimicking recurrence of gastrointestinal stromal tumor
    T Luedde
    Dept of Gastroenterology, Hepatology and Endocrinology, Hanover Medical School, Germany
    Scand J Gastroenterol 39:609-12. 2004
    ..In conclusion, GISTs have a high likelihood of recurrence even after complete resection, but an asymptomatic infection such as yersiniosis must be considered as a differential diagnosis to GIST recurrence...
  21. ncbi request reprint [Neuroendocrine tumors of the stomach. Surgery therapy and prognosis]
    H Bektas
    Klinik für Viszeral und Transplantationschirurgie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Chirurg 73:331-5. 2002
    ..A local excision was performed on one patient with type I tumor. After a mean follow-up of 8 years, 5 of 7 patients are alive without recurrence...
  22. ncbi request reprint [The development of myelofibrosis in prefibrotic cIMF. An investigation of the progression by sequential bone marrow biopsies in 38 patients]
    T Buhr
    Institut fur Pathologie, Medizinische Hochschule, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Pathologe 23:433-7. 2002
    ..6%) patients, whereas 3 patients remained "prefibrotic" even after up to 6 years of follow-up...
  23. ncbi request reprint Amplification of growth regulatory genes in intraductal breast cancer is associated with higher nuclear grade but not with the progression to invasiveness
    S Glockner
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Lab Invest 81:565-71. 2001
    ....
  24. ncbi request reprint [The monthly interesting case - case no. 56. Adult rhabdomyoma]
    B Schwab
    HNO Klinik der Medizinischen Hochschule Hannover
    Laryngorhinootologie 82:286-8. 2003
  25. ncbi request reprint Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML)
    M Tessema
    1Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Street 1, Hannover, Germany
    Leukemia 17:910-8. 2003
    ..We conclude that aberrant gene methylation is a frequent event in CMML that might contribute to the pathogenesis of this MDS/MPD...
  26. ncbi request reprint [Histopathology of leukaemic non-Hodgkin's lymphoma in bone marrow]
    T Buhr
    Institut fur Pathologie, Medizinische Hochschule, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Pathologe 23:438-47. 2002
    ....
  27. ncbi request reprint [Osteosarcoma of the pelvisTwo case reports and review of the literature]
    S Bading
    Unfallchirurgische Klinik, Medizinische Hochschule, Hannover
    Unfallchirurg 107:625-32. 2004
    ..Based on a review of the literature, diagnosis, treatment, and complications of two cases of sacrum osteosarcoma are introduced...
  28. ncbi request reprint Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    J Pathol 214:17-24. 2008
    ..8). In conclusion, this study demonstrates that various microRNA genes are also affected by epigenetic inactivation due to aberrant hypermethylation and that this is an early and frequent event in breast cancer development...
  29. doi request reprint Pathological characteristics of a series of rare chronic histiocytic intervillositis of the placenta
    J Traeder
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Placenta 31:1116-9. 2010
    ..Our approach revealed that assisted reproduction-induced pregnancy had been performed in 2 of 4 CHI cases, but other factors and comorbidities are likely to contribute to CHI...
  30. doi request reprint [Pulmonary manifestations of inflammatory bowel disease]
    O Bachmann
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover, Deutschland
    Internist (Berl) 51:264-8. 2010
    ..The best therapeutic results have been obtained with topic and systemic steroids, while classic immunosuppressants are commonly not efficacious. Several case reports describe a beneficial effect of infliximab...
  31. ncbi request reprint [Epigenetic changes in breast cancer shown by aberrant promoter methylation]
    U Lehmann
    Institut fur Pathologie, Medizinische Hochschule Hannover
    Zentralbl Gynakol 126:272-4. 2004
    ..The occurrence of specific aberrant methylation patterns is associated with the histological grade and subtype of mammary carcinoma biopsies...