Klaus Krampfl

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Kinetic analysis of the agonistic and blocking properties of pentobarbital on recombinant rat alpha(1)beta(2)gamma(2S) GABA(A) receptor channels
    Klaus Krampfl
    Department of Neurology of the Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Eur J Pharmacol 435:1-8. 2002
  2. ncbi request reprint Molecular analysis of the A322D mutation in the GABA receptor alpha-subunit causing juvenile myoclonic epilepsy
    Klaus Krampfl
    Neurologische Klinik, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur J Neurosci 22:10-20. 2005
  3. ncbi request reprint Effects of propofol on recombinant AMPA receptor channels
    Klaus Krampfl
    Neurological Department of the Medizinische Hochschule Hannover, Germany
    Eur J Pharmacol 511:1-7. 2005
  4. ncbi request reprint Amyotrophic lateral sclerosis (ALS) and mirror movements in a patient with polymicrogyria
    Klaus Krampfl
    Department of Neurology, Medizinische Hochschule, Hannover, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:266-9. 2003
  5. ncbi request reprint GABA(A)-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    J Neurol Sci 250:124-32. 2006
  6. doi request reprint Modulation of glycine receptor function by the synthetic cannabinoid HU210
    Reyhan Demir
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Pharmacology 83:270-4. 2009
  7. ncbi request reprint The mRNA expression of AMPA type glutamate receptors in the primary motor cortex of patients with amyotrophic lateral sclerosis: an in situ hybridization study
    Susanne Petri
    Department of Neurology, Hannover Medical School, D 30623 Hannover, Germany
    Neurosci Lett 360:170-4. 2004
  8. doi request reprint The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover, Germany
    Pharmacology 83:217-22. 2009
  9. doi request reprint The non-anaesthetic propofol analogue 2,6-di-tert-butylphenol fails to modulate GABA(A) receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 83:95-8. 2009
  10. ncbi request reprint Characterization and differentiation potential of rat ventral mesencephalic neuronal progenitor cells immortalized with SV40 large T antigen
    André Nobre
    Institute of Neuroanatomy, Hannover Medical School, 30625, Hannover, Germany
    Cell Tissue Res 340:29-43. 2010

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Kinetic analysis of the agonistic and blocking properties of pentobarbital on recombinant rat alpha(1)beta(2)gamma(2S) GABA(A) receptor channels
    Klaus Krampfl
    Department of Neurology of the Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Eur J Pharmacol 435:1-8. 2002
    ..A kinetic scheme was constructed allowing the quantitative analysis of the pentobarbital activated ionic currents through GABA(A) receptor channels...
  2. ncbi request reprint Molecular analysis of the A322D mutation in the GABA receptor alpha-subunit causing juvenile myoclonic epilepsy
    Klaus Krampfl
    Neurologische Klinik, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur J Neurosci 22:10-20. 2005
    ..These molecular defects could decrease and shorten the resulting inhibitory postsynaptic currents (IPSCs) in vivo, which can induce a hyperexcitability of the postsynaptic membrane and explain the occurrence of epileptic seizures...
  3. ncbi request reprint Effects of propofol on recombinant AMPA receptor channels
    Klaus Krampfl
    Neurological Department of the Medizinische Hochschule Hannover, Germany
    Eur J Pharmacol 511:1-7. 2005
    ..The pharmacological effect described resembles in part that of compounds like cyclothiazide and aniracetam which are known to interact with channel desensitization...
  4. ncbi request reprint Amyotrophic lateral sclerosis (ALS) and mirror movements in a patient with polymicrogyria
    Klaus Krampfl
    Department of Neurology, Medizinische Hochschule, Hannover, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:266-9. 2003
    ..The corpus callosum was completely developed and of normal size. We hypothesize an enrolment of the dysplastic right frontal lobe pathophysiology of the observed mirror movements...
  5. ncbi request reprint GABA(A)-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    J Neurol Sci 250:124-32. 2006
    ..In the occipital and cerebellar cortex, we did not see disease-specific differences of the mRNA expression of the investigated subunits...
  6. doi request reprint Modulation of glycine receptor function by the synthetic cannabinoid HU210
    Reyhan Demir
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Pharmacology 83:270-4. 2009
    ..7 +/- 46.2 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for HU210 mediating some of its anti-inflammatory and anti-nociceptive properties...
  7. ncbi request reprint The mRNA expression of AMPA type glutamate receptors in the primary motor cortex of patients with amyotrophic lateral sclerosis: an in situ hybridization study
    Susanne Petri
    Department of Neurology, Hannover Medical School, D 30623 Hannover, Germany
    Neurosci Lett 360:170-4. 2004
    ..Using in situ hybridization histochemistry we did not detect any significant differences in the distribution of AMPA receptor mRNA in the motor cortex of ALS patients compared to controls...
  8. doi request reprint The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover, Germany
    Pharmacology 83:217-22. 2009
    ..3 micromol/l and alpha(1)beta = 144.3 +/- 22.7 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for cannabidiol mediating some of its anti-inflammatory and neuroprotective properties...
  9. doi request reprint The non-anaesthetic propofol analogue 2,6-di-tert-butylphenol fails to modulate GABA(A) receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 83:95-8. 2009
    ..Our results support the assumption that modulation of inhibitory GABA(A) receptor function is responsible for the anaesthetic effects of propofol in vivo...
  10. ncbi request reprint Characterization and differentiation potential of rat ventral mesencephalic neuronal progenitor cells immortalized with SV40 large T antigen
    André Nobre
    Institute of Neuroanatomy, Hannover Medical School, 30625, Hannover, Germany
    Cell Tissue Res 340:29-43. 2010
    ..SV40Tag cells are suitable for carrying out controlled genetic modifications as shown by overexpression of enhanced green fluorescence protein after efficient non-viral transfection...
  11. ncbi request reprint Competitive and open channel block of recombinant nAChR channels by different antibiotics
    Friedrich Schlesinger
    Department of Neurology of the Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Neuromuscul Disord 14:307-12. 2004
    ..From our in-vitro results we conclude that competitive inhibition of nAChR channels by antibiotics is an important mechanism underlying the impairment of neuromuscular transmission under clinical conditions...
  12. pmc 4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors
    Jeanne de la Roche
    Clinic for Anesthesia and Critical Care Medicine, OE 8050, Hannover Medical School, Carl Neuberg Str, 1, 30625, Hannover, Germany
    BMC Neurol 12:104. 2012
    ..The aim of this in vitro study was to characterize the effects of 4-chloropropofol (4-chloro-2,6-dimethylphenol) at four glycine receptor mutations...
  13. doi request reprint A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor
    Jorg Ahrens
    Department of Anesthesiology, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Anesth Analg 107:1875-83. 2008
    ..In the present study we investigated the role of this residue on the interaction of propofol with the glycine alpha(1) and alpha(1)beta receptor...
  14. ncbi request reprint Dopaminergic properties and function after grafting of attached neural precursor cultures
    Marco Timmer
    Department of Neuroanatomy, Center of Anatomy, OE 4140, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    Neurobiol Dis 21:587-606. 2006
    ....
  15. ncbi request reprint Correlation between distal motor latency and compound muscle action potential in amyotrophic lateral sclerosis
    Bahram Mohammadi
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Hannover, Germany
    Neurol Res 29:425-8. 2007
    ..The measurement of motor conduction of peripheral nerves is of major importance to recognize other possible causes of progressive muscle wasting. However, there are also pathologic changes in nerve conduction studies in ALS patients...
  16. ncbi request reprint 2,6 di-tert-butylphenol, a nonanesthetic propofol analog, modulates alpha1beta glycine receptor function in a manner distinct from propofol
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Anesth Analg 99:91-6. 2004
    ..Propofol and its nonanesthetic structural analog do not differ in their ability to coactivate the glycine receptor but differ in their ability to directly activate the receptor in the absence of the natural agonist...
  17. doi request reprint The anaesthetic steroid alphaxalone positively modulates alpha1-glycine receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 82:228-32. 2008
    ..9 +/- 21.5 micromol/l. Taking into account the results of other groups, our study suggests that neuroactive steroids might be an interesting class of compounds to probe subunit-specific effects of glycine receptors...
  18. doi request reprint Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis
    Sonja Körner
    Department of Neurology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Muscle Nerve 43:636-42. 2011
    ..There is ongoing discussion as to whether ALS is primarily a disease of UMNs or LMNs...
  19. ncbi request reprint Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 379:371-8. 2009
    ..9 +/- 21.5 microM and alpha(1)beta = 154.3 +/- 32.1 microM). These in vitro results demonstrate that ajulemic acid modulates strychnine-sensitive glycine receptors in clinically relevant concentrations...
  20. ncbi request reprint A mutation in the GABA(A) receptor alpha(1)-subunit is associated with absence epilepsy
    Snezana Maljevic
    Neurologische Klinik, Universitat Ulm, Ulm, Germany
    Ann Neurol 59:983-7. 2006
    ..To detect mutations in GABRA1 in idiopathic generalized epilepsy...
  21. doi request reprint Nerve compression syndromes in ALS: a retrospective analysis in 554 patients
    Katja Kollewe
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Hannover, Germany
    Amyotroph Lateral Scler 12:349-51. 2011
    ..32) of the diagnosis of ALS. Survival was no different between group A and the cohort. It can also be concluded that the misdiagnoses could have been avoided by thorough electrophysiological examination using a standardized protocol...
  22. doi request reprint Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis
    Alexander Sarlette
    Department of Neurology Neuroanatomy, and Institute for Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    J Neuropathol Exp Neurol 67:1055-62. 2008
    ..These results suggest that alterations in this signaling cascade occur in motor neurons in ALS and that they may contribute to chronic motor neuron degeneration...
  23. ncbi request reprint Two different modes of action of pentobarbital at glycine receptor channels
    Bahram Mohammadi
    Department of Neurology, Medical University Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Eur J Pharmacol 489:151-6. 2004
    ..After the end of glycine+pentobarbital pulses, off-currents occurred suggestive for a channel block mechanism. Pentobarbital had no agonistic effects at glycine receptor channels...
  24. ncbi request reprint Mirror movements and ipsilateral motor evoked potentials in ALS
    Klaus Krampfl
    Department of Neurology, Medical University of Hannover, Hannover, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:154-63. 2004
    ..Central motor conduction times were prolonged in 15 ALS patients (27%). It is concluded that MMs, especially if studied by EMG and TMS (IMEPs) can essentially improve detection of UMN involvement, especially in early stages of ALS...
  25. ncbi request reprint Interaction of topiramate with glycine receptor channels
    Bahram Mohammadi
    Department of Neurology, Medical University Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Pharmacol Res 51:587-92. 2005
    ..However, in presence of 1 mM glycine + 1 mM TPM, the desensitization got faster and the peak current amplitude decreased. After the end of glycine + TPM pulses, off-currents occurred, suggestive for a specific channel block mechanism...
  26. doi request reprint Speech therapy and communication device: impact on quality of life and mood in patients with amyotrophic lateral sclerosis
    Sonja Körner
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Amyotroph Lateral Scler Frontotemporal Degener 14:20-5. 2013
    ..In conclusion, communication systems improve or at least stabilize quality of life and mood in dysarthric ALS patients, and should be provided early in the disease course...
  27. ncbi request reprint Selective and nonselective benzodiazepine agonists have different effects on motor cortex excitability
    Bahram Mohammadi
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Muscle Nerve 33:778-84. 2006
    ..This selective modulation of the CSP and the LICI points to a specific role of BZ1 receptors in the control of inhibitory neuronal loops within the primary motor cortex...
  28. doi request reprint Synaptic currents and transmitter responses in human NT2 neurons differentiated in aggregate culture
    Grzegorz Podrygajlo
    Div of Cell Biology, Institute of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany
    Neurosci Lett 468:207-10. 2010
    ..These cultured spontaneously active networks may be a useful tool to analyze factors that modulate the formation and efficacy of synapses between human neurons...
  29. doi request reprint Preserved expression of fibroblast growth factor (FGF)-2 and FGF receptor 1 in brain and spinal cord of amyotrophic lateral sclerosis patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    Histochem Cell Biol 131:509-19. 2009
    ..The distribution of cells expressing FGF-2 and FGFR1 transcripts showed no differences between ALS and controls. Our data suggest that FGF-2 and FGFR1 expression is preserved in the motor system in end stage ALS...
  30. doi request reprint Topical antiseptics for the treatment of sore throat block voltage-gated neuronal sodium channels in a local anaesthetic-like manner
    Vanessa Buchholz
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 380:161-8. 2009
    ..Both drugs show an increased effect at depolarised membrane potentials or in conditions of high-frequency discharges...
  31. doi request reprint ALSFRS-R score and its ratio: a useful predictor for ALS-progression
    Katja Kollewe
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Neurol Sci 275:69-73. 2008
    ..We conclude that the ratio of ALSFRS-R score within 100 days is a useful parameter for clinical trials and daily clinical work in a tertiary ALS-clinic...
  32. ncbi request reprint Control of kinetic properties of GluR2 flop AMPA-type channels: impact of R/G nuclear editing
    Klaus Krampfl
    Department of Neurology, Medizinische Hochschule Hannover, 31623 Hannover, Germany
    Eur J Neurosci 15:51-62. 2002
    ..Quantitative analysis by computer simulation using a circular kinetic scheme allows the prediction of the main experimental results...
  33. ncbi request reprint Kinetic properties of human AMPA-type glutamate receptors expressed in HEK293 cells
    Julian Grosskreutz
    Department of Neurology, Medizinische Hochschule Hannover, 30625 Hannover
    Eur J Neurosci 17:1173-8. 2003
    ..Thus, subunit interaction seems likely during recovery but not desensitization. Both parameters might influence the ability of AMPA receptors to mediate glutamate induced chronic excitotoxicity in neurodegenerative diseases...
  34. ncbi request reprint Distribution of GABAA receptor mRNA in the motor cortex of ALS patients
    Susanne Petri
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    J Neuropathol Exp Neurol 62:1041-51. 2003
    ..This may indicate specific alterations of the GABAA receptor subunit composition and result in distinct physiological and pharmacological properties of these receptors in ALS patients...
  35. ncbi request reprint Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra
    Susanne Petri
    Hannover Medical School, Department of Neurology, D 30623 Hannover, Germany
    J Comp Neurol 452:360-6. 2002
    ..This might represent a negative feedback loop between the striatum and the SNc and be a target of pharmacologic interventions in neurodegenerative diseases such as Parkinson's disease...
  36. ncbi request reprint Amyotrophic lateral sclerosis: new developments in diagnostic markers
    Reinhard Dengler
    Department of Neurology, Medical School Hannover, Hannover, Germany
    Neurodegener Dis 2:177-84. 2005
    ..Voxel-based morphometry can reliably demonstrate regional cortical atrophy in motor areas and beyond although it is not appropriate for use in individual patients...
  37. ncbi request reprint Block of recombinant nicotinic receptor channels by IgG from myasthenic patients
    Klaus Krampfl
    Department of Neurology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Muscle Nerve 25:433-7. 2002
    ..The reversible pharmacological blockade of adult-type nAChR channels by myasthenic IgG may be one factor responsible for rapid fluctuations of weakness or rapid recovery of muscle strength after plasmapheresis in MG...
  38. pmc Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors
    Friedrich Schlesinger
    Neurological Department of the Medical School of Hannover, Karl Neuberg Str 1, 30623 Hannover, Germany
    Br J Pharmacol 145:656-63. 2005
    ..6. The data were interpreted in the frame of a molecular scheme with two binding sites of IEM-1460 at the receptor, one at the unliganded resting and the other at the fully liganded open state of the channels...
  39. doi request reprint Endotoxin reduces availability of voltage-gated human skeletal muscle sodium channels at depolarized membrane potentials
    Gertrud Haeseler
    Department of Anesthesiology, Hannover Medical School, Germany
    Crit Care Med 36:1239-47. 2008
    ..This study was designed to investigate a potential direct interaction of lipopolysaccharides from Escherichia coli with voltage-gated human skeletal muscle sodium channels (NaV1.4) in vitro...
  40. pmc Structural features of phenol derivatives determining potency for activation of chloride currents via alpha(1) homomeric and alpha(1)beta heteromeric glycine receptors
    Gertrud Haeseler
    Department of Anaesthesiology, OE 8050, Hannover Medical School, D 30623 Hannover, Germany
    Br J Pharmacol 145:916-25. 2005
    ..The presence of the beta subunit is not required for both effects...
  41. doi request reprint Treatment of phantom limb pain with botulinum toxin type A
    Lingjing Jin
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Hannover, Germany
    Pain Med 10:300-3. 2009
    ..We report on three phantom and stump pain patients, refractive to previous treatments, who were successfully treated with botulinum toxin A (BoNT-A)...
  42. ncbi request reprint Reduced delayed rectifier K+ current, altered electrophysiology, and increased ventricular vulnerability in MLP-deficient mice
    Ajmal Gardiwal
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    J Card Fail 13:687-93. 2007
    ..In humans, MLP-expression is downregulated both in ischemic and dilative cardiomyopathy. In this study, we investigated the effects of MLP on the electrophysiologic phenotype in vivo and on outward potassium currents...
  43. pmc Canine muscle cell culture and consecutive patch-clamp measurements - a new approach to characterize muscular diseases in dogs
    Henning Christian Schenk
    Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany
    BMC Vet Res 8:227. 2012
    ....
  44. ncbi request reprint Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyltransferase
    Carolin Schmidt
    Department of Neurology, and Genzentrum, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Neuromuscul Disord 13:245-51. 2003
    ..The observation of the same mutation (I336T) in two independent Turkish kinships may suggest a common origin, i.e. founder...
  45. ncbi request reprint Molecular analysis of the interaction of the pyrazine derivatives RPR119990 and RPR117824 with human AMPA-type glutamate receptor channels
    Klaus Krampfl
    Neurological Department of the Medizinische Hochschule Hannover and Centre of Systems Neuroscience ZSN, Germany
    Neuropharmacology 50:479-90. 2006
    ..Quantitative analysis of the experimental data using computerized simulations are compatible with a competitive block mechanism and provides hints to binding sites at unliganded and liganded closed states of the receptor...
  46. ncbi request reprint Triple stimulation technique (TST) in amyotrophic lateral sclerosis
    Leonid Komissarow
    Medical State Academy Kasan, Tatarstan, Russia
    Clin Neurophysiol 115:356-60. 2004
    ..The authors studied amyotrophic lateral sclerosis (ALS) patients using triple stimulation technique (TST) to detect upper motor neuron (UMN) involvement...
  47. ncbi request reprint Desensitization and resensitization are independently regulated in human recombinant GluR subunit coassemblies
    Friedrich Schlesinger
    Neurological Department of Medical School Hannover, 30623 Hannover, Germany
    Synapse 55:176-82. 2005
    ..The same holds true for tau(rec) except GluR2 flip channels were coexpressed with GluR1 channels. In this case, tau(rec) had values close to that of fast resensitizing GluR2 flip channels, even in the case of an abundance of GluR1 cDNA...