T Kofidis

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Clinically established hemostatic scaffold (tissue fleece) as biomatrix in tissue- and organ-engineering research
    T Kofidis
    Division of Thoracic and Cardiovascular Surgery and Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Hannover, Germany
    Tissue Eng 9:517-23. 2003
  2. ncbi request reprint From vision to mission in myocardial restoration
    Theo Kofidis
    Asian Cardiovasc Thorac Ann 16:91-2. 2008
  3. ncbi request reprint A novel bioartificial myocardial tissue and its prospective use in cardiac surgery
    Theo Kofidis
    Division of Thoracic and Cardiovascular Surgery and the Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Eur J Cardiothorac Surg 22:238-43. 2002
  4. ncbi request reprint Traveling after heart transplantation
    T Kofidis
    Department of Thoracic and Cardiovascular Surgery, Transplantation Unit, Hannover Medical School, Germany
    Clin Transplant 16:280-4. 2002
  5. ncbi request reprint In vitro engineering of heart muscle: artificial myocardial tissue
    T Kofidis
    Division of Thoracic and Cardiovascular Surgery and Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Germany
    J Thorac Cardiovasc Surg 124:63-9. 2002
  6. ncbi request reprint Clinical relevance of intracranial high intensity transient signals in patients following prosthetic aortic valve replacement
    Theo Kofidis
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur J Cardiothorac Surg 21:22-6. 2002
  7. ncbi request reprint Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury
    Theo Kofidis
    Cardiovascular Surgery, Stanford University Medical School, Stanford, California, USA
    Circulation 112:I173-7. 2005
  8. ncbi request reprint Pulsatile perfusion and cardiomyocyte viability in a solid three-dimensional matrix
    T Kofidis
    Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Biomaterials 24:5009-14. 2003
  9. ncbi request reprint [In vivo detection of integration of grafted cells after myocardial transplantation]
    A Ruhparwar
    Abteilung für Thorax, Herz und Gefässchirurgie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Zentralbl Chir 131:420-4. 2006
  10. ncbi request reprint Impact of vascular branching sites on focal progression of allograft vasculopathy in transplanted hearts
    K Pethig
    Department of Thoracic and Cardiovascular Surgery, Division of Surgery, Hannover Medical School, D 30623 Hannover, Germany
    Atherosclerosis 158:155-60. 2001

Detail Information

Publications53

  1. ncbi request reprint Clinically established hemostatic scaffold (tissue fleece) as biomatrix in tissue- and organ-engineering research
    T Kofidis
    Division of Thoracic and Cardiovascular Surgery and Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Hannover, Germany
    Tissue Eng 9:517-23. 2003
    ..Tissue Fleece constitutes an effective scaffold to engineer solid organ structures, which could be used for repair of congenital defects or replacement of diseased tissue...
  2. ncbi request reprint From vision to mission in myocardial restoration
    Theo Kofidis
    Asian Cardiovasc Thorac Ann 16:91-2. 2008
  3. ncbi request reprint A novel bioartificial myocardial tissue and its prospective use in cardiac surgery
    Theo Kofidis
    Division of Thoracic and Cardiovascular Surgery and the Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Eur J Cardiothorac Surg 22:238-43. 2002
    ..We have developed a contractile bioartificial myocardial tissue, which offers new perspectives for various reconstructive surgical interventions, including congenital heart surgery...
  4. ncbi request reprint Traveling after heart transplantation
    T Kofidis
    Department of Thoracic and Cardiovascular Surgery, Transplantation Unit, Hannover Medical School, Germany
    Clin Transplant 16:280-4. 2002
    ..The aim of this study was to analyze traveling activities and complications in a large cohort of heart transplant recipients, with the intention to develop adequate safety and behavioral guidelines...
  5. ncbi request reprint In vitro engineering of heart muscle: artificial myocardial tissue
    T Kofidis
    Division of Thoracic and Cardiovascular Surgery and Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Germany
    J Thorac Cardiovasc Surg 124:63-9. 2002
    ....
  6. ncbi request reprint Clinical relevance of intracranial high intensity transient signals in patients following prosthetic aortic valve replacement
    Theo Kofidis
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur J Cardiothorac Surg 21:22-6. 2002
    ..In addition, HITS rates were correlated with clinical, echocardiographical and laboratory findings...
  7. ncbi request reprint Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury
    Theo Kofidis
    Cardiovascular Surgery, Stanford University Medical School, Stanford, California, USA
    Circulation 112:I173-7. 2005
    ..With the liquid bioartificial tissue compound used in this study, we achieved targeted large-scale support of the infarcted left ventricular wall and improvement of heart function...
  8. ncbi request reprint Pulsatile perfusion and cardiomyocyte viability in a solid three-dimensional matrix
    T Kofidis
    Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Biomaterials 24:5009-14. 2003
    ..We introduce a novel concept of pulsatile tissue culture perfusion to promote ubiquitous cellular viability and metabolism...
  9. ncbi request reprint [In vivo detection of integration of grafted cells after myocardial transplantation]
    A Ruhparwar
    Abteilung für Thorax, Herz und Gefässchirurgie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Zentralbl Chir 131:420-4. 2006
    ..Further technical adjustments should allow for thoracoscopic/endoscopic application of this method, making it appropriate for use in other organs and in clinical studies...
  10. ncbi request reprint Impact of vascular branching sites on focal progression of allograft vasculopathy in transplanted hearts
    K Pethig
    Department of Thoracic and Cardiovascular Surgery, Division of Surgery, Hannover Medical School, D 30623 Hannover, Germany
    Atherosclerosis 158:155-60. 2001
    ..As a model for differences in focal blood flow dynamics, we analyzed progression of intimal hyperplasia at vascular bifurcational sites using intravascular ultrasound (IVUS)...
  11. doi request reprint The minimized extracorporeal circulation system causes less inflammation and organ damage
    T Kofidis
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Perfusion 23:147-51. 2008
    ..It may also be the circuit in patients with chronic obstructive pulmonary disease (COPD)...
  12. ncbi request reprint [Ross procedure with combined replacement of the ascending aorta: impact on autograft root function and distensibility]
    R G Leyh
    Medizinische Hochschule Hannover Carl Neuberg Str 1 30623 Hannover, Germany
    Z Kardiol 92:392-7. 2003
    ....
  13. ncbi request reprint [Tissue engineering: in vitro creation of tissue substitutes]
    O E Teebken
    Klinik fur Herz, Thorax, Transplantations und Gefässchirurgie, Medizinische Hochschule Hannover, 30625 Hannover
    Zentralbl Chir 132:236-46. 2007
    ....
  14. ncbi request reprint Restoration of blood flow and evaluation of corresponding angiogenic events by scanning electron microscopy after a single dose of VEGF in a model of peripheral vascular disease
    T Kofidis
    Div of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Angiogenesis 5:87-92. 2002
    ..02). We have developed a simple and effective experimental model of ischemia. For the study of angiogenic phenomena, 3-D imaging of the microvasculature offers a direct and conclusive method for the study of angiogenic events...
  15. ncbi request reprint Minimally invasive coronary artery revascularization on the beating heart
    J T Cremer
    Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Germany
    Ann Thorac Surg 69:1787-91. 2000
    ..The quality of surgical beating heart revascularization is frequently questioned, especially when the surgical access is limited. Nevertheless, the number of off-pump coronary procedures is expanding worldwide...
  16. ncbi request reprint Aortic prosthesis re-replacement due to concealed stenosing subvalvular pannus ring
    M Emmert
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Thorac Cardiovasc Surg 55:331-2. 2007
    ..Intraoperatively, a stenosing pannus ring was found and excised. This pathological entity should be considered in cases of unclear transprosthetic gradient and early operation should be encouraged in symptomatic patients...
  17. ncbi request reprint In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 26:273-80. 2007
    ..In this study we introduce two new experimental models for longitudinal in vivo survival studies of cardiac cell grafts using optical bioluminescence imaging...
  18. ncbi request reprint Ross procedure with a quadricuspid pulmonary autograft
    Sebastian Patrick Sommer
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Thorac Cardiovasc Surg 130:212-3. 2005
  19. ncbi request reprint Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium
    Rutger Jan Swijnenburg
    Department of Surgery, Leiden University School of Medicine, The Netherlands
    Circulation 112:I166-72. 2005
    ..We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection...
  20. ncbi request reprint Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California, USA
    Circulation 114:I167-73. 2006
    ..Cardiac cell transplantation is limited by poor graft viability. We aimed to enhance the survival of transplanted cardiomyoblasts using growth factor-supplemented collagen matrices...
  21. ncbi request reprint Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t
    Takayasu Arai
    Division of Cardiovascular Medicine, Stanford University, California 94305 5233, USA
    Magn Reson Med 55:203-9. 2006
    ..Thus, in vivo MRI enables simultaneous detection of transplanted mESC and their therapeutic effect on the injured myocardium...
  22. ncbi request reprint Anastomotic obstruction after magnetic vascular coupling after minimally invasive direct coronary artery bypass grafting
    Uwe Klima
    Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Ann Thorac Surg 81:728-9. 2006
    ..It was also determined that the patient had been noncompliant in following the prescribed postoperative antiplatelet therapy...
  23. ncbi request reprint Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California, USA
    Circulation 114:I174-80. 2006
    ..Therefore, we studied the potential benefit of hBcl-2 transgene expression on the survival of cardiomyoblast grafts in ischemic rat hearts...
  24. ncbi request reprint Creatine kinase isoenzyme MB relative index as predictor of mortality on extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock in adult patients
    Ruoyu Zhang
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur J Cardiothorac Surg 30:617-20. 2006
    ..We tried to find measurable values during ECMO support that could predict the patient mortality on ECMO support...
  25. ncbi request reprint Iatrogenic type A dissection after attempted stenting of a descending aortic aneurysm
    Ruoyu Zhang
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Ann Thorac Surg 82:1523-5. 2006
    ..Other than the known causes, the described retrograde type A dissection resulted from guidewire manipulation and iatrogenic creation of a false lumen, which was erroneously dilated and stented...
  26. ncbi request reprint Long-term cardiac allograft valves after heart transplant are functionally and structurally preserved, in contrast to homografts and bioprostheses
    Mathias H Wilhelmi
    Division for Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Heart Valve Dis 15:777-82. 2006
    ..To further evaluate this hypothesis, the valvular morphology and function, as well as comorbidities predisposing to deteriorative processes, were evaluated in patients who had undergone heart transplant more than 10 years previously...
  27. ncbi request reprint MRI-based safety evaluation of the ventrica magnetic coronary anastomotic system
    Uwe Klima
    Department of Cardiac, Thoracic and Vascular Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, 119074 Singapore
    Asian Cardiovasc Thorac Ann 15:24-9. 2007
    ..Clinically relevant tests such as cranial magnetic resonance imaging may be safe after use of the Ventrica system for coronary artery revascularization...
  28. ncbi request reprint Myocardial restoration and tissue engineering of heart structures
    Theo Kofidis
    Division of Thoracic and Cardiovascular Surgery, Hanover Medical School, Germany
    Methods Mol Med 140:273-90. 2007
    ..The main goal envisioned here is long-term patency following implantation in vivo. This review surveys upon recent developments and indicates caveats in the field of tissue engineering of cardiac, valvular, and vascular structures...
  29. ncbi request reprint Myocardial restoration with embryonic stem cell bioartificial tissue transplantation
    Theo Kofidis
    Department of Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, California, USA
    J Heart Lung Transplant 24:737-44. 2005
    ..The present study utilizes embryonic stem cells as the substrate of bioartificial myocardial tissue and evaluates engraftment in, and functional recovery of, the recipient heart...
  30. ncbi request reprint Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury
    Theo Kofidis
    Department of Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, Calif 94305, USA
    Circulation 111:2486-93. 2005
    ..We examine the potential of growth factors to enhance cell engraftment and differentiation and to promote functional improvement after transfer of undifferentiated embryonic stem cells into the injured heart...
  31. ncbi request reprint Caspase-3 inhibition preserves myocardial geometry and long-term function after infarction
    Leora B Balsam
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Surg Res 124:194-200. 2005
    ..We hypothesized that inhibition of caspase-3 activity might limit dysfunction and remodeling after permanent coronary artery ligation...
  32. ncbi request reprint Replacement of the aortic root for acute prosthetic valve endocarditis: prosthetic composite versus aortic allograft root replacement
    Rainer G Leyh
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 127:1416-20. 2004
    ..Here we report on our experience with prosthetic composite and aortic allograft root replacement in such patients during a 10-year interval...
  33. ncbi request reprint Distinct cell-to-fiber junctions are critical for the establishment of cardiotypical phenotype in a 3D bioartificial environment
    Theo Kofidis
    Department of Cardiothoracic Surgery, Falk Research Center, 2fl, Stanford University Medical School, 300 Pasteur Dr, Stanford, CA94305, USA
    Med Eng Phys 26:157-63. 2004
    ..Moreover, given the appropriate porosity of the scaffold, pre-hydration promotes migration and affinity of cells to host structures...
  34. ncbi request reprint A few critical aspects--and Achilles heels--of tissue engineering approaches to restore injured myocardium
    Theo Kofidis
    J Thorac Cardiovasc Surg 126:2113-4; author reply 2114-6. 2003
  35. ncbi request reprint Bioartificial grafts for transmural myocardial restoration: a new cardiovascular tissue culture concept
    Theo Kofidis
    Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Eur J Cardiothorac Surg 24:906-11. 2003
    ..Engineering of myocardial tissue is limited because of lack of vascularization. We introduce a new concept to obtain bioartificial myocardial grafts in which perfusion by a macroscopic core vessel is simulated...
  36. ncbi request reprint Antegrade versus retrograde perfusion of the donor lung: impact on the early reperfusion phase
    Theo Kofidis
    Department of Thoracic and Cardiovascular Surgery, Hanover Medical School, Hanover, Germany
    Transpl Int 16:801-5. 2003
    ..Retrograde perfusion of the donor lung had a positive impact on graft function during early reperfusion. Transpulmonary hemodynamic monitoring can be a powerful tool for intra- and postoperative management of transplant patients...
  37. ncbi request reprint Methylene blue: the drug of choice for catecholamine-refractory vasoplegia after cardiopulmonary bypass?
    Rainer G Leyh
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 125:1426-31. 2003
    ..The guanylate cyclase inhibitor methylene blue could be an attractive treatment alternative in such cases. This study examines the results of methylene blue therapy for norepinephrine-refractory vasoplegia after cardiopulmonary bypass...
  38. ncbi request reprint In vivo repopulation of xenogeneic and allogeneic acellular valve matrix conduits in the pulmonary circulation
    Rainer G Leyh
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Ann Thorac Surg 75:1457-63; discussion 1463. 2003
    ..Therefore, we evaluated the calcification of acellularized allogenic ovine (AVMC) and xenogenic porcine (XVMC) valve matrix conduits in the pulmonary circulation in a sheep model...
  39. ncbi request reprint Aortic root reimplantation for successful repair of an insufficient pulmonary autograft valve after the Ross procedure
    Rainer G Leyh
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 124:1048-9. 2002
  40. ncbi request reprint High failure rate after valve-sparing aortic root replacement using the "remodeling technique" in acute type A aortic dissection
    Rainer G Leyh
    Division of Thoracic and Cardiovascular Surgery, Hanover Medical School, Hanover, Germany
    Circulation 106:I229-33. 2002
    ..Here we report on our experience on valve sparing aortic root replacement inpatients with acute type A dissection...
  41. ncbi request reprint Surfactant function in lung transplantation after 24 hours of ischemia: advantage of retrograde flush perfusion for preservation
    Martin Struber
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 123:98-103. 2002
    ..This study was designed to define the impact of retrograde flush perfusion on graft and surfactant function after an extended period of ischemia...
  42. ncbi request reprint Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, CA 94305 5407, USA
    Circulation 110:II194-9. 2004
    ..Here, we examined whether limiting ischemia-reperfusion injury inhibits graft coronary artery disease (GCAD) and improves murine cardiac allografting...
  43. ncbi request reprint Cyclosporine mitigates graft coronary artery disease in murine cardiac allografts: description and validation of a novel fully allogeneic model
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    J Heart Lung Transplant 24:446-53. 2005
    ..We developed a novel allogeneic mouse model of heart transplantation and investigated the effect of CsA on acute rejection and GCAD...
  44. ncbi request reprint They are not stealthy in the heart: embryonic stem cells trigger cell infiltration, humoral and T-lymphocyte-based host immune response
    Theo Kofidis
    Cardiothoracic Surgery Falk Research Center, Stanford University Medical School, Stanford, CA, USA
    Eur J Cardiothorac Surg 28:461-6. 2005
    ..At present, there is only in vitro evidence of MHC I expression by this cell population but vivid speculation about their immune-privileged state. The immunology aspect of ESC transplantation deserves thorough investigation...
  45. ncbi request reprint Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration
    Theo Kofidis
    Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, CA 94305, USA
    Stem Cells 22:1239-45. 2004
    ..01). IGF did not affect the cellular response to the donor cells or tumorigenicity. IGF-1 promotes expression of cardiomyocyte phenotype in ESCs in vivo. It should be considered as an adjuvant to cell transfer for myocardial restoration...
  46. ncbi request reprint Injectable bioartificial myocardial tissue for large-scale intramural cell transfer and functional recovery of injured heart muscle
    Theo Kofidis
    Cardiothoracic Surgery Falk Research Center, Stanford University Medical School, CA 94305, USA
    J Thorac Cardiovasc Surg 128:571-8. 2004
    ..Most tissue-engineering approaches to restore injured heart muscle result in distortion of left ventricular geometry. In the present study we suggest seeding embryonic stem cells in a liquid matrix for myocardial restoration...
  47. ncbi request reprint Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, Calif, USA
    Circulation 110:II200-6. 2004
    ..Ischemia-reperfusion injury is an important risk factor for graft coronary artery disease (GCAD). We hypothesized that overexpression of SOD1 in donor hearts would suppress ischemia-reperfusion injury and thereby reduce GCAD...
  48. ncbi request reprint Intra-vital fluorescence microscopy for intra-myocardial graft detection following cell transplantation
    Arjang Ruhparwar
    The Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Int J Cardiovasc Imaging 21:569-74. 2005
    ..A major limitation of all clinical studies for myocardial restoration through cell transfer is the inability to track the fate of the transplanted cells...
  49. ncbi request reprint Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    ..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates...
  50. ncbi request reprint Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury
    Theo Kofidis
    Cardiothoracic Surgery Falk Research Center, Stanford University Medical School, Stanford, CA, USA
    Eur J Cardiothorac Surg 29:50-5. 2006
    ....
  51. ncbi request reprint Giant, free flotating tendinous cord in the left ventricle
    Theo Kofidis
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Eur J Cardiothorac Surg 27:710. 2005
  52. ncbi request reprint Early inhibition of caspase-3 activity lessens the development of graft coronary artery disease
    Leora B Balsam
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 24:827-32. 2005
    ..We hypothesized that early inhibition of apoptosis with a caspase-3 inhibitor would also lessen the development of GCAD...
  53. ncbi request reprint Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, 300 Pasteur Dr CVRB, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Blood 104:3789-96. 2004
    ..In conclusion, our findings suggest that the modulation of Bcl-2 expression by pharmacologic up-regulation or gene transfer may be of clinical benefit in the short- and long-term function of cardiac allografts...