Affiliation: Hannover Medical School
Knudsen L, Atochina Vasserman E, Massa C, Birkelbach B, Guo C, Scott P, et al
. The role of inducible nitric oxide synthase for interstitial remodeling of alveolar septa in surfactant protein D-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2015;309:L959-69 pubmed publisher
Knudsen L, Boxler L, Mühlfeld C, Schaefer I, Becker L, Bussinger C, et al
. Lung preservation in experimental ischemia/reperfusion injury and lung transplantation: a comparison of natural and synthetic surfactants. J Heart Lung Transplant. 2012;31:85-93 pubmed publisher
..Taken together, Curosurf achieved the best structural and functional lung preservation, whereas Survanta was inferior to both Curosurf and SPC-33. ..
Birkelbach B, Lutz D, Ruppert C, Henneke I, Lopez Rodriguez E, GÃ¼nther A, et al
. Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model. Am J Physiol Lung Cell Mol Physiol. 2015;309:L63-75 pubmed publisher
..We conclude that ultrastructural alterations of AE2 cells including the surfactant system are tightly correlated with the progression of fibrotic remodeling. ..
Lopez Rodriguez E, Boden C, Echaide M, Perez Gil J, Kolb M, Gauldie J, et al
. Surfactant dysfunction during overexpression of TGF-Î²1 precedes profibrotic lung remodeling in vivo. Am J Physiol Lung Cell Mol Physiol. 2016;310:L1260-71 pubmed publisher
..Initial TTF-1 dysfunction is potentially linked to downregulation of surfactant proteins. ..
Knudsen L, Ruppert C, Ochs M. Tissue remodelling in pulmonary fibrosis. Cell Tissue Res. 2017;367:607-626 pubmed publisher
..Dysfunctional AE2 cells, instable alveoli and mechanical stress trigger remodelling that consists of collapsed alveoli absorbed by fibrotic tissue (i.e., collapse induration). ..
Schneider J, Arkenau M, Knudsen L, Wedekind D, Ochs M. Lung remodeling in aging surfactant protein D deficient mice. Ann Anat. 2017;211:158-175 pubmed publisher
..Furthermore, data from wt mice point to an ongoing alveolarization during adult life in C57Bl/6NCrl mice. Our data may promote further studies on the morphological development of the aging lung and the role of SP-D in this process. ..
Steffen L, Ruppert C, Hoymann H, Funke M, Ebener S, Kloth C, et al
. Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model. Am J Physiol Lung Cell Mol Physiol. 2017;313:L313-L327 pubmed publisher
..Hence, SRT modifies disease progression to collapse induration. ..