Philipp Kümpers

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?
    Matijs van Meurs
    Department of Critical Care, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands
    Crit Care 13:207. 2009
  2. doi Serum leptin and ghrelin correlate with disease activity in ANCA-associated vasculitis
    P Kümpers
    Department of Nephrology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Rheumatology (Oxford) 47:484-7. 2008
  3. doi Legionnaires' disease in immunocompromised patients: a case report of Legionella longbeachae pneumonia and review of the literature
    Philipp Kümpers
    Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    J Med Microbiol 57:384-7. 2008
  4. pmc Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, D 30171, Germany
    Crit Care 12:R147. 2008
  5. doi Circulating angiopoietin-2 is a marker and potential mediator of endothelial cell detachment in ANCA-associated vasculitis with renal involvement
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Nephrol Dial Transplant 24:1845-50. 2009
  6. pmc Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 13:R64. 2009
  7. doi The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus
    P Kümpers
    Department of Nephrology, Hanover Medical School, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    Ann Rheum Dis 68:1638-43. 2009
  8. doi Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Intensive Care Med 36:462-70. 2010
  9. pmc Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Crit Care 14:R9. 2010
  10. pmc Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays
    Alexander Lukasz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 12:R94. 2008

Detail Information

Publications51

  1. pmc Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?
    Matijs van Meurs
    Department of Critical Care, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands
    Crit Care 13:207. 2009
    ..In this review we describe this signalling system, giving special attention to what is known about it in critically ill patients and its potential as a target for therapy...
  2. doi Serum leptin and ghrelin correlate with disease activity in ANCA-associated vasculitis
    P Kümpers
    Department of Nephrology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Rheumatology (Oxford) 47:484-7. 2008
    ..To study serum levels of leptin and ghrelin in ANCA-associated vasculitis (AAV)...
  3. doi Legionnaires' disease in immunocompromised patients: a case report of Legionella longbeachae pneumonia and review of the literature
    Philipp Kümpers
    Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    J Med Microbiol 57:384-7. 2008
    ..The features of Legionnaires' disease in immunocompromised patients with special emphasis on significance and detection of non-pneumophila species are reviewed...
  4. pmc Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, D 30171, Germany
    Crit Care 12:R147. 2008
    ..Here, we examine whether circulating Ang-1 and/or Ang-2 independently predict mortality in a cohort of critically ill medical patients...
  5. doi Circulating angiopoietin-2 is a marker and potential mediator of endothelial cell detachment in ANCA-associated vasculitis with renal involvement
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Nephrol Dial Transplant 24:1845-50. 2009
    ..Here, we ask whether circulating Ang-2 correlates with the severity of endothelial damage in ANCA-associated vasculitis (AAV) with renal involvement...
  6. pmc Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 13:R64. 2009
    ....
  7. doi The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus
    P Kümpers
    Department of Nephrology, Hanover Medical School, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    Ann Rheum Dis 68:1638-43. 2009
    ..Recently, the endothelial-specific Ang-Tie ligand-receptor system has been identified as a major regulator of vascular responsiveness to inflammatory stimuli...
  8. doi Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Intensive Care Med 36:462-70. 2010
    ....
  9. pmc Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Crit Care 14:R9. 2010
    ..The aim of this study was to evaluate the predictive value of serum NGAL in patients with established AKI at inception of RRT in the intensive care unit (ICU)...
  10. pmc Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays
    Alexander Lukasz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 12:R94. 2008
    ..The use of circulating Ang-1 and Ang-2 as novel biomarkers of endothelial integrity has therefore gained much attention. The preclinical characteristics and clinical applicability of angiopoietin immunoassays, however, remain elusive...
  11. doi Angiopoietin 2 and cardiovascular disease in dialysis and kidney transplantation
    Sascha David
    Department of Medicine, Division of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Am J Kidney Dis 53:770-8. 2009
    ....
  12. doi Circulating angiopoietin-2 levels increase with progress of chronic kidney disease
    Sascha David
    Division of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 25:2571-6. 2010
    ..In addition, we aimed to detect a potential link between the nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) and the Ang-2 levels...
  13. doi Circulating miR-210 predicts survival in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Clin J Am Soc Nephrol 6:1540-6. 2011
    ..We tested whether circulating miRNAs in the plasma of critically ill patients with acute kidney injury (AKI) at the inception of renal replacement therapy are deregulated and may predict survival...
  14. doi Podocalyxin-positive glomerular epithelial cells in urine correlate with a positive outcome in FSGS
    Janina Mueller-Deile
    Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, Hannover, Germany
    J Nephrol 25:802-9. 2012
    ..We previously published that excretion of podocalyxin (PDX)-positive PECs in the urine correlates with disease activity in different glomerular diseases...
  15. doi Shedding of the endothelial receptor tyrosine kinase Tie2 correlates with leukemic blast burden and outcome after allogeneic hematopoietic stem cell transplantation for AML
    Christian Koenecke
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, 30625 Hannover, Germany
    Ann Hematol 89:459-67. 2010
    ..Furthermore, our data indicate that Tie2 shedding and Ang-2 release seem to reflect overlapping, but nevertheless distinctive features in leukemia-associated neoangiogenesis...
  16. doi Angiopoietin-2 levels predict mortality in CKD patients
    Sascha David
    Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 27:1867-72. 2012
    ..Furthermore, Ang-2 levels are associated with the prevalent vascular burden of CKD patients. Thus, we aimed to investigate its impact on outcome in CKD, the population most likely to die of cardiovascular events...
  17. doi Osteopontin predicts survival in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Department of Medicine, Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Nephrol Dial Transplant 26:531-7. 2011
    ..We have tested the hypothesis that osteopontin levels might serve as a biomarker predicting outcome in critically ill patients requiring renal replacement therapy after acute kidney injury...
  18. doi Removal of elevated circulating angiopoietin-2 by plasma exchange--a pilot study in critically ill patients with thrombotic microangiopathy and anti-glomerular basement membrane disease
    Svjetlana Lovric
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Thromb Haemost 104:1038-43. 2010
    ..0001). PE is an effective method to remove excess circulating Ang-2. It remains to be elucidated if the removal of Ang-2 is crucial to ameliorate endothelial damage in critically ill patients with severely altered endothelial integrity...
  19. doi Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis
    Sascha David
    Department of Nephrology and Hypertension, Hannover Medical School, Carl NeubergStrasse1, D 30625, Hannover, Germany
    Cytokine 55:251-9. 2011
    ..In order to reverse the effects of the sepsis-induced suppression of Ang-1 and elevation of Ang-2 we aimed to investigate whether an intravenous injection of recombinant human (rh) Ang-1 protects against MODS in murine sepsis...
  20. doi Quantification of experimental acute kidney injury by computer-assisted imaging of lectin phytohemagglutinin E
    Sascha David
    Division of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    J Nephrol 26:385-8. 2013
    ..Our aim was to establish a rather simple, fast, and reproducible staining protocol to quantify loss of brush border (BB) in septic AKI...
  21. doi Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin
    Sascha David
    Department of Medicine, Division of Nephrology and Hypertension, Medical School Hanover, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    J Hypertens 27:1641-7. 2009
    ..We aimed at studying the effect of ARB and/or 3-hydroxy-3-methyl-glutaryl-CoA blockade on Ang-2 and the association between vascular inflammation markers and Ang-2 levels in hypertensive patients...
  22. doi Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies
    Philipp Kümpers
    Center for Internal Medicine, Hannover Medical School, Hannover, Germany
    Blood 112:2139-48. 2008
    ..Because few predictors for DFS exist in the setting of allo-HSCT, Ang-2 may be used as a readily available powerful biomarker to pre-estimate DFS and may open new perspectives for risk-adapted treatment of high-risk myeloid malignancies...
  23. ncbi Vascular endothelial damage and repair in antineutrophil cytoplasmic antibody-associated vasculitis
    K de Groot
    Hannover Medical School, Hannover, Germany
    Arthritis Rheum 56:3847-53. 2007
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to play a pivotal role in the regeneration of damaged endothelium. The aim of this study was to investigate whether EPCs are involved in vascular repair in AAV...
  24. doi Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass
    Christian Clajus
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Cytokine 60:352-9. 2012
    ..We aimed to study the time course and potential triggering factors of Ang-2 release after CPB, as well as the association of Ang-2 changes with surrogates of increased vascular permeability, organ dysfunction, and outcome...
  25. ncbi Diagnostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for left ventricular dysfunction in patients with chronic kidney disease stage 5 on haemodialysis
    Sascha David
    Department of Nephrology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nephrol Dial Transplant 23:1370-7. 2008
    ..We hypothesized that a serum NT-proBNP cut-off value adjusted for patients with CKD could serve as a biochemical marker to detect LVD in patients on haemodialysis treatment regardless of chronic fluid overload...
  26. doi Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease
    Kirstin Worthmann
    Department of Medicine Nephrology, Hannover Medical School, Carl Neuberg Street 1, Hannover, Germany
    Growth Factors 28:129-38. 2010
    ..We conclude that the local expression of IGFBPs in podocytes and endothelial cells might contribute to the pathogenesis of glomerular disease and that IGFBP-1 and -3 are potential non-invasive markers of FSGS...
  27. doi B-cell-attracting chemokine CXCL13 as a marker of disease activity and renal involvement in systemic lupus erythematosus (SLE)
    Lena Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Munchen, Germany
    Nephrol Dial Transplant 24:3708-12. 2009
    ..Here, we ask whether serum levels of CXCL13 correlate with disease activity and renal involvement in SLE patients...
  28. doi Rituximab as rescue therapy in anti-neutrophil cytoplasmic antibody-associated vasculitis: a single-centre experience with 15 patients
    Svjetlana Lovric
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 24:179-85. 2009
    ..Data are limited and most reports describe single patients or small numbers of patients followed prospectively...
  29. doi Angiopoietin-2 in acute liver failure
    Johannes Hadem
    Department of Gastroenterology, Hepatology, and Endocrinology, The Institute of Pathology, Hannover Medical School, Hannover, Germany
    Crit Care Med 40:1499-505. 2012
    ..We examined whether the release of Angiopoietin-2 correlates with surrogates of organ dysfunction and outcome in patients with acute liver failure...
  30. doi Prospective evaluation of an in-centre conversion from conventional haemodialysis to an intensified nocturnal strategy
    Sascha David
    Division of Nephrology, Department of Medicine, Medical School Hanover, Hanover, Germany
    Nephrol Dial Transplant 24:2232-40. 2009
    ....
  31. ncbi Influence of a novel rapamycin analogon SDZ RAD on endothelial tissue factor and adhesion molecule expression
    M Haubitz
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    Transplant Proc 34:1124-6. 2002
  32. doi Diagnostic role of endothelial microparticles in vasculitis
    U Erdbruegger
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Rheumatology (Oxford) 47:1820-5. 2008
    ..More recently, endothelial microparticles (EMPs) were found to be increased in active childhood vasculitis. The role of EMP in adult AAV and the relationship between EMP and CEC is unclear...
  33. ncbi Exploring new territory: the move towards individualised treatment
    M Haubitz
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    Lupus 16:227-31. 2007
    ..Thus treatment of lupus nephritis is evolving from standardised therapy to individualised therapy based on analysis of organ involvement, risk factors and cytokine, antibody or cell profiles...
  34. ncbi ANCA-associated vasculitis: diagnosis, clinical characteristics and treatment
    M Haubitz
    Department of Nephrology, Medical School Hannover, Germany
    Vasa 36:81-9. 2007
    ..Thus cyclophosphamide is only used in patients with generalized disease or - regarding Churg-Strauss-syndrome - patients with risk factors. For maintenance of remission azathioprine should be used in most of the patients...
  35. pmc Circulating endothelial cells in relapse and limited granulomatous disease due to ANCA associated vasculitis
    A Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Rheum Dis 65:164-8. 2006
    ..To evaluate numbers of circulating endothelial cells (CECs) in ANCA associated vasculitis and compare vasculitic relapse with limited granulomatous disease...
  36. ncbi Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol
    A Woywodt
    Department of Medicine, Division of Nephrology, Hannover Medical School, Hannover, Germany
    J Thromb Haemost 4:671-7. 2006
    ..CD146-driven immunomagnetic isolation has gained widespread use, but the technique is hampered by the lack of a definition of CECs and the absence of a consensus for their enumeration...
  37. pmc Smoking habits in patients diagnosed with ANCA associated small vessel vasculitis
    M Haubitz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Rheum Dis 64:1500-2. 2005
    ..To study the prevalence of smoking at onset of symptoms in patients with small vessel vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA)...
  38. ncbi Circulating endothelial cells and endothelial progenitor cells after angioplasty: news from the endothelial rescue squad
    A Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Thromb Haemost 4:976-8. 2006
  39. pmc Endothelial tissue factor stimulation by proteinase 3 and elastase
    M Haubitz
    Department of Nephrology, Medical School Hannover, Germany
    Clin Exp Immunol 126:584-8. 2001
    ..These results show that PR3 and elastase stimulate TF expression in human endothelial cells. In ANCA-associated vasculitis the increased release of proteases may contribute to the development of microthrombi and consecutive necrosis...
  40. ncbi Endothelial microparticles as a diagnostic aid in Churg-Strauss vasculitis-induced cardiomyopathy
    P Kümpers
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Clin Exp Rheumatol 26:S86-9. 2008
    ..Endothelial microparticles might be an additional tool to diagnose and monitor cases of suspected vasculitic cardiac involvement in CSS...
  41. ncbi An improved assay for enumeration of circulating endothelial cells
    A Woywodt
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Ann Hematol 83:491-4. 2004
    ..The assay is simple and easy to use, thus allowing for a more widespread use of circulating endothelial cells as a marker of vascular damage...
  42. pmc A novel multimedia tool to improve bedside teaching of cardiac auscultation
    A Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, Hannover, Germany
    Postgrad Med J 80:355-7. 2004
    ..Amalgamating traditional phonocardiography with a multimedia approach, this system represents a novel tool for bedside teaching of cardiac auscultation...
  43. ncbi Counting the cost: markers of endothelial damage in hematopoietic stem cell transplantation
    A Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Bone Marrow Transplant 34:1015-23. 2004
    ..The challenge ahead is to establish and evaluate novel markers of endothelial damage to permit early detection of disease, monitor response to treatment and evaluate different conditioning regimens...
  44. doi Mending leaky blood vessels: the angiopoietin-Tie2 pathway in sepsis
    Sascha David
    Department of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    J Pharmacol Exp Ther 345:2-6. 2013
    ..Here we summarize recent work in mice and men to highlight the therapeutic potential in this pathway to prevent or even reverse microvascular dysfunction in this deadly disease...
  45. ncbi Tolerance of mycophenolate mofetil in end-stage renal disease patients with ANCA-associated vasculitis
    M Haubitz
    Department of Nephrology, University Hospital Hannover, Germany
    Clin Nephrol 57:421-4. 2002
    ..Since all the treated patients who have been reported so far had no or only moderate renal insufficiency when MMF was initiated, no data are available regarding side effects in patients with end-stage renal disease (ESRD)...
  46. pmc Angiopoietin-2 in adults with congenital heart disease and heart failure
    Alexander Lukasz
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e66861. 2013
    ..Their role in ACHD has not been studied...
  47. ncbi Leptin is a coactivator of TGF-beta in unilateral ureteral obstructive kidney disease
    Philipp Kümpers
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Am J Physiol Renal Physiol 293:F1355-62. 2007
    ..Therefore, selective blockade of the leptin axis might provide a therapeutic possibility to prevent or delay fibrotic kidney disease...
  48. ncbi Fish, flesh and a good red herring: a case of ascending upper limb infection in a renal transplant patient
    S Lovric
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Clin Nephrol 72:402-4. 2009
    ..Sporotrichoid lesions in renal transplant patients are rare and a diagnostic challenge for the physician. A thorough history and a low threshold for skin biopsies could prevent painful and unnecessary surgical interventions...
  49. ncbi C-reactive protein and chronic Chlamydia pneumoniae infection--long-term predictors for cardiovascular disease and survival in patients on peritoneal dialysis
    M Haubitz
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 16:809-15. 2001
    ..CRP and C. pneumoniae antibodies may indicate a chronic inflammatory process as an underlying cause and/or result of arteriosclerosis...
  50. ncbi Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides
    S Borgmann
    Department of Medical Microbiology, University of Tubingen, Germany
    Clin Exp Rheumatol 22:S79-86. 2004
    ..Although, in practice, it is sometimes difficult to differentiate between WG and MPA, the diseases appear to be based on different genetic backgrounds...
  51. pmc Severe relapse of Wegener's granulomatosis during the early postpartum period
    A Woywodt
    Ann Rheum Dis 65:137. 2006