Sabine Klebba FÃ¤rber
Affiliation: Hannover Medical School
Koch A, Saran S, Tran D, Klebba FÃ¤rber S, Thiesler H, Sewald K, et al
. Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo. Cell Commun Signal. 2014;12:73 pubmed publisher
..This method may also prove useful for identification of genes in liver-resident cells that support cancer invasion by using PCLS from transgenic liver. ..
Saran S, Tran D, Klebba Färber S, Morán Losada P, Wiehlmann L, Koch A, et al
. THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier. BMC Cell Biol. 2013;14:51 pubmed publisher
..These data imply that THOC5 may be a useful tool for studying intestinal stem cells, for modifying the differentiation processes and for cancer therapy. ..
Mancini A, Niemann Seyde S, Pankow R, El Bounkari O, Klebba Färber S, Koch A, et al
. THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol. 2010;8:1 pubmed publisher
..Furthermore, mechanistically depletion of THOC5/Fms interacting protein causes the down-regulation of its direct interacting partner, THOC1 which may contribute to altered THO complex function and cell death. ..