Matthias Karst

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Computerized tomography-guided epidural blood patch in the treatment of spontaneous low cerebrospinal fluid pressure headache
    M Karst
    Department of Anesthesiology, Pain Clinic, Medical School of Hannover, D 30623 Hannover, Germany
    Acta Anaesthesiol Scand 45:649-51. 2001
  2. ncbi request reprint Effect of celecoxib and dexamethasone on postoperative pain after lumbar disc surgery
    Matthias Karst
    Department of Anesthesiology, Hannover Medical School, Hannover, Germany
    Neurosurgery 53:331-6; discussion 336-7. 2003
  3. ncbi request reprint Auricular acupuncture for dental anxiety: a randomized controlled trial
    Matthias Karst
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Anesth Analg 104:295-300. 2007
  4. ncbi request reprint Abnormality in the self-monitoring mechanism in patients with fibromyalgia and somatoform pain disorder
    Matthias Karst
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, D 30625 Hannover, Germany
    Psychosom Med 67:111-5. 2005
  5. ncbi request reprint [Pain management in children and in the elderly]
    M Karst
    Zentrum Anasthesiologie, Medizinische Hochschule Hannover
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:519-20. 2004
  6. ncbi request reprint Acupuncture in the treatment of alcohol withdrawal symptoms: a randomized, placebo-controlled inpatient study
    Matthias Karst
    Department of Anesthesiology, Pain Clinic, Medical School of Hannover, D 30623 Hannover, Germany
    Addict Biol 7:415-9. 2002
  7. ncbi request reprint Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial
    Matthias Karst
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    JAMA 290:1757-62. 2003
  8. ncbi request reprint Cannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective
    Matthias Karst
    Pain Clinic, Hannover Medical School, Department of Anesthesiology, Carl Neuberg Street 1, 30625 Hannover, Germany
    Expert Opin Investig Drugs 18:125-33. 2009
  9. doi request reprint Role of cannabinoids in the treatment of pain and (painful) spasticity
    Matthias Karst
    Department of Anaesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Drugs 70:2409-38. 2010
  10. ncbi request reprint Effect of acupuncture on the neutrophil respiratory burst: a placebo-controlled single-blinded study
    M Karst
    Department of Anaesthesiology, Intensive Care Medicine and Pain Clinic, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30625, Germany
    Complement Ther Med 11:4-10. 2003

Detail Information

Publications49

  1. ncbi request reprint Computerized tomography-guided epidural blood patch in the treatment of spontaneous low cerebrospinal fluid pressure headache
    M Karst
    Department of Anesthesiology, Pain Clinic, Medical School of Hannover, D 30623 Hannover, Germany
    Acta Anaesthesiol Scand 45:649-51. 2001
    ..Magnetic resonance imaging (MRI) myelography confirmed ventral leakage but failed to locate the exact site. Computerized tomography (CT)-guided epidural blood patching between T1 and T2 completely relieved the headache...
  2. ncbi request reprint Effect of celecoxib and dexamethasone on postoperative pain after lumbar disc surgery
    Matthias Karst
    Department of Anesthesiology, Hannover Medical School, Hannover, Germany
    Neurosurgery 53:331-6; discussion 336-7. 2003
    ..This study was designed to assess the efficacy of perioperative administration of celecoxib (Celebrex; Pharmacia GmbH, Erlangen, Germany) in reducing pain and opioid requirements after single-level lumbar microdiscectomy...
  3. ncbi request reprint Auricular acupuncture for dental anxiety: a randomized controlled trial
    Matthias Karst
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Anesth Analg 104:295-300. 2007
    ..032 and 0.049, respectively). In conclusion, both, auricular acupuncture and intranasal midazolam were similarly effective for the treatment of dental anxiety...
  4. ncbi request reprint Abnormality in the self-monitoring mechanism in patients with fibromyalgia and somatoform pain disorder
    Matthias Karst
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, D 30625 Hannover, Germany
    Psychosom Med 67:111-5. 2005
    ..It is unclear if chronic central pain disorders such as fibromyalgia and somatoform pain disorders also involve a defect of the self-monitoring mechanism...
  5. ncbi request reprint [Pain management in children and in the elderly]
    M Karst
    Zentrum Anasthesiologie, Medizinische Hochschule Hannover
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:519-20. 2004
  6. ncbi request reprint Acupuncture in the treatment of alcohol withdrawal symptoms: a randomized, placebo-controlled inpatient study
    Matthias Karst
    Department of Anesthesiology, Pain Clinic, Medical School of Hannover, D 30623 Hannover, Germany
    Addict Biol 7:415-9. 2002
    ..We conclude that acupuncture as an adjunctive treatment to carbamazepine medication shows promise for the treatment of alcohol withdrawal symptoms. Further investigation of this treatment modality appears to be warranted...
  7. ncbi request reprint Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial
    Matthias Karst
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    JAMA 290:1757-62. 2003
    ..Therefore, CT-3 may be an effective analgesic for poorly controlled resistant neuropathic pain...
  8. ncbi request reprint Cannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective
    Matthias Karst
    Pain Clinic, Hannover Medical School, Department of Anesthesiology, Carl Neuberg Street 1, 30625 Hannover, Germany
    Expert Opin Investig Drugs 18:125-33. 2009
    ..Available data from these approaches are summarised and their more and less promising aspects are discussed...
  9. doi request reprint Role of cannabinoids in the treatment of pain and (painful) spasticity
    Matthias Karst
    Department of Anaesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Drugs 70:2409-38. 2010
    ..Therefore, different methods of administration and other types of cannabinoids, such as endocannabinoid modulators, should be tested in future trials...
  10. ncbi request reprint Effect of acupuncture on the neutrophil respiratory burst: a placebo-controlled single-blinded study
    M Karst
    Department of Anaesthesiology, Intensive Care Medicine and Pain Clinic, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30625, Germany
    Complement Ther Med 11:4-10. 2003
    ..This trial was performed to examine whether multiple acupuncture treatment affects the respiratory burst (RB) of neutrophils, a recognised measure of their cytotoxicity...
  11. ncbi request reprint Acupuncture has no immediate treatment effect on the neutrophil respiratory burst: a randomized single-blinded two-period crossover study
    Matthias Karst
    Department of Anaesthesiology, Intensive Care Medicine and Pain Clinic, Medical School of Hannover, Pain Clinic, Carl Neuberg Str 1, 30625 Hannover, Germany
    Brain Behav Immun 16:813-6. 2002
    ..There was a drop-out of two volunteers. No period or carryover effects were found in the remaining fourteen volunteers. No effect of acupuncture on the neutrophil RB was observed...
  12. ncbi request reprint Pressure pain threshold and needle acupuncture in chronic tension-type headache--a double-blind placebo-controlled study
    M Karst
    Department of Anesthesiology, Medical School of Hannover, D 30623 Hannover, Germany
    Pain 88:199-203. 2000
    ..The findings of our study support the hypothesis that peripheral mechanisms - such as increased muscle tenderness - only play a minor role in the pathogenesis of chronic tension-type headache...
  13. ncbi request reprint Needle acupuncture in tension-type headache: a randomized, placebo-controlled study
    M Karst
    Department of Anaesthesiology, Medical School of Hannover, Hannover, Germany
    Cephalalgia 21:637-42. 2001
    ..A study with needle acupuncture was performed in tension-type headache employing a new placebo acupuncture..
  14. doi request reprint The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover, Germany
    Pharmacology 83:217-22. 2009
    ..3 micromol/l and alpha(1)beta = 144.3 +/- 22.7 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for cannabidiol mediating some of its anti-inflammatory and neuroprotective properties...
  15. doi request reprint Lack of positive allosteric modulation of mutated alpha(1)S267I glycine receptors by cannabinoids
    Nilufar Foadi
    Clinic for Anaesthesia and Critical Care Medicine OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:477-82. 2010
    ..An investigation of the impact of such mutations on the in vivo interaction of cannabinoids with glycine receptors should permit a better understanding of the molecular determinants of action of cannabinoids...
  16. doi request reprint Modulation of glycine receptor function by the synthetic cannabinoid HU210
    Reyhan Demir
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Pharmacology 83:270-4. 2009
    ..7 +/- 46.2 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for HU210 mediating some of its anti-inflammatory and anti-nociceptive properties...
  17. doi request reprint Association of TNF-α polymorphism rs1800629 with multisomatoform disorder in a group of German patients and healthy controls: an explorative study
    Katharina C Harms
    Institute of Human Genetics, Hannover Medical School, Hannover, Germany
    Cytokine 61:389-93. 2013
    ..Pain is a major symptom of MSD and polymorphisms of different proinflammatory cytokines have been found associated with pain in former studies. Therefore, we presumed that cytokine polymorphisms could also be associated with MSD...
  18. ncbi request reprint Interaction of the dopaminergic and serotonergic systems significantly influences the risk for multisomatoform disorder: a controlled pilot study
    Lisa Pahl
    Institute of Human Genetics, Hannover Medical School, Hannover, Germany
    Genet Test Mol Biomarkers 16:892-6. 2012
    ..To conclude, our results reveal an involvement of polymorphisms in dopaminergic and serotonergic genes in the etiology of MSD in patients of German descent, but their exact role in MSD requires further investigation...
  19. ncbi request reprint Gender differences in coping with tension-type headaches
    Jens D Rollnik
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Germany
    Eur Neurol 50:73-7. 2003
    ..To study gender differences of coping with illness strategies in tension-type headaches...
  20. doi request reprint Acupuncture induces a pro-inflammatory immune response intensified by a conditioning-expectation effect
    Matthias Karst
    Dept of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Forsch Komplementmed 17:21-7. 2010
    ..Since this result could have been affected by a placebo effect, a study has been designed that controls for the different facets of placebo mechanisms such as expectancy, suggestibility, and conditioning...
  21. ncbi request reprint Effects of different subanesthetic doses of (S)-ketamine on neuropsychology, psychopathology, and state of consciousness in man
    Torsten Passie
    Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Carl Neuberg Strasse 1, DE 30625 Hannover, Germany
    Neuropsychobiology 51:226-33. 2005
    ..Implications of these findings for the neuropsychology of attention and schizophrenia are discussed...
  22. ncbi request reprint Needle acupuncture in chronic poststroke leg spasticity
    Matthias Fink
    Department of Physical Medicine and Rehabilitation, Medical School of Hannover, Germany
    Arch Phys Med Rehabil 85:667-72. 2004
    ..To determine whether needle acupuncture may be useful in the reduction of leg spasticity in a chronic state...
  23. doi request reprint Adjuvant auricular electroacupuncture and autogenic training in rheumatoid arthritis: a randomized controlled trial. Auricular acupuncture and autogenic training in rheumatoid arthritis
    Michael Bernateck
    Department of Anesthesiology, Pain Clinic, Hannover, Germany
    Forsch Komplementmed 15:187-93. 2008
    ..In contrast to psychological interventions the usefulness of acupuncture as an adjuvant therapy in rheumatoid arthritis (RA) has not yet been demonstrated...
  24. doi request reprint Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence
    Torsten Passie
    Hannover Medical School, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover, Germany
    Drug Test Anal 4:649-59. 2012
    ..It is concluded that further studies are warranted in order to evaluate the therapeutic potential of cannabinoids in PTSD...
  25. ncbi request reprint Effects of different subanaesthetic doses of (S)-ketamine on psychopathology and binocular depth inversion in man
    Torsten Passie
    Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Hannover, Germany
    J Psychopharmacol 17:51-6. 2003
    ..Implications related to memory function, perceptogenesis and 'bottom-up' processing in ketamine model psychosis and schizophrenia are discussed...
  26. doi request reprint The first scintigraphic detection of tumor necrosis factor-alpha in patients with complex regional pain syndrome type 1
    Michael Bernateck
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    Anesth Analg 110:211-5. 2010
    ..Our findings support the growing evidence for neuroimmune disturbance in patients with CRPS and may have important further implications for specific anticytokine treatment in patients with CRPS...
  27. doi request reprint First non-contingent respiratory biofeedback placebo versus contingent biofeedback in patients with chronic low back pain: a randomized, controlled, double-blind trial
    Karl Peter Kapitza
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, 30625, Hannover, Germany
    Appl Psychophysiol Biofeedback 35:207-17. 2010
    ..Nonetheless, tendencies suggest that contingent feedback patients compared to placebo patients profit more from RFB in the long run regarding reduction of chronic pain and psychological distress...
  28. ncbi request reprint Successful intravenous regional block with low-dose tumor necrosis factor-alpha antibody infliximab for treatment of complex regional pain syndrome 1
    Michael Bernateck
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Anesth Analg 105:1148-51, table of contents. 2007
    ..A significant improvement of clinical variables was observed 24 h after infliximab treatment. Almost complete remission was reached within 8 wk, but sensory signs improved only after 6 mo. No adverse events were observed...
  29. doi request reprint [Pain relief with cannabinoids-- the importance of endocannabinoids and cannabinoids for pain therapy]
    Matthias Karst
    Klinik fur Anasthesiologie, Medizinische Hochschule Hannover
    Anasthesiol Intensivmed Notfallmed Schmerzther 43:522-8. 2008
    ..A further approach in this direction is the use of enzymes which metabolize endocannabinoids...
  30. ncbi request reprint Efficacy of a flexible orthotic device in patients with osteoporosis on pain and activity of daily living
    Matthias Fink
    Department of Physical Medicine and Rehabilitation, Hanover Medical School, Germany
    J Rehabil Med 39:77-80. 2007
    ..To study the efficacy of a flexible orthotic device in patients with osteoporosis...
  31. ncbi request reprint Acupuncture in the treatment of painful dysfunction of the temporomandibular joint -- a review of the literature
    Matthias Fink
    Weston Park Hospital, Sheffield University, UK
    Forsch Komplementmed 13:109-15. 2006
    ..The aim of the present study was to analyze the results of randomized clinical trials on the efficacy of acupuncture in the treatment of painful dysfunction of the temporomandibular joint...
  32. ncbi request reprint Effects of fentanyl on cellular immune functions in man
    R Jacobs
    Division of Clinical Immunology, Hannover Medical School, Germany
    Int J Immunopharmacol 21:445-54. 1999
    ..These results suggest a transient effect of fentanyl on NK cell circulation which seemed to be centrally mediated rather than a direct effect of this opioid on NK cells...
  33. ncbi request reprint Effects of fentanyl and low doses of alcohol on neuropsychological performance in healthy subjects
    U Schneider
    Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Germany
    Neuropsychobiology 39:38-43. 1999
    ..After application of low doses of alcohol (BAC 0.03%) only visual reaction time was impaired in comparison to placebo...
  34. doi request reprint [Placebo therapy. Analysis of extent and expectations in a tertiary referral center]
    M Bernateck
    Bereich Schmerzmedizin, Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, 30625 Hannover, Deutschland
    Schmerz 23:47-53. 2009
    ..The aim of this report was to examine the frequency, indications and the intentions of placebo use at the Medical University of Hannover (MHH)...
  35. ncbi request reprint Inhibition of voltage-gated Na⁺ channels by the synthetic cannabinoid ajulemic acid
    Nilufar Foadi
    From the Department of Anesthesia and Critical Care Medicine, and Department of Neurology and Clinical Neurophysiology, Medizinische Hochschule Hannover, Hannover, Germany
    Anesth Analg 118:1238-45. 2014
    ..Cannabinoids interact with several molecules within the pain circuit, including a potent inhibition of voltage-gated sodium channels. In this study, we closely characterized this property on neuronal and nonneuronal sodium channels...
  36. ncbi request reprint Brain-derived neurotrophic factor and exercise in fibromyalgia syndrome patients: a mini review
    Boya Nugraha
    Department of Rehabilitation Medicine, Hannover Medical School, Carl Neuberg Str 1, Hannover, Germany
    Rheumatol Int 32:2593-9. 2012
    ..Exercise leads to changes in serum BDNF levels, too. This association highlights the importance of exercise in FMS and other chronic pain conditions...
  37. pmc Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol?
    Carina Jarzimski
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Br J Clin Pharmacol 74:54-9. 2012
    ..Inhibition of enzymatic degradation of anandamide could explain some of the characteristics of propofol. Direct measurements have not been reported yet in humans...
  38. pmc In vivo myograph measurement of muscle contraction at optimal length
    Niels Rahe-Meyer
    Department of Anaesthesiology, Hannover Medical School, Carl Neuberg Str, 1, D 30625 Hannover, Germany
    Biomed Eng Online 6:1. 2007
    ..Consequently, for clinical testing only semi-quantitative methods have been used...
  39. doi request reprint Sustained effects of comprehensive inpatient rehabilitative treatment and sleeping neck support in patients with chronic cervicobrachialgia: a prospective and randomized clinical trial
    Michael Bernateck
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Int J Rehabil Res 31:342-6. 2008
    ..001 after 3 months, respectively, P<0.05 after 12 months). Inpatient rehabilitative treatment has sustained effects in patients suffering from chronic cervicobrachialgia, particularly when a sleeping neck support is added...
  40. ncbi request reprint Coping strategies in episodic and chronic tension-type headache
    J D Rollnik
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Germany
    Headache 41:297-302. 2001
    ..CONCLUSIONS: We conclude that disadvantageous coping with illness strategies might contribute to a transformation to chronic TTH...
  41. ncbi request reprint Repetitive transcranial magnetic stimulation for the treatment of chronic pain - a pilot study
    Jens D Rollnik
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Germany
    Eur Neurol 48:6-10. 2002
    ..0 +/- 15.6%; sham rTMS: -2.3 +/- 8.8%). Further studies using different rTMS stimulation parameters (duration and frequency of rTMS) or stimulation sites (e.g. anterior cingulate gyrus) are strongly encouraged...
  42. ncbi request reprint Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 379:371-8. 2009
    ..9 +/- 21.5 microM and alpha(1)beta = 154.3 +/- 32.1 microM). These in vitro results demonstrate that ajulemic acid modulates strychnine-sensitive glycine receptors in clinically relevant concentrations...
  43. doi request reprint Catechol-O-methyltransferase gene polymorphisms are not associated with multisomatoform disorder in a group of German multisomatoform disorder patients and healthy controls
    Jana Jakobi
    Institute of Human Genetics, Hannover Medical School, Hannover, Germany
    Genet Test Mol Biomarkers 14:293-7. 2010
    ..We conclude that COMT polymorphisms on their own do not seem to play a relevant role as major genetic risk factors for MSD...
  44. ncbi request reprint Acupuncture in chronic epicondylitis: a randomized controlled trial
    M Fink
    Department of Physical Medicine and Rehabilitation, Hannover Medical School, Hannover, Germany
    Rheumatology (Oxford) 41:205-9. 2002
    ..To evaluate the clinical efficacy of acupuncture in the treatment of chronic lateral epicondylitis...
  45. ncbi request reprint Fatal outcome in a child after ingestion of a transdermal fentanyl patch
    Jörg Teske
    Institute of Legal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Int J Legal Med 121:147-51. 2007
    ..9 ng/ml, and liver 235 and 26 ng/g, respectively. The cause of death was determined to be a fentanyl overdose. The investigation established that the child has unintentionally swallowed the patch, which had been lying on the floor...
  46. ncbi request reprint Botulinum toxin type A and EMG: a key to the understanding of chronic tension-type headaches?
    J D Rollnik
    Department of Neurology, Medical School of Hannover, Germany
    Headache 41:985-9. 2001
    ..The pathogenesis of chronic tension-type headache remains unclear, and the role of muscle tension is especially controversial. Botulinum toxin type A, a potent inhibitor of muscle tone, has been used to treat chronic tension-type headache...
  47. ncbi request reprint Ajulemic acid: A novel cannabinoid produces analgesia without a "high"
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Life Sci 75:1513-22. 2004
    ..Data on its mechanism of action are not yet complete; however, the activation of PPAR-gamma, and regulation of eicosanoid and cytokine production, appear to be important for its potential therapeutic effects...
  48. ncbi request reprint Comments on "cannabimimetic properties of ajulemic acid"
    Matthias Karst
    J Pharmacol Exp Ther 322:420-1. 2007
  49. ncbi request reprint Determination of ajulemic acid and its glucuronide in human plasma by gas chromatography-mass spectrometry
    Catarina Batista
    Laboratory for Phytopharmacology, Bioanalytics and Pharmacokinetics, Department of Clinical Research, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 820:77-82. 2005
    ..For example, plasma levels of 599.4+/-37.2 ng/ml (mean+/-R.S.D., n=9) AJA were obtained for samples taken 2 h after the administration of an oral dose of 20 mg AJA. The mean AJA glucuronide concentration at 2h was 63.8+/-127.9 ng/ml...