I Just

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Large clostridial cytotoxins
    I Just
    Institut fur Toxikologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Rev Physiol Biochem Pharmacol 152:23-47. 2004
  2. pmc Proteomic evaluation of sheep serum proteins
    Elisabetta Chiaradia
    Department of Pathologic, Diagnostic, and Clinical Veterinary Medicine, University of Perugia, Perugia, Italy
    BMC Vet Res 8:66. 2012
  3. pmc Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotope-coded protein labeling and LC-MALDI
    Nelli Jochim
    Hannover Medical School, Institute of Toxicology, Carl Neuberg Str, 1, D 30625 Hannover, Germany
    Proteome Sci 9:48. 2011
  4. ncbi request reprint Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins
    I Just
    Institut fur Toxikologie, Medizinische Hochschule Hannover, Germany
    Int J Med Microbiol 291:243-50. 2001
  5. doi request reprint Therapeutic effects of Clostridium botulinum C3 exoenzyme
    Ingo Just
    Institut fur Toxikologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 383:247-52. 2011
  6. doi request reprint Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis
    M V Muetzelburg
    Institute of Toxicology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1344-51. 2009
  7. ncbi request reprint Clostridial Rho-inhibiting protein toxins
    K Aktories
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, 79104 Freiburg, Germany
    Curr Top Microbiol Immunol 291:113-45. 2005
  8. pmc ADP-ribosylation of Drosophila indirect-flight-muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin
    I Just
    Institut fur Pharmakologie und Toxikologie, Universitat des Saarlandes, Homburg, Germany
    Biochem J 291:409-12. 1993
  9. ncbi request reprint Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an IL-1beta-dependent pathway
    M Neunlist
    Institut National de la Santé et de la Recherche Médicale U539 Hôtel Dieu Hospital, 1, Place Alexis Ricordeau, 44035 Nantes, France
    Am J Physiol Gastrointest Liver Physiol 285:G1049-55. 2003

Collaborators

  • Astrid Rohrbeck
  • K Aktories
  • Elisabetta Chiaradia
  • Andreas Pich
  • Nelli Jochim
  • M V Muetzelburg
  • M Neunlist
  • Micaela Tartaglia
  • Alberto Gaiti
  • Fausto Scoppetta
  • Luca Avellini
  • Zoltan Czentnar
  • Ralf Gerhard
  • A Pich
  • F Hofmann
  • J Barouk
  • T Oreshkova
  • K Michel
  • J P Galmiche
  • M Schemann

Detail Information

Publications9

  1. ncbi request reprint Large clostridial cytotoxins
    I Just
    Institut fur Toxikologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Rev Physiol Biochem Pharmacol 152:23-47. 2004
    ..g., antibiotic-associated pseudomembranous colitis caused by Clostridium difficile) are less clear...
  2. pmc Proteomic evaluation of sheep serum proteins
    Elisabetta Chiaradia
    Department of Pathologic, Diagnostic, and Clinical Veterinary Medicine, University of Perugia, Perugia, Italy
    BMC Vet Res 8:66. 2012
    ....
  3. pmc Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotope-coded protein labeling and LC-MALDI
    Nelli Jochim
    Hannover Medical School, Institute of Toxicology, Carl Neuberg Str, 1, D 30625 Hannover, Germany
    Proteome Sci 9:48. 2011
    ..abstract:..
  4. ncbi request reprint Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins
    I Just
    Institut fur Toxikologie, Medizinische Hochschule Hannover, Germany
    Int J Med Microbiol 291:243-50. 2001
    ..Glucosylation as well as ADP-ribosylation result in functional inactivation of Rho causing disassembly of the actin cytoskeleton...
  5. doi request reprint Therapeutic effects of Clostridium botulinum C3 exoenzyme
    Ingo Just
    Institut fur Toxikologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 383:247-52. 2011
    ..Thus, in a proof-of-principle experiment, C3 peptide was shown to be efficacious in post-traumatic neuro-regeneration...
  6. doi request reprint Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis
    M V Muetzelburg
    Institute of Toxicology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1344-51. 2009
    ..C3bot altered the concentration of 55 proteins (at least 1.3-fold) and several proteins were identified as possible biomarker candidates that indicate C3bot-induced cellular changes...
  7. ncbi request reprint Clostridial Rho-inhibiting protein toxins
    K Aktories
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, 79104 Freiburg, Germany
    Curr Top Microbiol Immunol 291:113-45. 2005
    ..Here Rho-inactivating toxins and effectors are reviewed, including the families of large clostridial cytotoxins and C3-like transferases, which inactivate Rho GTPases by glucosylation and ADP-ribosylation, respectively...
  8. pmc ADP-ribosylation of Drosophila indirect-flight-muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin
    I Just
    Institut fur Pharmakologie und Toxikologie, Universitat des Saarlandes, Homburg, Germany
    Biochem J 291:409-12. 1993
    ..botulinum C2 toxin and by C. perfringens iota toxin, neither toxin modified the N-terminal O-12 deletion mutant...
  9. ncbi request reprint Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an IL-1beta-dependent pathway
    M Neunlist
    Institut National de la Santé et de la Recherche Médicale U539 Hôtel Dieu Hospital, 1, Place Alexis Ricordeau, 44035 Nantes, France
    Am J Physiol Gastrointest Liver Physiol 285:G1049-55. 2003
    ..Therefore, toxin B of C. difficile activates VIP-positive submucosal neurons, at least in part, via an indirect IL-1beta-dependent pathway...