Jens Jordan

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc Liver afferents contribute to water drinking-induced sympathetic activation in human subjects: a clinical trial
    Marcus May
    Institute of Clinical Pharmacology, Medical School Hannover, Hannover, Germany
    PLoS ONE 6:e25898. 2011
  2. pmc Physiological phenomenology of neurally-mediated syncope with management implications
    Christoph Schroeder
    Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e26489. 2011
  3. pmc Atrial natriuretic peptide and adiponectin interactions in man
    Andreas L Birkenfeld
    Department of Endocrinology, Diabetes and Nutrition, Center for Cardiovascular Research CCR, Charite University School of Medicine, Berlin, Germany
    PLoS ONE 7:e43238. 2012
  4. pmc Cardiorespiratory fitness and insulin sensitivity in overweight or obese subjects may be linked through intrahepatic lipid content
    Sven Haufe
    Franz Volhard Clinical Research Center at Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Diabetes 59:1640-7. 2010
  5. doi request reprint Electrical carotid sinus stimulation in treatment resistant arterial hypertension
    Jens Jordan
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Auton Neurosci 172:31-6. 2012
  6. doi request reprint Joint statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and difficult to treat arterial hypertension
    Jens Jordan
    Institute of Clinical Pharmacology, Medical School Hannover, Germany
    J Hypertens 30:1047-55. 2012
  7. doi request reprint Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation
    Sebastian Strempel
    Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
    J Appl Physiol (1985) 104:756-60. 2008
  8. doi request reprint Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women
    Stefan Engeli
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    Heart 99:944-8. 2013
  9. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
  10. doi request reprint Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients
    Karsten Heusser
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Hypertension 55:619-26. 2010

Detail Information

Publications86

  1. pmc Liver afferents contribute to water drinking-induced sympathetic activation in human subjects: a clinical trial
    Marcus May
    Institute of Clinical Pharmacology, Medical School Hannover, Hannover, Germany
    PLoS ONE 6:e25898. 2011
    ..Our findings support the idea that osmosensitive hepatic afferents are involved in water drinking-induced sympathetic activation in human subjects...
  2. pmc Physiological phenomenology of neurally-mediated syncope with management implications
    Christoph Schroeder
    Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e26489. 2011
    ..We hypothesized that true cardioinhibitory syncope in which the decrease in heart rate precedes the fall in blood pressure is a very rare finding which might explain the lack of efficacy of pacemakers in neurally-mediated syncope...
  3. pmc Atrial natriuretic peptide and adiponectin interactions in man
    Andreas L Birkenfeld
    Department of Endocrinology, Diabetes and Nutrition, Center for Cardiovascular Research CCR, Charite University School of Medicine, Berlin, Germany
    PLoS ONE 7:e43238. 2012
    ..Our study could have implications for the physiological regulation of adiponectin and for disease states associated with altered natriuretic peptide availability...
  4. pmc Cardiorespiratory fitness and insulin sensitivity in overweight or obese subjects may be linked through intrahepatic lipid content
    Sven Haufe
    Franz Volhard Clinical Research Center at Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Diabetes 59:1640-7. 2010
    ..Given the close relationship between intrahepatic lipid content (IHL) and insulin sensitivity, we hypothesized that the direct relationship between fitness and insulin sensitivity may be explained by IHL...
  5. doi request reprint Electrical carotid sinus stimulation in treatment resistant arterial hypertension
    Jens Jordan
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Auton Neurosci 172:31-6. 2012
    ..Yet, not all patients respond to treatment. Additional clinical trials are required. Patients equipped with an electrical carotid sinus stimulator provide a unique opportunity gaining insight in human baroreflex physiology...
  6. doi request reprint Joint statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and difficult to treat arterial hypertension
    Jens Jordan
    Institute of Clinical Pharmacology, Medical School Hannover, Germany
    J Hypertens 30:1047-55. 2012
    ..Most obese hypertensive patients require two or more antihypertensive drugs. Finally, how to combine weight loss strategies and antihypertensive treatment to achieve an optimal clinical outcome is unresolved...
  7. doi request reprint Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation
    Sebastian Strempel
    Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
    J Appl Physiol (1985) 104:756-60. 2008
    ..Redistribution of sympathetic activity to the heart or changes in baroreflex responses could explain the excessive tachycardia that we observed...
  8. doi request reprint Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women
    Stefan Engeli
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    Heart 99:944-8. 2013
    ..To explore whether increased adipocyte-derived serum fatty acid binding protein 4 (FABP4) predisposes to cardiac remodelling and left ventricular dysfunction in human obesity...
  9. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..This notion has not been tested in overweight and obese patients...
  10. doi request reprint Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients
    Karsten Heusser
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Hypertension 55:619-26. 2010
    ..The depressor response was mediated through sympathetic inhibition...
  11. doi request reprint Cardiovascular autonomic regulation in Non-Obese Diabetic (NOD) mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Auton Neurosci 138:108-13. 2008
    ..In conclusion the use of diabetic NOD mice as a functional model for human diabetes may be questioned...
  12. ncbi request reprint Baroreflex buffering and susceptibility to vasoactive drugs
    Jens Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 105:1459-64. 2002
    ..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known...
  13. doi request reprint Myocardial steatosis, cardiac remodelling and fitness in insulin-sensitive and insulin-resistant obese women
    Wolfgang Utz
    Working Group Cardiac MR Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Heart 97:1585-9. 2011
    ..Lipotoxic injury from altered myocardial metabolism may be causative. Whether such association also exists in obese, non-diabetic women is unknown...
  14. doi request reprint Sympathetic and cardiovascular responses to glossopharyngeal insufflation in trained apnea divers
    Karsten Heusser
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Appl Physiol (1985) 109:1728-35. 2010
    ..We speculate that lower MAP despite increased MSNA after packing might be explained by vasodilator substances released by the lungs. This idea should be addressed in future studies...
  15. ncbi request reprint Yohimbine attenuates baroreflex-mediated bradycardia in humans
    Jens Tank
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 50:899-903. 2007
    ..In contrast, yohimbine did not alter the sympathetic baroreflex curve. Yohimbine selectively attenuates baroreflex heart rate control in normotensive young men possibly through parasympathetic mechanisms...
  16. ncbi request reprint Alpha-2 adrenergic transmission and human baroreflex regulation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1035-41. 2004
    ..alpha-2 Adrenoceptor stimulation greatly augments baroreflex-mediated bradycardia, most likely by parasympathetic activation...
  17. doi request reprint Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women
    Wolfgang Utz
    Working Group Cardiac MR, Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Int J Cardiol 167:905-9. 2013
    ..Previous studies suggest that MTG could be mobilized through lifestyle interventions. We assessed influences of moderate dietary weight loss in non diabetic obese and overweight women on MTG content and cardiac function...
  18. ncbi request reprint Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans
    Antje F Mayer
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Max Delbrueck Centrum, and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:120-6. 2006
    ..All of these changes are physiologically relevant because they lead to corresponding changes in organ function...
  19. ncbi request reprint Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Charité Campus Buch and Helio Klinikum, Berlin, Germany
    Clin Pharmacol Ther 76:480-9. 2004
    ..St John's wort (Hypericum perforatum) is a popular over-the-counter antidepressant. Its antidepressive effect has been attributed in part to inhibition of monoamine transporters and monoamine oxidase, on the basis of in vitro studies...
  20. ncbi request reprint Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice
    Hantz C Hercule
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Exp Physiol 92:1014-22. 2007
    ..Our findings suggest that RGS2 deletion promotes Ang II-dependent hypertension primarily through an increase of myogenic tone and vasoreactivity, probably by sensitization of AT(1) receptors...
  21. doi request reprint Hormonal influences on cardiovascular norepinephrine transporter responses in healthy women
    Iryna Moldovanova
    Medical University Charité, Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 51:1203-9. 2008
    ..The phenomenon may be explained by an effect of female sex hormones on norepinephrine transporter function, on compensatory cardiovascular responses, or both...
  22. doi request reprint Orthostatic tolerance is difficult to predict in recurrent syncope patients
    Christoph Schroeder
    Experimental Clinical Research Center, Max Delbrueck Centrum for Molecular Medicine, Medical University Charité, Lindenberger Weg 80, Berlin, Germany
    Clin Auton Res 21:37-45. 2011
    ..In addition, we tested whether orthostatic tolerance is related to syncope frequency in real life...
  23. pmc Atrial natriuretic peptide induces postprandial lipid oxidation in humans
    Andreas L Birkenfeld
    Experimental and Clinical Research Center, Charité and HELIOS Klinikum, Berlin, Germany
    Diabetes 57:3199-204. 2008
    ..We hypothesized that ANP increases postprandial free fatty acid (FFA) availability and energy expenditure while decreasing arterial blood pressure...
  24. ncbi request reprint Influence of sibutramine treatment on sympathetic vasomotor tone in obese subjects
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinkum, Berlin, Germany
    Clin Pharmacol Ther 79:500-8. 2006
    ..Direct measurements of muscle sympathetic nerve activity (MSNA) in sibutramine-treated patients have not been conducted...
  25. doi request reprint Circulating endocannabinoid concentrations during orthostatic stress
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Clin Auton Res 19:343-6. 2009
    ..In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition...
  26. ncbi request reprint Norepinephrine transporter inhibition prevents tilt-induced pre-syncope
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Am Coll Cardiol 48:516-22. 2006
    ..We tested the hypothesis that pharmacological norepinephrine reuptake transporter (NET) inhibition delays the onset of head-up tilt-induced presyncope in healthy subjects...
  27. ncbi request reprint Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1042-7. 2004
    ..The effect of clonidine on baroreflex HR regulation is mediated by the parasympathetic nervous system. These murine data fit well with recent human observations regarding parasympathetic activation via alpha-2 adrenoceptors...
  28. doi request reprint Influences of normobaric hypoxia training on physical fitness and metabolic risk markers in overweight to obese subjects
    Susanne Wiesner
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Medical Faculty of the Charite, Berlin, Germany
    Obesity (Silver Spring) 18:116-20. 2010
    ..The fact that workload and, therefore, mechanic strain can be reduced in hypoxia could be particularly beneficial in obese patients with orthopedic comorbidities...
  29. ncbi request reprint Influences of gender on the interaction between sympathetic nerve traffic and central adiposity
    Jens Tank
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Clin Endocrinol Metab 93:4974-8. 2008
    ..A difference in the relationship between adiposity and sympathetic activity between women and men could contribute to the known gender difference in cardiovascular disease risk...
  30. doi request reprint Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation
    Andrey C da Costa-Goncalves
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 52:702-7. 2008
    ..The elevated blood pressure in SPL(-/-) mice was associated with attenuated baroreflex sensitivity and decreased parasympathetic activity. Our study is the first to show a role for the spinophilin gene in blood pressure regulation...
  31. pmc Peripheral endocannabinoid system activity in patients treated with sibutramine
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Obesity (Silver Spring) 16:1135-7. 2008
    ..Weight loss interventions may influence obesity-associated risk indirectly through modulation of the peripheral ECS. We investigated the effect of acute and chronic treatment with sibutramine on components of the peripheral ECS...
  32. ncbi request reprint Catechol-o-methyltransferase and blood pressure in humans
    Jens Jordan
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:460-5. 2002
    ..Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown...
  33. doi request reprint Left ventricular mass and function with reduced-fat or reduced-carbohydrate hypocaloric diets in overweight and obese subjects
    Sven Haufe
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medical Faculty and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 59:70-5. 2012
    ..However, n-3 polyunsaturated fatty acid ingestion may have an independent beneficial effect on left ventricular mass...
  34. ncbi request reprint Baroreflex regulation of heart rate and sympathetic vasomotor tone in women and men
    Jens Tank
    Franz Volhard Clinical Research Center, Medical Faculty, Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 45:1159-64. 2005
    ..06% for burst rate, 0.4% for burst incidence, and 0.01% for burst area. In women, the MSNA baroreflex curve may be shifted to slightly lower blood pressure such that at a given blood pressure MSNA tends to be lower...
  35. pmc Enhanced human tissue microdialysis using hydroxypropyl-ß-cyclodextrin as molecular carrier
    Marcus May
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e60628. 2013
    ..Our findings suggest that HP-ß-CD is a suitable supplement in clinical microdialysis to enhance recovery of lipophilic molecules from human interstitial fluid...
  36. ncbi request reprint Water drinking acutely improves orthostatic tolerance in healthy subjects
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2806-11. 2002
    ..In patients with severe autonomic dysfunction, water drinking elicits an acute pressor response and improves orthostatic hypotension. We tested the hypothesis that water drinking also improves orthostatic tolerance in healthy subjects...
  37. ncbi request reprint Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Clin Endocrinol Metab 92:1560-3. 2007
    ..The serotonin and norepinephrine transporter inhibitor sibutramine is a widely used antiobesity drug. In acute studies, the peripheral sympathomimetic effect of sibutramine was counteracted by a central sympatholytic action...
  38. doi request reprint The Valsalva maneuver: screening for drug-induced baroreflex dysfunction
    Christoph Schroeder
    Medical University Charité, Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Clin Auton Res 19:32-8. 2009
    ..Many drugs can interfere with baroreflex mechanisms thereby impairing blood pressure control, but few have undergone sufficient testing. The state of affairs may be explained by the lack of simple and inexpensive screening tests...
  39. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  40. ncbi request reprint European Society of Hypertension Working Group on Obesity: background, aims and perspectives
    Jens Jordan
    Franz Volhard Clinical Research Center and Department of Nephrology, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    J Hypertens 25:897-900. 2007
  41. ncbi request reprint Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  42. doi request reprint Spinophilin regulates central angiotensin II-mediated effect on blood pressure
    Andrey C da Costa Goncalves
    Leibniz Institute for Molecular Pharmacology, Berlin, Germany
    J Mol Med (Berl) 89:1219-29. 2011
    ..SPL is a hitherto unrecognized molecule with regard to central blood pressure control and may pave the way to novel strategies for the treatment of hypertension...
  43. doi request reprint Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case series
    Julia Brinkmann
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Hypertension 60:1485-90. 2012
    ..We conclude that reduced central sympathetic inhibition may be the exception rather than the rule after renal nerve ablation in unselected patients with difficult-to-control arterial hypertension...
  44. ncbi request reprint Pressor effect of water drinking in tetraplegic patients may be a spinal reflex
    Jens Tank
    HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 41:1234-9. 2003
    ..This observation might suggest that water drinking activates postganglionic sympathetic neurons either directly or through a spinal reflex mechanism...
  45. ncbi request reprint Direct Renin inhibition with aliskiren in obese patients with arterial hypertension
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 49:1047-55. 2007
    ..In conclusion, combination treatment with aliskiren is a highly effective and well-tolerated therapeutic option for obese patients with hypertension who fail to achieve blood pressure control with first-line thiazide diuretic treatment...
  46. doi request reprint Aliskiren penetrates adipose and skeletal muscle tissue and reduces renin-angiotensin system activity in obese hypertensive patients
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Berlin, Germany
    J Hypertens 30:561-6. 2012
    ..Therefore, we investigated whether aliskiren attains tissue concentrations sufficient to inhibit local renin-angiotensin system (RAS) activity in patients...
  47. ncbi request reprint Heterogeneity of autonomic regulation in hypertension and neurovascular contact
    Jens Jordan
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    J Hypertens 20:701-6. 2002
    ..We tested the hypothesis that similar abnormalities are present in patients with essential hypertension who have NVC...
  48. doi request reprint A validated, rapid UPLC-MS/MS method for simultaneous ivabradine, reboxetine, and metoprolol analysis in human plasma and its application to clinical trial samples
    Alexander A Zoerner
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 927:105-11. 2013
    ..We successfully measured ivabradine, reboxetine, and metoprolol concentrations in 107 human plasma samples from a clinical trial. Quality control samples processed in parallel confirmed the method's reliability in a clinical setting...
  49. doi request reprint Unique pentafluorobenzylation and collision-induced dissociation for specific and accurate GC-MS/MS quantification of the catecholamine metabolite 3,4-dihydroxyphenylglycol (DHPG) in human urine
    Alexander A Zoerner
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 879:1444-56. 2011
    ..2 μg/g creatinine). Given the unique derivatization reaction and collision-induced dissociation, and the straightforwardness the present method is highly specific, accurate, precise, and should be useful in clinical settings...
  50. doi request reprint Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease
    Frauke Adams
    Experimental and Clinical Research Center, A Cooperation with Max Delbrueck Center for Molecular Medicine, Charite Campus Buch, and HELIOS Klinikum, Berlin, Germany
    Eur J Clin Pharmacol 64:863-70. 2008
    ..We assessed systemic and local metabolic responses to levodopa/benserazide in patients with idiopathic Parkinson's disease...
  51. ncbi request reprint Resistant hypertension: baroreflex stimulation as a new tool
    Jan Menne
    Department of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 28:288-95. 2013
    ....
  52. pmc Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol?
    Carina Jarzimski
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Br J Clin Pharmacol 74:54-9. 2012
    ..Inhibition of enzymatic degradation of anandamide could explain some of the characteristics of propofol. Direct measurements have not been reported yet in humans...
  53. doi request reprint Research needs in the area of device-related treatments for hypertension
    Jens Jordan
    Hannover Medical School, Institute of Clinical Pharmacology, Hannover, Germany
    Kidney Int 84:250-5. 2013
    ..However, whether or not the effects are sustained over time is unknown. No 'end-point' data are available for either treatment. Devices should be subjected to evidence-based standards before widespread introduction. ..
  54. doi request reprint Patients with continuous-flow left ventricular assist devices provide insight in human baroreflex physiology
    Jens Tank
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Hypertension 60:849-55. 2012
    ..75±0.79%/mm Hg in patients and -3.80±0.55%/mm Hg in controls. We conclude that low pulse pressure levels are sufficient to restrain sympathetic nervous system activity through baroreflex mechanisms...
  55. doi request reprint Genetic influences on human baroreflex regulation
    Jens Jordan
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Auton Neurosci 172:23-5. 2012
    ..Studies including families may be preferable to traditional association studies. Knowledge gathered in these large scale studies could be complemented by carefully conducted clinical studies in relevant genetically defined conditions...
  56. ncbi request reprint Heritability of left ventricular and papillary muscle heart size: a twin study with cardiac magnetic resonance imaging
    Christoph A Busjahn
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Experimental and Clinical Research Center and Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Eur Heart J 30:1643-7. 2009
    ..We performed a twin study relying on CMR, focusing on left ventricular (LV) mass and papillary muscle, since there are no genetic reports on this structure...
  57. doi request reprint Influences of normobaric hypoxia training on metabolic risk markers in human subjects
    Sven Haufe
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Berlin, Germany
    Med Sci Sports Exerc 40:1939-44. 2008
    ..We hypothesized that training under hypoxia results in similar or even greater metabolic improvement compared with exercise under normoxia at a lower workload...
  58. doi request reprint Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extractio
    Alexander A Zoerner
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 883:161-71. 2012
    ..In urine, AEA was not detectable and 2AG was detected in only 3 out of 19 samples from healthy subjects at 160, 180 and 212 pM corresponding to 12.3, 14.5 and 9.9 pmol/mmol creatinine, respectively...
  59. ncbi request reprint Blood oxygen level-dependent MRI of tissue oxygenation: relation to endothelium-dependent and endothelium-independent blood flow changes
    Wolfgang Utz
    Medical Faculty of the Charite, Franz Volhard Klinik HELIOS Klinikum Berlin at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Arterioscler Thromb Vasc Biol 25:1408-13. 2005
    ..Muscle blood oxygen level-dependent MRI (BOLD MRI) provides data largely dependent on hemoglobin (Hb) oxygenation. We used BOLD MRI to assess endothelium-dependent signal intensity (SI) changes...
  60. doi request reprint Beta-2 adrenoreceptor gene polymorphisms and sympathetic outflow in humans
    Jens Tank
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hanover, Germany
    Clin Auton Res 21:333-8. 2011
    ..We reasoned that measurements of resting sympathetic nerve traffic could increase the sensitivity of defining a gene phenotype relationship...
  61. doi request reprint Quantification of endocannabinoids in biological systems by chromatography and mass spectrometry: a comprehensive review from an analytical and biological perspective
    Alexander A Zoerner
    Hannover Medical School, Hannover, Germany
    Biochim Biophys Acta 1811:706-23. 2011
    ..Currently available LC-MS/MS and GC-MS/MS methods should be useful to investigate the metabolism of AEA and 2AG beyond hydrolysis, i.e., by β- and ω-oxidation pathways...
  62. ncbi request reprint Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  63. doi request reprint Peripheral endocannabinoid microdialysis: in vitro characterization and proof-of-concept in human subjects
    Alexander A Zoerner
    Institute for Clinical Pharmacology, Hannover Medical School, Germany
    Anal Bioanal Chem 402:2727-35. 2012
    ..Our study suggests that the microdialysis technique is not suitable for the exact quantification of tissue EC concentrations, but it allows for their rough estimation...
  64. doi request reprint Stable-isotope dilution GC-MS method for ethanol in vapour ethanol and microdialysis systems based on carbonate-catalyzed extractive pentafluorobenzoylation
    Mani Haschemi Nassab
    Center for Addiction Research, Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany
    Analyst 137:2480-5. 2012
    ..The method was used to optimize experimental conditions in a custom-made ethanol vapour system utilized for studies examining ethanol influences on neuronal cell lines and in microdialysis...
  65. doi request reprint Stable-isotope dilution GC-MS approach for nitrite quantification in human whole blood, erythrocytes, and plasma using pentafluorobenzyl bromide derivatization: nitrite distribution in human blood
    Alexandra Schwarz
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 879:1485-95. 2011
    ..The present GC-MS method is useful to investigate distribution and metabolism of endogenous and exogenous nitrite in blood compartments under basal conditions and during hyperemia...
  66. doi request reprint Circulating anandamide and blood pressure in patients with obstructive sleep apnea
    Stefan Engeli
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    J Hypertens 30:2345-51. 2012
    ..Therefore, we hypothesized that increased blood pressure in patients with obstructive sleep apnea is associated with increased circulating endocannabinoid concentrations...
  67. doi request reprint Quantification of acetaminophen (paracetamol) in human plasma and urine by stable isotope-dilution GC-MS and GC-MS/MS as pentafluorobenzyl ether derivative
    Arne Trettin
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 879:2274-80. 2011
    ..By this method, acetaminophen can be reliably quantified in small plasma and urine sample volumes (e.g., 10 μL). The analytical performance of the method makes it especially useful in pediatrics...
  68. pmc Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: a randomized, placebo controlled, crossover study
    Jens Tank
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e18737. 2011
    ..Ozone concentrations in ambient air are related to cardiopulmonary perturbations in the aging population. Increased central sympathetic nerve activity induced by local airway inflammation may be one possible mechanism...
  69. doi request reprint UPLC-MS/MS measurement of S-nitrosoglutathione (GSNO) in human plasma solves the S-nitrosothiol concentration enigma
    Dimitrios Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 927:147-57. 2013
    ....
  70. doi request reprint Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity
    Christin Rakers
    Institute of Clinical Pharmacology, Hannover Medical School, 30623 Hannover, Germany
    Anal Biochem 421:699-705. 2012
    ..Substrate specificity of other fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton. In human whole blood, we detected FAAH activity that was inhibited by oloxa...
  71. pmc Clinical Evaluation of Extracellular ADMA Concentrations in Human Blood and Adipose Tissue
    Marcus May
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strase 1, 30625 Hannover, Germany
    Int J Mol Sci 15:1189-200. 2014
    ..Adipose tissue DDAH activity was negligible compared to liver tissue. Thus, adipose tissue ADMA plays a minor role in NO-dependent regulation of adipose tissue blood flow and metabolism. ..
  72. doi request reprint Cardiovascular regulation during apnea in elite divers
    Karsten Heusser
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Hypertension 53:719-24. 2009
    ..Our results are relevant to conditions featuring periodic apnea...
  73. ncbi request reprint Specific GC-MS/MS stable-isotope dilution methodology for free 9- and 10-nitro-oleic acid in human plasma challenges previous LC-MS/MS reports
    Dimitrios Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30623 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2895-908. 2009
    ..In this article we discuss analytical and biological ramifications potentially associated with measurement of nitrated biomolecules in biological systems...
  74. doi request reprint The osmopressor response to water drinking
    Marcus May
    Institute of Clinical Pharmacology, Hannover, Germany
    Am J Physiol Regul Integr Comp Physiol 300:R40-6. 2011
    ..The phenomenon should be recognized as an important confounder in cardiovascular and metabolic studies...
  75. doi request reprint Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II
    Kristine Chobanyan-Jürgens
    Department of Paediatrics, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Amino Acids 43:805-11. 2012
    ..While this would tend to limit development of endothelial dysfunction, it is not clear whether this might be medication-induced or represent a primary change in HCh-II children...
  76. doi request reprint Autonomic failure in a HIV-infected patient
    Jens Tank
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Clin Auton Res 20:263-5. 2010
    ..Clinical and pharmacological autonomic function testing supported the diagnosis of peripheral autonomic failure. Simple physiological manoeuvres substantially improved symptoms...
  77. doi request reprint Orthostatic heart rate responses after prolonged space flights
    Jens Tank
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Clin Auton Res 21:121-4. 2011
    ..Cardiovascular countermeasures may have attenuated POTS. Another possible interpretation is that cardiovascular deconditioning is not sufficient to elicit full blown POTS in the absence of additional genetic or environmental factors...
  78. doi request reprint Oxidized and nitrated oleic acid in biological systems: analysis by GC-MS/MS and LC-MS/MS, and biological significance
    Dimitrios Tsikas
    Hannover Medical School, Hannover, Germany
    Biochim Biophys Acta 1811:694-705. 2011
    ..These techniques are particularly suited to delineate the oleic acid cascade...
  79. doi request reprint High-performance liquid chromatography ultraviolet assay for human erythrocytic catalase activity by measuring glutathione as o-phthalaldehyde derivative
    Anke Böhmer
    Institute of Clinical Pharmacology, Hannover Medical School, 30625 Hannover, Germany
    Anal Biochem 410:296-303. 2011
    ..The novel CAT activity assay works under redox conditions that more closely resemble those prevailing in cells and allows high-throughput analysis despite the required HPLC step...
  80. doi request reprint Simultaneous gas chromatography-tandem mass spectrometry quantification of symmetric and asymmetric dimethylarginine in human urine
    Dimitrios Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, 30625 Hannover, Germany
    Anal Biochem 413:60-2. 2011
    ..The GC-MS/MS method was validated for SDMA and ADMA in spot urine samples of 19 healthy adults. In these samples, the creatinine-corrected excretion rate was 3.23±0.63 μmol/mmol for SDMA and 3.14±0.98 μmol/mmol for ADMA...
  81. doi request reprint Management of neurogenic orthostatic hypotension in patients with autonomic failure
    Christoph Schroeder
    Institute of Clinical Pharmacology, OE 5350, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Germany
    Drugs 73:1267-79. 2013
    ..Here we review treatment options for neurogenic orthostatic hypotension and include an algorithm for its management that emphasizes the importance of non-pharmacologic measures and provides guidance on pharmacologic treatment options. ..
  82. doi request reprint Novel metabolic drugs and blood pressure: implications for the treatment of obese hypertensive patients?
    Stefan Engeli
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hannover, Germany
    Curr Hypertens Rep 15:470-4. 2013
    ....
  83. pmc Natriuretic peptides enhance the oxidative capacity of human skeletal muscle
    Stefan Engeli
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    J Clin Invest 122:4675-9. 2012
    ..We propose that NP could contribute to exercise training-induced improvement in skeletal muscle fat oxidative capacity in humans...
  84. doi request reprint Evidence by gas chromatography-mass spectrometry of ex vivo nitrite and nitrate formation from air nitrogen oxides in human plasma, serum, and urine samples
    Dimitrios Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, 30625 Hannover, Germany
    Anal Biochem 397:126-8. 2010
    ..These artifacts can be effectively reduced by closing sample-containing vials during sample treatment...
  85. pmc Antihypertensive treatment in patients with class 3 obesity
    Jens Jordan
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Ther Adv Endocrinol Metab 3:93-8. 2012
    ....
  86. doi request reprint Targeted stable-isotope dilution GC-MS/MS analysis of the endocannabinoid anandamide and other fatty acid ethanol amides in human plasma
    Alexander A Zoerner
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2909-23. 2009
    ..The plasma concentrations of OEA, PEA and other FAEA are higher than that of AEA. This GC-MS/MS method is straightforward, accurate, precise, highly specific for FAEA and useful in basic and clinical research...