Kais Hussein


Affiliation: Hannover Medical School
Country: Germany


  1. request reprint
    Hussein K, Theophile K, Dralle W, Wiese B, Kreipe H, Bock O. MicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia. Platelets. 2009;20:391-400 pubmed
    ..Increased accumulation of miR-146b was observed in cellular stage PMF (p = 0.0125) but not ET megakaryopoiesis. In conclusion, this is the first microRNA profiling of in situ-derived PMF, ET and normal megakaryocytes. ..
  2. Hussein K. Gene expression profiling in laser-microdissected bone marrow megakaryocytes. Methods Mol Biol. 2011;755:429-39 pubmed publisher
    ..Two different laser microdissection devices are presented, and the details of RNA extraction and subsequent real-time qPCR gene expression analysis of mRNA and microRNA are provided...
  3. Hussein K, Stucki Koch A, Müller A, Arnold R, Kreipe H, Feist H. Complement receptor-associated CD163+/CD18+/CD11c+/CD206-/CD209- expression profile in chronic histiocytic intervillositis of the placenta. Placenta. 2019;78:23-28 pubmed publisher
    ..CD163 expression indicates a M2-like polarisation. CD11c and CD18 form the complement receptor 4 which could be related to a complement mediated trigger for aberrant cell accumulation in CIUE. ..
  4. Hussein K, Stucki Koch A, Kreipe H. Profile of fibrosis-related gene transcripts and megakaryocytic changes in the bone marrow of myelodysplastic syndromes with fibrosis. Ann Hematol. 2018;: pubmed publisher
    ..In summary, fibrosis in MDS-MF and PMF shows many molecular and morphological similarities. ..
  5. Bartels S, Adisa A, Aladelusi T, Lemound J, Stucki Koch A, Hussein S, et al. Molecular defects in BRAF wild-type ameloblastomas and craniopharyngiomas-differences in mutation profiles in epithelial-derived oropharyngeal neoplasms. Virchows Arch. 2018;472:1055-1059 pubmed publisher
    ..In conclusion, mutation profiles of BRAF wild-type craniopharyngiomas and ameloblastomas share mutations of FGFR genes and have additional mutations with potential for targeted therapy. ..
  6. Hussein K, Brix A, Matin E, Jonigk D. [Tutankhamun: evidence-based paleopathology versus "curse of the pharaoh"]. Pathologe. 2015;36:186-92 pubmed publisher
    ..In addition to many artificial post-mortem alterations, chronic and acute diseases could be verified in Tutankhamun, although the underlying causes are partially unknown. ..
  7. Abraham L, Kreipe H, Raab P, Hussein K. [Clinical and pathological characteristics of intravascular lymphomas]. Pathologe. 2018;39:242-248 pubmed publisher
    ..Because of the rarity of this disease, little is known about therapy and prognosis, whereby therapy is mainly similar to non-IVL lymphomas. The prognosis is poor; median survival after diagnosis is approximately one year. ..
  8. Hussein K, Peter C, Sedlacek L, Kaisenberg C, Kreipe H. [Necrotizing funisitis : Histopathological indicator of occult congenital syphilis]. Pathologe. 2017;38:312-316 pubmed publisher
  9. Müller A, Hussein K. Meta-analysis of teeth from European populations before and after the 18th century reveals a shift towards increased prevalence of caries and tooth loss. Arch Oral Biol. 2017;73:7-15 pubmed publisher
    ..It is likely that changes in nutrition (more sugar) and dental health (possibly higher frequency of tooth extraction) could be the underlying factors which led to this minor to moderate shift of dental disease frequencies in Europe. ..

More Information


  1. Lemound J, Schenk M, Keller G, Stucki Koch A, Witting S, Kreipe H, et al. Cytogenetic and immunohistochemical biomarker profiling of therapy-relevant factors in salivary gland carcinomas. J Oral Pathol Med. 2016;45:655-663 pubmed publisher
    ..HER2 overexpression in a subfraction of SGC and low frequencies of EGFR mutations are known. Here, we established receptor and cell signalling profiles of 17 therapy-relevant factors and propose a molecular diagnostic algorithm for SGC...
  2. Hussein K, Theophile K, Denzer K, Kreipe H, Bock O. Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases. J Thromb Thrombolysis. 2009;28:299-303 pubmed publisher
    ..CD239 was expressed in a constitutive fashion in PV-derived bone marrow cells and thus a pro-thrombotic function does not seem to be mediated by increased CD239 expression alone. ..
  3. Hussein K, Dralle W, Theophile K, Kreipe H, Bock O. Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm. Ann Hematol. 2009;88:325-32 pubmed publisher
    ..No association to thrombocytosis, JAK2(V617F) mutations or cytoreductive treatment (bone marrow cells) were observed. ..
  4. Keller G, Steinmann D, Quaas A, Grünwald V, Janssen S, Hussein K. New concepts of personalized therapy in salivary gland carcinomas. Oral Oncol. 2017;68:103-113 pubmed publisher
  5. Cramer L, Brix A, Matin E, Rühli F, Hussein K. Computed Tomography-Detected Paleopathologies in Ancient Egyptian Mummies. Curr Probl Diagn Radiol. 2018;47:225-232 pubmed publisher
    ..The cause of death is rarely verifiable, but CT scan could be the clue. Although well known in Egyptian mummies, artificial changes may lead to misinterpretation of CT findings. ..
  6. Hussein K, Panning B. [Reconstruction of the examination of the laryngeal carcinoma of Emperor Frederick III by Rudolf Virchow]. Pathologe. 2018;39:172-177 pubmed publisher
    ..The answer has been the same for more than a hundred years: the clinician is dissatisfied with the histopathological diagnosis, so the pathologist is to blame. ..
  7. Hussein K, Stucki Koch A, Alchalby H, Triviai I, Kröger N, Kreipe H. Cytokine Expression Pattern in Bone Marrow Microenvironment after Allogeneic Stem Cell Transplantation in Primary Myelofibrosis. Biol Blood Marrow Transplant. 2016;22:644-650 pubmed publisher
    ..This is the first systematic analysis of cytokine expression in post-ASCT PMF bone marrow that shows that normalization of bone marrow microenvironment is paralleled by decreased expression of TIMP and PDGFA. ..
  8. Hussein K, Theophile K, Büsche G, Schlegelberger B, Göhring G, Kreipe H, et al. Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome. Leuk Res. 2010;34:328-34 pubmed publisher
    ..We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q). ..