Kais Hussein

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint MicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia
    Kais Hussein
    Institute of Pathology, 30625, Hannover, Germany
    Platelets 20:391-400. 2009
  2. doi request reprint Gene expression profiling in laser-microdissected bone marrow megakaryocytes
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Methods Mol Biol 755:429-39. 2011
  3. doi request reprint Paleopathology of the juvenile Pharaoh Tutankhamun-90th anniversary of discovery
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hanover, Germany
    Virchows Arch 463:475-9. 2013
  4. doi request reprint [Pathobiology of the microRNA system]
    K Hussein
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 33:70-8. 2012
  5. doi request reprint Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Thromb Thrombolysis 28:299-303. 2009
  6. doi request reprint Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30615 Hanover, Germany
    Ann Hematol 88:325-32. 2009
  7. pmc Array-CGH and quantitative PCR genetic analysis in a case with bilateral hypoplasia of pulmonary arteries and lungs and simultaneous unilateral renal agenesis
    Kais Hussein
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Int J Clin Exp Pathol 3:723-9. 2010
  8. doi request reprint Aberrant microRNA expression pattern in myelodysplastic bone marrow cells
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:1169-74. 2010
  9. doi request reprint Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Ann Hematol 90:307-13. 2011
  10. doi request reprint Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:328-34. 2010

Collaborators

Detail Information

Publications41

  1. ncbi request reprint MicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia
    Kais Hussein
    Institute of Pathology, 30625, Hannover, Germany
    Platelets 20:391-400. 2009
    ..Increased accumulation of miR-146b was observed in cellular stage PMF (p = 0.0125) but not ET megakaryopoiesis. In conclusion, this is the first microRNA profiling of in situ-derived PMF, ET and normal megakaryocytes...
  2. doi request reprint Gene expression profiling in laser-microdissected bone marrow megakaryocytes
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Methods Mol Biol 755:429-39. 2011
    ..Two different laser microdissection devices are presented, and the details of RNA extraction and subsequent real-time qPCR gene expression analysis of mRNA and microRNA are provided...
  3. doi request reprint Paleopathology of the juvenile Pharaoh Tutankhamun-90th anniversary of discovery
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hanover, Germany
    Virchows Arch 463:475-9. 2013
    ..The most likely cause of death is the severe acute knee fracture and/or the malaria, while a suspected eighteenth dynasty syndrome cannot be proven. ..
  4. doi request reprint [Pathobiology of the microRNA system]
    K Hussein
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Pathologe 33:70-8. 2012
    ....
  5. doi request reprint Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Thromb Thrombolysis 28:299-303. 2009
    ..CD239 was expressed in a constitutive fashion in PV-derived bone marrow cells and thus a pro-thrombotic function does not seem to be mediated by increased CD239 expression alone...
  6. doi request reprint Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30615 Hanover, Germany
    Ann Hematol 88:325-32. 2009
    ..No association to thrombocytosis, JAK2(V617F) mutations or cytoreductive treatment (bone marrow cells) were observed...
  7. pmc Array-CGH and quantitative PCR genetic analysis in a case with bilateral hypoplasia of pulmonary arteries and lungs and simultaneous unilateral renal agenesis
    Kais Hussein
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Int J Clin Exp Pathol 3:723-9. 2010
    ..This case might represent an extreme form of previously reported, rare cases with simultaneous dysorganogenesis of lungs and kidneys...
  8. doi request reprint Aberrant microRNA expression pattern in myelodysplastic bone marrow cells
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:1169-74. 2010
    ..Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS. These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells...
  9. doi request reprint Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Ann Hematol 90:307-13. 2011
    ..Therefore, the link of deregulated microRNA expression to disease-related phenotype and the underlying molecular mechanism are still unknown...
  10. doi request reprint Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:328-34. 2010
    ..We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q)...
  11. doi request reprint JAK2(V617F) allele burden discriminates essential thrombocythemia from a subset of prefibrotic-stage primary myelofibrosis
    Kais Hussein
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Exp Hematol 37:1186-1193.e7. 2009
    ..Among Philadelphia chromosome-negative myeloproliferative neoplasms (Ph(-) MPN), essential thrombocythemia (ET) and the prefibrotic phase of primary myelofibrosis (PMF) represent two subtypes with considerable overlap...
  12. ncbi request reprint Different involvement of the megakaryocytic lineage by the JAK2 V617F mutation in Polycythemia vera, essential thrombocythemia and chronic idiopathic myelofibrosis
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Ann Hematol 86:245-53. 2007
    ....
  13. ncbi request reprint The suppressor of cytokine signalling-1 (SOCS-1) gene is overexpressed in Philadelphia chromosome negative chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Leuk Res 31:799-803. 2007
    ..We conclude that up-regulation of the SOCS-1 gene might reflect a compensatory feedback mechanism with different emphasis among Ph(-) CMPD subtypes independent of an underlying JAK2 (V617F) mutation...
  14. pmc Obliterative airway remodeling: molecular evidence for shared pathways in transplanted and native lungs
    Danny Jonigk
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Am J Pathol 178:599-608. 2011
    ..These distinct expression patterns warrant further investigation as potential markers of impending airway remodeling, especially for prospective longitudinal molecular profiling...
  15. pmc Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines
    Oliver Bock
    Assistant Professor, Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Am J Pathol 172:951-60. 2008
    ..We conclude that BMP family members may play an important role in the pathogenesis of myelofibrosis in PMF and are apparently induced by cytokines such as TGFbeta-1...
  16. ncbi request reprint Histological and molecular classification of chronic myeloproliferative disorders in the age of JAK2: persistence of old questions despite new answers
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Pathobiology 74:72-80. 2007
    ....
  17. doi request reprint Aberrant proplatelet formation in chronic myeloproliferative neoplasms
    Michaela Muth
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:1424-9. 2010
    ..001). This study demonstrates that besides megakaryocytic proliferation extensive pseudopodial proplatelet formation provides a hallmark of MPN. Fibrosing differ from non-fibrosing MPN by density and size of aberrant proplatelets...
  18. doi request reprint Thrombospondin-1 (TSP-1) in primary myelofibrosis (PMF) - a megakaryocyte-derived biomarker which largely discriminates PMF from essential thrombocythemia
    Michaela Muth
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Hematol 90:33-40. 2011
    ..On the other hand, TSP-1 is a factor acting (ineffectively) against exaggerated angiogenesis. Both features suggest TSP-1 to be a biomarker for monitoring a PMF-targeted therapy...
  19. doi request reprint Identification of new target molecules PTK2, TGFBR2 and CD9 overexpressed during advanced bone marrow remodelling in primary myelofibrosis
    Oliver Bock
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Br J Haematol 146:510-20. 2009
    ..We conclude that PTK2, TGFBR2 and CD9 represent new target molecules involved in bone marrow remodelling of PMF and warrant further investigation for potential targeted therapy...
  20. pmc Expression analysis of leukocytes attracting cytokines in chronic histiocytic intervillositis of the placenta
    Lukas Freitag
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Int J Clin Exp Pathol 6:1103-11. 2013
    ..Characteristically it shows accumulation of CD68+ cells in the intervillous space but no destructive tissue infiltration. An immunopathological background is likely but it is unknown what attracts circulating monocytes to the placenta...
  21. pmc "Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression"
    Michaela Muth
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Transl Med 8:33. 2010
    ..Whether the response of fibroblasts to stress factors also involves the miRNA system is largely unknown...
  22. doi request reprint Obliterative airway remodelling in transplanted and non-transplanted lungs
    Danny Jonigk
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Virchows Arch 457:369-80. 2010
    ..BMPs, especially BMP-7, warrant further investigation as possible markers for the aggravation of airway remodelling...
  23. doi request reprint Expression profiling of apoptosis-related genes in megakaryocytes: BNIP3 is downregulated in primary myelofibrosis
    Katharina Theophile
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Exp Hematol 36:1728-38. 2008
    ....
  24. doi request reprint Opposite expression pattern of Src kinase Lyn in acute and chronic haematological malignancies
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Hematol 88:1059-67. 2009
    ..We conclude that tyrosine kinase Lyn contributes to the malignant phenotype in certain leukaemia subtypes and therefore attracts targeted therapy...
  25. doi request reprint Myelofibrosis in Philadelphia chromosome-negative myeloproliferative neoplasms is associated with aberrant karyotypes
    Gesa Hauck
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Cancer Genet 206:116-23. 2013
    ..In conclusion, aberrant karyotypes in Ph¯ MPN reflect the chromosomal instability in these diseases and, in comparison with pre-fibrotic stages, Ph¯ MPN with fibrosis has the highest frequency of cytogenetic aberrations...
  26. pmc Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression
    Michaela Muth
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Transl Med 9:24. 2011
    ..After publication of our article 1, we realized the need for posting a correction note in order to prevent i) overinterpretation of some results by the readers and ii) concerns about potentially unintended misguidance by the authors...
  27. ncbi request reprint Transcription factor Fli-1 expression by bone marrow cells in chronic myeloproliferative disorders is independent of an underlying JAK2 (V617F) mutation
    Oliver Bock
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Eur J Haematol 77:463-70. 2006
    ....
  28. pmc Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment
    Danny Jonigk
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Am J Pathol 179:167-79. 2011
    ..Neoplastic models of angiogenesis seem to be of limited use in further study of plexiform vasculopathy...
  29. ncbi request reprint Stem cell defects in Philadelphia chromosome negative chronic myeloproliferative disorders: a phenotypic and molecular puzzle?
    Oliver Bock
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Curr Stem Cell Res Ther 2:253-63. 2007
    ..This review will focus on previous and recent findings in the field of molecular defects in Ph(-) CMPD...
  30. doi request reprint Posttransplant lymphoproliferative disorder in pediatric patients
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Pathobiology 80:289-96. 2013
    ..Surgical debulking of tumor mass and anti-CD20-antibody treatment with or without chemotherapy (usually at lower dosages than in immunocompetent patients) constitute the basis of additional therapy. ..
  31. doi request reprint Epstein-Barr virus-associated smooth muscle tumours after transplantation, infection with human immunodeficiency virus and congenital immunodeficiency syndromes
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Pathobiology 80:297-301. 2013
    ..In HIV-SMT and CI-SMT, surgery should be performed. In all 3 tumour types, adverse prognosis is mainly related to comorbidities associated with immunosuppression but not with the extent of histological atypia or tumour size. ..
  32. doi request reprint Risk factors and prognosis in T-cell posttransplantation lymphoproliferative diseases: reevaluation of 163 cases
    Christina Tiede
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Transplantation 95:479-88. 2013
    ..Therefore, we aimed to provide an overview and a retrospective analysis of this rare PTLD subtype...
  33. doi request reprint EBV-specific T-cell immunity in pediatric solid organ graft recipients with posttransplantation lymphoproliferative disease
    Nadine Wilsdorf
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Transplantation 95:247-55. 2013
    ..We present data on EBV-specific T cells in children treated with rituximab with or without chemotherapy on the pediatric PTLD Pilot 2005 protocol...
  34. pmc Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Am J Pathol 169:471-81. 2006
    ..We conclude that the expression of matrix-modeling genes in cIMF is not influenced by the JAK2 mutation status but is predominantly related to the stage of disease...
  35. doi request reprint Simultaneous and sequential concurrent myeloproliferative and lymphoproliferative neoplasms
    Gesa Hauck
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Acta Haematol 129:187-96. 2013
    ..Although a common aberrant progenitor has been reported in some cases in the literature, we found evidence of two independent chronic-stage myeloid and lymphoid/plasmacytoid neoplasms...
  36. doi request reprint Expression of angiogenic factors is increased in metastasised renal cell carcinomas
    Mahmoud Abbas
    Institut fur Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover, Deutschland, Germany
    Virchows Arch 464:197-202. 2014
    ..Increased expression of angiogenic factors in metastases might be related to development of resistance after anti-angiogenic therapy but might also be an inherent biological characteristic. ..
  37. ncbi request reprint Multiplexing clonality: combining RGB marking and genetic barcoding
    Kerstin Cornils
    Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany, Institute for Medical Informatics and Biometry, Faculty of Medicine, Technische Universitat Dresden, Dresden 01307, Germany, ALS Automated Lab Solutions GmbH, Jena 07747, Germany, Department of Neuropathology, Hannover Medical School, Institute of Pathology, Hannover 30625, Germany, Department of Internal Medicine I, University Medical Center Hamburg Eppendorf, Hamburg 20246, Germany, Deep Sequencing Group SFB 655, Biotechnology Center, Technische Universitat Dresden, Dresden 01307, Germany
    Nucleic Acids Res 42:e56. 2014
    ..Moreover, the introduction of color-specific signatures in barcodes will facilitate studies on the impact of different variables (e.g. vector type, transgenes, culture conditions) in the context of competitive repopulation studies. ..
  38. pmc Expression of caspase 14 and filaggrin in oral squamous carcinoma
    Constance Scharenberg
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Head Neck Pathol 7:327-33. 2013
    ..In summary, in contrast to cervical carcinomas, partial loss of caspase 14 is not associated with dedifferentiation in neoplastic lesions of the oral mucosa or HPV infection. ..
  39. doi request reprint Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Nat Med 18:1550-9. 2012
    ..These data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo...
  40. ncbi request reprint Hypoxia Induces Mesenchymal Gene Expression in Renal Tubular Epithelial Cells: An in vitro Model of Kidney Transplant Fibrosis
    Stephanie Zell
    Institute of Pathology, Hannover Medical School, Hannover, Germany Integrated Research and Treatment Center Transplantation IFB Tx, Hannover Medical School, Hannover, Germany
    Nephron Extra 3:50-8. 2013
    ..One potential driver of EMT in developing interstitial fibrosis and tubular atrophy is chronic hypoxia...
  41. doi request reprint Characteristics of early and late PTLD development in pediatric solid organ transplant recipients
    Tilmann Schober
    Department of Pediatric Hematology Oncology, Hannover Medical School, Hannover, Germany
    Transplantation 95:240-6. 2013
    ..The purpose of this study was to identify the factors associated with the development of early- and late-onset PTLD in pediatric solid organ transplant recipients...