Marius M Hoeper

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint [Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists]
    M M Hoeper
    Medizinische Hochschule Hannover, Abteilung Pneumologie, 30623 Hannover
    Dtsch Med Wochenschr 131:S308-10. 2006
  2. ncbi request reprint Severe pulmonary arterial hypertension: a forme fruste of cancer?
    Marc Humbert
    Am J Respir Crit Care Med 178:551-2. 2008
  3. ncbi request reprint Chronic thromboembolic pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School and German Centre for Lung Research DZL, Hannover, Germany Electronic address
    Lancet Respir Med 2:573-82. 2014
  4. doi request reprint Definitions and diagnosis of pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine and German Center for Lung Research, Hannover Medical School, Hannover, Germany Electronic address
    J Am Coll Cardiol 62:D42-50. 2013
  5. ncbi request reprint Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry
    Marius M Hoeper
    Department of Respiratory Medicine and German Center of Lung Research, Hannover Medical School, Hannover, Germany Electronic address
    Int J Cardiol 168:871-80. 2013
  6. doi request reprint Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Circulation 127:1128-38. 2013
  7. ncbi request reprint Pregnancy outcomes in pulmonary arterial hypertension in the modern management era
    Xavier Jais
    Univ Paris Sud, Faculté de Me decine, Le Kremlin Bicetre, France
    Eur Respir J 40:881-5. 2012
  8. doi request reprint Pulmonary hypertension due to chronic lung disease: updated Recommendations of the Cologne Consensus Conference 2011
    Marius M Hoeper
    Clinic for Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Int J Cardiol 154:S45-53. 2011
  9. doi request reprint The prognostic impact of follow-up assessments in patients with idiopathic pulmonary arterial hypertension
    N Nickel
    Dept of Respiratory Medicine, Hanover Medical School, Hanover, Germany
    Eur Respir J 39:589-96. 2012
  10. pmc Effect of acute kidney injury requiring extended dialysis on 28 day and 1 year survival of patients undergoing interventional lung assist membrane ventilator treatment
    Jan T Kielstein
    Department Nephrology and Hypertension, Medical School Hannover, Germany
    BMC Nephrol 12:15. 2011

Detail Information

Publications90

  1. ncbi request reprint [Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists]
    M M Hoeper
    Medizinische Hochschule Hannover, Abteilung Pneumologie, 30623 Hannover
    Dtsch Med Wochenschr 131:S308-10. 2006
    ..Almost all current guidelines list bosentan as of equal value to sildenafil or prostacyclin analogues in the first-line treatment of patients in NYHA functional class III and also, with narrower indications, of those in class IV...
  2. ncbi request reprint Severe pulmonary arterial hypertension: a forme fruste of cancer?
    Marc Humbert
    Am J Respir Crit Care Med 178:551-2. 2008
  3. ncbi request reprint Chronic thromboembolic pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School and German Centre for Lung Research DZL, Hannover, Germany Electronic address
    Lancet Respir Med 2:573-82. 2014
    ..For patients with inoperable CTEPH, various medical and interventional therapies are being developed. ..
  4. doi request reprint Definitions and diagnosis of pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine and German Center for Lung Research, Hannover Medical School, Hannover, Germany Electronic address
    J Am Coll Cardiol 62:D42-50. 2013
    ....
  5. ncbi request reprint Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry
    Marius M Hoeper
    Department of Respiratory Medicine and German Center of Lung Research, Hannover Medical School, Hannover, Germany Electronic address
    Int J Cardiol 168:871-80. 2013
    ..We aimed to describe the characteristics of such patients and their survival under clinical practice conditions...
  6. doi request reprint Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Circulation 127:1128-38. 2013
    ..By its inhibitory effect on platelet-derived growth factor signaling, imatinib could be efficacious in treating patients with pulmonary arterial hypertension (PAH)...
  7. ncbi request reprint Pregnancy outcomes in pulmonary arterial hypertension in the modern management era
    Xavier Jais
    Univ Paris Sud, Faculté de Me decine, Le Kremlin Bicetre, France
    Eur Respir J 40:881-5. 2012
    ..These data must be confirmed by larger series before the general recommendation to avoid pregnancy in all patients with PAH is reconsidered...
  8. doi request reprint Pulmonary hypertension due to chronic lung disease: updated Recommendations of the Cologne Consensus Conference 2011
    Marius M Hoeper
    Clinic for Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Int J Cardiol 154:S45-53. 2011
    ..This manuscript describes in detail the results and recommendations of this working group which were last updated in October 2011...
  9. doi request reprint The prognostic impact of follow-up assessments in patients with idiopathic pulmonary arterial hypertension
    N Nickel
    Dept of Respiratory Medicine, Hanover Medical School, Hanover, Germany
    Eur Respir J 39:589-96. 2012
    ..Changes in established predictors of outcome during the course of the disease provide important prognostic information in patients with IPAH...
  10. pmc Effect of acute kidney injury requiring extended dialysis on 28 day and 1 year survival of patients undergoing interventional lung assist membrane ventilator treatment
    Jan T Kielstein
    Department Nephrology and Hypertension, Medical School Hannover, Germany
    BMC Nephrol 12:15. 2011
    ..ARDS is frequently accompanied by acute kidney injury; however it is so far unknown how the combination of these two conditions affects long term survival of critically ill patients...
  11. ncbi request reprint Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
    M M Hoeper
    Hannover Medical School, Dept of Respiratory Medicine, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Respir J 28:691-4. 2006
    ..Further studies involving larger sample sizes and long-term follow-up are needed to determine the efficacy of adding inhaled iloprost to bosentan in patients with idiopathic pulmonary arterial hypertension...
  12. ncbi request reprint Experience with inhaled iloprost and bosentan in portopulmonary hypertension
    M M Hoeper
    Dept of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Eur Respir J 30:1096-102. 2007
    ..Patients treated with bosentan had higher survival rates, but prospective controlled studies are required to confirm these findings...
  13. ncbi request reprint Chronic thromboembolic pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Circulation 113:2011-20. 2006
  14. ncbi request reprint Update in pulmonary hypertension 2005
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Am J Respir Crit Care Med 173:499-505. 2006
  15. ncbi request reprint Goal-oriented treatment and combination therapy for pulmonary arterial hypertension
    M M Hoeper
    Hannover Medical School, Dept of Respiratory Medicine, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Respir J 26:858-63. 2005
    ....
  16. ncbi request reprint Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Chest 128:2363-7. 2005
    ..We performed an open-label multicenter study to evaluate the safety and efficacy of the dual endothelin receptor antagonist bosentan in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH)...
  17. ncbi request reprint Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 48:2546-52. 2006
    ..This study sought to assess the risks associated with right heart catheter procedures in patients with pulmonary hypertension...
  18. ncbi request reprint Prognostic value of blood gas analyses in patients with idiopathic pulmonary arterial hypertension
    M M Hoeper
    Dept of Respiratory Medicine, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Respir J 29:944-50. 2007
    ..In patients with idiopathic pulmonary arterial hypertension, hypocapnia (carbon dioxide arterial tension <4.25 kPa) is an independent marker of mortality...
  19. doi request reprint [Pulmonary hypertension due to chronic lung disease. Recommendations of the Cologne Consensus Conference 2010]
    M M Hoeper
    Klinik fur Pneumologie, Medizinische Hochschule Hannover, Hannover
    Pneumologie 65:208-18. 2011
    ..One of the working groups was dedicated to the diagnosis and treatment of PH in patients with chronic lung disease. The recommendations of this working group are summarized in the present paper...
  20. doi request reprint [Pulmonary hypertension due to chronic lung disease. Recommendations of the Cologne Consensus Conference 2010]
    M M Hoeper
    Klinik fur Pneumologie, Medizinische Hochschule Hannover, Hannover
    Dtsch Med Wochenschr 135:S115-24. 2010
    ..One of the working groups was dedicated to the diagnosis and treatment of PH in patients with chronic lung disease. The recommendations of this working group are summarized in the present paper...
  21. ncbi request reprint [Pulmonary hypertension - historical development, current therapy and perspectives]
    M M Hoeper
    Klinik fur Pneumologie, Medizinische Hochschule Hannover, Hannover
    Pneumologie 64:577-82. 2010
    ..Many aspects of the disease, however, remain poorly understood and a cure is still not achievable for the majority of the affected patients...
  22. ncbi request reprint Definition, classification, and epidemiology of pulmonary arterial hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Semin Respir Crit Care Med 30:369-75. 2009
    ..Modifications have been made in some of these groups, such as the addition of schistosomiasis-related pulmonary hypertension and pulmonary hypertension in patients with chronic hemolytic anemia to group 1...
  23. doi request reprint [Dana Point: what is new in the treatment of pulmonary hypertension?]
    M M Hoeper
    Abteilung Pneumologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 133:S191-5. 2008
    ..A number of promising novel compounds are currently under investigation. These include sGC stimulators, tyrosine kinase inhibitors, and serotonin antagonists...
  24. ncbi request reprint Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, University of Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 54:S85-96. 2009
    ..Given the lack of robust clinical trials addressing PH in any of these conditions, it is important to conduct further studies to establish the role of medical therapy in non-PAH PH...
  25. ncbi request reprint Long-term outcome with intravenous iloprost in pulmonary arterial hypertension
    M M Hoeper
    Hanover Medical School, Department of Respiratory Medicine, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Respir J 34:132-7. 2009
    ..In conclusion, despite initial haemodynamic and clinical improvement, overall long-term survival with i.v. iloprost therapy was limited...
  26. ncbi request reprint Drug treatment of pulmonary arterial hypertension: current and future agents
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Drugs 65:1337-54. 2005
    ..Thus, combining substances with different modes of action is expected to improve symptoms, haemodynamics and survival in PAH patients, although combination therapy has yet to undergo the scrutiny of large randomised clinical trials...
  27. ncbi request reprint [Treatment algorithm for pulmonary arterial hypertension]
    Marius M Hoeper
    Abteilung Pneumologie, Medizinische Hochschule Hannover
    Herz 30:326-31. 2005
    ..These guidelines have incorporated treatment algorithms, which, fortunately, are virtually identical. The present review article summarizes the current guidelines to the management of patients with PAH...
  28. ncbi request reprint Outcome after cardiopulmonary resuscitation in patients with pulmonary arterial hypertension
    Marius M Hoeper
    Dept of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Am J Respir Crit Care Med 165:341-4. 2002
    ..Our data indicate that CPR for circulatory arrest in patients with PAH is rarely successful unless the cause of the cardiopulmonary decompensation can be corrected...
  29. ncbi request reprint Pulmonary hypertension in collagen vascular disease
    M M Hoeper
    Hannover Medical School, Dept of Pulmonary Medicine, Germany
    Eur Respir J 19:571-6. 2002
    ....
  30. ncbi request reprint New treatments for pulmonary arterial hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Am J Respir Crit Care Med 165:1209-16. 2002
  31. ncbi request reprint Intravenous iloprost for treatment failure of aerosolised iloprost in pulmonary arterial hypertension
    M M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Germany
    Eur Respir J 20:339-43. 2002
    ..Since it was impossible to predict the individual effects of this approach, intravenous prostaglandin treatment should be considered in pulmonary arterial hypertension patients who deteriorate while receiving iloprost aerosol...
  32. ncbi request reprint Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids
    M M Hoeper
    Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Eur Respir J 22:330-4. 2003
    ..Therefore, rigorous studies should address whether combination treatment is more effective than either therapeutic intervention alone...
  33. ncbi request reprint Portopulmonary hypertension and hepatopulmonary syndrome
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Lancet 363:1461-8. 2004
    ..Data from several centres have contributed to provide criteria that allow improved prediction of which patients may, or may not, benefit from liver transplantation alone...
  34. ncbi request reprint End points and clinical trial designs in pulmonary arterial hypertension: clinical and regulatory perspectives
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 43:48S-55S. 2004
    ..Finally, cardiopulmonary exercise testing, echocardiographic studies, and biochemical parameters, such as brain natriuretic peptide or troponin T, may also prove useful as secondary end points in the future...
  35. ncbi request reprint Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension
    M M Hoeper
    Hannover Medical School, Dept of Respiratory Medicine, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Respir J 24:1007-10. 2004
    ..The combination of bosentan and sildenafil was well tolerated by all patients. These preliminary data suggest that combining bosentan and sildenafil may be safe and effective in patients with idiopathic pulmonary arterial hypertension...
  36. ncbi request reprint Bosentan therapy for portopulmonary hypertension
    M M Hoeper
    Dept of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Eur Respir J 25:502-8. 2005
    ..s.L(-1). The medication was well tolerated by all patients, and there was no evidence of drug-related liver injury. In conclusion, bosentan proved to be efficacious and safe in a small number of patients with portopulmonary hypertension...
  37. doi request reprint Intensive care unit management of patients with severe pulmonary hypertension and right heart failure
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Am J Respir Crit Care Med 184:1114-24. 2011
    ..Herein we have developed an approach based on the current understanding of RV failure in PAH and have attempted to develop a treatment paradigm based on physiological principles and available evidence...
  38. doi request reprint Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)
    Karen M Olsson
    Department of Respiratory Medicine and German Center of Lung Research DZL, Hannover Medical School, Hannover, Germany K M O, M M H Department of Pneumology, University Hospitals of Leuven, Leuven, Belgium M D University of Giessen and Marburg Lung Center UGMLC, German Center for Lung Research DZL, Hannover, Germany H A G, H T Department of Rheumatology and Clinical Immunology, Charite University Hospital, and Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany D H Clinic of Internal Medicine, University Hospital, Zurich, Switzerland R S University Hospital Heidelberg, Heidelberg, Germany E G Medical Clinic I, Clinic Loewenstein, Loewenstein, Germany G S Clinic III for Internal Medicine Cardiology, and Center for Molecular Medicine Cologne CMMC, University of Cologne, Germany S R Internal Medicine I, University Hospital Carl Gustav Carus of Technical University Dresden, Dresden, Germany M Halank Department of Internal Medicine, Respiratory Medicine and Cardiology, Mission Medical Hospital, Wurzburg, Germany M Held Department of Internal Medicine II, Division of Pneumology, University Medical Center Regensburg, Regensburg
    Circulation 129:57-65. 2014
    ....
  39. ncbi request reprint Interventional lung assist: a new concept of protective ventilation in bridge to lung transplantation
    Stefan Fischer
    Division of Thoracic and Cardiovascular Surgery, Hannover Thoracic Transplant and Cardiac Assist Program, Hannover Medical School, Germany
    ASAIO J 54:3-10. 2008
    ..The main goal was to translate previous clinical experience with the ILA into a consensus for the use of the ILA as a bridge to lung transplantation...
  40. pmc Tissue concentration of paraquat on day 32 after intoxication and failed bridge to transplantation by extracorporeal membrane oxygenation therapy
    Anna Bertram
    Department of Nephrology, Hannover Medical School, Carl Neuberg Street 1, Hannover 30625, Germany
    BMC Pharmacol Toxicol 14:45. 2013
    ..Bridging the time to complete depletion of paraquat from the body could render this exceptional therapy strategy possible, but not much is known on the time interval after which transplantation can safely be performed...
  41. ncbi request reprint Extracorporeal membrane oxygenation in awake patients as bridge to lung transplantation
    Thomas Fuehner
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Am J Respir Crit Care Med 185:763-8. 2012
    ..The use of extracorporeal membrane oxygenation (ECMO) in patients who are awake and spontaneously breathing may represent a novel bridging strategy toward lung transplantation (LuTx)...
  42. doi request reprint Indications for and outcomes after combined lung and liver transplantation: a single-center experience on 13 consecutive cases
    Gerrit Grannas
    Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany
    Transplantation 85:524-31. 2008
    ..For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this procedure is limited...
  43. ncbi request reprint Bridge to lung transplantation with the extracorporeal membrane ventilator Novalung in the veno-venous mode: the initial Hannover experience
    Stefan Fischer
    Hannover Thoracic Transplant Program, Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    ASAIO J 53:168-70. 2007
    ....
  44. pmc Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension
    Nils P Nickel
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Respir Res 14:130. 2013
    ..To determine the levels of circulating copeptin in patients with pulmonary arterial hypertension (PAH), and to evaluate its relation with disease severity, outcome and response to treatment...
  45. ncbi request reprint Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension
    Jan T Kielstein
    Department of Internal Medicine, Division of Nephrology, Medical School Hannover, Hannover, Germany
    Arterioscler Thromb Vasc Biol 25:1414-8. 2005
    ..ADMA infusion in healthy volunteers increased pulmonary vascular resistance (68.9+/-7.6 versus 95.6+/-6.3 dyne x s x cm(-5); P<0.05) and decreased stroke volume (101.1+/-6.7 mL versus 95.6+/-6.3 mL; P<0.05)...
  46. ncbi request reprint Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression
    Clemens L Bockmeyer
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    J Heart Lung Transplant 31:764-72. 2012
    ..Specific miRNAs in plexiform vasculopathy of severe pulmonary arterial hypertension (PAH) in humans have not yet been investigated...
  47. pmc Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment
    Danny Jonigk
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Am J Pathol 179:167-79. 2011
    ..Neoplastic models of angiogenesis seem to be of limited use in further study of plexiform vasculopathy...
  48. ncbi request reprint Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension
    Nils Nickel
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Am J Respir Crit Care Med 178:534-41. 2008
    ..Circulating levels of GDF-15 provide independent prognostic information in patients with acute pulmonary embolism and chronic left-sided heart failure...
  49. doi request reprint Riociguat for interstitial lung disease and pulmonary hypertension: a pilot trial
    Marius M Hoeper
    Hannover Medical School, Hannover, Germany
    Eur Respir J 41:853-60. 2013
    ..Riociguat was well tolerated by most patients and improved cardiac output and PVR, but not mPAP. Further studies are necessary to evaluate the safety and efficacy of riociguat in patients with PH-ILD...
  50. pmc Long-term effects of intravenous iloprost in patients with idiopathic pulmonary arterial hypertension deteriorating on non-parenteral therapy
    Lars Knudsen
    Department of Respiratory Medicine, Hannover Medical School, Hanover, Germany
    BMC Pulm Med 11:56. 2011
    ..If these treatments fail, current guidelines recommend the addition of parenteral prostanoid therapy. There is, however, limited evidence for the efficacy of parenteral prostanoids when added to combinations of non-parenteral therapies...
  51. pmc GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells
    Nils Nickel
    Clinic for Pulmonary Medicine, Hannover Medical School, Hannover, Germany
    Respir Res 12:62. 2011
    ..The aim of the study was to examine the expression and biological roles of GDF-15 in the lung of patients with pulmonary arterial hypertension (PAH)...
  52. doi request reprint Atrial flutter and fibrillation in patients with pulmonary hypertension
    Karen M Olsson
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Int J Cardiol 167:2300-5. 2013
    ..We sought to determine the incidence and clinical impact of these arrhythmias in patients with pulmonary hypertension...
  53. ncbi request reprint Bridge to lung transplantation with the novel pumpless interventional lung assist device NovaLung
    Stefan Fischer
    Hannover Thoracic Transplant Program, Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 131:719-23. 2006
    ..We have, for the first time, applied the novel pumpless interventional lung assist NovaLung for bridge to lung transplantation in patients with severe ventilation-refractory hypercapnia. We report on our initial experience...
  54. doi request reprint Osteopontin in patients with idiopathic pulmonary hypertension
    Johan M Lorenzen
    Department of Nephrology and Hypertension, Centre of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Chest 139:1010-7. 2011
    ..OPN plasma levels may be related to disease severity and mortality in patients with PAH...
  55. ncbi request reprint Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans
    Jan T Kielstein
    Department of Internal Medicine, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Circulation 109:172-7. 2004
    ..We evaluated systemic cardiovascular effects of ADMA infusion in healthy subjects using invasive techniques, ie, right heart catheter and inulin/para-aminohippurate clearance...
  56. doi request reprint Treatment of pulmonary arterial hypertension (PAH): updated Recommendations of the Cologne Consensus Conference 2011
    H Ardeschir Ghofrani
    Department of Respiratory Medicine, Medical Clinic II, University Hospital Gießen and Marburg, Gießen Branch, Giesen, Germany
    Int J Cardiol 154:S20-33. 2011
    ..This commentary describes in detail the results and recommendations of the working group on treatment of PAH which were last updated in October 2011...
  57. doi request reprint Vascular complications in patients undergoing femoral cannulation for extracorporeal membrane oxygenation support
    Theodosios Bisdas
    Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Ann Thorac Surg 92:626-31. 2011
    ..Patients undergoing ECMO support through femoral vessels are prone to vascular complications. The aim of this study was to evaluate such complications to outline basic technical principles for their prevention...
  58. ncbi request reprint Chronic thromboembolic pulmonary hypertension: evaluation with 64-detector row CT versus digital substraction angiography
    Angela Reichelt
    Department of Diagnostic Radiology, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    Eur J Radiol 71:49-54. 2009
    ..1-100% at main/lobar level and 84.3-90.5% and 92-98.7% at segmental level, respectively. Our results show that CT is an accurate and reliable non-invasive alternative to conventional DSA in the diagnostic workup in patients with CTEPH...
  59. ncbi request reprint Technical advances of pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension
    Christian Hagl
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Eur J Cardiothorac Surg 23:776-81; discussion 781. 2003
    ..To minimize the side-effects of circulatory arrest times and profound hypothermia in patients undergoing pulmonary thromboendarterectomy (PTE) for chronic thromboembolic pulmonary hypertension (CTEPH)...
  60. doi request reprint Bridge to thoracic organ transplantation in patients with pulmonary arterial hypertension using a pumpless lung assist device
    M Strueber
    Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Am J Transplant 9:853-7. 2009
    ..Although all patients presented in cardiogenic shock, hemodynamic unloading of the right ventricle using the low-resistance LAD stabilized the hemodynamic situation immediately so that no pump support was subsequently required...
  61. ncbi request reprint Effects of inhaled salbutamol in primary pulmonary hypertension
    E Spiekerkoetter
    Dept of Respiratory Medicine, Hannover Medical School, Germany
    Eur Respir J 20:524-8. 2002
    ..5 kPa (45+/-19 mmHg) to 5.1+/-2.9 kPa (38+/-22 mmHg), respectively. Inhaled salbutamol has beneficial acute effects on pulmonary function, blood gases and haemodynamics in patients with primary pulmonary hypertension...
  62. ncbi request reprint A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group
    M M Hoeper
    Department of Pulmonary Medicine, Hannover Medical School, Germany
    J Am Coll Cardiol 35:176-82. 2000
    ..We sought to compare the acute hemodynamic effects of inhaled nitric oxide (NO) and aerosolized iloprost in primary pulmonary hypertension (PPH)...
  63. ncbi request reprint [Diagnosis and treatment of pulmonary hypertension]
    M M Hoeper
    Abteilung Pneumologie Leiter Prof Dr med T Welte, Medizinische Hochschule Hannover, Hannover
    Pneumologie 60:428-40; quiz 441-2. 2006
  64. ncbi request reprint Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue
    M M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Germany
    N Engl J Med 342:1866-70. 2000
    ..Recently, aerosolized iloprost, a stable prostacyclin analogue, has been introduced as an alternative therapy for severe pulmonary hypertension...
  65. doi request reprint Novel approaches to the pharmacotherapy of pulmonary arterial hypertension
    Karen M Olsson
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Drug Discov Today 14:284-90. 2009
    ..Several of these compounds hold promise for the future therapy of PAH, especially as regression of pulmonary vascular remodeling appears to become a realistic possibility with the combination of established and novel treatments...
  66. doi request reprint Evaluation of a 24-hour emergency bronchoscopy service in a tertiary care hospital
    Thomas Fuehner
    Department of Respiratory Medicine, Medizinische Hochschule Hannover, Hannover, Germany
    Ther Adv Respir Dis 3:65-71. 2009
    ..The aim of this study was to evaluate the usage of a 24-hour emergency service in a large university hospital with a 1 year prospective analysis of emergency bronchoscopy service in a tertiary care centre...
  67. ncbi request reprint [Long-term treatment of primary pulmonary hypertension with inhaled iloprost]
    M M Hoeper
    Abteilung Pneumologie, Medizinische Hochschule Hannover
    Pneumologie 55:38-43. 2001
    ..Recently, administration of aerosolized iloprost, a stable prostacyclin analogue, has been introduced as an alternative therapy for severe pulmonary hypertension...
  68. doi request reprint Extracorporeal membrane oxygenation in nonintubated patients as bridge to lung transplantation
    K M Olsson
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Am J Transplant 10:2173-8. 2010
    ..All of them made a full recovery after transplantation, which demonstrates the feasibility of using ECMO support in nonintubated patients with cardiopulmonary failure as a bridging strategy to lung transplantation...
  69. doi request reprint Outcomes of noncardiac, nonobstetric surgery in patients with PAH: an international prospective survey
    Stephanie Meyer
    Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Eur Respir J 41:1302-7. 2013
    ..5, 95% CI 1.2-2.7; p=0.03) and the need for emergency surgery (OR 2.4, 95% CI 1.4-3.6; p=0.01). Major surgery in patients with PAH continues to be a high-risk procedure, particularly when emergency interventions are needed...
  70. ncbi request reprint Absence of Kaposi's sarcoma-associated herpesvirus in patients with pulmonary arterial hypertension
    Cornelia Henke-Gendo
    Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Am J Respir Crit Care Med 172:1581-5. 2005
    ..Recently, evidence of KSHV infection was reported in plexiform lesions of idiopathic pulmonary arterial hypertension (IPAH) as well as in adjacent parenchyma and bronchial epithelial cells...
  71. ncbi request reprint Incidence and clinical relevance of supraventricular tachyarrhythmias in pulmonary hypertension
    Joern Tongers
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Am Heart J 153:127-32. 2007
    ..Supraventricular tachyarrhythmias (SVTs) may compromise cardiac function and threaten prognosis in patients with PH, but the incidence and clinical relevance of SVTs in PH and chronic right ventricular failure have not been evaluated...
  72. ncbi request reprint Determination of cardiac output by the Fick method, thermodilution, and acetylene rebreathing in pulmonary hypertension
    M M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Am J Respir Crit Care Med 160:535-41. 1999
    ..We conclude that thermodilution and acetylene rebreathing are useful tools for assessing cardiac output in patients with pulmonary hypertension, even in the presence of low cardiac output or severe tricuspid regurgitation...
  73. pmc Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection
    Gernot Beutel
    Departments of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Crit Care 15:R80. 2011
    ....
  74. ncbi request reprint Elastase-induced lung emphysema in rats is not reduced by hematopoietic growth factors when applied preventionally
    Andreas Schmiedl
    Department of Functional and Applied Anatomy, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Virchows Arch 452:675-88. 2008
    ..Blood cell number has significantly increased in the Elastase/GF group. The application of GF-enhanced pulmonary emphysema, presumable because of increased inflammatory activity, was a result of a preventive treatment...
  75. ncbi request reprint Pulmonary arterial hypertension: pathobiology, diagnosis and treatment
    H A Golpon
    Department of Pneumology, Hanover Medical School, Hanover, Germany
    Minerva Med 96:303-14. 2005
    ..Several of these new insights have led to the development and clinical application of novel treatments that includes new classes of drugs such as prostanoids, endothelin receptor antagonists and type 5 phosphodiesterase inhibitors...
  76. ncbi request reprint Evaluation of right ventricular performance with a right ventricular ejection fraction thermodilution catheter and MRI in patients with pulmonary hypertension
    M M Hoeper
    Department of Pulmonary Medicine, Hannover Medical School, Hannover, Germany
    Chest 120:502-7. 2001
    ..We sought to compare catheter studies using a right ventricular ejection fraction (REF) catheter together with echocardiography and MRI in patients with pulmonary hypertension...
  77. ncbi request reprint Medical therapies for chronic thromboembolic pulmonary hypertension: an evolving treatment paradigm
    Paul Bresser
    Department of Pulmonology, Academic Medical Center, P O Box 22660, Amsterdam 1100 DD, The Netherlands
    Proc Am Thorac Soc 3:594-600. 2006
    ..However, direct evidence from clinical trials in CTEPH is limited to date. This article reviews evidence supporting, and issues surrounding, the possible use of novel PAH medications in CTEPH...
  78. ncbi request reprint Safety experience with bosentan in 146 children 2-11 years old with pulmonary arterial hypertension: results from the European Postmarketing Surveillance program
    Maurice Beghetti
    Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
    Pediatr Res 64:200-4. 2008
    ..They also suggest that Tracleer may be better tolerated in children than in adults. This observation confirms the value of monthly monitoring of liver function for the duration of bosentan treatment...
  79. ncbi request reprint Inhaled iloprost for severe pulmonary hypertension
    Horst Olschewski
    Department of Internal Medicine II, University Clinic, Giessen, Germany
    N Engl J Med 347:322-9. 2002
    ..Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and exercise capacity in patients with pulmonary hypertension...
  80. ncbi request reprint Diagnosis of pulmonary arterial hypertension in a patient with systemic sclerosis
    Jörg H W Distler
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Hanover, Germany
    Nat Clin Pract Rheumatol 4:160-4. 2008
    ..Lung function tests also performed at that time revealed a decreased diffusion capacity for carbon monoxide of 54% and normal lung volumes, and high-resolution CT scan of the lungs was normal...
  81. ncbi request reprint Impairment of respiratory muscle function in pulmonary hypertension
    Hans Joachim Kabitz
    Department of Pneumology, University Hospital Freiburg, D 79106 Freiburg Germany
    Clin Sci (Lond) 114:165-71. 2008
    ..Furthermore, the 6-min walking distance is significantly linked to parameters assessing inspiratory muscle strength...
  82. ncbi request reprint Signaling molecules in pulmonary hypertension
    Marius M Hoeper
    N Engl J Med 348:2151; author reply 2151. 2003
  83. ncbi request reprint Primary pulmonary hypertension may be a heterogeneous disease with a second locus on chromosome 2q31
    Matthias Rindermann
    Institute of Human Genetics, University of Heidelberg, Germany
    J Am Coll Cardiol 41:2237-44. 2003
    ....
  84. ncbi request reprint Pulmonary arterial hypertension: the race for the most effective treatment
    Vallerie V McLaughin
    Am J Respir Crit Care Med 171:1199-201. 2005
  85. ncbi request reprint Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension
    Derliz Mereles
    Department of Cardiology and Pneumology, University of Heidelberg, Heidelberg, Germany
    Circulation 114:1482-9. 2006
    ..The present study is the first prospective randomized study to evaluate the effects of exercise and respiratory training in patients with severe symptomatic PH...
  86. ncbi request reprint Current and future management of chronic thromboembolic pulmonary hypertension: from diagnosis to treatment responses
    Lewis J Rubin
    University of California, San Diego, CA, USA
    Proc Am Thorac Soc 3:601-7. 2006
    ..Continued research and clinical trials investigating possible applications of new medical treatments are required...
  87. ncbi request reprint Sildenafil citrate therapy for pulmonary arterial hypertension
    Marius M Hoeper
    N Engl J Med 354:1091-3; author reply 1091-3. 2006
  88. ncbi request reprint Adult patients with congenital heart disease and pulmonary arterial hypertension: first open prospective multicenter study of bosentan therapy
    Ingram Schulze-Neick
    German Heart Institute, Berlin, Germany
    Am Heart J 150:716. 2005
    ....
  89. ncbi request reprint HHV-8 in pulmonary hypertension
    Cornelia Henke-Gendo
    N Engl J Med 350:194-5; author reply 194-5. 2004
  90. ncbi request reprint Systemic inflammation, COPD, and pulmonary hypertension
    Marius M Hoeper
    Chest 131:634-5; author reply 635. 2007