Peter Hillemanns

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Gynecol Oncol 100:271-5. 2006
  2. ncbi Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Medical University Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Arch Gynecol Obstet 289:1281-6. 2014
  3. ncbi Integration of HPV-16 and HPV-18 DNA in vulvar intraepithelial neoplasia
    Peter Hillemanns
    Department of Obstetrics and Gynecology of the University of Munich Grosshadern, Germany
    Gynecol Oncol 100:276-82. 2006
  4. pmc Estimation of the incidence of genital warts and the cost of illness in Germany: a cross-sectional study
    Peter Hillemanns
    Klinik fur Frauenheilkunde und Geburtshilfe, Medizinische Hochschule Hannover, Hannover, Germany
    BMC Infect Dis 8:76. 2008
  5. ncbi Lymph node metastasis detection of ovarian cancer by porphyrin fluorescence photodetection: case report
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Lasers Med Sci 22:131-5. 2007
  6. ncbi Pharmacokinetics and selectivity of porphyrin synthesis after topical application of hexaminolevulinate in patients with cervical intraepithelial neoplasia
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
    Am J Obstet Gynecol 198:300.e1-7. 2008
  7. ncbi Improved prenatal aneuploidy screening using the novel advanced first-trimester screening algorithm: a multicenter study of 10,017 pregnancies
    Peter Schmidt
    Department of Obstetrics and Gynecology, Medical University of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Clin Ultrasound 36:397-402. 2008
  8. ncbi Evaluation of prognostic factors following flow-cytometric DNA analysis after cytokeratin labelling: II. Cervical and endometrial cancer
    Pauline Wimberger
    Department of Obstetrics and Gynecology, University of Essen, Hufelandstr 55, D 45122 Essen, Germany
    Anal Cell Pathol 24:147-58. 2002
  9. pmc Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer
    Franziska Pern
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e47993. 2012
  10. ncbi Advanced first trimester screening (AFS): an improved test strategy for the individual risk assessment of fetal aneuploidies and malformations
    Peter Schmidt
    Department of Obstetrics and Gynecology, Medical University Hannover, Bahnhofstrasse 4, 38300 Wolfenbüttel, Germany
    Arch Gynecol Obstet 276:159-66. 2007

Detail Information

Publications64

  1. ncbi Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Gynecol Oncol 100:271-5. 2006
    ..To evaluate various treatment modalities for vulvar intraepithelial neoplasia (VIN) in relation to possible risk factors for recurrence...
  2. ncbi Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Medical University Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Arch Gynecol Obstet 289:1281-6. 2014
    ..An exploratory clinical investigation was designed to evaluate E6-AP mRNA expression levels in different stages of cervical intraepithelial neoplasia and during the menstrual cycle...
  3. ncbi Integration of HPV-16 and HPV-18 DNA in vulvar intraepithelial neoplasia
    Peter Hillemanns
    Department of Obstetrics and Gynecology of the University of Munich Grosshadern, Germany
    Gynecol Oncol 100:276-82. 2006
    ..Integration of HPV DNA into host chromosome has been hypothesized to be a critical step in the carcinogenesis of cervical neoplasia resulting in altered expression of two viral transforming genes E6 and E7...
  4. pmc Estimation of the incidence of genital warts and the cost of illness in Germany: a cross-sectional study
    Peter Hillemanns
    Klinik fur Frauenheilkunde und Geburtshilfe, Medizinische Hochschule Hannover, Hannover, Germany
    BMC Infect Dis 8:76. 2008
    ..HPV is also responsible for benign condylomata acuminata, also known as genital warts. We assessed the incidence of genital warts in Germany and collected information on their management to estimate the annual cost of disease...
  5. ncbi Lymph node metastasis detection of ovarian cancer by porphyrin fluorescence photodetection: case report
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Lasers Med Sci 22:131-5. 2007
    ..This data is a proof of the concept that porphyrin fluorescence-guided lymph node metastasis detection is possible in ovarian cancer and should stimulate further research in this field...
  6. ncbi Pharmacokinetics and selectivity of porphyrin synthesis after topical application of hexaminolevulinate in patients with cervical intraepithelial neoplasia
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
    Am J Obstet Gynecol 198:300.e1-7. 2008
    ..The purpose of this study was to examine the pharmacokinetics and selectivity of porphyrin synthesis after topical application of hexaminolevulinate (HAL) in patients with cervical intraepithelial neoplasia (CIN)...
  7. ncbi Improved prenatal aneuploidy screening using the novel advanced first-trimester screening algorithm: a multicenter study of 10,017 pregnancies
    Peter Schmidt
    Department of Obstetrics and Gynecology, Medical University of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Clin Ultrasound 36:397-402. 2008
    ..In this study, we tested a new algorithm known as advanced first-trimester screening (AFS), which disregards maternal age...
  8. ncbi Evaluation of prognostic factors following flow-cytometric DNA analysis after cytokeratin labelling: II. Cervical and endometrial cancer
    Pauline Wimberger
    Department of Obstetrics and Gynecology, University of Essen, Hufelandstr 55, D 45122 Essen, Germany
    Anal Cell Pathol 24:147-58. 2002
    ..In conclusion, our investigations showed that the determination of DNA-ploidy should be done in endometrial carcinoma. In cervical cancer no clinical significance for determination of DNA-parameters was found...
  9. pmc Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer
    Franziska Pern
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e47993. 2012
    ..Triple-negative breast cancer should be considered as an additional criterion for future genetic counselling and diagnostic sequencing...
  10. ncbi Advanced first trimester screening (AFS): an improved test strategy for the individual risk assessment of fetal aneuploidies and malformations
    Peter Schmidt
    Department of Obstetrics and Gynecology, Medical University Hannover, Bahnhofstrasse 4, 38300 Wolfenbüttel, Germany
    Arch Gynecol Obstet 276:159-66. 2007
    ..It was the aim of this study to investigate the potential value of a novel risk assessment algorithm explicitly disregarding the maternal age...
  11. doi Treatment of high grade cervical intraepithelial neoplasia by photodynamic therapy using hexylaminolevulinate may be costeffective compared to conisation procedures due to decreased pregnancy-related morbidity
    Philipp Soergel
    University Women s Hospital, Hannover Medical School, Hannover, Germany
    Lasers Surg Med 43:713-20. 2011
    ..This study aims to evaluate the economical aspect of CIN treatment including associated pregnancy complications by comparing both methods...
  12. ncbi Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate
    Philipp Soergel
    Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
    Lasers Surg Med 40:611-5. 2008
    ..This study assessed the feasibility and response rate of PDT with hexaminolevulinate (HAL) in cervical intraepithelial neoplasia (CIN) and human papillomavirus (HPV) infection...
  13. pmc Mutation analysis of the ERCC4/FANCQ gene in hereditary breast cancer
    Sandra Kohlhase
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
    PLoS ONE 9:e85334. 2014
    ..We conclude that the contribution of ERCC4/FANCQ coding mutations to hereditary breast cancer in Central and Eastern Europe is likely to be small...
  14. ncbi Episiotomy and perineal tears presumed to be imminent: the influence on the urethral pressure profile, analmanometric and other pelvic floor findings--follow-up study of a randomized controlled trial
    Christian Dannecker
    Department of Obstetrics and Gynecology, University of Munich Grosshadern, Munich, Germany
    Acta Obstet Gynecol Scand 84:65-71. 2005
    ..The influence of the restrictive use of episiotomy at perineal tears judged to be imminent on the urethral pressure profile, analmanometric, and other pelvic floor findings is unknown...
  15. ncbi Prevalence of PALB2 mutation c.509_510delGA in unselected breast cancer patients from Central and Eastern Europe
    Monika Noskowicz
    Department of Obstetrics and Gynaecology, Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
    Fam Cancer 13:137-42. 2014
    ..509_510delGA mutation is prevalent in about 1 in 400 breast cancer patients from Central and Eastern Europe, and the low occurrence of familial clustering is consistent with a moderate penetrance of this mutation...
  16. pmc Real-time ultrasound elastography in 180 axillary lymph nodes: elasticity distribution in healthy lymph nodes and prediction of breast cancer metastases
    Sebastian Wojcinski
    Hannover Medical School, Department for Obstetrics and Gynecology, OE 6410, Carl Neuberg Strase 1, Hannover 30625, Germany
    BMC Med Imaging 12:35. 2012
    ..To determine the general appearance of normal axillary lymph nodes (LNs) in real-time tissue sonoelastography and to explore the method's potential value in the prediction of LN metastases...
  17. ncbi The cost efficiency of HPV vaccines is significantly underestimated due to omission of conisation-associated prematurity with neonatal mortality and morbidity
    Philipp Soergel
    University Women s Hospital, Hannover Medical School, Hannover, Germany
    Hum Vaccin Immunother 8:243-51. 2012
    ..HPV vaccination has therefore the potential to decrease neonatal morbidity and mortality. This has not been taken into account in published cost-effectiveness models...
  18. pmc TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study
    Magda A Blaut
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Negat Results Biomed 9:9. 2010
    ..004). We conclude that there is no evidence for the TOPBP1*Arg309Cys variant to confer an increased risk for breast cancer in the German population...
  19. ncbi A nonsense mutation (E1978X) in the ATM gene is associated with breast cancer
    Natalia Bogdanova
    Department of Obstetrics and Gynaecology, Hannover Medical School, Carl Neuberg St 1, 30625, Hannover, Germany
    Breast Cancer Res Treat 118:207-11. 2009
    ..6, 95% CI: 1.3-21.4, P = 0.01). Taken together, this study provides first evidence for the association of a common A-T causing mutation with breast cancer in Eastern European founder populations...
  20. doi Effects of photodynamic therapy using topical applied hexylaminolevulinate and methylaminolevulinate upon the integrity of cervical epithelium
    Philipp Soergel
    University Women s Clinic, Hannover Medical School, 30625 Hannover, Germany
    Lasers Surg Med 42:624-30. 2010
    ..However, it has not been analyzed yet if the PDT itself leads to sustained damage of the cervical tissue. This study aims at evaluating the effect of hexylaminolevulinate (HAL) and methylaminolevulinate (MAL) PDT on cervical tissue...
  21. ncbi Is there a place for sentinel technique in treatment of vaginal cancer?: feasibility, clinical experience, and results
    Hermann Hertel
    Department of Obstetrics and Gynecology, Institut of Biometry, Tumour Centre, Institute of Pathology, and Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany
    Int J Gynecol Cancer 23:1692-8. 2013
    ..To evaluate the clinical feasibility of sentinel lymph node (SLN) technique and the role of single-photon emission computed tomography with CT (SPECT/CT) compared to lymphoscintigraphy for detection of SLN in vaginal cancer...
  22. pmc Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line
    Bianca Schröder-Heurich
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Carl Neuberg Strase 1, D 30625 Hannover, Germany
    BMC Cancer 14:434. 2014
    ..The p.R215W missense mutation occurs at sub-polymorphic frequencies in several populations. We aimed to investigate its functional impact in breast cancer cells from a carrier of this NBN mutation...
  23. pmc Diagnostic performance and inter-observer concordance in lesion detection with the automated breast volume scanner (ABVS)
    Sebastian Wojcinski
    Department of Ob Gyn, Hannover Medical School, OE 6410, Carl Neuberg Strase 1, 30625 Hannover, Germany
    BMC Med Imaging 13:36. 2013
    ..We investigated the diagnostic performance and inter-observer concordance of the Automated Breast Volume Scanner (ABVS) ACUSON S2000™ and questioned its implications in breast cancer diagnostics...
  24. doi Photodynamic therapy of cervical intraepithelial neoplasia 1-3 and human papilloma virus (HMV) infection with methylaminolevulinate and hexaminolevulinate--a double-blind, dose-finding study
    Philipp Soergel
    Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
    Lasers Surg Med 44:468-74. 2012
    ..Standard treatment is surgical and may be associated with subsequent pregnancy complications. Photodynamic therapy (PDT) of CIN may be an interesting alternative...
  25. ncbi Pregnancy complications, obstetric risks, and neonatal outcome in singleton and twin pregnancies after GIFT and IVF
    Robert Ochsenkuhn
    Department of Obstetrics and Gynecology, University Munich Grosshadern, 81377 Munich, Germany
    Arch Gynecol Obstet 268:256-61. 2003
    ..Our purpose is to compare the obstetric and neonatal characteristics of singleton and twin pregnancies after GIFT and IVF with those conceived spontaneously...
  26. doi Quality assured ultrasound simulator training for the detection of fetal malformations
    Ismini Staboulidou
    Department of Gynecology and Obstetrics, University Medical School of Hannover, Hannover, Germany
    Acta Obstet Gynecol Scand 89:350-4. 2010
    ..In order to improve professional education, a training concept was devised utilizing an ultrasound simulator system...
  27. ncbi The influence of lunar cycle on frequency of birth, birth complications, neonatal outcome and the gender: a retrospective analysis
    Ismini Staboulidou
    Department of Gynaecology and Obstetrics, University Medical School of Hannover, Hannover, Germany
    Acta Obstet Gynecol Scand 87:875-9. 2008
    ....
  28. ncbi Acoustic radiation force impulse imaging with virtual touch tissue quantification: measurements of normal breast tissue and dependence on the degree of pre-compression
    Sebastian Wojcinski
    Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany Electronic address
    Ultrasound Med Biol 39:2226-32. 2013
    ..001; 360 measurements in 60 patients). VTTQ of breast tissue is a feasible method with high accuracy; however, the degree of pre-compression applied may significantly influence the measurements...
  29. pmc Ultrasound real-time elastography can predict malignancy in BI-RADS®-US 3 lesions
    Sebastian Wojcinski
    Hannover Medical School, Department of Ob Gyn, Hannover, Germany
    BMC Cancer 13:159. 2013
    ..In our study, we focus exclusively on BI-RADS®-US 3 lesions and hypothesize that sonoelastography as an adjunct to conventional ultrasound can identify a high-risk-group and a low-risk-group within these patients...
  30. doi The risk of ectopic pregnancy following tubal reconstructive microsurgery and assisted reproductive technology procedures
    Cordula Schippert
    Division of Reproductive Medicine, Department of Gynecology and Obstetrics, Medical School of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Arch Gynecol Obstet 285:863-71. 2012
    ..1 and 11%. EP is also an adverse effect of tubal surgery with incidences up to 40% depending on the type, location, and severity of tubal disease and the surgical procedure...
  31. doi Mutation analysis of the SLX4/FANCP gene in hereditary breast cancer
    Rosa Landwehr
    Clinics of Obstetrics and Gynaecology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Breast Cancer Res Treat 130:1021-8. 2011
    ..G700R substitution could make a minor contribution...
  32. ncbi Are nuchal translucency, pregnancy associated plasma protein-A or free-beta-human chorionic gonadotropin depending on maternal age? A multicenter study of 8,116 pregnancies
    Peter Schmidt
    University Women s Hospital, Hannover, Germany
    Arch Gynecol Obstet 276:259-62. 2007
    ..It was the aim of this study to investigate if likelihood ratios should better take care of it...
  33. ncbi Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low-grade cervical intraepithelial neoplasia
    Peter Hillemanns
    Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
    Lasers Surg Med 46:456-61. 2014
    ..The aim of this study was to assess the efficacy and safety of hexaminolevulinate (HAL) photodynamic therapy (PDT) in the treatment of patients with CIN 1...
  34. doi Evaluation of a multiplex real time PCR assay for the detection of human papillomavirus infections on self-collected cervicovaginal lavage samples
    Matthias Jentschke
    Department of Gynaecology and Obstetrics, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Virol Methods 193:131-4. 2013
    ..6% (RealTime) and 51.3% (HC2). This study shows that RealTime can be used for HR-HPV testing of self-collected lavage samples in a referral population with at least equal quality and performance as HC2. ..
  35. doi Value and advantages of preoperative sentinel lymph node imaging with SPECT/CT in cervical cancer
    Ruediger Klapdor
    Department of Obstetrics and Gynecology, Institute of Biometry, Institute of Pathology, and Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany
    Int J Gynecol Cancer 24:295-302. 2014
    ..We assess the use of single photon emission computed tomography combined with computed tomography (SPECT/CT) as an alternative to lymphoscintigraphy (LSG) for preoperative identification of SLN...
  36. doi Evaluation of a new multiplex real-time polymerase chain reaction assay for the detection of human papillomavirus infections in a referral population
    Matthias Jentschke
    Department of Gynaecology and Obstetrics, Hannover Medical School, Germany
    Int J Gynecol Cancer 22:1050-6. 2012
    ..This study was conducted to evaluate the analytical and clinical performance of the Abbott RealTime High-Risk HPV assay (RealTime) in a referral population, in comparison to the Qiagen Hybrid Capture 2 High-Risk HPV DNA Test (hc2)...
  37. doi Enzyme-linked immunosorbent assay for p16(INK4a) - a new triage test for the detection of cervical intraepithelial neoplasia?
    Matthias Jentschke
    Department of Gynaecology and Obstetrics, Hannover Medical School, Hannover, Germany
    Acta Obstet Gynecol Scand 92:160-4. 2013
    ....
  38. ncbi Comparison of Nicolaides' risk evaluation for Down's syndrome with a novel software: an analysis of 1,463 cases
    Peter Schmidt
    Department of Obstetrics and Gynecology, Division of General Gynecology and Perinatal Medicine, Medical University of Hannover, Hannover, Germany
    Arch Gynecol Obstet 275:469-74. 2007
    ....
  39. ncbi The significance of intracardiac Doppler sonography in terms of fetal growth retardation
    Ismini Staboulidou
    Department of Obstetrics and Gynecology, University Medical School of Hanover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Arch Gynecol Obstet 276:35-42. 2007
    ..This study aimed at evaluating the clinical value of the intracardiac Doppler sonography (IDS) and at scrutinizing its usefulness during the supervision of the pregnancy of intrauterine growth restricted (IUGR) fetuses...
  40. ncbi Prenatal diagnosis of an epignathus associated with a 49,XXXXY karyotype--a case report
    Ismini Staboulidou
    Department of Obstetrics and Gynecology, University Medical School of Hannover, Hannover, Germany
    Fetal Diagn Ther 24:313-7. 2008
    ..It is usually not associated with chromosomal aberrations. We present a case of prenatally diagnosed epignathus associated with a gonosomal pentasomy 49,XXXXY...
  41. ncbi The significance of uterine notching in Doppler sonography in early pregnancy as a predictor for pathologic outcome of the pregnancy
    Ismini Staboulidou
    Department of Obstetrics and Gynecology, Division Prenatal Medicine and General Gynecology, University Medical School of Hannover, Carl Neuberg Str 1, Hannover 30625, Germany
    Arch Gynecol Obstet 276:21-8. 2007
    ....
  42. ncbi Episiotomy and perineal tears presumed to be imminent: randomized controlled trial
    Christian Dannecker
    Department of Obstetrics and Gynecology, University of Munich Grosshadern, Munich, Germany
    Acta Obstet Gynecol Scand 83:364-8. 2004
    ..The indication of the restricted use of episiotomy at tears presumed to be imminent is not clear...
  43. doi Photodynamic therapy for intraepithelial neoplasia of the lower genital tract
    Philipp Soergel
    University Women s Hospital, Hanover Medical School, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    Photodiagnosis Photodyn Ther 7:10-4. 2010
    ..PDT has been successfully evaluated in human papillomavirus-related (HPV) genital dysplasia like CIN and VIN. The aim of this review is to give an overview about current applications...
  44. ncbi Apoptosis gene polymorphisms and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy
    Andreas Meyer
    Clinic of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Urol Oncol 31:74-81. 2013
    ..Prostate cancer has a genetic component, and single nucleotide polymorphisms (SNPs) can contribute to the risk. We aimed to investigate the role of polymorphisms in 10 candidate genes with a key function in apoptosis...
  45. doi Association between women's self-diagnosis of labor and labor duration after admission
    Mechthild M Gross
    Department of Obstetrics, Gynecology and Reproductive Medicine, Midwifery Research Unit, Hannover Medical School, Germany
    J Perinat Med 38:33-8. 2010
    ..To examine the association between women's perception of onset and the duration of labor after hospital admission...
  46. ncbi Nijmegen Breakage Syndrome mutations and risk of breast cancer
    Natalia Bogdanova
    Gynecology Research Unit, Hannover Medical School, Hannover, Germany
    Int J Cancer 122:802-6. 2008
    ..1; 95%CI 1.4-6.6) and indicate that the 657del5 deletion and perhaps the R215W substitution contribute to inherited breast cancer susceptibility in Central and Eastern Europe...
  47. ncbi Vaccination trial with HPV16 L1E7 chimeric virus-like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3)
    Andreas M Kaufmann
    Klinik fur Frauenheilkunde und Geburtshilfe, Friedrich Schiller Universitat, Bachstrasse 18, 07740 Jena, Germany
    Int J Cancer 121:2794-800. 2007
    ..Fifty-six percent of the responders were also HPV16 DNA-negative by the end of the study. Therefore, we demonstrated evidence for safety and a nonsignificant trend for the clinical efficacy of the HPV16 L1E7 CVLP vaccine...
  48. ncbi Interference of Ca2+ with the proliferation of SCCOHT-1 and ovarian adenocarcinoma cells
    Anna Otte
    Biochemistry and Tumor Biology Laboratory, Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
    Int J Oncol 45:1151-8. 2014
    ....
  49. doi Vaginal sacrocolporectopexy for the surgical treatment of uterine and vaginal vault prolapses: confirmation of the surgical method and perioperative results of 101 cases
    Hermann Hertel
    Clinic for Obstetrics and Gynecology, Medical University of Hannover, Carl Neubergstr 1, 30625, Hannover, Germany
    Arch Gynecol Obstet 286:1463-71. 2012
    ..We describe the approach which offers a vaginal, safe alternative to sacrospinous repair, laparoscopic or open vaginosacropexy and the use of synthetic meshes to treat pelvic organ prolapse...
  50. doi A tumor-derived population (SCCOHT-1) as cellular model for a small cell ovarian carcinoma of the hypercalcemic type
    Anna Otte
    Department of Obstetrics and Gynecology, Medical University, Hannover, Germany
    Int J Oncol 41:765-75. 2012
    ..In conclusion, SCCOHT-1 cells provide a study platform to investigate this rare disease and to examine effective and sufficient therapeutic strategies for this rather unknown type of cancer...
  51. ncbi Quality of life and satisfaction after breast cancer operation
    Jing Han
    Department of Gynecology, Hannover Medical School, Hannover, Germany
    Arch Gynecol Obstet 282:75-82. 2010
    ..To investigate the quality of life and satisfaction after different operations in patients with breast cancer, which are breast conserving therapy (BCT), mastectomy and reconstruction after breast BCT or mastectomy...
  52. ncbi Maternal and neonatal morbidity of emergency caesarean sections with a decision-to-delivery interval under 30 minutes: evidence from 10 years
    Peter Hillemanns
    Department of Obstetrics and Gynaecology, Ludwig Maximilian University of Munich, Klinikum Grosshadern, 81377 Munich, Germany
    Arch Gynecol Obstet 268:136-41. 2003
    ..The purpose was to investigate the decision-to-delivery interval for emergency caesarean section and to compare the perioperative maternal and neonatal morbidity to that of intrapartum non-emergent caesarean section...
  53. ncbi Onset of labour: women's experiences and midwives' assessments in relation to first stage duration
    Mechthild M Gross
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Hannover Medical School, Germany
    Arch Gynecol Obstet 280:899-905. 2009
    ..The study aimed to assess the time of labour onset and its symptoms as perceived by women in labour and midwives, and the relationship between these and first stage duration...
  54. ncbi Quantitative enzyme-linked immunosorbent assay determination of an abundant hemoglobin-derived anti-infective peptide in human placenta
    Ludger Ständker
    Clinic of Immunology and Rheumatology, Experimental and Clinical Peptide Chemistry, Medical University Hannover, 30625 Hannover, Germany
    Anal Biochem 401:53-60. 2010
    ..57mg/g. This abundant concentration supports an important physiological role of hHEMbeta111-146 in the placenta infective barrier...
  55. ncbi Evaluation of prognostic factors following flow-cytometric DNA analysis after cytokeratin labelling: I. Breast cancer
    Pauline Wimberger
    Department of Obstetrics and Gynecology, University of Essen, Hufelandstr 55, D 45122 Essen, Germany
    Anal Cell Pathol 24:135-45. 2002
    ..Multivariate analysis could not confirm prognostic evidence of DNA-ploidy and S-phase fraction. In conclusion, in breast cancer no clinical significance for determination of DNA-parameters was found...
  56. ncbi Variations in the Elasticity of Breast Tissue During the Menstrual Cycle Determined by Real-time Sonoelastography
    Sebastian Wojcinski
    Department of Obstetrics and Gynecology, Franziskus Hospital, Bielefeld, Germany
    J Ultrasound Med 31:63-72. 2012
    ..The purpose of this study was to determine the dependence of breast tissue elasticity on the menstrual cycle of healthy volunteers by means of real-time sonoelastography...
  57. ncbi Multivariate analysis of the prognostic significance of DNA-ploidy and S-phase fraction in ovarian cancer determined by flow cytometry following detection of cytokeratin-labeled tumor cells
    Rainer Kimmig
    Department of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, D 81377, Germany
    Gynecol Oncol 84:21-31. 2002
    ..Valid prognostic factors are necessary to estimate the course of the disease and to define biologically similar subgroups for analysis of therapeutic efficacy...
  58. ncbi Study of protoporphyrin IX (PpIX) pharmacokinetics after topical application of 5-aminolevulinic acid in urethral condylomata acuminata
    Xiu Li Wang
    Shanghai Skin Diseases and STD Hospital, Shanghai, China, and University of Colorado at Denver, USA
    Photochem Photobiol 83:1069-73. 2007
    ..DNA typing showed that all patients were positive for low risk-HPV DNA and among them 18.3% of patients harbored high risk-HPV DNA...
  59. ncbi [Fluorescence diagnosis with 5-ALA thermogel of cervical intraepithelial neoplasia]
    Vaagn Andikyan
    Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe, Ludwig Maximilians Universitat Munchen, Munchen, Deutschland
    Gynakol Geburtshilfliche Rundsch 44:31-7. 2004
    ..The novel thermogel Pluronic F127 is liquid at cold temperatures and turns into a gel-like consistency at body temperature, thereby improving adhesion of 5-ALA to the cervix uteri...
  60. ncbi Uterine dehiscence in a nullipara, diagnosed by MRI, following use of unipolar electrocautery during laparoscopic myomectomy: Case report
    Uwe Hasbargen
    Departments of Obstetrics and Gynaecology and Diagnostic Radiology, Klinikum der Universitat Munchen, Grosshadern, Marchioninistr 15, D 81377 Munich, Germany
    Hum Reprod 17:2180-2. 2002
    ....
  61. ncbi Autofluorescence spectroscopy for the diagnosis of cervical intraepithelial neoplasia
    Helmut Weingandt
    Department of Obstetrics and Gynaecology, University Munich Grosshadern, 81377 Munich, Germany
    BJOG 109:947-51. 2002
    ..To assess the feasibility of autofluorescence spectroscopy in the diagnosis of cervical intraepithelial neoplasia (CIN) using broadband light excitation...
  62. ncbi Radical vaginal trachelectomy (RVT) combined with laparoscopic pelvic lymphadenectomy: prospective multicenter study of 100 patients with early cervical cancer
    Hermann Hertel
    Department of Gynecology, Medical School Hanover, Germany
    Gynecol Oncol 103:506-11. 2006
    ..We also wanted to prove the surgical safety of RVT...
  63. ncbi HPV16-E6 mRNA is superior to cytokeratin 19 mRNA as a molecular marker for the detection of disseminated tumour cells in sentinel lymph nodes of patients with cervical cancer by quantitative reverse-transcription PCR
    Norman Häfner
    Frauenklinik der Friedrich Schiller Universität Jena, Jena, Germany
    Int J Cancer 120:1842-6. 2007
    ..It is concluded that HPV16 E6 mRNA is more specific and more sensitive for the detection of tumour cells in SLN than CK19 mRNA. The specificity of CK19 is limited because of low level expression in uninvolved pelvic lymph nodes...
  64. ncbi The German cervical cancer screening model: development and validation of a decision-analytic model for cervical cancer screening in Germany
    Uwe Siebert
    Department of Public Health, Medical Decision Making and Health Technology Assessment, UMIT University of Health Sciences, Medical Informatics and Technology, Hall i T, Austria
    Eur J Public Health 16:185-92. 2006
    ..We sought to develop and validate a decision-analytic model for the natural history of cervical cancer for the German health care context and to apply it to cervical cancer screening...