Denise Hilfiker-Kleiner

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi Prolactin: a new therapeutic target in peripartum cardiomyopathy
    Hatice Yamac
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Heart 96:1352-7. 2010
  2. ncbi 16-kDa prolactin and bromocriptine in postpartum cardiomyopathy
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Curr Heart Fail Rep 9:174-82. 2012
  3. ncbi Peripartum cardiomyopathy: recent insights in its pathophysiology
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, D 30625 Hannover, Germany
    Trends Cardiovasc Med 18:173-9. 2008
  4. ncbi A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, MHH, 30625 Hannover, Germany
    Cell 128:589-600. 2007
  5. ncbi Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Circulation 122:145-55. 2010
  6. ncbi JunD attenuates phenylephrine-mediated cardiomyocyte hypertrophy by negatively regulating AP-1 transcriptional activity
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cardiovasc Res 71:108-17. 2006
  7. ncbi Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Circulation 112:1470-7. 2005
  8. ncbi STAT3-mediated activation of myocardial capillary growth
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Trends Cardiovasc Med 15:152-7. 2005
  9. ncbi Many good reasons to have STAT3 in the heart
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, Hannover 30625, Germany
    Pharmacol Ther 107:131-7. 2005
  10. ncbi Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Circulation 109:2227-33. 2004

Detail Information

Publications45

  1. ncbi Prolactin: a new therapeutic target in peripartum cardiomyopathy
    Hatice Yamac
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Heart 96:1352-7. 2010
    ....
  2. ncbi 16-kDa prolactin and bromocriptine in postpartum cardiomyopathy
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Curr Heart Fail Rep 9:174-82. 2012
    ....
  3. ncbi Peripartum cardiomyopathy: recent insights in its pathophysiology
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, D 30625 Hannover, Germany
    Trends Cardiovasc Med 18:173-9. 2008
    ..In this review, we are highlighting the current knowledge on risk factors, potential pathomechanisms, and treatment options for PPCM...
  4. ncbi A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, MHH, 30625 Hannover, Germany
    Cell 128:589-600. 2007
    ..Thus, a biologically active derivative of the pregnancy hormone prolactin mediates PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM...
  5. ncbi Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Circulation 122:145-55. 2010
    ..By analyzing cardiomyocyte-specific gp130(Y757F) mutant mice, we investigated the effect of disturbed gp130 signaling after myocardial infarction...
  6. ncbi JunD attenuates phenylephrine-mediated cardiomyocyte hypertrophy by negatively regulating AP-1 transcriptional activity
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cardiovasc Res 71:108-17. 2006
    ..In the present study we analyzed the mechanistic role of JunD in cardiomyocyte hypertrophy in vitro in response to alpha-adrenergic agonist phenylephrine (PE)...
  7. ncbi Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Circulation 112:1470-7. 2005
    ..In the present study we analyzed the role of JunD in survival, hypertrophy, and angiogenesis in the pressure-overloaded mouse heart after thoracic aortic constriction...
  8. ncbi STAT3-mediated activation of myocardial capillary growth
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Trends Cardiovasc Med 15:152-7. 2005
    ....
  9. ncbi Many good reasons to have STAT3 in the heart
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, Hannover 30625, Germany
    Pharmacol Ther 107:131-7. 2005
    ..These observations should be taken into account in designing novel therapeutic strategies for the prevention of cardiac failure...
  10. ncbi Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Circulation 109:2227-33. 2004
    ..Because these conditions occur in myocardial ischemia and pressure overload, we investigated the regulation of CCN1 in cardiomyocytes in vitro and in the heart in vivo...
  11. ncbi Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 110:1933-9. 2004
    ....
  12. ncbi Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury
    Denise Hilfiker-Kleiner
    Department of Cardiology, Medical School Hannover, Germany
    Circ Res 95:187-95. 2004
    ....
  13. ncbi Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction
    Martin Fuchs
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    FASEB J 17:2118-20. 2003
    ....
  14. ncbi Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction
    Carola Doerries
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Hannover, Germany
    Circ Res 100:894-903. 2007
    ..The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI...
  15. ncbi Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies
    Melanie Hoch
    Department of Cardiology and Angiology, Medical School Hannover, 30625 Hannover, Germany
    Cell Stem Cell 9:131-43. 2011
    ..Thus, low-dose EPO treatment could potentially be exploited as a therapeutic strategy to reduce the risk of heart failure in certain treatment regimens...
  16. ncbi Stretch-inducible expression of the angiogenic factor CCN1 in vascular smooth muscle cells is mediated by Egr-1
    Karsten Grote
    Department of Cardiology and Angiology, Medical School of Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 279:55675-81. 2004
    ....
  17. ncbi Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis
    Bernhard Schieffer
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Circulation 110:3493-500. 2004
    ..Mediators of inflammation, ie, interleukin (IL)-6, are elevated in patients with acute coronary syndromes and may contribute to the exacerbation of atherosclerosis...
  18. ncbi Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy
    Edith K Podewski
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Circulation 107:798-802. 2003
    ..Importantly, tyrosine-phosphorylation of JAK2 is reduced in the face of increased gp130 phosphorylation, indicating impaired downstream activation of this critical pathway in DCM...
  19. ncbi Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon
    Gunnar Klein
    Department of Cardiovascular Medicine, Hannover Medical School, Germany
    Circ Res 96:748-55. 2005
    ....
  20. ncbi Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment
    Florian P Limbourg
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    Eur J Heart Fail 7:722-9. 2005
    ..However, the cell population mediating myocardial recovery and the fate of the transplanted cells are still controversial...
  21. ncbi Evaluation of Tissue Doppler Tei index for global left ventricular function in mice after myocardial infarction: comparison with Pulsed Doppler Tei index
    Arnd Schaefer
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur J Echocardiogr 6:367-75. 2005
    ..Thus, the aim of our study was to validate TDI and Pulsed Doppler Tei index and their reproducibility in mice after experimental anterior myocardial infarction (MI)...
  22. ncbi The pro-angiogenic factor CCN1 enhances the re-endothelialization of biological vascularized matrices in vitro
    Antonia Bär
    Leibniz Research Laboratory for Biotechnology and Artificial Organs, Department of Thoracic and Cardiovascular Surgery, Hanover Medical School, Carl Neuberg Str 1, Hanover 30625, Germany
    Cardiovasc Res 85:806-13. 2010
    ..To prevent vessel occlusion upon implantation, a functional endothelium must line the graft vessel bed. Here we tested whether the pro-angiogenic factor CCN1 could improve the re-endothelialization of BioVaM in vitro...
  23. ncbi Transcoronary delivery of bone marrow cells to the infarcted murine myocardium: feasibility, cellular kinetics, and improvement in cardiac function
    Christian Templin
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Basic Res Cardiol 101:301-10. 2006
    ..In conclusion, BMCs delivered by transcoronary injection increase capillary density and improve LV function after MI although homing to the ischemic heart is only transient...
  24. ncbi STAT3 and cardiac remodeling
    Arash Haghikia
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Heart Fail Rev 16:35-47. 2011
    ..Finally, we highlight and critically discuss STAT3 signaling as a possible target for future therapeutic approaches in the setting of cardiac remodeling...
  25. ncbi Reviewing peripartum cardiomyopathy: current state of knowledge
    Tina Selle
    Hannover Medical School, Department of Cardiology and Agiology, Carl Neuberg Str 1, Hannover 30625, Germany
    Future Cardiol 5:175-89. 2009
    ..The present article provides an overview on the clinical appearance and management, risk factors and potential pathophysiological mechanisms of PPCM...
  26. ncbi Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?
    Niels Engberding
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 110:2175-9. 2004
    ..We therefore studied the effect of long-term treatment with allopurinol, a potent XO inhibitor, on myocardial ROS production and LV remodeling and dysfunction after MI...
  27. ncbi Cytochrome P450 2C9 is involved in flow-dependent vasodilation of peripheral conduit arteries in healthy subjects and in patients with chronic heart failure
    Dieter Fischer
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Heart Fail 9:770-5. 2007
    ..Recently, a cytochrome P450 (CYP) epoxygenase of the 2C family was linked to NO- and prostacyclin-independent relaxation of conduit arteries. We therefore evaluated the contribution of CYP 2C9 to FMD in humans...
  28. ncbi Bromocriptine treatment associated with recovery from peripartum cardiomyopathy in siblings: two case reports
    Gerd Peter Meyer
    Department of Cardiology and Angiology, MHH, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Med Case Reports 4:80. 2010
    ..Peripartum cardiomyopathy is a rare form of cardiomyopathy, with heterogeneous presentation occurring in women between one-month antepartum and six months postpartum. It carries a poor prognosis and a high risk of mortality...
  29. ncbi Expression of CYR61, an angiogenic immediate early gene, in arteriosclerosis and its regulation by angiotensin II
    Andres Hilfiker
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    Circulation 106:254-60. 2002
    ....
  30. ncbi Effects of anesthesia on diastolic function in mice assessed by echocardiography
    Arnd Schaefer
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Echocardiography 22:665-70. 2005
    ..However, the effect on diastolic function has not been investigated yet. The following study was conducted to evaluate the influence of different agents on diastolic left ventricular function in mice...
  31. ncbi Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling
    Frank Echtermeyer
    Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cardiovasc Res 92:123-31. 2011
    ..Here, we characterize the effects of Sdc4 deficiency in murine myocardial ischaemia and permanent infarction...
  32. ncbi Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose
    Christian Templin
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    J Mol Cell Cardiol 45:394-403. 2008
    ..Ex vivo expanded HPCs improve cardiac function and remodeling post MI in a cell number- and beta-catenin-dependent manner...
  33. ncbi TNFalpha decreases alphaMHC expression by a NO mediated pathway: role of E-box transcription factors for cardiomyocyte specific gene regulation
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
    Cardiovasc Res 53:460-9. 2002
    ..Our data obtained in cultured CM and in TNFalpha transgenic mice support the notion that TNFalpha exerts these effects by NO and E-box dependent mechanisms in vitro and possibly in vivo...
  34. ncbi Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes
    Arash Haghikia
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Eur Heart J 32:1287-97. 2011
    ..We investigated the impact of STAT3-mediated regulation of microRNAs for pathophysiological alterations in the heart...
  35. ncbi Preclinical testing of tissue-engineered heart valves re-endothelialized under simulated physiological conditions
    Artur Lichtenberg
    Department of Thoracic and Cardiovascular Surgery, Medical School Hannover, Hannover, Germany
    Circulation 114:I559-65. 2006
    ..The aim of this study was to evaluate function, morphological changes, and cellular composition of decellularized versus re-endothelialized ovine pulmonary valves (PV) after implantation into lambs for 1 or 3 months...
  36. ncbi Survival pathways in hypertrophy and heart failure: the gp130-STAT axis
    Philipp Fischer
    Department of Cardiology and Angiology, Medical School Hannover, Germany
    Basic Res Cardiol 102:393-411. 2007
    ....
  37. ncbi Low-dose Erythropoietin reduces risk of heart failure induced by anti-cancer therapy
    Melanie Hoch
    Department of Cardiology and Angiology, Medical School Hannover, 30625 Hannover
    Oncotarget 2:825. 2011
    ..However, further evaluation of EPO in tumor research is required, especially with regard to its effect on tumor growth and anti-tumor treatment strategies...
  38. ncbi Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc
    Joerg Heineke
    Department of Cardiology, Hanover Medical School, 30625 Hanover, Germany
    Proc Natl Acad Sci U S A 102:1655-60. 2005
    ..Our study reveals a link between the stress sensor MLP and the calcineurin-NFAT pathway at the sarcomeric Z-disk in cardiomyocytes and indicates that reduced MLP-calcineurin signaling predisposes to adverse remodeling after MI...
  39. ncbi Disease-modifying mutations in familial hypertrophic cardiomyopathy: complexity from simplicity
    Denise Hilfiker-Kleiner
    Circulation 117:1775-7. 2008
  40. ncbi Peripartum cardiomyopathy: inflammatory markers as predictors of outcome in 100 prospectively studied patients
    Karen Sliwa
    Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, PO Bertsham 2013, Johannesburg, South Africa
    Eur Heart J 27:441-6. 2006
    ..We evaluated the prognostic role of multiple inflammatory markers in the plasma of a large cohort of African patients with PPCM...
  41. ncbi Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice
    Kerstin Boengler
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Circ Res 102:131-5. 2008
    ..Thus, cardioprotection by iPoco is dependent on the postconditioning protocol in aged and STAT3-deficient hearts. The reduced levels of STAT3 with increasing age may contribute to the age-related loss of iPoco...
  42. ncbi Recovery from postpartum cardiomyopathy in 2 patients by blocking prolactin release with bromocriptine
    Denise Hilfiker-Kleiner
    J Am Coll Cardiol 50:2354-5. 2007
  43. ncbi Peripartum cardiomyopathy--a new treatment option by inhibition of prolactin secretion
    Boriana G Jahns
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Am J Obstet Gynecol 199:e5-6. 2008
    ..Recent experimental data implicate a causal role of prolactin. We report a patient with PPCM who responded well to treatment with Bromocriptine in addition to standard therapy of heart failure...
  44. ncbi ACE inhibition improves cardiac force generation after myocardial infarction
    Denise Hilfiker-Kleiner
    J Mol Cell Cardiol 34:1127-30. 2002
  45. ncbi Sex determination in Drosophila melanogaster and Musca domestica converges at the level of the terminal regulator doublesex
    Monika Hediger
    Zoological Institute, University Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Dev Genes Evol 214:29-42. 2004
    ..These results strongly support a role of Md-dsx as the final regulatory gene in the sex-determining hierarchy of the housefly...