Joerg Heineke

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc Finding good biomarkers for sarcopenia
    Gesine Scharf
    Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Rebirth Cluster of Excellence, Carl Neuberg Str 1, 30625, Hannover, Germany
    J Cachexia Sarcopenia Muscle 3:145-8. 2012
  2. doi request reprint Screening for novel calcium-binding proteins that regulate cardiac hypertrophy: CIB1 as an example
    Joerg Heineke
    Klinik für Kardiologie und Angiologie, Rebirth Cluster of Excellence, Medizinische Hochschule Hannover, Hannover, Germany
    Methods Mol Biol 963:279-301. 2013
  3. doi request reprint Cardiomyocyte calcineurin signaling in subcellular domains: from the sarcolemma to the nucleus and beyond
    Joerg Heineke
    Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Rebirth Cluster of Excellence, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Mol Cell Cardiol 52:62-73. 2012
  4. pmc CIB1 is a regulator of pathological cardiac hypertrophy
    Joerg Heineke
    Howard Hughes Medical Institute, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA
    Nat Med 16:872-9. 2010
  5. pmc Calcineurin protects the heart in a murine model of dilated cardiomyopathy
    Joerg Heineke
    Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Howard Hughes Medical Institute, 240 Albert Sabin Way, Cincinnati, OH 45229, USA
    J Mol Cell Cardiol 48:1080-7. 2010
  6. pmc Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart
    Joerg Heineke
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Clin Invest 117:3198-210. 2007
  7. pmc Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting
    Astrid Breitbart
    Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Rebirth Cluster of Excellence, Carl Neuberg Str 1, 30625 Hannover, Germany
    Am J Physiol Heart Circ Physiol 300:H1973-82. 2011
  8. pmc Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure
    Joerg Heineke
    Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
    Circulation 121:419-25. 2010
  9. pmc GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling
    Natali Froese
    Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Institut fur Molekularbiologie, Rebirth Cluster of Excellence, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 286:5680-90. 2011
  10. ncbi request reprint Regulation of cardiac hypertrophy by intracellular signalling pathways
    Joerg Heineke
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Division of Molecular Cardiovascular Biology, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Nat Rev Mol Cell Biol 7:589-600. 2006

Collaborators

Detail Information

Publications11

  1. pmc Finding good biomarkers for sarcopenia
    Gesine Scharf
    Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Rebirth Cluster of Excellence, Carl Neuberg Str 1, 30625, Hannover, Germany
    J Cachexia Sarcopenia Muscle 3:145-8. 2012
    ..Importantly, sarcopenia biomarkers will have to be tested and validated in clinical trials...
  2. doi request reprint Screening for novel calcium-binding proteins that regulate cardiac hypertrophy: CIB1 as an example
    Joerg Heineke
    Klinik für Kardiologie und Angiologie, Rebirth Cluster of Excellence, Medizinische Hochschule Hannover, Hannover, Germany
    Methods Mol Biol 963:279-301. 2013
    ..I also describe cell culture-based models for cardiomyocyte hypertrophy as well as mouse models for pathological or physiological hypertrophy and strategies to analyze the impact of candidate genes on the development of hypertrophy...
  3. doi request reprint Cardiomyocyte calcineurin signaling in subcellular domains: from the sarcolemma to the nucleus and beyond
    Joerg Heineke
    Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Rebirth Cluster of Excellence, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Mol Cell Cardiol 52:62-73. 2012
    ..We also suggest that knowledge about subcellular signaling could help to develop inhibitors of calcineurin in specific microdomains to avoid side-effects that may arise from complete calcineurin inhibition...
  4. pmc CIB1 is a regulator of pathological cardiac hypertrophy
    Joerg Heineke
    Howard Hughes Medical Institute, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA
    Nat Med 16:872-9. 2010
    ..Thus, CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation...
  5. pmc Calcineurin protects the heart in a murine model of dilated cardiomyopathy
    Joerg Heineke
    Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Howard Hughes Medical Institute, 240 Albert Sabin Way, Cincinnati, OH 45229, USA
    J Mol Cell Cardiol 48:1080-7. 2010
    ..Collectively, these results reveal an important and previously unrecognized protective function of endogenous myocardial calcineurin in a mouse model of dilated cardiomyopathy...
  6. pmc Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart
    Joerg Heineke
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Clin Invest 117:3198-210. 2007
    ..To our knowledge, these results demonstrate [corrected] a previously unrecognized function for GATA4 as a regulator of cardiac angiogenesis through a nonhypoxic, load, and/or disease-responsive mechanism...
  7. pmc Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting
    Astrid Breitbart
    Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Rebirth Cluster of Excellence, Carl Neuberg Str 1, 30625 Hannover, Germany
    Am J Physiol Heart Circ Physiol 300:H1973-82. 2011
    ....
  8. pmc Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure
    Joerg Heineke
    Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
    Circulation 121:419-25. 2010
    ..Myostatin is a cytokine of the transforming growth factor-beta superfamily that is known to control muscle wasting...
  9. pmc GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling
    Natali Froese
    Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie, Institut fur Molekularbiologie, Rebirth Cluster of Excellence, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 286:5680-90. 2011
    ..Together, these findings indicate that GATA6 plays a crucial role for endothelial cell function and survival, at least in part, by suppressing autocrine TGFβ expression and ALK5-dependent signaling...
  10. ncbi request reprint Regulation of cardiac hypertrophy by intracellular signalling pathways
    Joerg Heineke
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Division of Molecular Cardiovascular Biology, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Nat Rev Mol Cell Biol 7:589-600. 2006
    ..Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation...
  11. ncbi request reprint Reduced delayed rectifier K+ current, altered electrophysiology, and increased ventricular vulnerability in MLP-deficient mice
    Ajmal Gardiwal
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    J Card Fail 13:687-93. 2007
    ..In humans, MLP-expression is downregulated both in ischemic and dilative cardiomyopathy. In this study, we investigated the effects of MLP on the electrophysiologic phenotype in vivo and on outward potassium currents...