H Haller

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint [Regenerative therapy in nephrology. Repair or construction?]
    H Haller
    Klinik für Nieren und Hochdruckkrankheiten, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Internist (Berl) 48:813-8. 2007
  2. doi request reprint Circulating angiopoietin-2 levels increase with progress of chronic kidney disease
    Sascha David
    Division of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 25:2571-6. 2010
  3. pmc Rationale and design of the RIACT-study: a multi-center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B-cell infiltrates in renal Transplant patients: study protocol for a rando
    Lena Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Carl Neuberg Str, 1, Hannover, 30625, Germany
    Trials 13:199. 2012
  4. pmc The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis
    Philipp Kümpers
    Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Munster, Albert Schweitzer Strasse 33, Münster 48149 Germany
    Crit Care 15:R261. 2011
  5. pmc Zinc-alpha2-glycoprotein in patients with acute and chronic kidney disease
    Inga Sörensen-Zender
    Department of Nephrology, Hannover Medical School, Carl Neuberg Str, 1, Hannover D 30625, Germany
    BMC Nephrol 14:145. 2013
  6. pmc Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, D 30171, Germany
    Crit Care 12:R147. 2008
  7. pmc Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 13:R64. 2009
  8. pmc Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays
    Alexander Lukasz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 12:R94. 2008
  9. doi request reprint [Current problems of kidney transplantation]
    H Haller
    Klinik für Nieren und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Hannover
    Internist (Berl) 50:523-35. 2009
  10. ncbi request reprint Preventing microalbuminuria in patients with diabetes: rationale and design of the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study
    Hermann Haller
    Nephrology Section, Hanover Medical School, Hanover, Germany
    J Hypertens 24:403-8. 2006

Collaborators

Detail Information

Publications145 found, 100 shown here

  1. ncbi request reprint [Regenerative therapy in nephrology. Repair or construction?]
    H Haller
    Klinik für Nieren und Hochdruckkrankheiten, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Internist (Berl) 48:813-8. 2007
    ..Initial results using this new technique in clinical phase I/II studies on patients with acute renal failure are promising...
  2. doi request reprint Circulating angiopoietin-2 levels increase with progress of chronic kidney disease
    Sascha David
    Division of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 25:2571-6. 2010
    ..In addition, we aimed to detect a potential link between the nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) and the Ang-2 levels...
  3. pmc Rationale and design of the RIACT-study: a multi-center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B-cell infiltrates in renal Transplant patients: study protocol for a rando
    Lena Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Carl Neuberg Str, 1, Hannover, 30625, Germany
    Trials 13:199. 2012
    ..Despite the promise of these observations, solid evidence is required before incorporating this treatment option into a general treatment recommendation...
  4. pmc The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis
    Philipp Kümpers
    Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Munster, Albert Schweitzer Strasse 33, Münster 48149 Germany
    Crit Care 15:R261. 2011
    ..Here we evaluate the efficacy of a novel polyethylene glycol (PEG)-clustered Tie2 agonist peptide, Vasculotide (VT), to protect against vascular leakage and mortality in a murine model of polymicrobial abdominal sepsis...
  5. pmc Zinc-alpha2-glycoprotein in patients with acute and chronic kidney disease
    Inga Sörensen-Zender
    Department of Nephrology, Hannover Medical School, Carl Neuberg Str, 1, Hannover D 30625, Germany
    BMC Nephrol 14:145. 2013
    ..In this study, serum AZGP1 levels were measured in acute and chronic kidney disease to test for a correlation to renal function and other clinical parameters...
  6. pmc Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, D 30171, Germany
    Crit Care 12:R147. 2008
    ..Here, we examine whether circulating Ang-1 and/or Ang-2 independently predict mortality in a cohort of critically ill medical patients...
  7. pmc Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 13:R64. 2009
    ....
  8. pmc Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays
    Alexander Lukasz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 12:R94. 2008
    ..The use of circulating Ang-1 and Ang-2 as novel biomarkers of endothelial integrity has therefore gained much attention. The preclinical characteristics and clinical applicability of angiopoietin immunoassays, however, remain elusive...
  9. doi request reprint [Current problems of kidney transplantation]
    H Haller
    Klinik für Nieren und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Hannover
    Internist (Berl) 50:523-35. 2009
    ..Furthermore, the patients must be screened for occurrence of neoplasia. There are no prospective studies covering all cardiovascular risk factors after kidney transplantation. This pertains particularly to the subject of hypertension...
  10. ncbi request reprint Preventing microalbuminuria in patients with diabetes: rationale and design of the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study
    Hermann Haller
    Nephrology Section, Hanover Medical School, Hanover, Germany
    J Hypertens 24:403-8. 2006
    ..The ROADMAP study will answer the question whether an ARB can prevent or delay the onset of microalbuminuria and whether this translates into protection against cardiovascular events and renal disease...
  11. pmc Effective management of hypertension with dihydropyridine calcium channel blocker-based combination therapy in patients at high cardiovascular risk
    H Haller
    Department of Medicine, Division of Nephrology, Hannover Medical School, Hannover, Germany
    Int J Clin Pract 62:781-90. 2008
    ..Implementation of this approach in clinical practice, together with adherence to global hypertension management guidelines will help ensure patients achieve and sustain BP targets, and reduce the risk of CV events...
  12. ncbi request reprint Stem cells and progenitor cells in renal disease
    Hermann Haller
    Department of Nephrology, Hannover Medical School, Germany
    Kidney Int 68:1932-6. 2005
    ..Such animal models improve our understanding of stem cell behavior in the kidney and may eventually contribute to novel therapies...
  13. doi request reprint Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes
    Hermann Haller
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    N Engl J Med 364:907-17. 2011
    ..We investigated whether treatment with an angiotensin-receptor blocker (ARB) would delay or prevent the occurrence of microalbuminuria in patients with type 2 diabetes and normoalbuminuria...
  14. ncbi request reprint Lymphatic neoangiogenesis in human renal allografts: results from sequential protocol biopsies
    S Stuht
    Department of Nephrology, Medizinische Hochschule Hannover, Hannover, Germany
    Am J Transplant 7:377-84. 2007
    ..In conclusion, lymphangiogenesis not only shows a clear association with cellular infiltrates but might also have an impact on the pathogenicity of these cellular infiltrates...
  15. doi request reprint The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus
    P Kümpers
    Department of Nephrology, Hanover Medical School, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    Ann Rheum Dis 68:1638-43. 2009
    ..Recently, the endothelial-specific Ang-Tie ligand-receptor system has been identified as a major regulator of vascular responsiveness to inflammatory stimuli...
  16. doi request reprint Acute tubular injury in protocol biopsies of renal grafts: prevalence, associated factors and effect on long-term function
    W Gwinner
    Division of Nephrology, Department of Internal Medicine, Medical School Hannover, Hannover, Germany
    Am J Transplant 8:1684-93. 2008
    ..Prevention of the potential pathogenetic factors identified in this study might be the key point to attain good long-term graft function...
  17. ncbi request reprint Vascular endothelial damage and repair in antineutrophil cytoplasmic antibody-associated vasculitis
    K de Groot
    Hannover Medical School, Hannover, Germany
    Arthritis Rheum 56:3847-53. 2007
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to play a pivotal role in the regeneration of damaged endothelium. The aim of this study was to investigate whether EPCs are involved in vascular repair in AAV...
  18. doi request reprint Diagnostic role of endothelial microparticles in vasculitis
    U Erdbruegger
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Rheumatology (Oxford) 47:1820-5. 2008
    ..More recently, endothelial microparticles (EMPs) were found to be increased in active childhood vasculitis. The role of EMP in adult AAV and the relationship between EMP and CEC is unclear...
  19. ncbi request reprint Expression of pro- and antifibrotic genes in protocol biopsies from renal allografts with interstitial fibrosis and tubular atrophy
    M Mengel
    Institute for Pathology, Medizinische Hochschule Hannover, Germany
    Clin Nephrol 69:408-16. 2008
    ..Better understanding of early onset of interstitial fibrosis and tubular atrophy (IF/TA), as the morphological surrogate of renal allograft deterioration might improve outcome after renal transplantation...
  20. pmc Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study
    E Ritz
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Diabetologia 53:49-57. 2010
    ..This may be important because even within the normoalbuminuric range, higher rates of albuminuria are known to be associated with higher renal and cardiovascular risk...
  21. ncbi request reprint Endothelial microparticles as a diagnostic aid in Churg-Strauss vasculitis-induced cardiomyopathy
    P Kümpers
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Clin Exp Rheumatol 26:S86-9. 2008
    ..Endothelial microparticles might be an additional tool to diagnose and monitor cases of suspected vasculitic cardiac involvement in CSS...
  22. ncbi request reprint Infiltrates in protocol biopsies from renal allografts
    M Mengel
    Institut fuer Pathologie, Medizinische Hochschule Hannover, Germany
    Am J Transplant 7:356-65. 2007
    ..As detected by sequential biopsies, persistence of any inflammation including those infiltrates currently not considered by the Banff classification should be regarded as a morphological correlate of ongoing allograft damage...
  23. doi request reprint Rosuvastatin protects against angiotensin II-induced renal injury in a dose-dependent fashion
    Joon Keun Park
    Department of Nephrology, Medical School Hannover, Germany
    J Hypertens 27:599-605. 2009
    ....
  24. ncbi request reprint Renal urokinase-type plasminogen activator (uPA) receptor but not uPA deficiency strongly attenuates ischemia reperfusion injury and acute kidney allograft rejection
    Faikah Gueler
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    J Immunol 181:1179-89. 2008
    ..Our results demonstrate that the local renal uPAR plays an important role in the apoptotic and inflammatory responses mediating IR-injury and transplant rejection...
  25. doi request reprint Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy
    Joon Keun Park
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 23:1844-53. 2008
    ..Although activation of p38MAPK has been previously shown in diabetes mellitus, our results indicate that blockade of the downstream MK2/Hsp25 signalling pathway does not interfere with the development of early diabetic nephropathy...
  26. ncbi request reprint Urokinase-induced activation of the gp130/Tyk2/Stat3 pathway mediates a pro-inflammatory effect in human mesangial cells via expression of the anaphylatoxin C5a receptor
    Nelli Shushakova
    Hannover Medical School, Germany
    J Cell Sci 118:2743-53. 2005
    ..The data suggest a novel role for uPA/uPAR in glomeruli-associated renal failure via a signaling cross-talk between the fibrinolytic and immune systems...
  27. ncbi request reprint Use of Doppler ultrasonography to predict the outcome of therapy for renal-artery stenosis
    J Radermacher
    Department of Nephrology, Medizinische Hochschule Hannover, Germany
    N Engl J Med 344:410-7. 2001
    ..We evaluated whether a high level of resistance to flow in the segmental arteries of both kidneys (indicated by resistance-index values of at least 80) can be used prospectively to select appropriate patients for treatment...
  28. ncbi request reprint Nephrotoxicity of selective COX-2 inhibitors
    A Woywodt
    Department of Medicine, University of Hannover School of Medicine, Germany
    J Rheumatol 28:2133-5. 2001
    ..Therefore, COX-2 inhibitors should be used with caution in renal transplant recipients and in patients with salt depletion and renal insufficiency...
  29. ncbi request reprint Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease
    J T Kielstein
    Institute of Clinical Pharmacology and Department of Nephrology, Hannover Medical School, 30625 Hannover, Germany
    Kidney Int Suppl 78:S9-13. 2001
    ..Clinical studies on the effect of ADMA are needed to further elucidate its pathophysiological role in atherosclerosis and uremia...
  30. doi request reprint Biopsy-diagnosed renal disease in patients after transplantation of other organs and tissues
    A Schwarz
    Department of Nephrology and Hypertension, Hannover Medical School, Integriertes Forschungs und Behandlungszentrum IFB Tx, Germany
    Am J Transplant 10:2017-25. 2010
    ..However, decreased renal function should not be routinely ascribed to CNI...
  31. ncbi request reprint Monocyte-expressed urokinase inhibits vascular smooth muscle cell growth by activating Stat1
    Sateesh Kunigal
    Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Blood 102:4377-83. 2003
    ..These results provide the first evidence that monocytes signal VSMCs by mechanisms involving the fibrinolytic system, and they imply an important link between the uPA/uPAR-related signaling machinery and human vascular disease...
  32. ncbi request reprint Early calcification of renal allografts detected by protocol biopsies: causes and clinical implications
    Wilfried Gwinner
    Division of Nephrology, Department of Internal Medicine, Medical School Hannover, Hannover, Germany
    Am J Transplant 5:1934-41. 2005
    ..05). Therefore, treatment of hyperparathyroidism should be considered earlier and more often in these patients...
  33. doi request reprint Course and relevance of arteriovenous fistulas after renal transplant biopsies
    A Schwarz
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Am J Transplant 8:826-31. 2008
    ..There is no established test predicting which patient will benefit from embolization; however, Doppler-determined resistive index may help in this regard...
  34. doi request reprint Elevation of serum CXCL13 in SLE as well as in sepsis
    L Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Germany
    Lupus 20:507-11. 2011
    ..45, p = 0.003) and SLE (r = 0.39, p = 0.02). In conclusion, CXCL13 is a stable serum marker for disease activity in SLE patients, but concomitant infections can also lead to increased CXCL13 levels...
  35. ncbi request reprint Postischemic acute renal failure is reduced by short-term statin treatment in a rat model
    Faikah Gueler
    Department of Internal Medicine Nephrology, Hannover Medical School, Hannover, Germany
    J Am Soc Nephrol 13:2288-98. 2002
    ..The chain of events may involve anti-inflammatory effects, with inhibition of mitogen-activated protein kinase activation and the redox-sensitive transcription factors nuclear factor-kappaB and activator protein-1...
  36. ncbi request reprint Elevated numbers of circulating endothelial cells in renal transplant recipients
    Alexander Woywodt
    Department of Medicine, Hannover Medical School, Hannover, Germany woywodt alexander mh hannover de
    Transplantation 76:1-4. 2003
    ..Circulating endothelial cells have recently been established as a novel marker of endothelial damage in a variety of vascular disorders...
  37. pmc Complement 5a receptor inhibition improves renal allograft survival
    Faikah Gueler
    Department of Nephrology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 19:2302-12. 2008
    ..These results demonstrate that C5aR plays an important role in mediating acute kidney allograft rejection, suggesting that pharmaceutical targeting of C5aR may have potential in transplantation medicine...
  38. ncbi request reprint Mechanisms of disease: erythropoietin--an old hormone with a new mission?
    Danilo Fliser
    Hannover Medical School, Hannover, Germany
    Nat Clin Pract Cardiovasc Med 3:563-72. 2006
    ..This review article summarizes the present knowledge on the cardiovascular and renal protective effects of erythropoietin and discusses the possible underlying mechanisms...
  39. ncbi request reprint Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    Sajoscha A Sorrentino
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 116:163-73. 2007
    ....
  40. ncbi request reprint Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease
    Jan T Kielstein
    Department of Internal Medicine and Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    J Am Soc Nephrol 13:170-6. 2002
    ..Thus, the early increase of ADMA levels may be of relevance for the excess cardiovascular morbidity and mortality due to arterio- and atherosclerotic complications in patients with renal disease...
  41. ncbi request reprint Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice
    Jan Menne
    Phenos, Hannover, Germany
    Diabetes 53:2101-9. 2004
    ..Therefore, PKC-alpha is a possible therapeutic target for the prevention of diabetic albuminuria...
  42. doi request reprint [Therapeutic targets in arterial hypertension and diabetes mellitus. Can medical prevention be harmful?]
    C Chatzikyrkou
    Abteilung für Nieren und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Internist (Berl) 53:882-92. 2012
    ....
  43. doi request reprint Serum leptin and ghrelin correlate with disease activity in ANCA-associated vasculitis
    P Kümpers
    Department of Nephrology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Rheumatology (Oxford) 47:484-7. 2008
    ..To study serum levels of leptin and ghrelin in ANCA-associated vasculitis (AAV)...
  44. doi request reprint Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice
    M Meier
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Diabetologia 52:765-75. 2009
    ..Defining and targeting mediators of increased intracellular activation in the diabetic microvasculature will have important clinical and therapeutic benefits and help in the design of novel effective therapies in the near future...
  45. ncbi request reprint Scleroderma-like acute renal crisis in a patient with scleromyxedema
    Wilfried Gwinner
    Division of Nephrology, Department of Internal Medicine, Medical School Hannover Carl Neuberg Str 1, 30625 Hannover, Germany
    Nephrol Dial Transplant 22:2063-7. 2007
  46. ncbi request reprint Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients
    Stefan Wittke
    Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany
    Am J Transplant 5:2479-88. 2005
    ..Further investigation is needed to establish polypeptide patterns in vascular rejection and to explore whether changes in the urinary proteome occur before the onset of histologically discernible rejection...
  47. ncbi request reprint Increased resistin blood levels are not associated with insulin resistance in patients with renal disease
    Jan T Kielstein
    Department of Internal Medicine, Division of Nephrology, Medical School Hannover, Hannover, Germany
    Am J Kidney Dis 42:62-6. 2003
    ..Resistin is a newly discovered insulin inhibitor secreted by adipocytes. We explored the potential role of resistin in the pathophysiological process of insulin resistance encountered in patients with renal disease...
  48. ncbi request reprint Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein kinase C-alpha
    Carsten Lindschau
    Department of Nephrology, Medical School Hannover, Germany
    Hypertension 42:335-41. 2003
    ..We propose that high glucose-induced TGF-beta1 and TGF-beta-R1 expression is mediated by PKC-alpha. Our findings suggest an autocrine feedback mechanism and a possible role for PKC-alpha in diabetic vascular disease...
  49. doi request reprint Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease
    Johan Lorenzen
    Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Eur J Clin Invest 40:294-300. 2010
    ..Therefore, we assessed the relationship between OPN plasma levels and renal function in patients at different stages of chronic kidney disease (CKD)...
  50. doi request reprint Angiotensin II receptor blocker and statins lower elevated levels of osteopontin in essential hypertension--results from the EUTOPIA trial
    Johan M Lorenzen
    Department of Medicine Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Atherosclerosis 209:184-8. 2010
    ..We aimed at studying the effect of olmesartan and/or pravastatin on osteopontin plasma levels, and the association between vascular inflammation markers and osteopontin in hypertensive patients...
  51. doi request reprint Renal comorbidity after solid organ and stem cell transplantation
    C Clajus
    Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Am J Transplant 12:1691-9. 2012
    ..Furthermore, we introduce the RECAST (REnal Comorbidity After Solid organ and hematopoietic stem cell Transplantation) registry...
  52. ncbi request reprint Low dialysance of asymmetric dimethylarginine (ADMA)--in vivo and in vitro evidence of significant protein binding
    J T Kielstein
    Division of Nephrology, Hannover Medical School, Hannover, Germany
    Clin Nephrol 62:295-300. 2004
    ..Despite its low molecular weight, available information on the impact of hemodialysis (HD) on ADMA plasma levels is controversial...
  53. pmc Smoking habits in patients diagnosed with ANCA associated small vessel vasculitis
    M Haubitz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Rheum Dis 64:1500-2. 2005
    ..To study the prevalence of smoking at onset of symptoms in patients with small vessel vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA)...
  54. ncbi request reprint The angiopoietin/Tie-2 axis: a novel player in chronic kidney disease
    S David
    Division of Nephrology and Hypertension, Medical School Hanover, Hanover, Germany
    Minerva Urol Nefrol 62:319-26. 2010
    ..Very recently, a clinical trial (in oncology) proved safety of a selective angiopoietin inhibitor. Those latest drugs might represent a future treatment option against CKD-associated micro-inflammation...
  55. pmc Circulating endothelial cells in relapse and limited granulomatous disease due to ANCA associated vasculitis
    A Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Rheum Dis 65:164-8. 2006
    ..To evaluate numbers of circulating endothelial cells (CECs) in ANCA associated vasculitis and compare vasculitic relapse with limited granulomatous disease...
  56. ncbi request reprint Erythropoietin and treatment of non-anemic conditions--cardiovascular protection
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Semin Hematol 44:212-7. 2007
    ..This review article summarizes present knowledge of cardiovascular and renal protective effects of EPO and discusses possible underlying mechanisms...
  57. ncbi request reprint CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes
    Irini Tossidou
    Division of Nephrology, Department of Medicine, and Division of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 282:7457-64. 2007
    ..Because repression of CIN85 protein leads to a restored RTK signaling response, our results support an important role of CD2AP/CIN85 protein balance in the normal signaling response of podocytes...
  58. ncbi request reprint CCL19-IgG prevents allograft rejection by impairment of immune cell trafficking
    Ekkehard Ziegler
    Address correspondence to Dr Ulrich Kunzendorf, University of Kiel, Department of Nephrology and Hypertension, Schittenhelmstrasse 12, 24105 Kiel, Germany
    J Am Soc Nephrol 17:2521-32. 2006
    ..This shows that in contrast to only limited prolongation of graft survival in CCR7 knockout models, the therapeutic application of a CCR7 ligand in a wild-type environment provides a benefit in terms of immunosuppression...
  59. pmc Endothelial progenitor cells and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study
    Johan Lorenzen
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    PLoS ONE 5:e11477. 2010
    ..Endothelial progenitor cells (EPCs) mediate vascular repair and regeneration. Their number in peripheral blood is related to cardiovascular events in individuals with normal renal function...
  60. ncbi request reprint Haemodialysis, atherosclerosis and inflammation-identifying molecular mechanisms of chronic vascular disease in ESDR patients
    Robert Walter
    Department of Nephrology, Medizinische Hochschule Hannover, Carl Neuberg Str 1 and Mosaiques GmbH, Hannover, Germany
    Nephrol Dial Transplant 17:24-9. 2002
  61. doi request reprint Osteopontin in antineutrophil cytoplasmic autoantibody-associated vasculitis: relation to disease activity, organ manifestation and immunosuppressive therapy
    Johan Lorenzen
    Hannover Medical School, Department of Internal Medicine, Division of Nephrology, 30625 Hannover, Germany
    Ann Rheum Dis 69:1169-71. 2010
    ..Osteopontin may play a role in the pathogenesis of AAV...
  62. doi request reprint Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients
    Karsten Heusser
    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    Hypertension 55:619-26. 2010
    ..The depressor response was mediated through sympathetic inhibition...
  63. pmc Stat1 nuclear translocation by nucleolin upon monocyte differentiation
    Uwe Jerke
    Hannover Medical School, Hannover, Germany
    PLoS ONE 4:e8302. 2009
    ..Alternatively, the transport is mediated via a carrier molecule belonging to the importin/karyopherin superfamily, which transmits the import into the nucleus through the NPC...
  64. ncbi request reprint Pharmacokinetics of moxifloxacin and levofloxacin in intensive care unit patients who have acute renal failure and undergo extended daily dialysis
    David Czock
    Division of Nephrology, University Hospital Ulm, Ulm, Germany
    Clin J Am Soc Nephrol 1:1263-8. 2006
    ..The levofloxacin dosage, however, should be reduced according to the intensity of renal replacement therapy...
  65. ncbi request reprint Local complement C3 expression is upregulated in humoral and cellular rejection of renal allografts
    Ebru Serinsoz
    Department of Pathology, Medizinische Hochschule Hannover, Germany
    Am J Transplant 5:1490-4. 2005
    ..Therefore, locally synthesized complement component C3 contributes to both humoral and cellular rejection, with tubular epithelial cells being a major source...
  66. doi request reprint Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies
    Philipp Kümpers
    Center for Internal Medicine, Hannover Medical School, Hannover, Germany
    Blood 112:2139-48. 2008
    ..Because few predictors for DFS exist in the setting of allo-HSCT, Ang-2 may be used as a readily available powerful biomarker to pre-estimate DFS and may open new perspectives for risk-adapted treatment of high-risk myeloid malignancies...
  67. doi request reprint Valsartan in combination with lisinopril versus the respective high dose monotherapies in hypertensive patients with microalbuminuria: the VALERIA trial
    Jan Menne
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    J Hypertens 26:1860-7. 2008
    ..The purpose of the VALERIA trial was a comparison of the efficacy and safety of combination therapy of valsartan and lisinopril with valsartan and lisinopril high-dose monotherapy in patients with hypertension and microalbuminuria...
  68. ncbi request reprint Proteomic analysis for the assessment of diabetic renal damage in humans
    Harald Mischak
    Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany
    Clin Sci (Lond) 107:485-95. 2004
    ..Longitudinal studies should explore the potential of this powerful diagnostic tool for early detection of diabetic renal damage...
  69. ncbi request reprint Incidence of C4d stain in protocol biopsies from renal allografts: results from a multicenter trial
    Michael Mengel
    Institut fuer Pathologie, Medizinische Hochschule Hannover, Germany
    Am J Transplant 5:1050-6. 2005
    ..Protocol biopsies show a significantly lower incidence of C4d deposition than indication biopsies. Subclinical C4d detection in protocol biopsies had no significant impact on allograft survival in our series...
  70. doi request reprint CXCL13 as a novel marker for diagnosis and disease monitoring in pediatric PTLD
    L Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Hannover, Germany
    Am J Transplant 12:1610-7. 2012
    ..sCXCL13, thus, may be a readily available surrogate marker for the diagnosis of PTLD and for monitoring of response to treatment in patients with initially elevated sCXCL13 levels...
  71. ncbi request reprint Side effects of sirolimus
    S Merkel
    Department of Nephrology, Medical School of Hannover, Hannover, Germany
    Transplant Proc 38:714-5. 2006
    ..Thus, we think that caution is required, particularly in connection with preexisting glomerular disease...
  72. ncbi request reprint Life-threatening complications of extracorporeal treatment in patients with severe eosinophilia
    W Gwinner
    Division of Nephrology, Department of Internal Medicine, Medical School Hannover, Hannover, Germany
    Int J Artif Organs 28:1224-7. 2005
    ..Our observations draw attention to the fact that extracorporeal therapies may initiate life-threatening complications in patients with severe eosinophilia...
  73. doi request reprint Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients
    J M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS Department of Medicine Division of Nephrology and Hypertension, Hannover Medical School, Hanover, Germany
    Am J Transplant 11:2221-7. 2011
    ..The miR-210 levels identify patients with acute rejection and predict long-term kidney function. Urinary miR-210 may thus serve as a novel biomarker of acute kidney rejection...
  74. ncbi request reprint Protocol biopsies in renal transplantation: insights into patient management and pathogenesis
    M Mengel
    Institute for Pathology, Hannover Medical School, Hannover, Germany
    Am J Transplant 7:512-7. 2007
    ..Wider application is expected in multicenter clinical trials to predict and validate outcomes. The principal barrier to wider use of protocol biopsies is knowledge of the benefits of intervention...
  75. doi request reprint [Diabetic nephropathy]
    J Menne
    Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Internist (Berl) 52:495-504. 2011
    ..A multifactorial intervention leads to the best results and can avoid the occurrence or progression of diabetic kidney disease and other micro- and/or macrovascular complications...
  76. ncbi request reprint Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo
    J Menne
    Phenos GmbH, Hannover, Germany
    Kidney Int 70:1456-62. 2006
    ..Our data suggest that PKCalpha activation may be an important intracellular signaling pathway in the regulation of nephrin expression and glomerular albumin permeability in the diabetic state...
  77. ncbi request reprint [Modern differential therapy with diuretics]
    D Fliser
    Abteilung Nephrologie, Zentrum fur Innere Medizin, Medizinische Hochschule Hannover
    Internist (Berl) 45:598-605. 2004
    ..Aldosterone antagonists are unique among diuretics because they improve survival in patients with heart failure independently of their effect on sodium metabolism...
  78. ncbi request reprint [New guidelines for treatment of hypertension]
    H Haller
    Abteilung Nephrologie, Zentrum Innere Medizin der Medizinischen Hochschulen Hannover
    Internist (Berl) 46:538-47. 2005
    ..In addition to the antihypertensive properties, substance-specific effects of ACE inhibitors and angiotensin receptor blockers have been described. Primarily, instead of monotherapy low-dose combination therapy can also be judicious...
  79. ncbi request reprint Biocompatibility parameters of different dialysis membranes assessed during systemic inflammation
    F Gueler
    Department of Internal Medicine, Medical School Hannover, DE 30625 Hannover, Germany
    Blood Purif 23:196-202. 2005
    ..We explored whether biocompatible dialyzer membranes modulate the inflammatory response during blood contact in patients with systemic inflammation...
  80. ncbi request reprint [Diagnostic errors in nephrology]
    A Schwarz
    Abteilung für Nephrologie, Medizinische Hochschule, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 43:595-6, 599-600, 603-6. 2002
  81. ncbi request reprint [Focal segmental glomerulosclerosis (FSGS). Molecular defects and clinical relevance]
    M Schiffer
    Abteilung für Nieren und Hochdruckkrankheiten, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 131:1541-5. 2006
  82. ncbi request reprint [Regeneration of renal tissue -- therapy of the future?]
    H Haller
    Abteilung für Nephrologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 131:896-8. 2006
  83. ncbi request reprint Prognostic value of cytotoxic T-lymphocytes and CD40 in biopsies with early renal allograft rejection
    Michael Mengel
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hanover, Germany
    Transpl Int 17:293-300. 2004
    ..These could become part of combined clinical and histological algorithms, allowing patient-specific risk estimation and customized therapy options to be made...
  84. ncbi request reprint Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans
    Jan T Kielstein
    Department of Internal Medicine, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Circulation 109:172-7. 2004
    ..We evaluated systemic cardiovascular effects of ADMA infusion in healthy subjects using invasive techniques, ie, right heart catheter and inulin/para-aminohippurate clearance...
  85. ncbi request reprint Kidney graft function determines endothelial progenitor cell number in renal transplant recipients
    Kirsten de Groot
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, 30625 Hannover, Germany
    Transplantation 79:941-5. 2005
    ..In uremic patients, the number of functionally active EPCs is reduced. Thus, we assessed EPCs in stable patients 6 months or more after renal transplantation...
  86. doi request reprint Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin
    Sascha David
    Department of Medicine, Division of Nephrology and Hypertension, Medical School Hanover, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    J Hypertens 27:1641-7. 2009
    ..We aimed at studying the effect of ARB and/or 3-hydroxy-3-methyl-glutaryl-CoA blockade on Ang-2 and the association between vascular inflammation markers and Ang-2 levels in hypertensive patients...
  87. ncbi request reprint Stimulation of endothelial progenitor cells: a new putative therapeutic effect of angiotensin II receptor antagonists
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hanover, Germany
    Hypertension 45:526-9. 2005
    ..Angiotensin II receptor antagonists increase the number of regenerative EPCs in patients with type 2 diabetes mellitus. This action may be of therapeutic relevance contributing to their beneficial cardiovascular effects...
  88. doi request reprint In vitro neutralization of tumor necrosis factor-alpha during Chlamydia pneumoniae infection impairs dendritic cells maturation/function and increases chlamydial progeny
    Florence Njau
    Department of Nephrology, Hannover Medical School, Germany
    FEMS Immunol Med Microbiol 55:215-25. 2009
    ..These data suggest a possible mechanism by which TNF-alpha inhibition enhances the risk of intracellular infections...
  89. doi request reprint Circulating angiopoietin-2 is a marker and potential mediator of endothelial cell detachment in ANCA-associated vasculitis with renal involvement
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Nephrol Dial Transplant 24:1845-50. 2009
    ..Here, we ask whether circulating Ang-2 correlates with the severity of endothelial damage in ANCA-associated vasculitis (AAV) with renal involvement...
  90. ncbi request reprint Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation
    Alexander Woywodt
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Blood 103:3603-5. 2004
    ..These observations provide a novel marker to investigate microvascular endothelial damage and the effects of different conditioning regimens in patients undergoing HSCT...
  91. ncbi request reprint From the Prague Spring to a chair in nephrology in Germany: Jan Brod (1912-1985)
    Alexander Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Nephrol Dial Transplant 19:1374-7. 2004
  92. doi request reprint Ageing mouse kidney--not always the SAME old story
    Roland Schmitt
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 24:3002-5. 2009
    ..We have observed that the aged animal's provenance can be an overlooked factor accounting for such experimental heterogeneity...
  93. doi request reprint Endothelial-derived thrombospondin-1 promotes macrophage recruitment and apoptotic cell clearance
    Torsten Kirsch
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Germany
    J Cell Mol Med 14:1922-34. 2010
    ....
  94. ncbi request reprint Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model
    Matthias Meier
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Diabetes 56:346-54. 2007
    ....
  95. doi request reprint The effect of cinacalcet on bone remodeling and renal function in transplant patients with persistent hyperparathyroidism
    Anke Schwarz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Transplantation 91:560-5. 2011
    ..Parathyroidectomy is associated with renal functional losses in transplant patients; cinacalcet offers an attractive alternative...
  96. ncbi request reprint The podocyte as a direct target of immunosuppressive agents
    Eva Schonenberger
    Correspondence and offprint requests to Eva Schönenberger E mail
    Nephrol Dial Transplant 26:18-24. 2011
    ..These direct effects could play a key role in the treatment concepts of podocytopathies with an important impact on the long-term renal function in patients with pharmacological immunosuppression...
  97. doi request reprint The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells
    Julia Kiyan
    Hannover Medical School, Carl Neuberg Strabetae 1, D 30625 Hannover, Germany
    Exp Cell Res 315:1029-39. 2009
    ..Our results demonstrate that SHP-2 plays an important role in uPA-directed signaling and functional control of human VSMC and suggest that this phosphatase might contribute to the pathogenesis of the uPA-related vascular remodeling...
  98. ncbi request reprint Renal resistance index and progression of renal disease
    Jörg Radermacher
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Hypertension 39:699-703. 2002
    ..A renal resistance index value of greater-than-or-equal to 80 reliably identifies patients at risk for progressive renal disease...
  99. ncbi request reprint A swollen neck
    Alexander Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, Hannover, Germany
    Lancet 360:1838. 2002
  100. ncbi request reprint Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha
    Dominique T Brandt
    Medizinische Hochschule Hannover, Department of Nephrology, 30625 Hannover, Germany
    J Biol Chem 278:34073-8. 2003
    ....
  101. ncbi request reprint The right diagnostic work-up: investigating renal and renovascular disorders
    Jörg Radermacher
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    J Hypertens Suppl 21:S19-24. 2003
    ..Identifying patients at risk for irreversible loss of renal function and who may benefit from intervention is a high research priority...