Matthias Gaestel

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation
    Matthias Gaestel
    Hannover Medical School, Institute of Biochemistry, Hannover, Germany
    Methods Mol Biol 795:35-44. 2012
  2. pmc p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins
    Manoj B Menon
    Institute of Biochemistry, Medical School Hannover, Hannover 30625, Germany
    J Biol Chem 285:33242-51. 2010
  3. doi MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization
    Tobias Thomas
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Eur J Neurosci 28:642-54. 2008
  4. doi Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production
    Manoj B Menon
    Institute of Physiological Chemistry, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Biochem J 456:163-72. 2013
  5. doi MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin
    Natalia Ronkina
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Biochem Pharmacol 80:1915-20. 2010
  6. pmc The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology
    Frank Brand
    Institute of Physiological Chemistry, Hannover Medical School, Hannover, Germany
    Mol Cell Biol 32:2467-78. 2012
  7. pmc MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells
    Jessica Schwermann
    Institute of Biochemistry, Hannover Medical School, Hannover, Germany
    EMBO J 28:1392-406. 2009
  8. pmc The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation
    Christopher Tiedje
    Institute of Biochemistry, Hannover Medical School, Hannover, Germany
    PLoS Genet 8:e1002977. 2012
  9. doi Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration
    Manoj B Menon
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Cell Motil Cytoskeleton 66:1041-7. 2009
  10. pmc Distinct cellular functions of MK2
    Alexey Kotlyarov
    Institute of Biochemistry, Medical School Hannover, Hannover 30625, Germany
    Mol Cell Biol 22:4827-35. 2002

Collaborators

  • Christoph Klein
  • Ruth Simon
  • Joachim D Meissner
  • Kenneth R Boheler
  • Sylvain Meloche
  • M Bishr Omary
  • Ursula Seidler
  • Oliver Pabst
  • M Lienhard Schmitz
  • Thomas Gp Grunewald
  • Bernhard Schieffer
  • Axel Schambach
  • Karl Welte
  • Elke Butt
  • Julia Skokowa
  • Katrin Marcus
  • Matthias Meier
  • Alexey Kotlyarov
  • Manoj B Menon
  • Natalia Ronkina
  • Christopher Tiedje
  • Jessica Schwermann
  • Edward Hitti
  • Stefanie Schumacher
  • Tobias Thomas
  • Shashi Kant
  • Yu Shi
  • Kathrin Laass
  • Madeleine Scharf
  • Frank Brand
  • Achim D Gruber
  • Mirita Franz-Wachtel
  • Ratnesh K Srivastav
  • Joon Keun Park
  • Kumaravelu Jagavelu
  • Anastassiia Vertii
  • Almuth Brandis
  • Theresia Kraft
  • Dorothee Krone
  • Heike Schneider
  • Lars S Maier
  • Kin Chow Chang
  • Timo Konen
  • Stefan Neef
  • ROBERT FREUND
  • Renate J Scheibe
  • Stephanie Groos
  • Cornelia Geers-Knörr
  • Juri Lafera
  • Helmut Holtmann
  • Stefan Britsch
  • Mohammad Tehrani
  • Sonam Dhamija
  • Benjamin Turgeon
  • Susan Schwede
  • Malte Klaus
  • Rainer Niedenthal
  • Anurag Kumar Singh
  • Maria Schubert
  • Chozhavendan Rathinam
  • Fatih Noyan
  • Haruhiko Koseki
  • Corinna Prohl
  • Konstantin Cesnulevicius
  • Hermann Haller
  • Jan Menne
  • Heidrun Potschka
  • Andreas Höft
  • Marco Timmer
  • Udo Bavendiek
  • Uwe J F Tietge
  • Helmut Drexler
  • Tatiana Iakovleva
  • Stefanie Deppenmeier
  • Danuta Radzioch
  • Andrew R Clark
  • Matthew Brook
  • Manvendra Kumar Singh
  • Cosima Hakim
  • Andreas Kispert
  • Perry J Blackshear
  • Axel Visel
  • Hans Dieter Volk
  • Helmut E Meyer
  • Kathrin Laabeta
  • Anke Friedrich
  • Susann Fritz
  • Jean Baptiste Telliez
  • Yvonne Yannoni
  • Deborah Pitman

Detail Information

Publications31

  1. doi Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation
    Matthias Gaestel
    Hannover Medical School, Institute of Biochemistry, Hannover, Germany
    Methods Mol Biol 795:35-44. 2012
    ..Finally, it is discussed how the results obtained by these methods can be further validated and which future strategies for the treatment of chronic inflammation will exist...
  2. pmc p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins
    Manoj B Menon
    Institute of Biochemistry, Medical School Hannover, Hannover 30625, Germany
    J Biol Chem 285:33242-51. 2010
    ..Therefore, MK2 and p38 MAPK function in concert to phosphorylate K8, K18, and K20 in intestinal epithelia...
  3. doi MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization
    Tobias Thomas
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Eur J Neurosci 28:642-54. 2008
    ..Together, our data suggest a possible role of MK2 in the cellular response after neuronal depolarization, in particular in excitotoxicity...
  4. doi Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production
    Manoj B Menon
    Institute of Physiological Chemistry, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Biochem J 456:163-72. 2013
    ..Interestingly, Ube2j1 is phosphorylated in response to LPS also in macrophages and contributes to MK2-dependent TNFα biosynthesis by a so far unknown mechanism...
  5. doi MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin
    Natalia Ronkina
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Biochem Pharmacol 80:1915-20. 2010
    ..A model is proposed, which demonstrates how this new function of transcriptional activation of TTP by MK2/3 cooperates with the role of MK2/3 in post-transcriptional gene expression to limit the inflammatory response...
  6. pmc The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology
    Frank Brand
    Institute of Physiological Chemistry, Hannover Medical School, Hannover, Germany
    Mol Cell Biol 32:2467-78. 2012
    ..Thus, the regulation of neuronal morphogenesis is proposed as the first physiological function of the ERK3/MK5 signaling module...
  7. pmc MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells
    Jessica Schwermann
    Institute of Biochemistry, Hannover Medical School, Hannover, Germany
    EMBO J 28:1392-406. 2009
    ..Thus, MK2 emerges as a regulator of HSC homeostasis, which could act through chromatin remodelling by the PcG complex...
  8. pmc The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation
    Christopher Tiedje
    Institute of Biochemistry, Hannover Medical School, Hannover, Germany
    PLoS Genet 8:e1002977. 2012
    ..The phosphorylation-regulated TTP/HuR exchange at target mRNAs provides a reversible switch between unstable/non-translatable and stable/efficiently translated mRNAs...
  9. doi Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration
    Manoj B Menon
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Cell Motil Cytoskeleton 66:1041-7. 2009
    ..In addition, migration of MK2/3-double-deficient cells is determined and the ability of MK3 to rescue cell migration in MK2/3-double-deficient fibroblasts is demonstrated...
  10. pmc Distinct cellular functions of MK2
    Alexey Kotlyarov
    Institute of Biochemistry, Medical School Hannover, Hannover 30625, Germany
    Mol Cell Biol 22:4827-35. 2002
    ..These data indicate that catalytic activity of MK2 is required for both cytokine production and cell migration. However, the proline-rich MK2 N terminus provides a distinct role restricted to cell migration...
  11. pmc Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination
    Yu Shi
    Institute of Biochemistry, Medical School Hannover, 30625 Hannover, Germany
    Mol Cell Biol 23:7732-41. 2003
    ..We conclude that the differences between the phenotypes of MK5- and MK2-deficient mice result from clearly different functional properties of both enzymes...
  12. ncbi Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress
    Anastassiia Vertii
    Institute of Biochemistry, Medical School Hannover, Hannover 30625, Germany
    J Biol Chem 281:26966-75. 2006
    ....
  13. pmc Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function
    Madeleine Scharf
    Department of Biochemistry, Hannover Medical School, Hannover, Germany
    Mol Cell Biol 33:2586-602. 2013
    ..Hence, the p38-MK2/3 axis may represent a novel target for the design of therapeutic strategies for diseases related to fiber type changes or impaired SERCA2 function...
  14. doi Targeting innate immunity protein kinase signalling in inflammation
    Matthias Gaestel
    Hannover Medical School, Institute of Biochemistry, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Rev Drug Discov 8:480-99. 2009
    ....
  15. ncbi MAPKAP kinases - MKs - two's company, three's a crowd
    Matthias Gaestel
    Department of Biochemistry, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Rev Mol Cell Biol 7:120-30. 2006
    ....
  16. doi Biological monitoring of non-thermal effects of mobile phone radiation: recent approaches and challenges
    Matthias Gaestel
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Biol Rev Camb Philos Soc 85:489-500. 2010
    ..If successful, this strategy should contribute to identification of new underlying molecular mechanisms of interaction between RF-EMFs and living beings distinct from absorption of thermal energy...
  17. doi NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Med 15:151-8. 2009
    ..G-CSF, in turn, further increases NAMPT levels. These results reveal a decisive role of the NAD(+) metabolic pathway in G-CSF-triggered myelopoiesis...
  18. doi Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines
    M Lienhard Schmitz
    Institute of Biochemistry, Justus Liebig University Giessen, Giessen, Germany
    Biochim Biophys Acta 1813:2165-75. 2011
    ....
  19. doi Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation
    Ratnesh K Srivastav
    Institute for Physiological Chemistry Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Biochem J 438:495-503. 2011
    ..The ability of TRS to monitor protein interactions in mammalian cells in vivo at levels similar to endogenous expression makes it an excellent new tool that can help in defining the protein interactome of mammalian cells...
  20. pmc SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition
    Manoj B Menon
    Institute of Biochemistry, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e23054. 2011
    ....
  21. ncbi MK2 and MK3--a pair of isoenzymes?
    Natalia Ronkina
    Department of Biochemistry, Hannover Medical School, Carl Neuberg Str 1, D30625 Hannover, Germany
    Front Biosci 13:5511-21. 2008
    ..MK2-knockout mice show decreased LPS-induced cytokine biosynthesis and increased protection against collagen-induced arthritis. Recently generated MK2/3 double knockout mice show further reduction of LPS-induced cytokine production...
  22. ncbi In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance
    Yu Shi
    Hannover Medical School, Institute of Biochemistry, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Biol Chem 383:1519-36. 2002
    ..For that reason, we will focus in this review on the different signalling events that are triggered by p38 activity, and analyse how these events contribute to specific gene expression and cellular responses...
  23. pmc Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element
    Edward Hitti
    Medical School Hannover, Institute of Biochemistry, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Mol Cell Biol 26:2399-407. 2006
    ..These data suggest that MK2 inhibits the mRNA destabilizing activity of TTP and, in parallel, codegradation of TTP together, with the target mRNA resulting in increased cellular levels of TTP...
  24. doi Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins
    Christopher Tiedje
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Biochem Soc Trans 38:1632-7. 2010
    ....
  25. ncbi Specificity of signaling from MAPKs to MAPKAPKs: kinases' tango nuevo
    Matthias Gaestel
    Department of Biochemistry, Hannover Medical School, Carl Neuberg Str 1, D30625 Hannover, Germany
    Front Biosci 13:6050-9. 2008
    ..These mechanisms enable specific MAPK pathways to act independently via specific MAPKAPKs but also allow different MAPK pathways to cooperate in downstream signalling in a coordinated fashion...
  26. pmc Scaffolding by ERK3 regulates MK5 in development
    Stefanie Schumacher
    Medical School Hannover, Institute of Biochemistry, Hannover, Germany
    EMBO J 23:4770-9. 2004
    ..Deletion of MK5 leads to strong reduction of ERK3 protein levels and embryonic lethality at about stage E11, where ERK3 expression in wild-type mice is maximum, indicating a role of this signalling module in development...
  27. ncbi Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5
    Shashi Kant
    Institute of Biochemistry, Medical School Hannover, Hannover 30625, Germany
    J Biol Chem 281:35511-9. 2006
    ..Interestingly, ERK4 dimerizes and/or oligomerizes with ERK3, suggesting that overexpressed inactive ERK3 recruits active endogenous ERK4 to MK5 for its activation. Hence, ERK3 and ERK4 cooperate in activation of MK5...
  28. doi MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation--relevance in a mouse model of Parkinson's disease
    Tobias Thomas
    Institute of Biochemistry, Hannover Medical School, Hannover, Germany
    J Neurochem 105:2039-52. 2008
    ....
  29. ncbi Peptides as signaling inhibitors for mammalian MAP kinase cascades
    Matthias Gaestel
    Department of Biochemistry, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Curr Pharm Des 15:2471-80. 2009
    ..In addition to specifically targeting protein-protein interactions, the ultimate efficacy of these peptide inhibitors in vivo also depends on their delivery, stability and toxicity in living cells and in the whole organism...
  30. doi Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy
    Joon Keun Park
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 23:1844-53. 2008
    ..Although activation of p38MAPK has been previously shown in diabetes mellitus, our results indicate that blockade of the downstream MK2/Hsp25 signalling pathway does not interfere with the development of early diabetic nephropathy...
  31. ncbi Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice
    Kumaravelu Jagavelu
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 01, 30625 Hannover, Germany
    Circ Res 101:1104-12. 2007
    ..Therefore, MK2 might represent an attractive novel target for the treatment of atherosclerotic cardiovascular disease...