A Franzke

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc Human regulatory T cells of G-CSF mobilized allogeneic stem cell donors qualify for clinical application
    Sya N Ukena
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e51644. 2012
  2. pmc Identification of novel regulators in T-cell differentiation of aplastic anemia patients
    Anke Franzke
    Department of Hematology, Hemostasis and Oncology, Hannover Medical School, Hannover, Germany
    BMC Genomics 7:263. 2006
  3. ncbi request reprint G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases
    Anke Franzke
    Department of Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Blood 102:734-9. 2003
  4. ncbi request reprint Classical Hodgkin's lymphoma: molecular evidence for specific alterations in circulating T lymphocytes
    Anke Franzke
    Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Hannover, Germany
    Tumour Biol 27:329-33. 2006
  5. ncbi request reprint Regulatory T-cells in the control of immunological diseases
    A Franzke
    Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Hannover, Germany
    Ann Hematol 85:747-58. 2006
  6. ncbi request reprint HLA phenotype and cytokine-induced tumor control in advanced renal cell cancer
    A Franzke
    Department of Hematology and Oncology, Medizinische Hochschule Hannover, Germany
    Cancer Biother Radiopharm 16:401-9. 2001
  7. pmc Prognostic impact of in vivo soluble cell adhesion molecules in metastatic renal cell carcinoma
    R Hoffmann
    Medizinische Hochschule Hannover, Department of Hematology and Oncology, Germany
    Br J Cancer 79:1742-5. 1999
  8. pmc Risk and outcome in metastatic malignant melanoma patients receiving DTIC, cisplatin, BCNU and tamoxifen followed by immunotherapy with interleukin 2 and interferon alpha2a
    R Hoffmann
    Department of Hematology and Oncology, Medizinische Hochschule Hannover, Germany
    Br J Cancer 78:1076-80. 1998
  9. pmc Elevated pretreatment serum levels of soluble vascular cell adhesion molecule 1 and lactate dehydrogenase as predictors of survival in cutaneous metastatic malignant melanoma
    A Franzke
    Department of Hematology and Oncology, Medizinische Hochschule Hanover, Germany
    Br J Cancer 78:40-5. 1998
  10. pmc Capecitabine in the treatment of metastatic renal cell carcinoma
    K Oevermann
    Department of Haematology and Oncology, Medizinische Hochshule Hannover, Carl Neuberg Strasse 1, Hannover, 30625, Germany
    Br J Cancer 83:583-7. 2000

Collaborators

Detail Information

Publications23

  1. pmc Human regulatory T cells of G-CSF mobilized allogeneic stem cell donors qualify for clinical application
    Sya N Ukena
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e51644. 2012
    ..Therefore, the adoptive transfer of Tregs from G-CSF mobilized SC donors seems to be a feasible and safe strategy for clinical application in allogeneic SCT...
  2. pmc Identification of novel regulators in T-cell differentiation of aplastic anemia patients
    Anke Franzke
    Department of Hematology, Hemostasis and Oncology, Hannover Medical School, Hannover, Germany
    BMC Genomics 7:263. 2006
    ..Two AA patients were additionally analyzed after achieving a partial remission following immunosuppression. The regulation of selected candidate genes was confirmed by real-time RT-PCR...
  3. ncbi request reprint G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases
    Anke Franzke
    Department of Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Blood 102:734-9. 2003
    ....
  4. ncbi request reprint Classical Hodgkin's lymphoma: molecular evidence for specific alterations in circulating T lymphocytes
    Anke Franzke
    Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Hannover, Germany
    Tumour Biol 27:329-33. 2006
    ..Here, we analyzed whether circulating T lymphocytes of cHL patients show specific alterations in gene expression with possible impact on anti-tumor immunity...
  5. ncbi request reprint Regulatory T-cells in the control of immunological diseases
    A Franzke
    Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Hannover, Germany
    Ann Hematol 85:747-58. 2006
    ..The therapeutical potential of Tregs to specifically suppress immune responses in autoimmunity and transplantation and their inhibitory effects in anti-tumor immune responses will be discussed...
  6. ncbi request reprint HLA phenotype and cytokine-induced tumor control in advanced renal cell cancer
    A Franzke
    Department of Hematology and Oncology, Medizinische Hochschule Hannover, Germany
    Cancer Biother Radiopharm 16:401-9. 2001
    ....
  7. pmc Prognostic impact of in vivo soluble cell adhesion molecules in metastatic renal cell carcinoma
    R Hoffmann
    Medizinische Hochschule Hannover, Department of Hematology and Oncology, Germany
    Br J Cancer 79:1742-5. 1999
    ..The possibility of defining a pretreatment risk model based on sICAM-1 level, ESR and CRP also warrants further investigation, with regard to a possible linkage between acute phase proteins and sICAM-1 levels...
  8. pmc Risk and outcome in metastatic malignant melanoma patients receiving DTIC, cisplatin, BCNU and tamoxifen followed by immunotherapy with interleukin 2 and interferon alpha2a
    R Hoffmann
    Department of Hematology and Oncology, Medizinische Hochschule Hannover, Germany
    Br J Cancer 78:1076-80. 1998
    ..Pretreatment risk, as defined by serum lactate dehydrogenase (LDH) and performance status, has a significant impact on treatment outcome and patient survival...
  9. pmc Elevated pretreatment serum levels of soluble vascular cell adhesion molecule 1 and lactate dehydrogenase as predictors of survival in cutaneous metastatic malignant melanoma
    A Franzke
    Department of Hematology and Oncology, Medizinische Hochschule Hanover, Germany
    Br J Cancer 78:40-5. 1998
    ....
  10. pmc Capecitabine in the treatment of metastatic renal cell carcinoma
    K Oevermann
    Department of Haematology and Oncology, Medizinische Hochshule Hannover, Carl Neuberg Strasse 1, Hannover, 30625, Germany
    Br J Cancer 83:583-7. 2000
    ..The substitution of capecitabine for 5-FU in the pre-existing biochemotherapy regimen did not result in a reduced therapeutic efficacy and showed significant anti-tumour activity in patients with advanced renal cell carcinoma...
  11. pmc Elevated serum levels of S100 and survival in metastatic malignant melanoma
    J Buer
    Department of Haematology and Oncology, Medizinische Hochschule Hannover, Germany
    Br J Cancer 75:1373-6. 1997
    ..Elevated serum levels of S100 correlated with poor outcome in metastatic malignant melanoma (P < 0.0001), univariate analysis). Upon multivariate analysis, however, S100 added no information to known clinical prognostic parameters...
  12. doi request reprint T helper type 2 differentiation is associated with induction of antibacterial defense mechanisms in blood lymphocytes of patients with sarcoidosis
    Sya N Ukena
    Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Germany
    Immunol Invest 38:49-66. 2009
    ..However, the results of our study indicate an unbalanced immune response towards Th2 in the peripheral blood of patients with sarcoidosis...
  13. doi request reprint Allogeneic stem cell transplantation from related and unrelated donors for aplastic anaemia in adults--a single-centre experience
    S Buchholz
    Zentrum Innere Medizin, Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzeltransplantation, Carl Neuberg Strasse 1, 30623, Hannover, Germany
    Ann Hematol 87:551-6. 2008
    ..Studies with greater cohorts of patients are warranted to better determine indication and timing of SCT especially from unrelated donors in AA...
  14. ncbi request reprint Comparative study of the acute nephrotoxicity from standard dose cisplatin +/- ifosfamide and high-dose chemotherapy with carboplatin and ifosfamide
    J T Hartmann
    Department of Hematology, Oncology, Immunology, UKT Medical Center II, University of Tubingen, Germany
    Anticancer Res 20:3767-73. 2000
    ..In the light of the long-term consequences of persistent renal damage prevention of nephrotoxicity should be further improved...
  15. pmc Pharmacokinetics of SDZ RAD and cyclosporin including their metabolites in seven kidney graft patients after the first dose of SDZ RAD
    G I Kirchner
    Institute for General Pharmacology, Medical School of Hannover, Germany
    Br J Clin Pharmacol 50:449-54. 2000
    ..Furthermore, we studied the influence of SDZ RAD on the pharmacokinetics of cyclosporin at steady state levels...
  16. ncbi request reprint Antigen-recognition sites of micromanipulated T cells in patients with acquired aplastic anemia
    Wenji Piao
    Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Germany
    Exp Hematol 33:804-10. 2005
    ..In order to investigate the clonal composition, we analyzed the gene rearrangements of the T cell receptor (TCR) variable beta chain (Vbeta) at the single-cell level...
  17. ncbi request reprint The role of G-CSF in adaptive immunity
    Anke Franzke
    Department of Hematology, Hemostasis and Oncology, Hannover Medical School, Hannover, Germany
    Cytokine Growth Factor Rev 17:235-44. 2006
    ..G-CSF represents a powerful and promising cytokine to promote T cell tolerance in pathological conditions associated with a TH1/TH2 imbalance...
  18. ncbi request reprint Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry
    G I Kirchner
    Institut fur Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Germany
    J Chromatogr B Biomed Sci Appl 721:285-94. 1999
    ..The mean recoveries of sirolimus and ciclosporin were 98 and 96%, respectively. The mean interday precision/accuracy was 8.6%/-4.8% for sirolimus and 9.3%/-2.9% for ciclosporin...
  19. doi request reprint Radioimmunotherapy with [188Re]-labelled anti-CD66 antibody in the conditioning for allogeneic stem cell transplantation for high-risk acute myeloid leukemia
    Christian Koenecke
    Department of Hematology, Hemostasis and Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Int J Hematol 87:414-21. 2008
    ..The combination of RIT with chemotherapeutic conditioning seems to be a therapy with an acceptable risk of treatment related morbidity and mortality as well as occurrence of severe acute GvHD...
  20. ncbi request reprint Inflammatory pseudotumor of the lung following invasive aspergillosis in a patient with chronic graft-vs.-host disease
    Constanze Priebe-Richter
    Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30623 Hannover, Germany
    Eur J Haematol 75:68-72. 2005
    ..Both clinical and radiographical signs resolved under long-term steroids and secondary antifungal prophylaxis...
  21. ncbi request reprint Regulatory T cells as therapeutic target in Hodgkin's lymphoma
    Christian Koenecke
    Hannover Medical School, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Carl Neuberg Street 1, D 30623, Hannover, Germany
    Expert Opin Ther Targets 12:769-82. 2008
    ..The clinical and pathological features of Hodgkin's lymphoma (HL) reflect an abnormal immune response that results from cytokines and chemokines secreted by Hodgkin/Reed-Sternberg (H/R-S) cells and/or the surrounding tissue...
  22. doi request reprint Pre T-cell receptor alpha (pTalpha) expression patterns and functional analysis in human T-cell lymphoblastic leukemia
    Philipp Ivanyi
    Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Medizinische Hochschule Hannover, Hannover, Germany
    Cell Oncol 32:101-8. 2010
    ..The pTalpha/preTCR regulates the beta-selection, a crucial T-cell developmental checkpoint, providing a most potent survival advantage to thymocytes mediated by the src-kinase p56(Lck)...
  23. pmc Signatures of human regulatory T cells: an encounter with old friends and new players
    Susanne Pfoertner
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Braunschweig, Germany
    Genome Biol 7:R54. 2006
    ..Thus far, genomic studies on TReg cells were restricted to murine systems, and requirements for their development, maintenance, and mode of action in humans are poorly defined...