D Fliser

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi Angiotensin II subtype 1-receptor antagonists in the treatment of diabetic nephropathy
    D Fliser
    Department of Internal Medicine, Hannover Medical School, Germany
    J Hypertens Suppl 19:S57-60. 2001
  2. ncbi Capillary electrophoresis coupled to mass spectrometry for clinical diagnostic purposes
    Danilo Fliser
    Medical School Hannover, Hannover, Germany
    Electrophoresis 26:2708-16. 2005
  3. ncbi [Modern differential therapy with diuretics]
    D Fliser
    Abteilung Nephrologie, Zentrum fur Innere Medizin, Medizinische Hochschule Hannover
    Internist (Berl) 45:598-605. 2004
  4. ncbi Technology Insight: treatment of renal failure in the intensive care unit with extended dialysis
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Clin Pract Nephrol 2:32-9. 2006
  5. ncbi Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study
    Danilo Fliser
    Department of Internal Medicine, Hannover Medical School, Germany
    J Am Soc Nephrol 18:2600-8. 2007
  6. ncbi Cardiovascular disease in renal patients--a matter of stem cells?
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Nephrol Dial Transplant 19:2952-4. 2004
  7. ncbi A single-pass batch dialysis system: an ideal dialysis method for the patient in intensive care with acute renal failure
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hannover, Germany
    Curr Opin Crit Care 10:483-8. 2004
  8. ncbi Asymmetric dimethylarginine (ADMA): the silent transition from an 'uraemic toxin' to a global cardiovascular risk molecule
    D Fliser
    Division Nephrol, Department of Int Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Eur J Clin Invest 35:71-9. 2005
  9. ncbi Insulin resistance and renal disease
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Contrib Nephrol 151:203-11. 2006
  10. ncbi Chronic angiotensin II receptor blockade reduces (intra)renal vascular resistance in patients with type 2 diabetes
    Danilo Fliser
    Department of Internal Medicine, Medical School Hannover, Germany
    J Am Soc Nephrol 16:1135-40. 2005

Collaborators

Detail Information

Publications89

  1. ncbi Angiotensin II subtype 1-receptor antagonists in the treatment of diabetic nephropathy
    D Fliser
    Department of Internal Medicine, Hannover Medical School, Germany
    J Hypertens Suppl 19:S57-60. 2001
    ..Currently, these drugs are a valuable substitute for angiotensin converting enzyme inhibitors in patients who experience side effects such as intractable cough...
  2. ncbi Capillary electrophoresis coupled to mass spectrometry for clinical diagnostic purposes
    Danilo Fliser
    Medical School Hannover, Hannover, Germany
    Electrophoresis 26:2708-16. 2005
    ..This review further presents examples of clinical applications of CE-MS for detection and identification of biomarkers in urine...
  3. ncbi [Modern differential therapy with diuretics]
    D Fliser
    Abteilung Nephrologie, Zentrum fur Innere Medizin, Medizinische Hochschule Hannover
    Internist (Berl) 45:598-605. 2004
    ..Aldosterone antagonists are unique among diuretics because they improve survival in patients with heart failure independently of their effect on sodium metabolism...
  4. ncbi Technology Insight: treatment of renal failure in the intensive care unit with extended dialysis
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Clin Pract Nephrol 2:32-9. 2006
    ....
  5. ncbi Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study
    Danilo Fliser
    Department of Internal Medicine, Hannover Medical School, Germany
    J Am Soc Nephrol 18:2600-8. 2007
    ..In conclusion, FGF23 is a novel independent predictor of progression of renal disease in patients with nondiabetic CKD. Its pathophysiological significance remains to be elucidated...
  6. ncbi Cardiovascular disease in renal patients--a matter of stem cells?
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Nephrol Dial Transplant 19:2952-4. 2004
  7. ncbi A single-pass batch dialysis system: an ideal dialysis method for the patient in intensive care with acute renal failure
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hannover, Germany
    Curr Opin Crit Care 10:483-8. 2004
    ..This review summarizes relevant information on these new hybrid techniques, and special attention is paid to the use of a single-pass batch dialysis system in the intensive care unit...
  8. ncbi Asymmetric dimethylarginine (ADMA): the silent transition from an 'uraemic toxin' to a global cardiovascular risk molecule
    D Fliser
    Division Nephrol, Department of Int Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Eur J Clin Invest 35:71-9. 2005
    ..being the culprit and not only an innocent biochemical marker of the atherosclerotic disease process...
  9. ncbi Insulin resistance and renal disease
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Contrib Nephrol 151:203-11. 2006
    ....
  10. ncbi Chronic angiotensin II receptor blockade reduces (intra)renal vascular resistance in patients with type 2 diabetes
    Danilo Fliser
    Department of Internal Medicine, Medical School Hannover, Germany
    J Am Soc Nephrol 16:1135-40. 2005
    ..In addition, it significantly reduces oxidative stress. These effects of angiotensin II receptor antagonists may contribute to their beneficial long-term renal effects in patients with type 2 diabetes...
  11. ncbi EPO: renoprotection beyond anemia correction
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Pediatr Nephrol 21:1785-9. 2006
    ....
  12. ncbi Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Circulation 110:1103-7. 2004
    ....
  13. ncbi Serum cystatin C concentration as a marker of renal dysfunction in the elderly
    D Fliser
    Division of Nephrology, Department of Internal Medicine, Ruperto Carola University Heidelberg, Germany
    Am J Kidney Dis 37:79-83. 2001
    ..30; P: < 0.02). Serum cystatin C concentration is a better marker of renal dysfunction (ie, reduced GFR) than plasma creatinine concentration, at least in elderly subjects with plasma creatinine concentrations within the normal range...
  14. ncbi Subpressor dose asymmetric dimethylarginine modulates renal function in humans through nitric oxide synthase inhibition
    J T Kielstein
    Department of Internal Medicine, Medical School Hannover, Germany
    Kidney Blood Press Res 27:143-7. 2004
    ..Whether chronic (intrarenal) NO synthase inhibition in individuals with increased ADMA blood levels may cause persistent renal vasoconstriction and sodium retention must be evaluated...
  15. doi Circulating angiopoietin-2 levels increase with progress of chronic kidney disease
    Sascha David
    Division of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 25:2571-6. 2010
    ..In addition, we aimed to detect a potential link between the nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) and the Ang-2 levels...
  16. ncbi Differential effects of ACE inhibitors and vasodilators on renal function curve in patients with primary hypertension
    D Fliser
    Department of Internal Medicine, University of Heidelberg, Germany
    Blood Press 2:296-300. 1993
    ....
  17. pmc Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Crit Care 14:R9. 2010
    ..The aim of this study was to evaluate the predictive value of serum NGAL in patients with established AKI at inception of RRT in the intensive care unit (ICU)...
  18. ncbi [Acute renal failure. Extracorporeal therapy]
    J T Kielstein
    Abteilung Nephrologie OE 6840, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 48:786-94. 2007
    ..Therefore, the choice of renal replacement therapy should be based on personal experience, the available resources/infrastructure as well as the needs of the individual patient...
  19. ncbi Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    Sajoscha A Sorrentino
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 116:163-73. 2007
    ....
  20. ncbi Low dialysance of asymmetric dimethylarginine (ADMA)--in vivo and in vitro evidence of significant protein binding
    J T Kielstein
    Division of Nephrology, Hannover Medical School, Hannover, Germany
    Clin Nephrol 62:295-300. 2004
    ..Despite its low molecular weight, available information on the impact of hemodialysis (HD) on ADMA plasma levels is controversial...
  21. ncbi Renal handling of drugs in the healthy elderly. Creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged
    D Fliser
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Eur J Clin Pharmacol 55:205-11. 1999
    ..Endogenous creatinine clearance or indirect estimates of this parameter are generally recommended for adapting drug dosage. The present study evaluates the validity of both assumptions...
  22. ncbi Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease
    Jan T Kielstein
    Department of Internal Medicine and Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany
    J Am Soc Nephrol 13:170-6. 2002
    ..Thus, the early increase of ADMA levels may be of relevance for the excess cardiovascular morbidity and mortality due to arterio- and atherosclerotic complications in patients with renal disease...
  23. ncbi Increased resistin blood levels are not associated with insulin resistance in patients with renal disease
    Jan T Kielstein
    Department of Internal Medicine, Division of Nephrology, Medical School Hannover, Hannover, Germany
    Am J Kidney Dis 42:62-6. 2003
    ..Resistin is a newly discovered insulin inhibitor secreted by adipocytes. We explored the potential role of resistin in the pathophysiological process of insulin resistance encountered in patients with renal disease...
  24. doi Angiotensin II receptor blocker and statins lower elevated levels of osteopontin in essential hypertension--results from the EUTOPIA trial
    Johan M Lorenzen
    Department of Medicine Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Atherosclerosis 209:184-8. 2010
    ..We aimed at studying the effect of olmesartan and/or pravastatin on osteopontin plasma levels, and the association between vascular inflammation markers and osteopontin in hypertensive patients...
  25. ncbi Pathophysiology of hypertensive renal damage
    E Ritz
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Am J Hypertens 6:241S-244S. 1993
    ..Several studies have provided encouraging evidence that antihypertensive therapy, particularly with angiotensin-converting enzyme inhibitors or calcium antagonists, can slow the progression of renal damage...
  26. ncbi Mechanisms of disease: erythropoietin--an old hormone with a new mission?
    Danilo Fliser
    Hannover Medical School, Hannover, Germany
    Nat Clin Pract Cardiovasc Med 3:563-72. 2006
    ..This review article summarizes the present knowledge on the cardiovascular and renal protective effects of erythropoietin and discusses the possible underlying mechanisms...
  27. ncbi Pharmacokinetics of moxifloxacin and levofloxacin in intensive care unit patients who have acute renal failure and undergo extended daily dialysis
    David Czock
    Division of Nephrology, University Hospital Ulm, Ulm, Germany
    Clin J Am Soc Nephrol 1:1263-8. 2006
    ..The levofloxacin dosage, however, should be reduced according to the intensity of renal replacement therapy...
  28. doi Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease
    Johan Lorenzen
    Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Eur J Clin Invest 40:294-300. 2010
    ..Therefore, we assessed the relationship between OPN plasma levels and renal function in patients at different stages of chronic kidney disease (CKD)...
  29. ncbi Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects
    Jan T Kielstein
    Department of Internal Medicine, Medical School Hannover, Germany
    Circulation 107:1891-5. 2003
    ....
  30. ncbi A hibernating kidney - ischemic preconditioning in a renal transplant recipient with a proximal stenosis of the iliac artery
    J Warncke
    Department of Internal Medicine Nephrology, Medical School Hannover, Germany
    Clin Nephrol 70:168-71. 2008
    ..Referring to the definition of hibernating myocardium, here we postulate a case of a hibernating kidney in context of ischemic preconditioning...
  31. ncbi Vascular endothelial damage and repair in antineutrophil cytoplasmic antibody-associated vasculitis
    K de Groot
    Hannover Medical School, Hannover, Germany
    Arthritis Rheum 56:3847-53. 2007
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to play a pivotal role in the regeneration of damaged endothelium. The aim of this study was to investigate whether EPCs are involved in vascular repair in AAV...
  32. ncbi Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure
    J T Kielstein
    University, Magdeburg, Magdeburg, Medical School Hannover, Germany
    Eur J Clin Invest 33:370-5. 2003
    ..Patients with heart failure are characterized by impaired nitric oxide-dependent endothelial vasodilation and, in addition, by reduced renal perfusion...
  33. ncbi One for all--a multi-use dialysis system for effective treatment of severe thallium intoxication
    J T Kielstein
    Division of Nephrology, Medical School Hanover, Germany
    Kidney Blood Press Res 27:197-9. 2004
    ..Furthermore, they can also be a safer, more effective and less costly alternative to traditional extracorporeal techniques in the treatment of severe intoxication. In a case-based approach, we review the increasing use of such a system...
  34. ncbi [Fulminant course of leptospirosis complicated by multiple organ failure]
    G I Kirchner
    Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover
    Z Gastroenterol 39:587-92. 2001
    ..4 weeks later he was able to return to work. The only residuum of this illness is a partial paresis of his right quadriceps muscle...
  35. ncbi [Regeneration of renal tissue -- therapy of the future?]
    H Haller
    Abteilung für Nephrologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 131:896-8. 2006
  36. ncbi Erythropoietin and treatment of non-anemic conditions--cardiovascular protection
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Semin Hematol 44:212-7. 2007
    ..This review article summarizes present knowledge of cardiovascular and renal protective effects of EPO and discusses possible underlying mechanisms...
  37. ncbi Pharmacokinetics and total elimination of meropenem and vancomycin in intensive care unit patients undergoing extended daily dialysis
    Jan T Kielstein
    Department of Medicine, Division of Nephrology, Medical School Hannover, Hannover, Germany
    Crit Care Med 34:51-6. 2006
    ..The aim of this study was to evaluate pharmacokinetics of meropenem and vancomycin in critically ill patients with renal failure undergoing EDD...
  38. ncbi Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers
    Jan Menne
    Department of Internal Medicine, Medical School Hannover, Carl Neuberg Strasse 1, Hannover 30625, Germany
    FASEB J 20:994-6. 2006
    ..These effects may result, at least in part, from inhibition of tissue inflammation as well as improved NO bioavailability. Modulation of PKC activity may be an important underlying intracellular mechanism...
  39. pmc Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages
    Faikah Gueler
    Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Am J Pathol 170:1192-9. 2007
    ..We hypothesize that local delivery of HO-1 from infiltrating macrophages exerts anti-inflammatory effects after IR injury and thereby may reduce tissue destruction...
  40. doi Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin
    Sascha David
    Department of Medicine, Division of Nephrology and Hypertension, Medical School Hanover, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    J Hypertens 27:1641-7. 2009
    ..We aimed at studying the effect of ARB and/or 3-hydroxy-3-methyl-glutaryl-CoA blockade on Ang-2 and the association between vascular inflammation markers and Ang-2 levels in hypertensive patients...
  41. ncbi Diagnostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for left ventricular dysfunction in patients with chronic kidney disease stage 5 on haemodialysis
    Sascha David
    Department of Nephrology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nephrol Dial Transplant 23:1370-7. 2008
    ..We hypothesized that a serum NT-proBNP cut-off value adjusted for patients with CKD could serve as a biochemical marker to detect LVD in patients on haemodialysis treatment regardless of chronic fluid overload...
  42. pmc Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, D 30171, Germany
    Crit Care 12:R147. 2008
    ..Here, we examine whether circulating Ang-1 and/or Ang-2 independently predict mortality in a cohort of critically ill medical patients...
  43. doi Erythropoietin prevents diabetes-induced podocyte damage
    Mario Schiffer
    Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Kidney Blood Press Res 31:411-5. 2008
    ..We studied the effects of different EPO molecules on podocyte signaling in vitro and on podocyte survival in an experimental model of diabetic kidney injury (db/db mouse)...
  44. doi Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Intensive Care Med 36:462-70. 2010
    ....
  45. doi Removal of asymmetric dimethylarginine during artificial liver support using fractionated plasma separation and adsorption
    Kinan Rifai
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Scand J Gastroenterol 45:1110-5. 2010
    ..Prometheus is an extracorporeal liver support system which allows the removal of protein-bound toxins. We assessed the efficiency of the Prometheus system in reducing high ADMA levels in patients with liver failure...
  46. pmc Endothelial progenitor cells and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study
    Johan Lorenzen
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    PLoS ONE 5:e11477. 2010
    ..Endothelial progenitor cells (EPCs) mediate vascular repair and regeneration. Their number in peripheral blood is related to cardiovascular events in individuals with normal renal function...
  47. ncbi Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 16:2456-61. 2005
    ..The endogenous NO synthase inhibitor ADMA is significantly associated with progression of nondiabetic kidney diseases. Lowering plasma ADMA concentrations may be a novel therapeutic target to prevent progressive renal impairment...
  48. ncbi Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure
    Ferdinand H Bahlmann
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Circulation 110:1006-12. 2004
    ....
  49. ncbi Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study
    Bjoern Becker
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 16:1091-8. 2005
    ..Moreover, hypoadiponectinemia is a novel putative CV risk factor in patients with mild and moderate renal failure...
  50. ncbi Kidney graft function determines endothelial progenitor cell number in renal transplant recipients
    Kirsten de Groot
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, 30625 Hannover, Germany
    Transplantation 79:941-5. 2005
    ..In uremic patients, the number of functionally active EPCs is reduced. Thus, we assessed EPCs in stable patients 6 months or more after renal transplantation...
  51. ncbi Proteomic analysis for the assessment of diabetic renal damage in humans
    Harald Mischak
    Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany
    Clin Sci (Lond) 107:485-95. 2004
    ..Longitudinal studies should explore the potential of this powerful diagnostic tool for early detection of diabetic renal damage...
  52. ncbi Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 111:2356-63. 2005
    ..We therefore tested the hypothesis that similar reductions in LDL cholesterol with simvastatin and ezetimibe, a novel cholesterol absorption inhibitor, result in different effects on endothelial function...
  53. ncbi Uremia causes endothelial progenitor cell deficiency
    Kirsten de Groot
    Division of Nephrology, Department of Internal Medicine Hannover Medical School, Hannover, Germany
    Kidney Int 66:641-6. 2004
    ..Their number in peripheral blood correlates with endothelial function and cardiovascular risk in humans. We explored whether uremia influences the number of EPCs...
  54. ncbi Stimulation of endothelial progenitor cells: a new putative therapeutic effect of angiotensin II receptor antagonists
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hanover, Germany
    Hypertension 45:526-9. 2005
    ..Angiotensin II receptor antagonists increase the number of regenerative EPCs in patients with type 2 diabetes mellitus. This action may be of therapeutic relevance contributing to their beneficial cardiovascular effects...
  55. ncbi Stem cells and progenitor cells in renal disease
    Hermann Haller
    Department of Nephrology, Hannover Medical School, Germany
    Kidney Int 68:1932-6. 2005
    ..Such animal models improve our understanding of stem cell behavior in the kidney and may eventually contribute to novel therapies...
  56. ncbi Erythropoietin regulates endothelial progenitor cells
    Ferdinand H Bahlmann
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Blood 103:921-6. 2004
    ..Erythropoietin increases the number of functionally active EPCs in humans. Administration of rhEPO or EPO analogs may open new therapeutic strategies in regenerative cardiovascular medicine...
  57. ncbi Identification of urinary protein pattern in type 1 diabetic adolescents with early diabetic nephropathy by a novel combined proteome analysis
    Matthias Meier
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover D 30625, Germany
    J Diabetes Complications 19:223-32. 2005
    ..Future prospective studies with the application of this technique may enable the earlier and more accurate detection of individuals at high risk to develop diabetic nephropathy...
  58. ncbi Efficacy and cardiovascular tolerability of extended dialysis in critically ill patients: a randomized controlled study
    Jan T Kielstein
    Department of Internal Medicine, Division of Nephrology, Medical School Hannover, Hannover, Germany
    Am J Kidney Dis 43:342-9. 2004
    ..Extended dialysis is an increasingly used modality of renal replacement therapy that theoretically offers advantages of both intermittent and continuous therapies in the intensive care unit (ICU)...
  59. ncbi Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hanover, Germany
    Kidney Int 64:1648-52. 2003
    ..We tested the hypothesis that darbepoetin alfa [i.e., a recombinant analogue of the cytokine erythropoietin (EPO)] stimulates proliferation and differentiation of EPCs...
  60. ncbi Efficiency of high-flux hemodialysis in the treatment of valproic acid intoxication
    J T Kielstein
    Division of Nephrology, Department of Clinical Chemistry, Medical School Hannover, Hannover, Germany
    J Toxicol Clin Toxicol 41:873-6. 2003
    ..Concentration of VPA in the total collected dialysate were measured...
  61. doi Chronic erythropoietin treatment affects different molecular pathways of diabetic cardiomyopathy in mouse
    N Shushakova
    Department of Internal Medicine, Hanover Medical School, Hanover, Germany
    Eur J Clin Invest 39:755-60. 2009
    ..We therefore explored the tissue-protective properties of chronic EPO treatment in an experimental model of the db/db mouse with diabetic heart injury...
  62. doi Pharmacokinetics of ertapenem in critically ill patients with acute renal failure undergoing extended daily dialysis
    Olaf Burkhardt
    Department of Pulmonary Medicine, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 24:267-71. 2009
    ..The aim of this study was to evaluate pharmacokinetics (PK) of ertapenem, the newest carbapenem with once-daily dosing, in critically ill patients with anuric acute renal failure (ARF) undergoing EDD. Patients and..
  63. ncbi Capillary electrophoresis coupled to mass spectrometer for automated and robust polypeptide determination in body fluids for clinical use
    Thorsten Kaiser
    Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany
    Electrophoresis 25:2044-55. 2004
    ..CE-MS detects many polypeptides in single samples and the application of the software to the search of identical polypeptides excreted in urine allows the unbiased diagnosis based on a pattern and does not rely on single disease markers...
  64. ncbi Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans
    Jan T Kielstein
    Department of Internal Medicine, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Circulation 109:172-7. 2004
    ..We evaluated systemic cardiovascular effects of ADMA infusion in healthy subjects using invasive techniques, ie, right heart catheter and inulin/para-aminohippurate clearance...
  65. ncbi The continuous erythropoietin receptor activator affects different pathways of diabetic renal injury
    Jan Menne
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Am Soc Nephrol 18:2046-53. 2007
    ..Long-term CERA treatment has beneficial dosage-dependent effects on molecular pathways of diabetic kidney damage. Low-dosage CERA does not affect hematocrit and therefore may be a feasible method of tissue protection in this setting...
  66. ncbi Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes
    Eva M Weissinger
    Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany
    Kidney Int 65:2426-34. 2004
    ..Proteomics applied in large scale may provide a useful diagnostic tool...
  67. ncbi Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension
    Jan T Kielstein
    Department of Internal Medicine, Division of Nephrology, Medical School Hannover, Hannover, Germany
    Arterioscler Thromb Vasc Biol 25:1414-8. 2005
    ..ADMA infusion in healthy volunteers increased pulmonary vascular resistance (68.9+/-7.6 versus 95.6+/-6.3 dyne x s x cm(-5); P<0.05) and decreased stroke volume (101.1+/-6.7 mL versus 95.6+/-6.3 mL; P<0.05)...
  68. ncbi Determination of peptides and proteins in human urine with capillary electrophoresis-mass spectrometry, a suitable tool for the establishment of new diagnostic markers
    Stefan Wittke
    Mosaiques Diagnostics and Therapeutics AG, Feodor Lynen Strasse 5, 30625 Hannover, Germany
    J Chromatogr A 1013:173-81. 2003
    ..Twenty-seven polypeptides were exclusively found in samples of patients. Another 13, present in controls, were missing. These data indicate that CE-MS can be applied as powerful tool in clinical diagnostics...
  69. ncbi Serum lipid changes on low salt diet. Effects of alpha 1-adrenergic blockade
    D Fliser
    Division of Nephrology, Ruperto-Carola University, Heidelberg, Germany
    Am J Hypertens 6:320-4. 1993
    ..The results confirm previous findings that levels of total cholesterol and LDL-cholesterol change inversely with salt intake in normotensive healthy volunteers.(ABSTRACT TRUNCATED AT 250 WORDS)..
  70. ncbi Biocompatibility parameters of different dialysis membranes assessed during systemic inflammation
    F Gueler
    Department of Internal Medicine, Medical School Hannover, DE 30625 Hannover, Germany
    Blood Purif 23:196-202. 2005
    ..We explored whether biocompatible dialyzer membranes modulate the inflammatory response during blood contact in patients with systemic inflammation...
  71. ncbi Erythropoietin: is it more than correcting anaemia?
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Nephrol Dial Transplant 19:20-2. 2004
  72. ncbi [Kidney and hypertension]
    Jan Menne
    Abteilung für Nephrologie, Medizinische Hochschule Hannover, Hannover
    Herz 31:317-21. 2006
    ..Several therapeutic intervention strategies affecting these mechanisms have already proven to be effective antihypertensive drugs...
  73. doi The Hannover Dialysis Outcome study: comparison of standard versus intensified extended dialysis for treatment of patients with acute kidney injury in the intensive care unit
    Robert Faulhaber-Walter
    Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 24:2179-86. 2009
    ..We therefore aimed to assess mortality and renal recovery of patients with AKI receiving either standard (SED) or intensified extended dialysis (IED) therapy in the intensive care unit...
  74. ncbi Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?
    Jan T Kielstein
    Department of Internal Medicine, Medical School Hannover, Germany
    Nephrol Dial Transplant 18:1245-8. 2003
  75. ncbi The past, presence and future of ADMA in nephrology
    Jan T Kielstein
    Division of Nephrology, Department of Internal Medicine, Medical School Hannover, 1, Carl Neuberg Strasse, 30625 Hannover, Germany
    Nephrol Ther 3:47-54. 2007
    ..We conclude with remarks on the usefulness of ADMA as a marker in the clinical setting as well as for emerging therapeutic strategies...
  76. ncbi Capillary electrophoresis coupled to mass spectrometry to establish polypeptide patterns in dialysis fluids
    Thorsten Kaiser
    Mosaiques Diagnostics and Therapeutics AG, Feodor Lynen Strasse 5, 30625 Hannover, Germany
    J Chromatogr A 1013:157-71. 2003
    ..We established a fast and sensitive technique, easily applicable to the monitoring of different modalities of dialyzers...
  77. doi Asymmetric dimethylarginine and symmetric dimethylarginine: axis of evil or useful alliance?
    Jan T Kielstein
    Department of Internal Medicine, Division of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Semin Dial 22:346-50. 2009
    ..We also allude to the potential physiological role these substances might have...
  78. ncbi ADMA increases arterial stiffness and decreases cerebral blood flow in humans
    Jan T Kielstein
    Department of Nephrology, Medical School, Hannover, Germany
    Stroke 37:2024-9. 2006
    ..The aim of this study was to investigate the influence of a systemic subpressor dose of ADMA on arterial stiffness and cerebral perfusion in humans...
  79. doi Toll-like receptor 2 and renal allograft function
    Kirsten de Groot
    Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Am J Nephrol 28:583-8. 2008
    ..Toll-like receptors (TLR) modulate the immune response. We analyzed the relationships between TLR expression in renal tissue with infection, rejection and graft function after kidney transplantation...
  80. doi Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The Mild to Moderate Kidney Disease (MMKD) Study
    Gisela Sturm
    Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Exp Gerontol 43:347-52. 2008
    ..In summary, our prospective 7 year follow-up study in patients with non-diabetic primary CKD did not support uric acid as an independent predictor for CKD progression...
  81. ncbi Symmetric dimethylarginine (SDMA) as endogenous marker of renal function--a meta-analysis
    Jan T Kielstein
    Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5406, USA
    Nephrol Dial Transplant 21:2446-51. 2006
    ..The purpose of this analysis was to identify the role of symmetric dimethylarginine (SDMA), the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function...
  82. ncbi Combined top-down and bottom-up mass spectrometric approach to characterization of biomarkers for renal disease
    Michael J Chalmers
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, 32310 4005, USA
    Anal Chem 77:7163-71. 2005
    ..Critically, we maintain connectivity between the CE TOF MS data and the ICR data used for biomarker identification...
  83. ncbi Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine
    Dan Theodorescu
    Paul Mellon Prostate Cancer Institute, University of Virginia, Charlottesville, VA 22908, USA
    Electrophoresis 26:2797-808. 2005
    ..In conclusion, this early pilot study suggests that CE-MS of urine warrants further investigation as a tool that can identify putative biomarkers for CaP...
  84. ncbi Advances in urinary proteome analysis and biomarker discovery
    Danilo Fliser
    Mosaiques Diagnostics and Therapeutics AG, Mellendorfer Strasse 7 9, D 30625 Hannover, Germany
    J Am Soc Nephrol 18:1057-71. 2007
    ..It is predicted that proteomics will play an important role in clinical nephrology in the very near future and that this progress will require interactive dialogue and collaboration between clinicians and analytical specialists...
  85. ncbi Ren sanus in corpore sano: the myth of the inexorable decline of renal function with senescence
    Danilo Fliser
    Nephrol Dial Transplant 20:482-5. 2005
  86. ncbi Lowering asymmetric dimethylarginine--a new mechanism mediating the renoprotective effects of renin-angiotensin system inhibitors in proteinuric patients?
    Jan T Kielstein
    Blood Purif 25:324-6. 2007
  87. ncbi B-type natriuretic peptide concentrations predict the progression of nondiabetic chronic kidney disease: the Mild-to-Moderate Kidney Disease Study
    Katharina Susanne Spanaus
    Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem 53:1264-72. 2007
    ..We examined the relevance of BNP and NT-proBNP as predictors of CKD progression...
  88. ncbi Apolipoprotein A-IV predicts progression of chronic kidney disease: the mild to moderate kidney disease study
    Eva Boes
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schopfstrasse 41, A 6020 Innsbruck, Austria
    J Am Soc Nephrol 17:528-36. 2006
    ..In summary, this prospective study in patients with nondiabetic primary kidney disease demonstrated that apolipoprotein A-IV concentration is a novel independent predictor of progression...
  89. ncbi Removal selectivity of Prometheus: a new extracorporeal liver support device
    Kinan Rifai
    Division of Gastroenterology, Hepatology and Endocrinology, Department of Internal Medicine, Medical School Hannover, Carl Neuberg Strasse 1, Hannover 30625, Germany
    World J Gastroenterol 12:940-4. 2006
    ..To evaluate whether treatment with the Prometheus reg system significantly affects cytokines, coagulation factors and other plasma proteins...