P Flemming

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Donor origin of de novo hepatocellular carcinoma in hepatic allografts
    Peer Flemming
    Institut fur Pathologie, Medizinische Hochschule Hannover, Hannover, Germany
    Transplantation 76:1625-7. 2003
  2. ncbi request reprint Benign cystic mesothelioma of the liver
    Peer Flemming
    Institut fuer Pathologie, Medizinische Hochschule Hannover, Germany
    Am J Surg Pathol 26:1523-7. 2002
  3. ncbi request reprint [Histopathological diagnosis of primary liver tumors]
    P Flemming
    Institut fur Pathologie, Medizinische, Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Pathologe 22:184-90. 2001
  4. ncbi request reprint Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype
    P Flemming
    Institut fur Pathologie, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 32:213-7. 2000
  5. ncbi request reprint Arterial chemoembolization before liver transplantation in patients with hepatocellular carcinoma: marked tumor necrosis, but no survival benefit?
    K J Oldhafer
    Klinik fur Abdominal und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany
    J Hepatol 29:953-9. 1998
  6. ncbi request reprint Differentiation of liver cell adenomas from well-differentiated hepatocellular carcinomas by comparative genomic hybridization
    L Wilkens
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Pathol 193:476-82. 2001
  7. ncbi request reprint Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C
    R Lichtinghagen
    Department of Clinical Chemistry, Medizinische Hochschule, Hannover, Germany
    J Hepatol 34:239-47. 2001
  8. ncbi request reprint [The monthly interesting case--Case No. 54. Chondrosarcoma of the larynx]
    B Schwab
    HNO Klinik der Medizinischen Hochschule Hannover, Germany
    Laryngorhinootologie 81:591-3. 2002
  9. ncbi request reprint [Clubbed fingers and dysphagia in a 38-year-old patient]
    C P Strassburg
    Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 43:99-104. 2002
  10. ncbi request reprint [The monthly interesting case--case no. 51. Tuberculoid mastoiditis on the right side]
    B Schwab
    HNO Klinik der Medizinischen Hochschule Hannover, Germany
    Laryngorhinootologie 81:60-2. 2002

Detail Information

Publications51

  1. ncbi request reprint Donor origin of de novo hepatocellular carcinoma in hepatic allografts
    Peer Flemming
    Institut fur Pathologie, Medizinische Hochschule Hannover, Hannover, Germany
    Transplantation 76:1625-7. 2003
    ..Because recent data demonstrated a mixed hepatocellular chimerism caused by the integration of host-derived stem cells, a study was conducted on the origin of tumor cells in de novo HCC...
  2. ncbi request reprint Benign cystic mesothelioma of the liver
    Peer Flemming
    Institut fuer Pathologie, Medizinische Hochschule Hannover, Germany
    Am J Surg Pathol 26:1523-7. 2002
  3. ncbi request reprint [Histopathological diagnosis of primary liver tumors]
    P Flemming
    Institut fur Pathologie, Medizinische, Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Pathologe 22:184-90. 2001
    ....
  4. ncbi request reprint Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype
    P Flemming
    Institut fur Pathologie, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 32:213-7. 2000
    ..The epithelioid subtype may give rise to intrahepatic metastasis...
  5. ncbi request reprint Arterial chemoembolization before liver transplantation in patients with hepatocellular carcinoma: marked tumor necrosis, but no survival benefit?
    K J Oldhafer
    Klinik fur Abdominal und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany
    J Hepatol 29:953-9. 1998
    ..This study aimed to investigate whether preoperative chemoembolization not only induces marked tumor necrosis but also has a survival benefit...
  6. ncbi request reprint Differentiation of liver cell adenomas from well-differentiated hepatocellular carcinomas by comparative genomic hybridization
    L Wilkens
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Pathol 193:476-82. 2001
    ..CGH is therefore helpful in distinguishing between LCA and well-differentiated HCC. Detection of one or more of the six most frequent aberrations in HCC supports the diagnosis of carcinoma and makes LCA unlikely...
  7. ncbi request reprint Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C
    R Lichtinghagen
    Department of Clinical Chemistry, Medizinische Hochschule, Hannover, Germany
    J Hepatol 34:239-47. 2001
    ..The relation of hepatic TIMP and MMP mRNA levels to disease stage and inflammatory activity underlines their potential as diagnostic markers in chronic liver disease...
  8. ncbi request reprint [The monthly interesting case--Case No. 54. Chondrosarcoma of the larynx]
    B Schwab
    HNO Klinik der Medizinischen Hochschule Hannover, Germany
    Laryngorhinootologie 81:591-3. 2002
  9. ncbi request reprint [Clubbed fingers and dysphagia in a 38-year-old patient]
    C P Strassburg
    Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 43:99-104. 2002
  10. ncbi request reprint [The monthly interesting case--case no. 51. Tuberculoid mastoiditis on the right side]
    B Schwab
    HNO Klinik der Medizinischen Hochschule Hannover, Germany
    Laryngorhinootologie 81:60-2. 2002
  11. pmc Diagnostic impact of fluorescence in situ hybridization in the differentiation of hepatocellular adenoma and well-differentiated hepatocellular carcinoma
    L Wilkens
    Department of Pathology, Hanover Medical School, Hanover, Germany
    J Mol Diagn 3:68-73. 2001
    ..Thus, FISH for chromosomes 1 and 8, extended by probes for chromosomes 6, 7 and X, represents a promising approach toward a more accurate differentiation between hepatocellular adenoma and carcinoma...
  12. ncbi request reprint [Spontaneous bleeding of focal nodular hyperplasia as a rare cause of acute abdomen]
    M Behrend
    Klinik für Viszeral und Transplantationschirurgie, Medizinische Hochschule Hannover
    Chirurg 72:1201-4. 2001
    ..Spontaneous complications are rare. When the diagnosis is known with reasonable accuracy, a nonoperative approach is in common use. We report here the rare case of spontaneous intraabdominal bleeding from FNH...
  13. ncbi request reprint Uncommon metastasis of a glioblastoma multiforme in liver and spleen
    A Widjaja
    Department of Gastroenterology and Hepatology, Hannover Medical School, Germany
    Digestion 61:219-22. 2000
    ..This rare case of an intracerebral glioblastoma metastasizing to liver and spleen was managed by systemic chemotherapy...
  14. ncbi request reprint Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated
    J Wiegand
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Z Gastroenterol 42:15-8. 2004
    ..The recently FDA approved nucleoside analogue adefovir dipivoxil has potent antiviral activity against lamivudine-resistant mutants and can prevent viral replication effectively...
  15. ncbi request reprint Subacute liver failure induced by phenprocoumon treatment
    H Mix
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    Digestion 60:579-82. 1999
    ..Because of the widespread use of oral anticoagulants, not only bleeding complications but also hepatotoxicity should be considered in therapy supervision...
  16. ncbi request reprint [Congenital absence of the portal vein (CAPV). Two cases of Abernethy malformation type 1 and review of the literature]
    K Ringe
    Abteilung Diagnostische Radiologie, Medizinische Hochschule Hannover, Carl Neuberg Strabe 1, 30625, Hannover
    Radiologe 48:493-502. 2008
    ..We report two cases diagnosed with a type 1 shunt, hepatic encephalopathy, and associated liver tumors who underwent successful liver transplantation after having considered all therapeutic options...
  17. ncbi request reprint [Severe drug hepatitis caused by Chelidonium]
    K Rifai
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover
    Internist (Berl) 47:749-51. 2006
    ..As no autoantibodies were detectable, an idiosyncratic reaction as the cause of drug-induced hepatitis is probable. In cases of unknown hepatitis, herbal medications should be taken into account as a possible cause...
  18. ncbi request reprint Steroid treatment for severe acute cryptogenic hepatitis
    A Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Z Gastroenterol 45:15-9. 2007
    ..Acute cryptogenic hepatitis may represent both a self-limited disease as well as the onset of chronic hepatitis. The aim of this analysis was to evaluate the effect of steroid treatment in patients with acute cryptogenic hepatitis...
  19. pmc Hepatic metastases from leiomyosarcoma: A single-center experience with 34 liver resections during a 15-year period
    H Lang
    Klinik fur Abdominal und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
    Ann Surg 231:500-5. 2000
    ..To describe a large single-center experience with hepatic resection for metastatic leiomyosarcoma...
  20. ncbi request reprint [Intestinal tuberculosis: Easier overlooked than diagnosed]
    M N Göke
    Abteilung Gastroenterologie und Hepatologie, Hannover, Germany
    Z Gastroenterol 39:1015-22. 2001
    ..Diagnosis of intestinal tuberculosis is made by identification of the causative microorganism in tissue specimens. As this may be difficult and time-consuming, a therapeutic trial with anti-tuberculous agents may be warranted...
  21. ncbi request reprint [An older female patient with refractory anemia and hemochromatosis]
    G C Sutor
    Abteilung Pneumologie, Hannover, Germany
    Dtsch Med Wochenschr 127:1754-8. 2002
    ..However, complete regression of organ siderosis was achieved by deferoxamine administration. The myelodysplastic syndrome itself did not show any progression even 7 years after the diagnosis was established...
  22. ncbi request reprint [Malignant transformation of a juvenile papilloma in a 11 year old boy]
    A Lesinski-Schiedat
    Klinik und Poliklinik der Medizinischen Hochschule Hannover für Hals, Nasen, Ohrenheilkunde, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Laryngorhinootologie 84:602-7. 2005
    ..g. nicotine). Similar reports of a malignant transformation of juvenile papillomas without additional risk factors is very rarely reported...
  23. pmc Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma
    Ludwig Wilkens
    Institutes of Cell and Molecular Pathology and Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 101:1309-14. 2004
    ..In conclusion, CIN may induce a stepwise increase of aneuploidy in HCC that is mirrored by the morphological dedifferentiation of tumor cells...
  24. ncbi request reprint Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma
    Ruben R Plentz
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Germany
    Hepatology 40:80-6. 2004
    ..In conclusion, our data suggest that the telomere hypothesis of cancer initiation applies to human HCC and that cell type-specific telomere length analysis might indicate the risk of HCC development...
  25. ncbi request reprint Epigenetic defects of hepatocellular carcinoma are already found in non-neoplastic liver cells from patients with hereditary haemochromatosis
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Hum Mol Genet 16:1335-42. 2007
    ..Thus, changes in DNA methylation patterns are an early event preceding morphological alterations of malignant transformation and represent promising targets for early detection...
  26. doi request reprint Gene expression profiling in hepatocellular carcinoma: upregulation of genes in amplified chromosome regions
    Britta Skawran
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Mod Pathol 21:505-16. 2008
    ..Expression analysis and comparative genomic hybridisation identified an upregulation of genes in amplified regions of 1q. These results may serve to further narrow down the number of candidate driver genes in hepatocarcinogenesis...
  27. ncbi request reprint Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling
    Ulrich Lehmann
    Institute of Pathology, Institute of Cell and Molecular Pathology, and Department of Visceral and Transplantation Surgery, Medizinische Hochschule Hannover, Hanover, Germany
    Clin Cancer Res 11:3654-60. 2005
    ..A comparative quantitative methylation profiling of hepatocellular carcinoma and the most frequent benign liver tumor, hepatocellular adenoma, was set up for the identification of tumor-specific methylation patterns...
  28. ncbi request reprint Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma
    Ruben R Plentz
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
    Hepatology 42:522-6. 2005
    ..In conclusion, our study gives direct evidence that telomere shortening is linked to a specific genetic alteration characteristic for human HCC...
  29. ncbi request reprint Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridization
    Doris Steinemann
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Clin Gastroenterol Hepatol 4:1283-91. 2006
    ....
  30. ncbi request reprint Donor origin of de novo hepatocellular carcinoma in hepatic allografts
    Peer Flemming
    Institut fur Pathologie, Institut fuer Pathologie, Medizinische Hochschule Hannover, Germany Flemming Peer mh hannover de
    Transplantation 76:871-3. 2003
    ..Because recent data demonstrated a mixed hepatocellular chimerism caused by the integration of host-derived stem cells, a study was conducted on the origin of tumor cells in de novo HCC...
  31. ncbi request reprint Comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) in the diagnosis of hepatocellular carcinoma
    Ludwig Wilkens
    Department of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Hepatobiliary Pancreat Surg 9:304-11. 2002
    ..Whether molecular cytogenetic analysis can contribute to the differential diagnosis of HCC was recently investigated by our group...
  32. ncbi request reprint Detection of chromosomal imbalances in hepatocellular carcinoma
    Ludwig Wilkens
    Institute of Cell and Molecular Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Expert Rev Mol Diagn 2:120-8. 2002
    ..These techniques allow the detection of genetic gains and losses of defined chromosomes in a histopathological context and can serve as a helpful tool in establishing diagnosis of liver cell proliferation...
  33. ncbi request reprint Detection of chromosomal aberrations in well-differentiated hepatocellular carcinoma by bright-field in situ hybridization
    Ludwig Wilkens
    Department of Pathology, Medizinische Hochschule, Hannover, Germany
    Mod Pathol 15:470-5. 2002
    ..Registration of imbalances contributes to a reliable differentiation between malignant and nonmalignant lesions of the liver...
  34. ncbi request reprint Lamivudine transiently reduces viral load and improves liver function in liver transplant recipients with fibrosing cholestatic hepatitis
    Hans L Tillmann
    Am J Gastroenterol 97:777-8. 2002
  35. ncbi request reprint Successful treatment of fibrosing cholestatic hepatitis using adefovir dipivoxil in a patient with cirrhosis and renal insufficiency
    Hans L Tillmann
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Liver Transpl 9:191-6. 2003
    ..Adefovir dipivoxil resulted in significant clinical improvement in this patient with hepatitis B virus-induced fibrosing cholestatic hepatitis, despite the presence of renal impairment and lamivudine resistance...
  36. ncbi request reprint High frequency of epithelial chimerism in liver transplants demonstrated by microdissection and STR-analysis
    Wolfram Kleeberger
    Institutes of Pathology and Legal Medicine, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 35:110-6. 2002
    ....
  37. ncbi request reprint Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C
    Klaus H W Boeker
    Department of Gastroenterology and Hepatology, Medizinische Hochschule, D 30623 Hanover, Germany
    Clin Chim Acta 316:71-81. 2002
    ..We evaluated their diagnostic potential in comparison to hepatic histology, serum hyaluronate and standard liver function tests...
  38. ncbi request reprint Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Oncogene 22:1866-71. 2003
    ..Thus, RASSF1A hypermethylation could be useful as a marker of malignancy and to distinguish between the distinct forms of highly differentiated liver neoplasm...
  39. ncbi request reprint Expression and coordinated regulation of matrix metalloproteinases in chronic hepatitis C and hepatitis C virus-induced liver cirrhosis
    Ralf Lichtinghagen
    Department of Clinical Chemistry, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Clin Sci (Lond) 105:373-82. 2003
    ..In conclusion, MMP expression during the course of chronic hepatitis C appears to be a closely regulated process, with different clusters of coordinately regulated MMP genes being identified...
  40. pmc Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    Lars Zender
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 125:1253-67. 2006
    ..Our results establish a tractable model of liver cancer, identify two oncogenes that cooperate by virtue of their coamplification in the same genomic locus, and suggest an efficient strategy for the annotation of human cancer genes...
  41. ncbi request reprint Expression of the interferon-induced Mx proteins in biliary atresia
    Abdul Nasser Al-Masri
    Department of Pediatric Surgery, Medical School Hannover, 30625 Hannover, Germany
    J Pediatr Surg 41:1139-43. 2006
    ..Although positive findings of viruses in patients with BA are still inconsistent, the present study retraces the progressive inflammatory process in BA one more step toward its beginning...
  42. pmc Caspase 8 small interfering RNA prevents acute liver failure in mice
    Lars Zender
    Department of Gastroenterology, Medical School Hannover, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 100:7797-802. 2003
    ..Consequently, our data raise hope for future successful application of siRNA in patients with acute liver failure...
  43. ncbi request reprint Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
    Stefanie U Wiemann
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Germany
    FASEB J 16:935-42. 2002
    ..The data imply that future therapies aiming to restore regenerative capacity during aging and chronic diseases will have to ensure efficient targeting of specific cell types within the affected organs...
  44. ncbi request reprint The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum
    Nicole Seidel
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Dusseldorf, Germany
    Hepatology 42:113-20. 2005
    ..More importantly, our data imply that measurement of caspase activation might be a sensitive serum biomarker to detect liver steatosis in patients with chronic HCV infection and other liver diseases...
  45. ncbi request reprint The role of the MDR1 gene in the development of multidrug resistance in human hepatoblastoma: clinical course and in vivo model
    Steven Warmann
    Department of Pediatric Surgery, University of Tubingen, Tubingen, Germany
    Cancer 95:1795-801. 2002
    ..The authors investigated the role of the MDR1 gene in the clinical course of patients with HB and in an in vivo model of HB. They also studied the effects of the MDR1 antagonizer PSC 833 on chemotherapy in mice xenotransplanted with HB...
  46. ncbi request reprint COACH syndrome associated with multifocal liver tumors
    Gabriele I Kirchner
    Department of Gastroenterology, Medical School of Hannover, Germany
    Am J Gastroenterol 97:2664-9. 2002
    ..The sizes of these tumors did not change over a period of 12 months. Our report presents the 10th case of COACH syndrome with a hitherto undescribed association with hepatic tumors...
  47. ncbi request reprint Regional and transient ischemia/reperfusion injury in the liver improves therapeutic efficacy of allogeneic intraportal hepatocyte transplantation in low-density lipoprotein receptor deficient Watanabe rabbits
    Masoumeh Attaran
    Department of Gastroenterology, Hepatology and Endocrinology, Center of Internal Medicine, Hannover Medical School, Carl Neubergstr 1, 30625 Hannover, Germany
    J Hepatol 41:837-44. 2004
    ..In a pre-clinical model we investigated the effect of regional transient ischemia reperfusion injury and repeated infusions of allogeneic hepatocytes on LDL cholesterol levels in LDL receptor deficient hyperlipidemic Watanabe rabbits...
  48. ncbi request reprint Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression
    Kai Breuhahn
    Institute of Pathology, Center for Molecular Medicine, and Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Cancer Res 64:6058-64. 2004
    ..This profiling may be of mechanistic and therapeutic impact because IGF-II overexpression has been linked to reduced apoptosis and increased proliferation and may be accessible to therapeutic intervention...
  49. ncbi request reprint Long-term outcome of liver transplantation for autoimmune hepatitis
    Arndt Vogel
    Department of a Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Clin Transplant 18:62-9. 2004
    ..The aim of this study was to evaluate the long-term outcome in serologically defined subgroups of AIH after transplantation...
  50. ncbi request reprint Effectiveness of peripheral hepatogastrostomy versus hepatojejunostomy in the treatment of obstructive cholestasis: results of an experimental model
    Marc H Dahlke
    Department for Hepatobiliary Surgery, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Surg Today 34:349-53. 2004
    ..An experimental study was designed to compare the bile drainage effectiveness of a hepatogastrostomy versus a hepatojejunostomy...
  51. ncbi request reprint LMNA mutations in cardiac transplant recipients
    Klaus Pethig
    Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Cardiology 103:57-62. 2005
    ..The p.R190W mutation has been reported in different populations and may therefore be useful for analyzing the impact of a specific LMNA mutation on the phenotype of muscle disease...