Oliver Bock

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring
    Haiyan Yu
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Plast Reconstr Aesthet Surg 59:221-9. 2006
  2. pmc Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines
    Oliver Bock
    Assistant Professor, Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Am J Pathol 172:951-60. 2008
  3. pmc Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Am J Pathol 169:471-81. 2006
  4. pmc Detection of the single hotspot mutation in the JH2 pseudokinase domain of Janus kinase 2 in bone marrow trephine biopsies derived from chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Mol Diagn 8:170-7. 2006
  5. ncbi request reprint The suppressor of cytokine signalling-1 (SOCS-1) gene is overexpressed in Philadelphia chromosome negative chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Leuk Res 31:799-803. 2007
  6. ncbi request reprint Osteosclerosis in advanced chronic idiopathic myelofibrosis is associated with endothelial overexpression of osteoprotegerin
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Br J Haematol 130:76-82. 2005
  7. ncbi request reprint Aberrant expression of transforming growth factor beta-1 (TGF beta-1) per se does not discriminate fibrotic from non-fibrotic chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Pathol 205:548-57. 2005
  8. doi request reprint Identification of new target molecules PTK2, TGFBR2 and CD9 overexpressed during advanced bone marrow remodelling in primary myelofibrosis
    Oliver Bock
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Br J Haematol 146:510-20. 2009
  9. ncbi request reprint Transcription factor Fli-1 expression by bone marrow cells in chronic myeloproliferative disorders is independent of an underlying JAK2 (V617F) mutation
    Oliver Bock
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Eur J Haematol 77:463-70. 2006
  10. ncbi request reprint Aberrant expression of insulin-like growth factor-2 (IGF-2) in Philadelphia chromosome negative chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Germany
    Leuk Res 28:1145-51. 2004

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring
    Haiyan Yu
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Plast Reconstr Aesthet Surg 59:221-9. 2006
    ..This could explain why TGFbeta signaling is not terminated in keloids leading to overexpression of extracellularmatrix in keloids. These data support a possible role of SMAD6 and 7 in the pathogenesis of keloids...
  2. pmc Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines
    Oliver Bock
    Assistant Professor, Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Am J Pathol 172:951-60. 2008
    ..We conclude that BMP family members may play an important role in the pathogenesis of myelofibrosis in PMF and are apparently induced by cytokines such as TGFbeta-1...
  3. pmc Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Am J Pathol 169:471-81. 2006
    ..We conclude that the expression of matrix-modeling genes in cIMF is not influenced by the JAK2 mutation status but is predominantly related to the stage of disease...
  4. pmc Detection of the single hotspot mutation in the JH2 pseudokinase domain of Janus kinase 2 in bone marrow trephine biopsies derived from chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Mol Diagn 8:170-7. 2006
    ....
  5. ncbi request reprint The suppressor of cytokine signalling-1 (SOCS-1) gene is overexpressed in Philadelphia chromosome negative chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Leuk Res 31:799-803. 2007
    ..We conclude that up-regulation of the SOCS-1 gene might reflect a compensatory feedback mechanism with different emphasis among Ph(-) CMPD subtypes independent of an underlying JAK2 (V617F) mutation...
  6. ncbi request reprint Osteosclerosis in advanced chronic idiopathic myelofibrosis is associated with endothelial overexpression of osteoprotegerin
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Br J Haematol 130:76-82. 2005
    ..We conclude that osteosclerosis in IMF is associated with increased endothelial OPG expression without concomitant RANKL downregulation...
  7. ncbi request reprint Aberrant expression of transforming growth factor beta-1 (TGF beta-1) per se does not discriminate fibrotic from non-fibrotic chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Pathol 205:548-57. 2005
    ....
  8. doi request reprint Identification of new target molecules PTK2, TGFBR2 and CD9 overexpressed during advanced bone marrow remodelling in primary myelofibrosis
    Oliver Bock
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Br J Haematol 146:510-20. 2009
    ..We conclude that PTK2, TGFBR2 and CD9 represent new target molecules involved in bone marrow remodelling of PMF and warrant further investigation for potential targeted therapy...
  9. ncbi request reprint Transcription factor Fli-1 expression by bone marrow cells in chronic myeloproliferative disorders is independent of an underlying JAK2 (V617F) mutation
    Oliver Bock
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Eur J Haematol 77:463-70. 2006
    ....
  10. ncbi request reprint Aberrant expression of insulin-like growth factor-2 (IGF-2) in Philadelphia chromosome negative chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Germany
    Leuk Res 28:1145-51. 2004
    ..We conclude that IGF-2 represents a new molecular target for evaluation of underlying fundamental pathomechanisms in Ph- CMPD...
  11. ncbi request reprint Thrombopoietin receptor (Mpl) expression by megakaryocytes in myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Pathol 203:609-15. 2004
    ..We conclude that, in CMPD, megakaryocytes and erythroid cells exhibit increased Mpl expression levels which may contribute to the sustained proliferation of both cell lineages in CMPD...
  12. ncbi request reprint Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Haematol 72:239-44. 2004
    ..The knowledge of FKBP51 and its expression in bone marrow cells and mature megakaryocytes in non-neoplastic haematopoiesis and IMF is sparse...
  13. ncbi request reprint Different expression levels of the telomerase catalytic subunit hTERT in myeloproliferative and myelodysplastic diseases
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 28:457-60. 2004
    ....
  14. ncbi request reprint The polycythaemia rubra vera-1 gene is constitutively expressed by bone marrow cells and does not discriminate polycythaemia vera from reactive and other chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Br J Haematol 123:472-4. 2003
    ....
  15. pmc Quantitative intra-individual monitoring of BCR-ABL transcript levels in archival bone marrow trephines of patients with chronic myeloid leukemia
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    J Mol Diagn 5:54-60. 2003
    ..To the best of our knowledge, this is the first study demonstrating the feasibility of large-scale quantitative expression analysis in archival bone marrow trephines for monitoring molecular markers over several years or even decades...
  16. ncbi request reprint Multiplex RT-PCR for the detection of common BCR-ABL fusion transcripts in paraffin-embedded tissues from patients with chronic myeloid leukemia and acute lymphoblastic leukemia
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hanover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Diagn Mol Pathol 12:119-23. 2003
    ....
  17. ncbi request reprint Stem cell defects in Philadelphia chromosome negative chronic myeloproliferative disorders: a phenotypic and molecular puzzle?
    Oliver Bock
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Curr Stem Cell Res Ther 2:253-63. 2007
    ..This review will focus on previous and recent findings in the field of molecular defects in Ph(-) CMPD...
  18. doi request reprint JAK2(V617F) allele burden discriminates essential thrombocythemia from a subset of prefibrotic-stage primary myelofibrosis
    Kais Hussein
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Exp Hematol 37:1186-1193.e7. 2009
    ..Among Philadelphia chromosome-negative myeloproliferative neoplasms (Ph(-) MPN), essential thrombocythemia (ET) and the prefibrotic phase of primary myelofibrosis (PMF) represent two subtypes with considerable overlap...
  19. ncbi request reprint Different involvement of the megakaryocytic lineage by the JAK2 V617F mutation in Polycythemia vera, essential thrombocythemia and chronic idiopathic myelofibrosis
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Ann Hematol 86:245-53. 2007
    ....
  20. ncbi request reprint Histological and molecular classification of chronic myeloproliferative disorders in the age of JAK2: persistence of old questions despite new answers
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Pathobiology 74:72-80. 2007
    ....
  21. ncbi request reprint Aberrant expression of beta-catenin discriminates acute myeloid leukaemia from acute lymphoblastic leukaemia
    Ebru Serinsoz
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Br J Haematol 126:313-9. 2004
    ..These data suggest different regulatory mechanisms in the expression and function of beta-catenin in haematopoietic cells...
  22. ncbi request reprint Local complement C3 expression is upregulated in humoral and cellular rejection of renal allografts
    Ebru Serinsoz
    Department of Pathology, Medizinische Hochschule Hannover, Germany
    Am J Transplant 5:1490-4. 2005
    ..Therefore, locally synthesized complement component C3 contributes to both humoral and cellular rejection, with tubular epithelial cells being a major source...
  23. doi request reprint Opposite expression pattern of Src kinase Lyn in acute and chronic haematological malignancies
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Hematol 88:1059-67. 2009
    ..We conclude that tyrosine kinase Lyn contributes to the malignant phenotype in certain leukaemia subtypes and therefore attracts targeted therapy...
  24. ncbi request reprint Quantitative mRNA expression analysis of co-stimulatory molecules in sequential biopsies from heart allografts
    Fatma Akdere
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Transpl Int 18:1197-202. 2005
    ..The present results suggest a simultaneous and long-term therapeutical blockade of more than one costimulatory pathway for the prevention of repetitive T-cell mediated acute rejection episodes after heart transplantation...
  25. doi request reprint Amplification of mRNA from laser-microdissected single or clustered cells in formalin-fixed and paraffin-embedded tissues for application in quantitative real-time PCR
    Katharina Theophile
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Diagn Mol Pathol 17:101-6. 2008
    ....
  26. doi request reprint Aberrant microRNA expression pattern in myelodysplastic bone marrow cells
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:1169-74. 2010
    ..Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS. These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells...
  27. pmc "Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression"
    Michaela Muth
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Transl Med 8:33. 2010
    ..Whether the response of fibroblasts to stress factors also involves the miRNA system is largely unknown...
  28. ncbi request reprint MicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia
    Kais Hussein
    Institute of Pathology, 30625, Hannover, Germany
    Platelets 20:391-400. 2009
    ..Increased accumulation of miR-146b was observed in cellular stage PMF (p = 0.0125) but not ET megakaryopoiesis. In conclusion, this is the first microRNA profiling of in situ-derived PMF, ET and normal megakaryocytes...
  29. ncbi request reprint The expression levels of telomerase catalytic subunit hTERT and oncogenic MYC in essential thrombocythemia are affected by the molecular subtype
    Katharina Theophile
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Ann Hematol 87:263-8. 2008
    ..Thus, the functional link between MYC and hTERT seems to be impaired depending on the molecular ET subtype, which in turn may have implications on the phenotype and course of the disease...
  30. doi request reprint Obliterative airway remodelling in transplanted and non-transplanted lungs
    Danny Jonigk
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    Virchows Arch 457:369-80. 2010
    ..BMPs, especially BMP-7, warrant further investigation as possible markers for the aggravation of airway remodelling...
  31. ncbi request reprint Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern
    Mathewos Tessema
    Institute of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Int J Oncol 26:499-507. 2005
    ..The data suggest a disturbed regulation of the IGF-2/H19 locus in myeloid leukemias which is not caused by loss of imprinting...
  32. doi request reprint Expression profiling of apoptosis-related genes in megakaryocytes: BNIP3 is downregulated in primary myelofibrosis
    Katharina Theophile
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Exp Hematol 36:1728-38. 2008
    ....
  33. doi request reprint Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Thromb Thrombolysis 28:299-303. 2009
    ..CD239 was expressed in a constitutive fashion in PV-derived bone marrow cells and thus a pro-thrombotic function does not seem to be mediated by increased CD239 expression alone...
  34. doi request reprint Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:328-34. 2010
    ..We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q)...
  35. doi request reprint Thrombospondin-1 (TSP-1) in primary myelofibrosis (PMF) - a megakaryocyte-derived biomarker which largely discriminates PMF from essential thrombocythemia
    Michaela Muth
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann Hematol 90:33-40. 2011
    ..On the other hand, TSP-1 is a factor acting (ineffectively) against exaggerated angiogenesis. Both features suggest TSP-1 to be a biomarker for monitoring a PMF-targeted therapy...
  36. doi request reprint Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30615 Hanover, Germany
    Ann Hematol 88:325-32. 2009
    ..No association to thrombocytosis, JAK2(V617F) mutations or cytoreductive treatment (bone marrow cells) were observed...
  37. doi request reprint Aberrant proplatelet formation in chronic myeloproliferative neoplasms
    Michaela Muth
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:1424-9. 2010
    ..001). This study demonstrates that besides megakaryocytic proliferation extensive pseudopodial proplatelet formation provides a hallmark of MPN. Fibrosing differ from non-fibrosing MPN by density and size of aberrant proplatelets...
  38. ncbi request reprint Bone marrow infiltration pattern in B-cell chronic lymphocytic leukemia is related to immunoglobulin heavy-chain variable region mutation status and expression of 70-kd zeta-associated protein (ZAP-70)
    Ulrika Schade
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Hum Pathol 37:1153-61. 2006
    ..The mixed type of infiltration is displayed by mutated as well as unmutated cases with a varying pattern of ZAP-70 expression...
  39. pmc Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression
    Michaela Muth
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Transl Med 9:24. 2011
    ..After publication of our article 1, we realized the need for posting a correction note in order to prevent i) overinterpretation of some results by the readers and ii) concerns about potentially unintended misguidance by the authors...
  40. doi request reprint Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Ann Hematol 90:307-13. 2011
    ..Therefore, the link of deregulated microRNA expression to disease-related phenotype and the underlying molecular mechanism are still unknown...
  41. ncbi request reprint Ancillary techniques in bone marrow pathology: molecular diagnostics on bone marrow trephine biopsies
    Falko Fend
    Institute of Pathology, Technical University Munich, Ismaningerstrasse 22, 81675 Munich, Germany
    Virchows Arch 447:909-19. 2005
    ..This article summarizes the current state of the art in molecular diagnostics applied to paraffin-embedded BM biopsies...
  42. ncbi request reprint Tubular chimerism occurs regularly in renal allografts and is not correlated to outcome
    Michael Mengel
    Institut fuer Pathologie, Medizinischen Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 15:978-86. 2004
    ..Probably recipient-derived stem cells contribute in a minor fashion to tissue homeostasis, and cell turnover in renal allografts is predominantly enabled by donor cell renewal...
  43. ncbi request reprint Health status of transgenic pigs expressing the human complement regulatory protein CD59
    Stefanie Deppenmeier
    Department of Pathology, School of Veterinary Medicine Hannover, Hannover, Germany
    Xenotransplantation 13:345-56. 2006
    ..Following microinjection the transgene is randomly integrated into the host genome which can be associated with insertional mutagenesis and unwanted pathological side effects...
  44. ncbi request reprint Reduced expression of H19 in bone marrow cells from chronic myeloproliferative disorders
    Oliver Bock
    Leukemia 17:815-6. 2003
  45. ncbi request reprint Aberrant expression of platelet-derived growth factor (PDGF) and PDGF receptor-alpha is associated with advanced bone marrow fibrosis in idiopathic myelofibrosis
    Oliver Bock
    Haematologica 90:133-4. 2005
    ..Increased expression of PDGFs and the corresponding PDGF receptor a could be demonstrated to be a feature of advanced fibrosis in IMF that is not demonstrable in the prefibrotic phase of the disease...
  46. ncbi request reprint Studies of transforming growth factors beta 1-3 and their receptors I and II in fibroblast of keloids and hypertrophic scars
    Oliver Bock
    Primary Health Care Center, Fabriksgatan 17, SE 552 85 Jönköping, Sweden
    Acta Derm Venereol 85:216-20. 2005
    ..Therefore our data support a possible role of TGFssRI and TGFssRII in combination with a certain TGFss expression pattern as fibrosis-inducing factors in keloids...
  47. ncbi request reprint Megakaryocytes from chronic myeloproliferative disorders show enhanced nuclear bFGF expression
    Oliver Bock
    Blood 100:2274-5. 2002
  48. ncbi request reprint B-CLL developing in a patient with PV is not affected by V617F mutation of the Janus kinase 2
    Kais Hussein
    Eur J Haematol 77:539-41. 2006
  49. ncbi request reprint Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation
    Kais Hussein
    Blood 109:4106-7. 2007
  50. ncbi request reprint Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels
    Ardeshir Bayat
    Centre for Integrated Genomic Medical Research and Division of Cells, Immunology, and Development, School of Biological Sciences, University of Manchester, England
    Plast Reconstr Surg 111:535-43; discussion 544-6. 2003
    ..To the authors' knowledge, this is the first report of a case-control association study in keloid disease and hypertrophic scars using any single nucleotide polymorphisms...
  51. ncbi request reprint Insights into JAK2-V617F mutation in CML
    Guntram Büsche
    Lancet Oncol 8:863-4. 2007