S C Bischoff

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Stem cell factor-dependent survival, proliferation and enhanced releasability of purified mature mast cells isolated from human intestinal tissue
    S C Bischoff
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany
    Int Arch Allergy Immunol 118:104-7. 1999
  2. ncbi request reprint Mast cell hyperplasia: role of cytokines
    Stephan C Bischoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
    Int Arch Allergy Immunol 127:118-22. 2002
  3. ncbi request reprint Substance P and other neuropeptides do not induce mediator release in isolated human intestinal mast cells
    S C Bischoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Neurogastroenterol Motil 16:185-93. 2004
  4. ncbi request reprint Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins
    Axel Lorentz
    Department of Internal Medicine Gastroenterology, Medical School of Hannover, D 30623 Hannover, Germany
    Blood 99:966-72. 2002
  5. pmc IL-4 enhances proliferation and mediator release in mature human mast cells
    S C Bischoff
    Department of Gastroenterology and Hepatology, Medical School of Hannover, D 30623 Hannover, Germany
    Proc Natl Acad Sci U S A 96:8080-5. 1999
  6. ncbi request reprint Allergy and the gut
    S C Bischoff
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Hannover, Germany
    Int Arch Allergy Immunol 121:270-83. 2000
  7. ncbi request reprint Interleukin-4 induces a switch of human intestinal mast cells from proinflammatory cells to Th2-type cells
    S C Bischoff
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany
    Int Arch Allergy Immunol 124:151-4. 2001
  8. ncbi request reprint Regulation of human intestinal mast cells by stem cell factor and IL-4
    A Lorentz
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany
    Immunol Rev 179:57-60. 2001
  9. pmc Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract
    L E Sander
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    Gut 55:498-504. 2006
  10. pmc Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1
    T Gebhardt
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Germany
    Gut 54:928-34. 2005

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Stem cell factor-dependent survival, proliferation and enhanced releasability of purified mature mast cells isolated from human intestinal tissue
    S C Bischoff
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany
    Int Arch Allergy Immunol 118:104-7. 1999
    ..Recently we reported about a stem cell factor (SCF)-dependent culture system for human mast cells (MC), isolated from intestinal mucosa. Here we present a method to obtain highly purified human intestinal MC...
  2. ncbi request reprint Mast cell hyperplasia: role of cytokines
    Stephan C Bischoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
    Int Arch Allergy Immunol 127:118-22. 2002
    ..However, several other cytokines such as IL-3 and IL-4 have been shown to influence mast cell proliferation and function also. This review focuses on the role of cytokines in the regulation of mast cell hyperplasia...
  3. ncbi request reprint Substance P and other neuropeptides do not induce mediator release in isolated human intestinal mast cells
    S C Bischoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Neurogastroenterol Motil 16:185-93. 2004
    ..In conclusion, our data show that SP and other neuropeptides do not act as secretagogues in human intestinal mast cells that have not been pre-activated by IgE receptor-crosslinking...
  4. ncbi request reprint Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins
    Axel Lorentz
    Department of Internal Medicine Gastroenterology, Medical School of Hannover, D 30623 Hannover, Germany
    Blood 99:966-72. 2002
    ..In conclusion, these data indicate that SCF induces the adhesion of cultured mast cells to ECM proteins, whereas IL-4 may promote detachment from the ECM...
  5. pmc IL-4 enhances proliferation and mediator release in mature human mast cells
    S C Bischoff
    Department of Gastroenterology and Hepatology, Medical School of Hannover, D 30623 Hannover, Germany
    Proc Natl Acad Sci U S A 96:8080-5. 1999
    ..Our data indicate that IL-4 is an important regulator of human MC function and suggest that mature MC retain the capacity to proliferate in a particular tissue environment...
  6. ncbi request reprint Allergy and the gut
    S C Bischoff
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Hannover, Germany
    Int Arch Allergy Immunol 121:270-83. 2000
    ....
  7. ncbi request reprint Interleukin-4 induces a switch of human intestinal mast cells from proinflammatory cells to Th2-type cells
    S C Bischoff
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany
    Int Arch Allergy Immunol 124:151-4. 2001
    ..During the last years, mast cells have been recognized as a potent cellular source of multiple cytokines. However, little is known about the regulation of cytokine production by mature human mast cells derived from mucosal sites...
  8. ncbi request reprint Regulation of human intestinal mast cells by stem cell factor and IL-4
    A Lorentz
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany
    Immunol Rev 179:57-60. 2001
    ..In conclusion, SCF may primarily regulate resident mast cell survival, whereas IL-4 may promote local proliferation of mast cells and their expression of Th2-type cytokines...
  9. pmc Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract
    L E Sander
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    Gut 55:498-504. 2006
    ..Most of this knowledge has been obtained from animal studies. In contrast, in humans, expression and distribution of histamine receptors (HR) within the human gastrointestinal tract are unclear...
  10. pmc Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1
    T Gebhardt
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Germany
    Gut 54:928-34. 2005
    ..Here, we asked whether human intestinal mast cells (MC) might also be subject to immunoregulation by TGF-beta1...
  11. ncbi request reprint Development of an in vitro system for the study of allergens and allergen-specific immunoglobulin E and immunoglobulin G: Fcepsilon receptor I supercross-linking is a possible new mechanism of immunoglobulin G-dependent enhancement of type I allergic reac
    G Sellge
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany
    Clin Exp Allergy 35:774-81. 2005
    ..In contrast, allergen-specific IgG Abs are thought to attenuate immediate allergic reactions by blocking IgE binding and by cross-linking the inhibitory Fcgamma receptor IIB on MCs...
  12. doi request reprint Colonoscopic allergen provocation test with rBet v 1 in patients with pollen-associated food allergy
    C N Pickert
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Allergy 67:1308-15. 2012
    ..The aim of this study was to evaluate the colonoscopic allergen provocation (COLAP) test using the recombinant birch pollen allergen Bet v 1 (rBet v 1) for in vivo diagnosis of pollen-associated food allergy manifesting in the GI tract...
  13. ncbi request reprint Epsilon germ-line and IL-4 transcripts are expressed in human intestinal mucosa and enhanced in patients with food allergy
    M Coeffier
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Allergy 60:822-7. 2005
    ..The levels of epsilonGT, IL-4, IL-13, IFN-gamma, IL-4Ralpha, STAT6 and FcepsilonRIalpha mRNA were analysed by real-time RT-PCR and compared with unpaired nonparametric Mann-Whitney test...
  14. ncbi request reprint [Clubbed fingers and dysphagia in a 38-year-old patient]
    C P Strassburg
    Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 43:99-104. 2002
  15. pmc Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa
    J Wedemeyer
    Department of Gastroenterology and Hepatology, Medical School of Hannover, D 30623 Hannover, Germany
    Gut 44:629-35. 1999
    ..The beta chemokine monocyte chemotactic protein 3 (MCP-3) has chemoattractant and activating capabilities in monocytes, lymphocytes, eosinophils, and basophils...
  16. ncbi request reprint Repeated administration of a vitamin preparation containing glycocholic acid in patients with hepatobiliary disease
    K Rifai
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
    Aliment Pharmacol Ther 23:1337-45. 2006
    ..However, little information exists about possible consequences of bile acid administration such as glycocholic acid, especially if liver disease is pre-existing...
  17. ncbi request reprint Elevated bound leptin correlates with energy expenditure in cirrhotics
    J Ockenga
    Department of Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany
    Gastroenterology 119:1656-62. 2000
    ..Our aim was to characterize leptin components and their relationships to body composition, resting energy expenditure (REE), and substrate use in patients with posthepatic liver cirrhosis...
  18. ncbi request reprint Glutamine-enriched total parenteral nutrition in patients with inflammatory bowel disease
    J Ockenga
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
    Eur J Clin Nutr 59:1302-9. 2005
    ..However, human data supporting this assumption are missing...
  19. ncbi request reprint Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3
    M Niehof
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 276:9016-27. 2001
    ..Our analysis describes a new mechanism by which STAT3 controls gene transcription and which has direct implication for the acute phase response in liver cells...
  20. ncbi request reprint Mast cell dynamics and involvement in the development of peritoneal adhesions in the rat
    Xiang Xu
    Department of Pharmacology, School of Pharmacy, The Hebrew Universiry Hadassah Medical School, Jerusalem, Israel
    Life Sci 70:951-67. 2002
    ..In vitro mast cell induced fibroplasia. Therefore, mast cells have a profibrogenic role in this model of peritoneal adhesions...
  21. ncbi request reprint Selective activation of human intestinal mast cells by Escherichia coli hemolysin
    Sigrid Krämer
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Stuttgart, Germany
    J Immunol 181:1438-45. 2008
    ..coli. Our data indicate that human intestinal mast cells interact with selected Gram-negative bacteria, establish E. coli Hly as a factor regulating MC effector functions, and argue further for a role of human MCs in innate immunity...
  22. doi request reprint Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells
    Leif E Sander
    Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Eur J Immunol 38:855-63. 2008
    ..In summary, our data show that mature human MC express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation...
  23. pmc Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study
    Anne Hafer
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    BMC Gastroenterol 7:36. 2007
    ..The aim of the present study was to investigate the clinical and histological efficacy of lactulose in patients with inflammatory bowel disease (IBD), for which probiotic therapy yielded promising results...
  24. ncbi request reprint Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release
    Thomas Gebhardt
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Eur J Immunol 32:2308-16. 2002
    ..In conclusion, our data show that human intestinal mast cells express functional IL-3R, indicating that IL-3 not only regulates growth and function of immature, but also that of mature human mast cells...
  25. ncbi request reprint Effect of orally administered probiotic E. coli strain Nissle 1917 on intestinal mucosal immune cells of healthy young pigs
    Swantje C Duncker
    Department of Physiology, School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany
    Vet Immunol Immunopathol 111:239-50. 2006
    ..The well-established preventive effects of EcN might therefore be relate to other mechanisms than simple modulation of immune cell distribution...
  26. ncbi request reprint Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells
    Axel Lorentz
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Allergy Clin Immunol 111:1062-8. 2003
    ..On activation by cross-linking the high-affinity IgE receptor (FcepsilonRI), expression of TNF-alpha, IL-3, IL-5, and IL-13 is induced in human intestinal mast cells...
  27. ncbi request reprint Isolation, culture, and characterization of intestinal mast cells
    Gernot Sellge
    Department of Cell Biology and Infection, Institute Pasteur, Paris, France
    Methods Mol Biol 315:123-38. 2006
    ..This chapter describes a rather new technique of mast cell isolation from human intestinal mucosal tissue yielding approx 1-5 million pure and viable human mast cells suitable to perform functional and cell culture experiments...
  28. ncbi request reprint Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor
    Gernot Sellge
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Immunol 172:260-7. 2004
    ..Such interactions between MCs and FBs may explain why MCs accumulate at sites of inflammatory bowel disease and intestinal fibrosis...
  29. ncbi request reprint IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-Fos
    Axel Lorentz
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Germany
    J Immunol 174:6751-6. 2005
    ..In summary, our data show that the IL-4 effects on human intestinal mast cell functions are reversible and accompanied by an increased activity of ERK1/2 and c-Fos...
  30. ncbi request reprint Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
    Sabine Thuy
    Department of Nutritional Medicine 180a, University of Hohenheim, 70599 Stuttgart, Germany
    J Nutr 138:1452-5. 2008
    ..01), and sucrose (Spearman r = 0.70; P < 0.01). In conclusion, our results suggest that dietary fructose intake, increased intestinal translocation of bacterial endotoxin, and PAI-1 may contribute to the development of NAFLD in humans...
  31. ncbi request reprint The European Competence Network on Mastocytosis (ECNM)
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria
    Wien Klin Wochenschr 116:647-51. 2004
    ..In addition, the ECNM is dedicated to provide the best available information about the disease to patients and physicians...
  32. pmc IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells
    Shafaqat Ali
    Immunology FB08, Justus Liebig University Giessen, Winchesterstrasse 2, D 35394 Giessen, Germany
    Proc Natl Acad Sci U S A 104:18660-5. 2007
    ..These data demonstrate that IL-1RAcP is indispensable for IL-33 signaling. Furthermore, they suggest that IL-1RAcP is used by more than one alpha-chain of the IL-1 receptor family and thus may resemble a common beta-chain of that family...
  33. ncbi request reprint Human mast cells, bacteria, and intestinal immunity
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Stuttgart, Germany
    Immunol Rev 217:329-37. 2007
    ..In particular, the role of bacteria and TLRs expression by mast cells for allergic reactions are discussed...
  34. ncbi request reprint Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Fruwirthstr 12, D 70593 Stuttgart, Germany
    Nat Rev Immunol 7:93-104. 2007
    ..This Review summarizes recent data on human mast cells, discusses differences with murine mast cells, and describes new tools to study this increasingly meaningful cell type in humans...
  35. ncbi request reprint Food allergies
    Stephan C Bischoff
    Department of Medicine, Nutritional Medicine and Prevention, 140b, University of Hohenheim, Stuttgart, Fruwirthstr 12, 70593 Stuttgart, Germany
    Curr Gastroenterol Rep 8:374-82. 2006
    ..Food intolerances (non-immunologic food incompatibilities often caused by specific enzyme deficiencies) must be diagnostically differentiated from food allergies...
  36. ncbi request reprint beta2-Adrenoceptor-mediated suppression of human intestinal mast cell functions is caused by disruption of filamentous actin dynamics
    Thomas Gebhardt
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Eur J Immunol 35:1124-32. 2005
    ..Furthermore, the data support the concept of neuroimmune interactions regulating intestinal MC distribution, density, and functionality in vivo...
  37. ncbi request reprint The stem cell factor-c-kit system and mast cells in human pancreatic cancer
    Irene Esposito
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Lab Invest 82:1481-92. 2002
    ..In conclusion, the SCF-c-kit system, possibly with the contribution of mast cells, may have a growth-regulating role in the normal pancreas, which is altered during malignant transformation...
  38. ncbi request reprint The German hospital malnutrition study
    Matthias Pirlich
    Medizinische Klinik Gastroenterologie, Hepatologie und Endokrinologie, Charite Universitatsmedizin Berlin, D 10098 Berlin, Germany
    Clin Nutr 25:563-72. 2006
    ..Malnutrition is frequently observed in chronic and severe diseases and associated with impaired outcome. In Germany general data on prevalence and impact of hospital malnutrition are missing...