Georg Mn Behrens

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Pathogenesis of the HAART-associated metabolic syndrome
    Georg M N Behrens
    Division of Clinical Immunology, Hannover Medical School, Hannover, Germany
    Adv Cardiol 40:83-96. 2003
  2. doi request reprint Switching to tenofovir/emtricitabine from abacavir/lamivudine in HIV-infected adults with raised cholesterol: effect on lipid profiles
    Georg Behrens
    Hannover Medical School, Department for Clinical Immunology and Rheumatology, Hannover, Germany
    Antivir Ther 17:1011-20. 2012
  3. pmc Platelet activation suppresses HIV-1 infection of T cells
    Theodros Solomon Tsegaye
    Institute of Virology, Hannover Medical School, Hannover, Germany
    Retrovirology 10:48. 2013
  4. doi request reprint Toll-like receptor-2 agonist-allergen coupling efficiently redirects Th2 cell responses and inhibits allergic airway eosinophilia
    Jayendra Kumar Krishnaswamy
    Department for Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    Am J Respir Cell Mol Biol 47:852-63. 2012
  5. doi request reprint [HIV 2012 : research update]
    G M N Behrens
    Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Internist (Berl) 53:1187-94. 2012
  6. doi request reprint Abacavir and cardiovascular risk
    Georg M N Behrens
    Clinic for Immunology and Rheumatology, Hannover Medical School, Carl Neuberg Street 1, 30625 Hannover, Germany
    Curr Opin Infect Dis 23:9-14. 2010
  7. ncbi request reprint Treatment options for lipodystrophy in HIV-positive patients
    Georg Mn Behrens
    Hannover Medical School, Clinical Immunology and Rheumatology, Carl Neuberg Street 1, 30625 Hannover, Germany
    Expert Opin Pharmacother 9:39-52. 2008
  8. ncbi request reprint [Metabolic syndrome and hyperlipidemia in HIV-positive patients]
    Georg M N Behrens
    Abteilung Klinische Immunologie, Medizinische Hochschule, Hannover
    Herz 30:458-66. 2005
  9. ncbi request reprint Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors
    G Behrens
    Department of Medicine, Hannover Medical School, Germany
    AIDS 13:F63-70. 1999
  10. ncbi request reprint [Lipodystrophy and metabolic disorders in anti-HIV therapy]
    G M Behrens
    Abteilung fur Klinische Immunologie, Medizinische Hochschule Hannover
    MMW Fortschr Med 142:68-71. 2000

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Pathogenesis of the HAART-associated metabolic syndrome
    Georg M N Behrens
    Division of Clinical Immunology, Hannover Medical School, Hannover, Germany
    Adv Cardiol 40:83-96. 2003
  2. doi request reprint Switching to tenofovir/emtricitabine from abacavir/lamivudine in HIV-infected adults with raised cholesterol: effect on lipid profiles
    Georg Behrens
    Hannover Medical School, Department for Clinical Immunology and Rheumatology, Hannover, Germany
    Antivir Ther 17:1011-20. 2012
    ....
  3. pmc Platelet activation suppresses HIV-1 infection of T cells
    Theodros Solomon Tsegaye
    Institute of Virology, Hannover Medical School, Hannover, Germany
    Retrovirology 10:48. 2013
    ..Platelets, anucleate cell fragments abundant in human blood, can capture HIV-1 and platelet counts have been associated with viral load and disease progression. However, the impact of platelets on HIV-1 infection of T cells is unclear...
  4. doi request reprint Toll-like receptor-2 agonist-allergen coupling efficiently redirects Th2 cell responses and inhibits allergic airway eosinophilia
    Jayendra Kumar Krishnaswamy
    Department for Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    Am J Respir Cell Mol Biol 47:852-63. 2012
    ..In conclusion, our data show for the first time that a single mucosal administration of a TLR 2/6 agonist-allergen conjugate can provoke IFN-γ responses in Th2-biased cells and alleviate allergic airway inflammation...
  5. doi request reprint [HIV 2012 : research update]
    G M N Behrens
    Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Internist (Berl) 53:1187-94. 2012
    ....
  6. doi request reprint Abacavir and cardiovascular risk
    Georg M N Behrens
    Clinic for Immunology and Rheumatology, Hannover Medical School, Carl Neuberg Street 1, 30625 Hannover, Germany
    Curr Opin Infect Dis 23:9-14. 2010
    ....
  7. ncbi request reprint Treatment options for lipodystrophy in HIV-positive patients
    Georg Mn Behrens
    Hannover Medical School, Clinical Immunology and Rheumatology, Carl Neuberg Street 1, 30625 Hannover, Germany
    Expert Opin Pharmacother 9:39-52. 2008
    ..Here, the treatment options of the HIV-lipodystrophy syndrome are summarized based on the present literature...
  8. ncbi request reprint [Metabolic syndrome and hyperlipidemia in HIV-positive patients]
    Georg M N Behrens
    Abteilung Klinische Immunologie, Medizinische Hochschule, Hannover
    Herz 30:458-66. 2005
    ....
  9. ncbi request reprint Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors
    G Behrens
    Department of Medicine, Hannover Medical School, Germany
    AIDS 13:F63-70. 1999
    ..To evaluate metabolic abnormalities, beta-cell function, lipid profile and vascular risk factors in HIV patients on protease inhibitors (PI)...
  10. ncbi request reprint [Lipodystrophy and metabolic disorders in anti-HIV therapy]
    G M Behrens
    Abteilung fur Klinische Immunologie, Medizinische Hochschule Hannover
    MMW Fortschr Med 142:68-71. 2000
    ..This paper summarizes the current state of investigations into the side effects of antiretroviral therapy and their clinical consequences...
  11. ncbi request reprint Lipodystrophy syndrome in HIV infection: what is it, what causes it and how can it be managed?
    G M Behrens
    Department for Clinical Immunology, Hannover Medical School, Germany
    Drug Saf 23:57-76. 2000
    ..In this article, we discuss the features, pathogenesis and treatment options for body fat redistribution and metabolic disturbances associated with HAART in HIV-1 infection...
  12. ncbi request reprint Immune reconstitution syndromes in human immuno-deficiency virus infection following effective antiretroviral therapy
    G M Behrens
    Department of Clinical Immunology, Hannover Medical School, Germany
    Immunobiology 202:186-93. 2000
    ..Pathogenetic implications and therapeutic management of these new immunopathologic syndromes are discussed...
  13. ncbi request reprint Switching to atazanavir improves metabolic disorders in antiretroviral-experienced patients with severe hyperlipidemia
    Ulrike Möbius
    Department of Clinical Immunology, Hannover Medical School, Hannover, Germany
    J Acquir Immune Defic Syndr 39:174-80. 2005
    ..To describe the efficacy and change in lipid profile in patients with severe hyperlipidemia after switch to an atazanavir-containing highly active antiretroviral therapy regimen...
  14. doi request reprint Impact of boostering for the strength of asthma parameters and dendritic cell numbers in a C57BL/6 model of allergic airway inflammation
    Christina Hartwig
    Functional and Applied Anatomy, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Exp Toxicol Pathol 60:425-34. 2008
    ..We aimed to assess the requirement of boostering needed in the BL/6 murine asthma model and its influence on DC populations in lungs and bronchial lymph nodes...
  15. doi request reprint The synthetic TLR2 agonist BPPcysMPEG leads to efficient cross-priming against co-administered and linked antigens
    Chittappen K Prajeeth
    Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    Eur J Immunol 40:1272-83. 2010
    ..Together, our data provide evidence that BPP is a potent stimulus to generate CTL via cross-priming...
  16. doi request reprint Fcgamma receptor-mediated antigen uptake by lung DC contributes to allergic airway hyper-responsiveness and inflammation
    Christina Hartwig
    Institute for Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Eur J Immunol 40:1284-95. 2010
    ..We conclude that FcgammaR-mediated enhanced antigen presentation and T-cell stimulation by lung DC has a significant impact on inflammatory responses following allergen challenge in asthma...
  17. doi request reprint Impaired lung dendritic cell migration and T cell stimulation induced by immunostimulatory oligonucleotides contribute to reduced allergic airway inflammation
    Hannelore Constabel
    Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    J Immunol 183:3443-53. 2009
    ..We conclude that CpG treatment can effectively impair the DC-mediated Ag transport from the lungs to the lymph nodes, resulting in reduced T cell activation and blunted airway inflammation...
  18. ncbi request reprint Contribution of direct and cross-presentation to CTL immunity against herpes simplex virus 1
    Adan Chari Jirmo
    Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    J Immunol 182:283-92. 2009
    ..We conclude that cross-presentation is of major importance for the induction of CTL immunity in mice...
  19. ncbi request reprint Relationship of mitochondrial DNA depletion and respiratory chain activity in preadipocytes treated with nucleoside reverse transcriptase inhibitors
    Metodi V Stankov
    Division of Clinical Immunology, Hannover Medical School, Hannover, Germany
    Antivir Ther 12:205-16. 2007
    ..To study the impact of adipocyte differentiation on nucleoside reverse transcriptase inhibitor (NRTI)-mediated mitochondrial DNA (mtDNA) depletion and to correlate mtDNA depletion with the activity of the respiratory chain complexes...
  20. ncbi request reprint Contribution of inflammation to fat redistribution and metabolic disturbances in HIV-1 infected patients
    Metodi V Stankov
    Clinic for Immunology and Rheumatology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Curr Pharm Des 16:3361-71. 2010
    ..Based on the current literature, we suggest a central role of systemic inflammation in triggering and deteriorating various components of the HIV-LS...
  21. pmc Zidovudine impairs adipogenic differentiation through inhibition of clonal expansion
    Metodi V Stankov
    Clinic for Clinical Immunology and Rheumatology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30625, Germany
    Antimicrob Agents Chemother 52:2882-9. 2008
    ..These effects of the drug are expected to contribute to disturbed adipose tissue homeostasis and to be influenced by differential drug concentration and penetration in individual patients...
  22. pmc Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1-infected patients with lipodystrophy
    Georg M N Behrens
    Department of Clinical Immunology, Hannover Medical School, Hannover, Germany
    J Clin Invest 110:1319-27. 2002
    ..To our knowledge, this is the first report providing in vivo evidence that, in lipodystrophic HIV patients, impaired glucose transport and phosphorylation cause reduced insulin-mediated glucose uptake...
  23. doi request reprint Impact of stimulatory pathways on adipogenesis and HIV-therapy associated lipoatrophy
    Metodi V Stankov
    Clinic for Immunology and Rheumatology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Exp Biol Med (Maywood) 234:1484-92. 2009
    ..We aimed to investigate the discrepancy between the anti-adipogenic effects of the HIV protease-inhibitor indinavir (IDV) in vitro and the lack of evidence that IDV inhibits adipogenesis in humans...
  24. doi request reprint Combined effect of C-reactive protein and stavudine on adipogenesis
    Metodi V Stankov
    Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
    Antivir Ther 14:819-29. 2009
    ..We hypothesized that C-reactive protein (CRP) might have an additive effect on nucleoside reverse transcriptase inhibitor (NRTI)-mediated peripheral fat loss...
  25. ncbi request reprint Clinical impact of HIV-related lipodystrophy and metabolic abnormalities on cardiovascular disease
    Georg M N Behrens
    Department of Clinical Immunology, Hannover Medical School, Hannover, Germany
    AIDS 17:S149-54. 2003
    ....
  26. pmc Mitochondrial DNA depletion and respiratory chain activity in primary human subcutaneous adipocytes treated with nucleoside analogue reverse transcriptase inhibitors
    Metodi V Stankov
    Clinic for Immunology and Rheumatology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Antimicrob Agents Chemother 54:280-7. 2010
    ..Severe NRTI-mediated mtDNA depletion in phsPA is not inevitably associated with impaired respiratory chain activity or altered mitochondrial membrane potential...
  27. pmc The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture
    Petra Schnorrer
    Immunology Division and Cooperative Research Centre for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:10729-34. 2006
    ..This conclusion has important implications for the design of vaccination strategies based on antigen targeting to DC...
  28. ncbi request reprint Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
    Nicholas S Wilson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:165-72. 2006
    ..Moreover, inhibition of cross-presentation was overcome by injection of dendritic cells bearing antigen, which provides a new strategy for generating immunity during immunosuppressive blood infections...
  29. ncbi request reprint Cardiovascular risk and body-fat abnormalities in HIV-infected adults
    Georg M N Behrens
    N Engl J Med 352:1721-2; author reply 1721-2. 2005
  30. ncbi request reprint Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    William R Heath
    Department of Immunology and The Cooperative Research Center for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Rev 199:9-26. 2004
    ..In this review, we examine the molecular basis for cross-presentation, discuss the role of DC subsets, and examine the contribution of this process to immunity, with some emphasis on DNA vaccination...
  31. ncbi request reprint Helper requirements for generation of effector CTL to islet beta cell antigens
    Georg M N Behrens
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 172:5420-6. 2004
    ..This provides insight into the helper requirements for adoptive transfer immunotherapy of tumors and suggests key points for inhibition of CTL-mediated autoimmunity...