Matthias Ballmaier

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets
    H Schulze
    Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
    Exp Hematol 28:294-304. 2000
  2. doi request reprint Congenital amegakaryocytic thrombocytopenia: clinical presentation, diagnosis, and treatment
    Matthias Ballmaier
    Department of Pediatric Hematology and Oncology Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Semin Thromb Hemost 37:673-81. 2011
  3. pmc Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system
    Anna Ivanova
    Department of Neonatology, Charite Universitatsmedizin, Germany
    BMC Dev Biol 10:77. 2010
  4. ncbi request reprint Advances in the understanding of congenital amegakaryocytic thrombocytopenia
    Matthias Ballmaier
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 146:3-16. 2009
  5. ncbi request reprint c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia
    M Ballmaier
    Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Germany
    Blood 97:139-46. 2001
  6. doi request reprint Phenotypically and functionally distinct subsets contribute to the expansion of CD56-/CD16+ natural killer cells in HIV infection
    Henoch S Hong
    Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany
    AIDS 24:1823-34. 2010
  7. pmc Loss of CCR7 expression on CD56(bright) NK cells is associated with a CD56(dim)CD16⁺ NK cell-like phenotype and correlates with HIV viral load
    Henoch S Hong
    Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 7:e44820. 2012
  8. doi request reprint Detection of putative cancer stem cells of the side population phenotype in human tumor cell cultures
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Methods Mol Biol 878:201-15. 2012
  9. pmc Down-regulation of the fetal stem cell factor SOX17 by H33342: a mechanism responsible for differential gene expression in breast cancer side population cells
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 285:6412-8. 2010
  10. doi request reprint In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropenia
    Manuela Germeshausen
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Blood 113:668-70. 2009

Detail Information

Publications44

  1. ncbi request reprint Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets
    H Schulze
    Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
    Exp Hematol 28:294-304. 2000
    ..Our aim was to elucidate which Stat-complexes are formed in TPO signal transduction in human blood platelets...
  2. doi request reprint Congenital amegakaryocytic thrombocytopenia: clinical presentation, diagnosis, and treatment
    Matthias Ballmaier
    Department of Pediatric Hematology and Oncology Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Semin Thromb Hemost 37:673-81. 2011
    ..The present review summarizes clinical and laboratory data for 96 patients with CAMT, reported since 1990...
  3. pmc Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system
    Anna Ivanova
    Department of Neonatology, Charite Universitatsmedizin, Germany
    BMC Dev Biol 10:77. 2010
    ..Herein, we analysed Mpl expression in the developing and adult murine CNS by immunohistochemistry and investigated the brain of mice with homozygous Mpl deficiency (Mpl-/-) by MRI...
  4. ncbi request reprint Advances in the understanding of congenital amegakaryocytic thrombocytopenia
    Matthias Ballmaier
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 146:3-16. 2009
    ..The essential roles of thrombopoietin as a lineage specific regulator of platelet production and as a regulator of haematopoietic stem cell function are reflected in the haematological defects seen in affected individuals...
  5. ncbi request reprint c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia
    M Ballmaier
    Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Germany
    Blood 97:139-46. 2001
    ..The type of mutations correlated with the clinical course of the disease. We propose a defective c-Mpl expression due to c-mpl mutations as the cause for thrombocytopenia and progression into pancytopenia seen in patients with CAMT...
  6. doi request reprint Phenotypically and functionally distinct subsets contribute to the expansion of CD56-/CD16+ natural killer cells in HIV infection
    Henoch S Hong
    Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany
    AIDS 24:1823-34. 2010
    ..We performed a comprehensive phenotypical and functional characterization of this population...
  7. pmc Loss of CCR7 expression on CD56(bright) NK cells is associated with a CD56(dim)CD16⁺ NK cell-like phenotype and correlates with HIV viral load
    Henoch S Hong
    Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 7:e44820. 2012
    ..Thus, chronic HIV-infection is associated with a phenotypic and functional shift of CD56(bright) NK cells, which provides a novel aspect of HIV-associated pathogenesis within the NK cell compartment...
  8. doi request reprint Detection of putative cancer stem cells of the side population phenotype in human tumor cell cultures
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Methods Mol Biol 878:201-15. 2012
    ..Here we provide a detailed protocol for the detection of putative cancer stem cells of the SP phenotype in human adherent breast cancer cell cultures...
  9. pmc Down-regulation of the fetal stem cell factor SOX17 by H33342: a mechanism responsible for differential gene expression in breast cancer side population cells
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 285:6412-8. 2010
    ..This has significant implications for the future interpretation of cancer SP cells...
  10. doi request reprint In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropenia
    Manuela Germeshausen
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Blood 113:668-70. 2009
    ....
  11. ncbi request reprint MPL mutations in 23 patients suffering from congenital amegakaryocytic thrombocytopenia: the type of mutation predicts the course of the disease
    Manuela Germeshausen
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Hum Mutat 27:296. 2006
    ..Using in vitro assays with hematopoietic progenitors from patients of both patient groups we could provide experimental evidence for a residual activity of the thrombopoietin receptor in CAMT II patients...
  12. doi request reprint Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia
    Dirk Heckl
    Department of Experimental Hematology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Blood 117:3737-47. 2011
    ..Transcriptome analysis of lineage(-)Sca1(+)cKit(+) cells in Mpl-corrected mice showed functional adjustment of genes involved in HSC self-renewal...
  13. pmc HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells
    Henoch S Hong
    Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Virol 84:1183-8. 2010
    ..Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells...
  14. pmc Multiple extrathymic precursors contribute to T-cell development with different kinetics
    Namita Saran
    Institute for Immunology, Hannover Medical School, Hannover, Germany
    Blood 115:1137-44. 2010
    ..In conclusion, our data suggest that the thymus functions to impose T-cell fate on any precursor capable of filling the limited number of progenitor niches...
  15. doi request reprint G-CSF receptor mutations in patients with congenital neutropenia
    Manuela Germeshausen
    Department of Pediatric Hematology Oncology, Medical University Hannover, Hannover, Germany
    Curr Opin Hematol 15:332-7. 2008
    ..Congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10/l...
  16. doi request reprint The spectrum of ELANE mutations and their implications in severe congenital and cyclic neutropenia
    Manuela Germeshausen
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Hum Mutat 34:905-14. 2013
    ..Specific ELANE mutations have limited predictive value for leukemogenesis; the risk for leukemia was correlated with disease severity rather than with occurrence of an ELANE mutation...
  17. pmc Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia
    Daniel C Wicke
    Department of Experimental Hematology, Hannover Medical School, Hannover, Germany
    Mol Ther 18:343-52. 2010
    ..Mice that received BM cells expressing Mpl from the Mpl promoter were free of any previously observed adverse reactions...
  18. doi request reprint KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Hannover, Germany
    Int J Cancer 123:2239-46. 2008
    ..Importantly, KAI1 might be reinducible by endocrine therapy with ER-antagonists in patients suffering from ER-positive breast cancer...
  19. pmc Digenic mutations in severe congenital neutropenia
    Manuela Germeshausen
    Department of Pediatric Hematology and Oncology Molecular Hematopoiesis, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Haematologica 95:1207-10. 2010
    ..Our results suggest that digenicity may underlie this disorder of myelopoiesis at least in some congenital neutropenia patients...
  20. doi request reprint Novel HAX1 mutations in patients with severe congenital neutropenia reveal isoform-dependent genotype-phenotype associations
    Manuela Germeshausen
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Blood 111:4954-7. 2008
    ..Therefore, our findings suggest that HAX1 isoforms may play a distinctive role in the neuronal system...
  21. doi request reprint Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells
    Ulf Tiemann
    Junior Research Group Stem Cell Biology, Cluster of Excellence REBIRTH, Hannover Medical School, 30625 Hannover, Germany
    Cytometry A 79:426-35. 2011
    ....
  22. doi request reprint Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene
    El Harith Abdelghaffar El-Harith
    Institute of Human Genetics, Medical University of Hannover, Hannover, Germany
    Br J Haematol 144:185-94. 2009
    ..In the families described the mode of inheritance could be regarded as autosomal-recessive with possible mild heterozygote manifestation rather than autosomal-dominant with high penetrance as usually seen in FT...
  23. doi request reprint Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
    J Pathol 217:620-32. 2009
    ..In summary, IPH-926 significantly extends the biological spectrum of the established breast cancer cell lines and will facilitate functional analyses of genuine human ILBC cells in vitro and in vivo...
  24. ncbi request reprint Congenital amegakaryocytic thrombocytopenia: a retrospective clinical analysis of 20 patients
    Stephanie King
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 131:636-44. 2005
    ..Fifteen patients were treated with haematopoietic stem cell transplantation, four of whom died of transplantation-related events...
  25. ncbi request reprint Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey
    Manuela Germeshausen
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany
    Blood 109:93-9. 2007
    ..Our results strongly suggest that acquisition of a CSF3R mutation is an early event in leukemogenesis that has to be accompanied by cooperating molecular events, which remain to be defined...
  26. ncbi request reprint Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine
    Julia Carlens
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 183:5600-7. 2009
    ....
  27. pmc Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells
    Natalia Zietara
    Institute for Immunology, Hannover Medical School, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 110:7407-12. 2013
    ..Our results define a critical role of miR-181a/b-1 in early iNKT cell development and show that miR-181a/b-1 sets a TCR signaling threshold for agonist selection...
  28. ncbi request reprint Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment
    Florian P Limbourg
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    Eur J Heart Fail 7:722-9. 2005
    ..However, the cell population mediating myocardial recovery and the fate of the transplanted cells are still controversial...
  29. ncbi request reprint Retroviral WASP gene transfer into human hematopoietic stem cells reconstitutes the actin cytoskeleton in myeloid progeny cells differentiated in vitro
    Ricardo A Dewey
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Exp Hematol 34:1161-9. 2006
    ..Compared with the conventional treatment using allogeneic bone marrow transplantation, hematopoietic stem cell gene therapy might offer more specific and less toxic therapeutic options...
  30. pmc Role of suppressor of cytokine signaling-1 in murine atherosclerosis
    Christina Grothusen
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e51608. 2012
    ..Its role in atherogenesis, however has not been elucidated so far...
  31. pmc Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration
    Mariam Al-Omari
    Department of Pulmonology, Hannover Medical School, Hannover, Germany
    Mol Med 17:865-74. 2011
    ....
  32. doi request reprint A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells
    Bastian Hoechst
    Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany
    Gastroenterology 135:234-43. 2008
    ..In this study, we have investigated the frequency and function of a new population of MDSC denoted here as CD14(+)HLA-DR(-/low) in HCC patients. We have also identified a novel, MDSC-mediated immune regulatory pathway in these patients...
  33. ncbi request reprint Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell line
    Matthias Christgen
    Institute of Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Mol Cell Biochem 306:201-12. 2007
    ..In summary, we established Cal-51 SP cells as a novel in vitro model to study differential gene expression in breast cancer-derived SP and NSP cells...
  34. ncbi request reprint Up-regulation of platelet-derived growth factor by peripheral-blood leukocytes during experimental allergic encephalomyelitis
    Niklas K U Koehler
    Department of Neurology, Hannover Medical School, Hannover, Germany
    J Neurosci Res 86:392-402. 2008
    ..The production of PDGF by lymphocytes may have potential therapeutic value when activating or modulating T-cell responses in demyelinating diseases...
  35. ncbi request reprint CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties
    Maria Luisa del Rio
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 181:6178-88. 2008
    ..Collectively, these data indicate that GFP(+)c-kit(+) cells contribute to the replenishment of CD103(+) DC in lymphoid and nonlymphoid organs...
  36. doi request reprint Exogenous HIV-1 Vpr disrupts IFN-alpha response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplay
    Henoch Sangjoon Hong
    Clinic for Immunology und Rheumatology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, Hannover, Germany
    Immunol Lett 125:100-4. 2009
    ..Thus, Vpr-mediated dysregulation of IFN-alpha and IFN-gamma production affects key components of the innate immune response supporting an essential role of Vpr in HIV pathogenesis...
  37. ncbi request reprint Thrombopoietin regulates differentiation of rhesus monkey embryonic stem cells to hematopoietic cells
    Zheng Wang
    Hannover Medical School, Department of Pediatric Hematology and Oncology, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann N Y Acad Sci 1044:29-40. 2005
    ..The in vitro differentiation of rhesus monkey ES cells provides an opportunity to better understand the mechanism of TPO function in the early stage of hematopoietic development from ES cells to mature hematopoietic cells...
  38. ncbi request reprint FACS-isolation of Salmonella-infected cells with defined bacterial load from mouse spleen
    Friederike Thöne
    Hannover Medical School, Junior Research Group Mucosal Infections OE 9421, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Microbiol Methods 71:220-4. 2007
    ..Our method will facilitate future characterization of the different subpopulations and the identification of bacterial and host factors that control Salmonella load and proliferation in vivo...
  39. ncbi request reprint Implications of mutations in hematopoietic growth factor receptor genes in congenital cytopenias
    M Germeshausen
    Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany
    Ann N Y Acad Sci 938:305-20; discussion 320-1. 2001
    ..In contrast, mutations in the G-CSF receptor in CN are acquired and are most probably connected with progression of the neutropenia into MDS/leukemia as a result of a loss of differentiation signaling...
  40. ncbi request reprint Thrombopoietin is essential for the maintenance of normal hematopoiesis in humans: development of aplastic anemia in patients with congenital amegakaryocytic thrombocytopenia
    M Ballmaier
    Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Ann N Y Acad Sci 996:17-25. 2003
    ..On the other hand, the incidence of development of aplastic anemia in CAMT is not clear owing to difficult and not consistent diagnosis of this disease...
  41. ncbi request reprint An acquired G-CSF receptor mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropenia
    M Germeshausen
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany
    Leukemia 19:611-7. 2005
    ..Our results provide direct evidence for the in vivo expression of a truncated G-CSFR in leukemic cells, which emerged in the absence of rh-G-CSF treatment and transduces proliferative signals...
  42. ncbi request reprint Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropenia
    M Germeshausen
    Department of Paediatric Haematology and Oncology, Medizinische Hochschule Hannover, Germany
    Br J Haematol 115:222-4. 2001
    ..We conclude that ELA2 mutations are not the single cause of CN although they might be a necessary prerequisite for the expression of the neutropenic phenotype in a subgroup of CN patients...
  43. ncbi request reprint Concentrations of thrombopoietin and interleukin-11 in the umbilical cord blood of patients with fetal alloimmune thrombocytopenia
    C Dame
    Department of Neonatology, University of Bonn, Germany
    Am J Perinatol 18:335-44. 2001
    ..Cord blood serum concentrations of TPO are not significantly elevated in FAITP and do not predict the severity of the thrombocytopenia. Elevated IL-11 may signal a more rapid platelet recovery in FAITP...
  44. ncbi request reprint Familial polycythemia vera with non-germline JAK2(V617F) mutation sparing the abnormal and clonal granulopoiesis
    K Hussein
    Leukemia 21:2566-8. 2007