Research Topics
Genomes and Genes
| Matthias BallmaierSummaryAffiliation: Hannover Medical School Country: Germany Publications
| Collaborators
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Detail Information
Publications
Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human plateletsH Schulze
Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
Exp Hematol 28:294-304. 2000..Our aim was to elucidate which Stat-complexes are formed in TPO signal transduction in human blood platelets...
Congenital amegakaryocytic thrombocytopenia: clinical presentation, diagnosis, and treatmentMatthias Ballmaier
Department of Pediatric Hematology and Oncology Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
Semin Thromb Hemost 37:673-81. 2011..The present review summarizes clinical and laboratory data for 96 patients with CAMT, reported since 1990...
Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous systemAnna Ivanova
Department of Neonatology, Charite Universitatsmedizin, Germany
BMC Dev Biol 10:77. 2010..Herein, we analysed Mpl expression in the developing and adult murine CNS by immunohistochemistry and investigated the brain of mice with homozygous Mpl deficiency (Mpl-/-) by MRI...- c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopeniaM Ballmaier
Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Germany
Blood 97:139-46. 2001..The type of mutations correlated with the clinical course of the disease. We propose a defective c-Mpl expression due to c-mpl mutations as the cause for thrombocytopenia and progression into pancytopenia seen in patients with CAMT... - Advances in the understanding of congenital amegakaryocytic thrombocytopeniaMatthias Ballmaier
Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
Br J Haematol 146:3-16. 2009..The essential roles of thrombopoietin as a lineage specific regulator of platelet production and as a regulator of haematopoietic stem cell function are reflected in the haematological defects seen in affected individuals... - Phenotypically and functionally distinct subsets contribute to the expansion of CD56-/CD16+ natural killer cells in HIV infectionHenoch S Hong
Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany
AIDS 24:1823-34. 2010..We performed a comprehensive phenotypical and functional characterization of this population... - Loss of CCR7 expression on CD56(bright) NK cells is associated with a CD56(dim)CD16⁺ NK cell-like phenotype and correlates with HIV viral loadHenoch S Hong
Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany
PLoS ONE 7:e44820. 2012..Thus, chronic HIV-infection is associated with a phenotypic and functional shift of CD56(bright) NK cells, which provides a novel aspect of HIV-associated pathogenesis within the NK cell compartment... - Detection of putative cancer stem cells of the side population phenotype in human tumor cell culturesMatthias Christgen
Institute of Pathology, Hannover Medical School, Hannover, Germany
Methods Mol Biol 878:201-15. 2012..Here we provide a detailed protocol for the detection of putative cancer stem cells of the SP phenotype in human adherent breast cancer cell cultures... - Down-regulation of the fetal stem cell factor SOX17 by H33342: a mechanism responsible for differential gene expression in breast cancer side population cellsMatthias Christgen
Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
J Biol Chem 285:6412-8. 2010..This has significant implications for the future interpretation of cancer SP cells... - In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropeniaManuela Germeshausen
Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
Blood 113:668-70. 2009.... - HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cellsHenoch S Hong
Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
J Virol 84:1183-8. 2010..Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells... - MPL mutations in 23 patients suffering from congenital amegakaryocytic thrombocytopenia: the type of mutation predicts the course of the diseaseManuela Germeshausen
Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
Hum Mutat 27:296. 2006..Using in vitro assays with hematopoietic progenitors from patients of both patient groups we could provide experimental evidence for a residual activity of the thrombopoietin receptor in CAMT II patients... - Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemiaDirk Heckl
Department of Experimental Hematology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
Blood 117:3737-47. 2011..Transcriptome analysis of lineage(-)Sca1(+)cKit(+) cells in Mpl-corrected mice showed functional adjustment of genes involved in HSC self-renewal... - Multiple extrathymic precursors contribute to T-cell development with different kineticsNamita Saran
Institute for Immunology, Hannover Medical School, Hannover, Germany
Blood 115:1137-44. 2010..In conclusion, our data suggest that the thymus functions to impose T-cell fate on any precursor capable of filling the limited number of progenitor niches... - G-CSF receptor mutations in patients with congenital neutropeniaManuela Germeshausen
Department of Pediatric Hematology Oncology, Medical University Hannover, Hannover, Germany
Curr Opin Hematol 15:332-7. 2008..Congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10/l... - KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancerMatthias Christgen
Institute of Pathology, Hannover Medical School, Hannover, Germany
Int J Cancer 123:2239-46. 2008..Importantly, KAI1 might be reinducible by endocrine therapy with ER-antagonists in patients suffering from ER-positive breast cancer... - Novel HAX1 mutations in patients with severe congenital neutropenia reveal isoform-dependent genotype-phenotype associationsManuela Germeshausen
Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
Blood 111:4954-7. 2008..Therefore, our findings suggest that HAX1 isoforms may play a distinctive role in the neuronal system... - Digenic mutations in severe congenital neutropeniaManuela Germeshausen
Department of Pediatric Hematology and Oncology Molecular Hematopoiesis, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
Haematologica 95:1207-10. 2010..Our results suggest that digenicity may underlie this disorder of myelopoiesis at least in some congenital neutropenia patients... - Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopeniaDaniel C Wicke
Department of Experimental Hematology, Hannover Medical School, Hannover, Germany
Mol Ther 18:343-52. 2010..Mice that received BM cells expressing Mpl from the Mpl promoter were free of any previously observed adverse reactions... - Congenital amegakaryocytic thrombocytopenia: a retrospective clinical analysis of 20 patientsStephanie King
Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
Br J Haematol 131:636-44. 2005..Fifteen patients were treated with haematopoietic stem cell transplantation, four of whom died of transplantation-related events... - Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cellsUlf Tiemann
Junior Research Group Stem Cell Biology, Cluster of Excellence REBIRTH, Hannover Medical School, 30625 Hannover, Germany
Cytometry A 79:426-35. 2011.... - Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancerMatthias Christgen
Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany
J Pathol 217:620-32. 2009..In summary, IPH-926 significantly extends the biological spectrum of the established breast cancer cell lines and will facilitate functional analyses of genuine human ILBC cells in vitro and in vivo... - Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL geneEl Harith Abdelghaffar El-Harith
Institute of Human Genetics, Medical University of Hannover, Hannover, Germany
Br J Haematol 144:185-94. 2009..In the families described the mode of inheritance could be regarded as autosomal-recessive with possible mild heterozygote manifestation rather than autosomal-dominant with high penetrance as usually seen in FT... - Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestineJulia Carlens
Institute of Immunology, Hannover Medical School, Hannover, Germany
J Immunol 183:5600-7. 2009.... - Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term surveyManuela Germeshausen
Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany
Blood 109:93-9. 2007..Our results strongly suggest that acquisition of a CSF3R mutation is an early event in leukemogenesis that has to be accompanied by cooperating molecular events, which remain to be defined... - Retroviral WASP gene transfer into human hematopoietic stem cells reconstitutes the actin cytoskeleton in myeloid progeny cells differentiated in vitroRicardo A Dewey
Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
Exp Hematol 34:1161-9. 2006..CONCLUSIONS: Our studies document the feasibility of WASP gene transfer into human CD34(+) cells and suggest that the phenotype of WASP-deficient myeloid cells can be restored upon retroviral gene transfer... - Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migrationMariam Al-Omari
Department of Pulmonology, Hannover Medical School, Hannover, Germany
Mol Med 17:865-74. 2011.... - A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cellsBastian Hoechst
Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany
Gastroenterology 135:234-43. 2008..In this study, we have investigated the frequency and function of a new population of MDSC denoted here as CD14(+)HLA-DR(-/low) in HCC patients. We have also identified a novel, MDSC-mediated immune regulatory pathway in these patients... - Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell lineMatthias Christgen
Institute of Pathology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
Mol Cell Biochem 306:201-12. 2007..In summary, we established Cal-51 SP cells as a novel in vitro model to study differential gene expression in breast cancer-derived SP and NSP cells... - Up-regulation of platelet-derived growth factor by peripheral-blood leukocytes during experimental allergic encephalomyelitisNiklas K U Koehler
Department of Neurology, Hannover Medical School, Hannover, Germany
J Neurosci Res 86:392-402. 2008..The production of PDGF by lymphocytes may have potential therapeutic value when activating or modulating T-cell responses in demyelinating diseases... - Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cellsNatalia Zietara
Institute for Immunology, Institute for Virology, and Department of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany
Proc Natl Acad Sci U S A 110:7407-12. 2013..Our results define a critical role of miR-181a/b-1 in early iNKT cell development and show that miR-181a/b-1 sets a TCR signaling threshold for agonist selection... - Exogenous HIV-1 Vpr disrupts IFN-alpha response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplayHenoch Sangjoon Hong
Clinic for Immunology und Rheumatology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, Hannover, Germany
Immunol Lett 125:100-4. 2009..Thus, Vpr-mediated dysregulation of IFN-alpha and IFN-gamma production affects key components of the innate immune response supporting an essential role of Vpr in HIV pathogenesis... - CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional propertiesMaria Luisa del Rio
Institute of Immunology, Hannover Medical School, Hannover, Germany
J Immunol 181:6178-88. 2008..Collectively, these data indicate that GFP(+)c-kit(+) cells contribute to the replenishment of CD103(+) DC in lymphoid and nonlymphoid organs... - FACS-isolation of Salmonella-infected cells with defined bacterial load from mouse spleenFriederike Thöne
Hannover Medical School, Junior Research Group Mucosal Infections OE 9421, Carl Neuberg Str 1, D 30625 Hannover, Germany
J Microbiol Methods 71:220-4. 2007..Our method will facilitate future characterization of the different subpopulations and the identification of bacterial and host factors that control Salmonella load and proliferation in vivo... - Thrombopoietin regulates differentiation of rhesus monkey embryonic stem cells to hematopoietic cellsZheng Wang
Hannover Medical School, Department of Pediatric Hematology and Oncology, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
Ann N Y Acad Sci 1044:29-40. 2005..The in vitro differentiation of rhesus monkey ES cells provides an opportunity to better understand the mechanism of TPO function in the early stage of hematopoietic development from ES cells to mature hematopoietic cells... - Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftmentFlorian P Limbourg
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
Eur J Heart Fail 7:722-9. 2005..However, the cell population mediating myocardial recovery and the fate of the transplanted cells are still controversial... - An acquired G-CSF receptor mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropeniaM Germeshausen
Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany
Leukemia 19:611-7. 2005..Our results provide direct evidence for the in vivo expression of a truncated G-CSFR in leukemic cells, which emerged in the absence of rh-G-CSF treatment and transduces proliferative signals... - Thrombopoietin is essential for the maintenance of normal hematopoiesis in humans: development of aplastic anemia in patients with congenital amegakaryocytic thrombocytopeniaM Ballmaier
Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
Ann N Y Acad Sci 996:17-25. 2003..On the other hand, the incidence of development of aplastic anemia in CAMT is not clear owing to difficult and not consistent diagnosis of this disease... - Implications of mutations in hematopoietic growth factor receptor genes in congenital cytopeniasM Germeshausen
Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany
Ann N Y Acad Sci 938:305-20; discussion 320-1. 2001..In contrast, mutations in the G-CSF receptor in CN are acquired and are most probably connected with progression of the neutropenia into MDS/leukemia as a result of a loss of differentiation signaling... - Familial polycythemia vera with non-germline JAK2(V617F) mutation sparing the abnormal and clonal granulopoiesisK Hussein
Leukemia 21:2566-8. 2007 - Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropeniaM Germeshausen
Department of Paediatric Haematology and Oncology, Medizinische Hochschule Hannover, Germany
Br J Haematol 115:222-4. 2001..We conclude that ELA2 mutations are not the single cause of CN although they might be a necessary prerequisite for the expression of the neutropenic phenotype in a subgroup of CN patients... - Concentrations of thrombopoietin and interleukin-11 in the umbilical cord blood of patients with fetal alloimmune thrombocytopeniaC Dame
Department of Neonatology, University of Bonn, Germany
Am J Perinatol 18:335-44. 2001..Cord blood serum concentrations of TPO are not significantly elevated in FAITP and do not predict the severity of the thrombocytopenia. Elevated IL-11 may signal a more rapid platelet recovery in FAITP...