Research Topics
Species | Christina AllmelingSummaryAffiliation: Hannover Medical School Country: Germany Publications
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Detail Information
Publications
Spider silk fibres in artificial nerve constructs promote peripheral nerve regenerationC Allmeling
Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
Cell Prolif 41:408-20. 2008..In our study, we describe the use of spider silk fibres as a new material in nerve tissue engineering, in a 20-mm sciatic nerve defect in rats...
Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduitChristina Allmeling
Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistr 380, D 30659 Hannover, Germany
J Cell Mol Med 10:770-7. 2006..In conclusion, our results show that artificial nerve grafts can be constructed successfully from spider silk, acellularized veins and SC mixed with matrigel...
Artificial skin--culturing of different skin cell lines for generating an artificial skin substitute on cross-weaved spider silk fibresHanna Wendt
Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Hannover, Germany
PLoS ONE 6:e21833. 2011..Additionally, it should degrade in an appropriate time period without releasing harmful substances, but not exert a pathological immune response. Spider dragline silk from Nephila spp meets these demands to a large extent...- AmbLOXe--an epidermal lipoxygenase of the Mexican axolotl in the context of amphibian regeneration and its impact on human wound closure in vitroBjoern Menger
Department of Plastic, Hand, and Reconstructive Surgery, Replantation and Burn Center of Lower Saxony, Laboratory of Experimental Plastic Surgery, Hannover Medical School, Hannover, Germany
Ann Surg 253:410-8. 2011..In this study we identified an amphibian lipoxygenase and evaluated its impact on human cells in an in vitro wound model... - First investigation of spider silk as a braided microsurgical sutureJoern W Kuhbier
Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
J Biomed Mater Res B Appl Biomater 97:381-7. 2011..With regards to the mechanical properties, these sutures were superior to nylon sutures. As spider silk displays high biocompatibility in nerve regeneration, its usage in microsurgical nerve repair should be considered... - Spider silk constructs enhance axonal regeneration and remyelination in long nerve defects in sheepChristine Radtke
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
PLoS ONE 6:e16990. 2011..We describe the use of nerve constructs consisting of decellularized vein grafts filled with spider silk fibers as a guiding material to bridge a 6.0 cm tibial nerve defect in adult sheep... - Interactions between spider silk and cells--NIH/3T3 fibroblasts seeded on miniature weaving framesJoern W Kuhbier
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
PLoS ONE 5:e12032. 2010..Not only does it own unique mechanical properties, its biocompatibility has been shown already in vivo. In our study, we used native spider dragline silk which is known as the strongest fibre in nature... - The yeast two hybrid system in a screen for proteins interacting with axolotl (Ambystoma mexicanum) Msx1 during early limb regenerationMehtap Abuqarn
Departmen tof Plastic, Hand and Reconstructive Surgery, Medical School of Hannover, Podbielskistrasse 380, D 30659 Hannover, Germany
Biochim Biophys Acta 1814:843-9. 2011..It is the first time, that the yeast two hybrid system was adapted to the axolotl animal model and successfully used in a screen for proteins interacting with Msx1 in the context of amphibian limb regeneration... - A normothermic perfusion bioreactor to preserve viability of rat groin flaps extracorporallyC Herold
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Transplant Proc 41:4382-8. 2009..This study was designed to evaluate the effect of permanent perfusion on fat flaps of the rat... - [In vitro fabrication of tendon substitutes using human mesenchymal stem cells and a collagen type I gel]S Kall
Labor für experimentelle Plastische Chirurgie, Klinik für Plastische, Hand und Wiederherstellungschirurgie, Medizinische Hochschule Hannover
Handchir Mikrochir Plast Chir 36:205-11. 2004..In this study we investigated whether long tendon-like substitutes can be fabricated in vitro from human mesenchymal stem cells (MSCs) and a collagen type I gel when cultured under cyclic stretching conditions... - Apoptosis in extracorporeal preserved inguinal fat flaps of the ratChristian Herold
Department of Plastic, Hand and Reconstructive Surgery, Hanover Medical School, Germany
Apoptosis 17:400-9. 2012..Based on these findings, further research to modify the apoptotic pathways to ameliorate viability of fat tissue can be performed... - Validation of differential gene expression in muscle engineered from rat groin adipose tissue by quantitative real-time PCRYang An
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Podbielskistr 380, 30659 Hannover, Germany
Biochem Biophys Res Commun 421:736-42. 2012..The use of β-2-microglobulin, RPL32 and RPL17 as internal standards may improve the accuracy of gene expression studies aimed at muscle tissue engineering under the proposed settings... - Schwann cell metabolic activity in various short-term holding conditions: implications for improved nerve graft viabilityInsa Janssen
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, 30625 Hannover, Germany
Int J Otolaryngol 2012:742183. 2012..Greater SC viability at the time of surgical nerve grafting could contribute to improved axonal regeneration and remyelination after nerve transplantation, and thus more successful functional recovery... - Resection of a large intra-abdominal tumor in the Mexican axolotl: a case reportBjoern Menger
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
Vet Surg 39:232-3. 2010..This case report describes the surgical removal of an intra-abdominal tumor from a Mexican axolotl (Ambystoma mexicanum). The animal was admitted with left abdominal swelling that had increased over 4 months... - Inhibition of apoptosis by expression of antiapoptotic proteins in recombinant human keratinocytesClaudia Y U Choi
Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, D 30625 Hannover, Germany
Cell Transplant 16:663-74. 2007..66), Faim (p = 0.42), or LFG (p = 0.44) expressing cells. Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection... - A Schwann cell-seeded intrinsic framework and its satisfactory biocompatibility for a bioartificial nerve graftZ L Shen
Clinic of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Germany
Microsurgery 21:6-11. 2001..We concluded that the arrangement of Schwann cell columns onto filaments was achieved, mimicking Bünger bands. It was shown that the biomaterials did not impede nerve regeneration... - Identification of the non-specific cytotoxic cell receptor protein 1 (NCCRP1) in regenerating axolotl limbsKerstin Reimers
Department for Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, 30659 Hannover, Germany
J Comp Physiol B 176:599-605. 2006..Our findings suggest the existence of NCC in axolotl and a role of the innate immune system in the processes of limb regeneration...