Jorg Ahrens

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. Ahrens J, Foadi N, Eberhardt A, Haeseler G, Dengler R, Leffler A, et al. Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells. Pharmacology. 2011;87:311-7 pubmed publisher
    ..Furthermore, only the loss of Sia had a significant effect on recovery from fast inactivation. Our data demonstrate for the first time that gating of voltage-gated sodium channels seems to be differentially regulated by polySia and Sia. ..
  2. Ahrens J, Leuwer M, Demir R, Krampfl K, de la Roche J, Foadi N, et al. Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors. Naunyn Schmiedebergs Arch Pharmacol. 2009;379:371-8 pubmed publisher
    ..9 +/- 21.5 microM and alpha(1)beta = 154.3 +/- 32.1 microM). These in vitro results demonstrate that ajulemic acid modulates strychnine-sensitive glycine receptors in clinically relevant concentrations. ..
  3. Ahrens J, Leuwer M, Stachura S, Krampfl K, Belelli D, Lambert J, et al. A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor. Anesth Analg. 2008;107:1875-83 pubmed publisher
    ....
  4. Ahrens J, Demir R, Leuwer M, de la Roche J, Krampfl K, Foadi N, et al. The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function. Pharmacology. 2009;83:217-22 pubmed publisher
    ..3 +/- 22.7 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for cannabidiol mediating some of its anti-inflammatory and neuroprotective properties. ..
  5. Haeseler G, Schaefers D, Prison N, Ahrens J, Liu X, Karch A. Combatting pain after orthopedic/trauma surgery- perioperative oral extended-release tapentadol vs. extended-release oxycodone/naloxone. BMC Anesthesiol. 2017;17:91 pubmed publisher
    ..Thus, we now use a prophylaxis against nausea and vomiting and pre-emptive laxatives as part of these concepts. https://eudract.ema.europa.eu (EudraCT- Nr. 2011-003238-15 ); October 24th, 2012. ..

Detail Information

Publications5

  1. Ahrens J, Foadi N, Eberhardt A, Haeseler G, Dengler R, Leffler A, et al. Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells. Pharmacology. 2011;87:311-7 pubmed publisher
    ..Furthermore, only the loss of Sia had a significant effect on recovery from fast inactivation. Our data demonstrate for the first time that gating of voltage-gated sodium channels seems to be differentially regulated by polySia and Sia. ..
  2. Ahrens J, Leuwer M, Demir R, Krampfl K, de la Roche J, Foadi N, et al. Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors. Naunyn Schmiedebergs Arch Pharmacol. 2009;379:371-8 pubmed publisher
    ..9 +/- 21.5 microM and alpha(1)beta = 154.3 +/- 32.1 microM). These in vitro results demonstrate that ajulemic acid modulates strychnine-sensitive glycine receptors in clinically relevant concentrations. ..
  3. Ahrens J, Leuwer M, Stachura S, Krampfl K, Belelli D, Lambert J, et al. A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor. Anesth Analg. 2008;107:1875-83 pubmed publisher
    ....
  4. Ahrens J, Demir R, Leuwer M, de la Roche J, Krampfl K, Foadi N, et al. The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function. Pharmacology. 2009;83:217-22 pubmed publisher
    ..3 +/- 22.7 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for cannabidiol mediating some of its anti-inflammatory and neuroprotective properties. ..
  5. Haeseler G, Schaefers D, Prison N, Ahrens J, Liu X, Karch A. Combatting pain after orthopedic/trauma surgery- perioperative oral extended-release tapentadol vs. extended-release oxycodone/naloxone. BMC Anesthesiol. 2017;17:91 pubmed publisher
    ..Thus, we now use a prophylaxis against nausea and vomiting and pre-emptive laxatives as part of these concepts. https://eudract.ema.europa.eu (EudraCT- Nr. 2011-003238-15 ); October 24th, 2012. ..