Uwe Karsten Hanisch

Summary

Country: Germany

Publications

  1. pmc Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin
    Smadar Hadas
    Dept of Medical Neurobiology, IMRIC, Hebrew University Faculty of Medicine, Ein Kerem, 12272, Jerusalem 91120, Israel
    J Neuroinflammation 9:166. 2012
  2. ncbi request reprint Proteins in microglial activation--inputs and outputs by subsets
    Uwe Karsten Hanisch
    Institute of Neuropathology, University of Gottingen, Gottingen, Germany
    Curr Protein Pept Sci 14:3-15. 2013
  3. doi request reprint Toll-like receptors: roles in neuroprotection?
    Uwe Karsten Hanisch
    Institute of Neuropathology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Trends Neurosci 31:176-82. 2008
  4. ncbi request reprint The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines
    Uwe Karsten Hanisch
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    J Biol Chem 279:51880-7. 2004
  5. ncbi request reprint The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level
    Oliver Kann
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Neurochem 90:513-25. 2004
  6. ncbi request reprint Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function
    Anja Hoffmann
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    J Neurosci 23:4410-9. 2003
  7. pmc Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes
    Sandra Ribes
    Institute of Neuropathology, University Medical Center Gottingen, Gottingen, Germany
    Infect Immun 81:1810-9. 2013
  8. doi request reprint Fibronectin stimulates Escherichia coli phagocytosis by microglial cells
    Sandra Ribes
    Department of Neurology, University of Gottingen, Robert Koch Strasse 40, Gottingen, Germany
    Glia 58:367-76. 2010
  9. ncbi request reprint Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages
    Karl Georg Häusler
    Max Delbruck Center for Molecular Medicine, Cellular Neurosciences, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    Eur J Neurosci 16:2113-22. 2002
  10. doi request reprint The nucleotide-binding oligomerization domain-containing-2 ligand muramyl dipeptide enhances phagocytosis and intracellular killing of Escherichia coli K1 by Toll-like receptor agonists in microglial cells
    Sandra Ribes
    Institute of Neuropathology, University Medical Center Gottingen, Gottingen, Germany
    J Neuroimmunol 252:16-23. 2012

Collaborators

Detail Information

Publications38

  1. pmc Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin
    Smadar Hadas
    Dept of Medical Neurobiology, IMRIC, Hebrew University Faculty of Medicine, Ein Kerem, 12272, Jerusalem 91120, Israel
    J Neuroinflammation 9:166. 2012
    ..Cofilin is an actin-depolymerizing protein that controls F-actin (filamentous actin) remodeling (i.e., disassembly and reassembly) by shifting between active unphosphorylated and inactive phosphorylated states...
  2. ncbi request reprint Proteins in microglial activation--inputs and outputs by subsets
    Uwe Karsten Hanisch
    Institute of Neuropathology, University of Gottingen, Gottingen, Germany
    Curr Protein Pept Sci 14:3-15. 2013
    ....
  3. doi request reprint Toll-like receptors: roles in neuroprotection?
    Uwe Karsten Hanisch
    Institute of Neuropathology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Trends Neurosci 31:176-82. 2008
    ..This article focuses on the yet less-addressed protective potential of TLR engagement within the CNS...
  4. ncbi request reprint The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines
    Uwe Karsten Hanisch
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    J Biol Chem 279:51880-7. 2004
    ..In addition, they could be relevant for the study of other cellular activities and their assignment to this protease...
  5. ncbi request reprint The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level
    Oliver Kann
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Neurochem 90:513-25. 2004
    ..The findings suggest that the AG126-sensitive PTK critically controls both sensory and executive features of the microglial activation process via sustained up-regulation of basal [Ca2+]i...
  6. ncbi request reprint Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function
    Anja Hoffmann
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    J Neurosci 23:4410-9. 2003
    ..Elevation of basal [Ca 2+]i could thus prove a central element in the regulation of executive functions in activated microglia...
  7. pmc Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes
    Sandra Ribes
    Institute of Neuropathology, University Medical Center Gottingen, Gottingen, Germany
    Infect Immun 81:1810-9. 2013
    ..These findings identify Toll-like receptor (TLR)-MyD88 signaling and neutrophil and monocyte activity as critical elements in the early host defense against E. coli meningitis...
  8. doi request reprint Fibronectin stimulates Escherichia coli phagocytosis by microglial cells
    Sandra Ribes
    Department of Neurology, University of Gottingen, Robert Koch Strasse 40, Gottingen, Germany
    Glia 58:367-76. 2010
    ..In conclusion, fibronectin increased proinflammatory and phagocytotic functions in microglia and partially synergized with microbial TLR agonists...
  9. ncbi request reprint Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages
    Karl Georg Häusler
    Max Delbruck Center for Molecular Medicine, Cellular Neurosciences, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    Eur J Neurosci 16:2113-22. 2002
    ....
  10. doi request reprint The nucleotide-binding oligomerization domain-containing-2 ligand muramyl dipeptide enhances phagocytosis and intracellular killing of Escherichia coli K1 by Toll-like receptor agonists in microglial cells
    Sandra Ribes
    Institute of Neuropathology, University Medical Center Gottingen, Gottingen, Germany
    J Neuroimmunol 252:16-23. 2012
    ..Dual pre-stimulation of Nod2 and TLR1/2 or 4 caused maximal phagocytosis and intracellular killing...
  11. doi request reprint CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS
    Tommy Regen
    Institute of Neuropathology, University of Gottingen, Germany
    Brain Behav Immun 25:957-70. 2011
    ..It thus proves as a sophisticated decision maker in infectious and non-infectious CNS challenges...
  12. doi request reprint The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells
    Sandra Ribes
    Institute of Neuropathology, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Neurosci Lett 482:17-20. 2010
    ..Our data encourage animal experiments with poly(I:C) derivatives to assess whether this approach can increase the resistance of the CNS against bacterial infections...
  13. pmc Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia
    Sandra Ribes
    Department of Geriatrics, Evang Krankenhaus Göttingen Weende, An der Lutter 24, D 37075 Gottingen, Germany
    Infect Immun 78:865-71. 2010
    ..Together, our data suggest that microglial stimulation by these TLRs may increase the resistance of the brain against pneumococcal infections...
  14. doi request reprint Physiology of microglia
    Helmut Kettenmann
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Physiol Rev 91:461-553. 2011
    ..Activated microglial cells can migrate to the site of injury, proliferate, and phagocytose cells and cellular compartments...
  15. doi request reprint Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia
    Jörg Scheffel
    Institute of Neuropathology, University of Gottingen, Gottingen, Germany
    Glia 60:1930-43. 2012
    ..Finally, subsets rather than a uniform population of microglia may assemble the reactive phenotypes in responses during infection, injury, and rebuilding, warranting consideration in experimental manipulation and therapeutic strategies...
  16. ncbi request reprint Microglia
    Denise van Rossum
    Institute for Neuropathology, University of Gottingen, D 37075 Gottingen, Germany
    Metab Brain Dis 19:393-411. 2004
    ....
  17. ncbi request reprint Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro
    Clemens Boucsein
    Max Delbruck Center for Molecular Medicine, Cellular Neuroscience, Robert Rössle Strasse10, D 13092, Berlin, Germany
    Eur J Neurosci 17:2267-76. 2003
    ..All these parameters were reduced in the presence of purinergic ligands, indicating that purinergic receptor activation attenuated indicators of microglial activation...
  18. pmc Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS
    Payam Dibaj
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    PLoS ONE 7:e43963. 2012
    ....
  19. doi request reprint Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way
    Tobias Pukrop
    Department of Hematology Oncology, University of Gottingen, Gottingen, Germany
    Glia 58:1477-89. 2010
    ..In conclusion, microglia are critical for the successful colonization of the brain by epithelial cancer cells, suggesting inhibition of proinvasive microglia as a promising antimetastatic strategy...
  20. ncbi request reprint Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
    Alexander Mildner
    Institute of Neuropathology, Georg August University, Gottingen, Germany
    Nat Neurosci 10:1544-53. 2007
    ..Our results identify Ly-6C(hi)CCR2(+) monocytes as direct precursors of microglia in the adult brain and establish the importance of local factors in the adult CNS for microglia engraftment...
  21. pmc Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination
    Wolfgang Bruck
    Department of Neuropathology, University Medical Center, Robert Koch Str 40, 37099, Gottingen, Germany
    Acta Neuropathol 124:411-24. 2012
    ..Modulation of astrocyte activation may be an attractive therapeutic target to prevent tissue damage in MS...
  22. doi request reprint Carcinoma cells misuse the host tissue damage response to invade the brain
    Han Ning Chuang
    Department of Hematology Oncology, University Medical Center, Gottingen, Germany
    Glia 61:1331-46. 2013
    ..Together, our findings point to a detrimental misuse of the glial damage response program by carcinoma cells resistant to glia-induced apoptosis...
  23. ncbi request reprint Fibronectin is elevated in the cerebrospinal fluid of patients suffering from bacterial meningitis and enhances inflammation caused by bacterial products in primary mouse microglial cell cultures
    Miriam Goos
    Department of Neurology, Georg August University, Gottingen, Germany
    J Neurochem 102:2049-60. 2007
    ..This additive or synergistic effect may contribute to neuronal damage during bacterial meningitis...
  24. pmc Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells
    Sandra Ribes
    Department of Neurology, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Infect Immun 77:557-64. 2009
    ..Our data suggest that microglial stimulation by the TLR system can increase bacterial phagocytosis and killing. This approach could improve central nervous system resistance to infections in immunocompromised patients...
  25. ncbi request reprint Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
    Denise van Rossum
    Institute for Neuropathology, University of Gottingen, D 37075, Gottingen, Germany
    Glia 56:271-83. 2008
    ..Nerve-exposed macrophages thus commit to a unique functional orientation...
  26. doi request reprint Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
    Dirk Fitzner
    Max Planck Institute for Experimental Medicine, Hermann Rein Str, D 37075 Gottingen, Germany
    J Cell Sci 124:447-58. 2011
    ..By designating the capacity for macropinocytosis and antigen presentation to distinct cells, degradation and immune function might be assigned to different subtypes of microglia...
  27. ncbi request reprint Microglia as a source and target of cytokines
    Uwe Karsten Hanisch
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Glia 40:140-55. 2002
    ..Dysregulation of microglial cytokine production could thereby promote harmful actions of the defense mechanisms, result in direct neurotoxicity, as well as disturb neural cell functions as they are sensitive to cytokine signaling...
  28. ncbi request reprint Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    Uwe Karsten Hanisch
    Institute of Neuropathology, University of Gottingen, D 37075 Gottingen, Germany
    Nat Neurosci 10:1387-94. 2007
    ..In this review, we focus on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain...
  29. pmc Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis
    Simone Wüst
    Institute for Multiple Sclerosis Research, University of Göttingen and Gemeinnützige Hertie Stiftung, Gottingen, Germany
    PLoS ONE 4:e8202. 2009
    ....
  30. ncbi request reprint c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia
    Vicki Waetzig
    Institute of Pharmacology, University Hospital Kiel, 24105 Kiel, Germany
    Glia 50:235-46. 2005
    ..In summary, JNKs are essential mediators of relevant pro-inflammatory functions in microglia with different contributions of the JNK isoforms...
  31. ncbi request reprint Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations
    Jonathan R Weinstein
    Department of Neurology, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Neurochem 95:1177-87. 2005
    ..In addition, these results suggest that previous studies examining thrombin's activation of microglia should be cautiously re-interpreted...
  32. ncbi request reprint Microglial phenotype: is the commitment reversible?
    Michal Schwartz
    The Weizmann Institute of Science, POB 26, Rehovot, 76100, Israel
    Trends Neurosci 29:68-74. 2006
    ....
  33. ncbi request reprint Activation of microglial cells by thrombin: past, present, and future
    Thomas Moller
    Department of Neurology, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Semin Thromb Hemost 32:69-76. 2006
    ..Prior reports using nonpharmaceutical-grade thrombin need to be reinterpreted critically given these new findings...
  34. pmc Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors
    Jonathan R Weinstein
    Department of Neurology, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Glia 56:16-26. 2008
    ..Careful attention to LPS levels and appropriate controls are necessary for future studies in the neuroinflammation field...
  35. doi request reprint Thrombin regulates CD40 expression in microglial cells
    Jonathan R Weinstein
    Department of Neurology, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Neuroreport 19:757-60. 2008
    ..Thrombin-induced CD40 regulation might play a role in diseases with breakdown of the blood-brain barrier such as multiple sclerosis or stroke...
  36. doi request reprint Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    Marco Prinz
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    Immunity 28:675-86. 2008
    ..In contrast, absence of IFNAR on myeloid cells led to severe disease with an enhanced effector phase and increased lethality, indicating a distinct protective function of type I IFNs during autoimmune inflammation of the CNS...
  37. pmc Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis
    Klemens Angstwurm
    Department of Neurology, Charite, Humboldt University Berlin, Berlin, Germany
    Infect Immun 72:3294-8. 2004
    ....
  38. ncbi request reprint Expression of proteinase-activated receptors in mouse microglial cells
    Stephanie Balcaitis
    Department of Neurosurgery, University of Washington, Seattle, 98195, USA
    Neuroreport 14:2373-7. 2003
    ..Demonstrating multiple PARs on microglia may enhance the attractiveness of PARs as therapeutic targets in neuroinflammatory disorders...