M Hallschmid

Summary

Country: Germany

Publications

  1. ncbi request reprint Drinking related direct current positive potential shift in the human EEG depends on thirst
    M Hallschmid
    Clinical Neuroendocrinology, Medical University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Neurosci Lett 311:173-6. 2001
  2. ncbi request reprint EEG synchronization upon reward in man
    M Hallschmid
    Clinical Neuroendocrinology, Medical University of Lubeck, Ratzeburger Allee 160, Haus 23a, Germany
    Clin Neurophysiol 113:1059-65. 2002
  3. ncbi request reprint NPY attenuates positive cortical DC-potential shift upon food intake in man
    M Hallschmid
    Klinische Forschergruppe Neuroendokrinologie, Medizinische Universitat Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 28:529-39. 2003
  4. ncbi request reprint Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain
    Manfred Hallschmid
    University of Lubeck, Institute of Neuroendocrinology, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Diabetes 53:2202-8. 2004
  5. ncbi request reprint Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man
    Manfred Hallschmid
    Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Physiol Behav 83:55-64. 2004
  6. ncbi request reprint Intranasal insulin reduces body fat in men but not in women
    Manfred Hallschmid
    Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Diabetes 53:3024-9. 2004
  7. ncbi request reprint Obese men respond to cognitive but not to catabolic brain insulin signaling
    M Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Int J Obes (Lond) 32:275-82. 2008
  8. doi request reprint Short-term nocturnal hypoglycaemia increases morning food intake in healthy humans
    S M Schmid
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Diabet Med 25:232-5. 2008
  9. ncbi request reprint Plasma glucagon decreases during night-time sleep in Type 1 diabetic patients and healthy control subjects
    K Jauch-Chara
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Diabet Med 24:684-7. 2007
  10. doi request reprint Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Regul Pept 149:79-83. 2008

Detail Information

Publications38

  1. ncbi request reprint Drinking related direct current positive potential shift in the human EEG depends on thirst
    M Hallschmid
    Clinical Neuroendocrinology, Medical University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Neurosci Lett 311:173-6. 2001
    ..The post-drinking positive DC-potential shift depending on the subject's motivational state can be considered an indicator of reward associated with quenching thirst, pointing to a lowered frontocortical excitability during reward...
  2. ncbi request reprint EEG synchronization upon reward in man
    M Hallschmid
    Clinical Neuroendocrinology, Medical University of Lubeck, Ratzeburger Allee 160, Haus 23a, Germany
    Clin Neurophysiol 113:1059-65. 2002
    ..It was tested whether reward in humans is associated with EEG synchronization similar to that seen in animals...
  3. ncbi request reprint NPY attenuates positive cortical DC-potential shift upon food intake in man
    M Hallschmid
    Klinische Forschergruppe Neuroendokrinologie, Medizinische Universitat Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 28:529-39. 2003
    ..NPY reduced this satiation associated positive shift (p<0.05) over all areas except P3 and Pz. Data suggest that NPY exerts its orexigenic influence by attenuating mechanisms of satiation...
  4. ncbi request reprint Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain
    Manfred Hallschmid
    University of Lubeck, Institute of Neuroendocrinology, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Diabetes 53:2202-8. 2004
    ..The rapid emergence of the DC potential shift, reflecting gross ionic changes in brain tissues, indicates that systemic insulin can serve as an immediate feedback signal in the control of hypothalamic and higher brain functions...
  5. ncbi request reprint Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man
    Manfred Hallschmid
    Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Physiol Behav 83:55-64. 2004
    ..The results corroborate in humans the significance of all three messengers for the central nervous regulation of adiposity and might contribute to the future development of medical strategies against body-weight-related disorders...
  6. ncbi request reprint Intranasal insulin reduces body fat in men but not in women
    Manfred Hallschmid
    Institute of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Diabetes 53:3024-9. 2004
    ..Our results provide a strong, first confirmation in humans that insulin acts as a negative feedback signal in the regulation of adiposity and point to a differential sensitivity to the catabolic effects of insulin based on sex...
  7. ncbi request reprint Obese men respond to cognitive but not to catabolic brain insulin signaling
    M Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Int J Obes (Lond) 32:275-82. 2008
    ..The present experiments aimed to generalize these findings to obese patients, with a view to evaluate the therapeutic potential of the compound...
  8. doi request reprint Short-term nocturnal hypoglycaemia increases morning food intake in healthy humans
    S M Schmid
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Diabet Med 25:232-5. 2008
    ..Given the background of frequent hypoglycaemic episodes during night-time sleep in diabetic patients, we investigated morning food intake after nocturnal hypoglycaemia...
  9. ncbi request reprint Plasma glucagon decreases during night-time sleep in Type 1 diabetic patients and healthy control subjects
    K Jauch-Chara
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Diabet Med 24:684-7. 2007
    ..The dynamics of spontaneous glucagon release have rarely been assessed. We monitored spontaneous glucagon release in T1DM patients and healthy subjects during a 7-h period of night-time sleep...
  10. doi request reprint Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Regul Pept 149:79-83. 2008
    ..Our results may contribute to the future development of therapeutic strategies in disorders like obesity and cognitive impairments that derive from dysfunctions of central nervous neuropeptidergic pathways...
  11. doi request reprint Early morning rise in hypothalamic-pituitary-adrenal activity: a role for maintaining the brain's energy balance
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Psychoneuroendocrinology 34:455-62. 2009
    ..Sleep is not critically involved in this glucose-glucocorticoid feedback loop but may reduce the brain's sensitivity to the anorexigenic effect of enhanced glucose supply...
  12. doi request reprint Altered neuroendocrine sleep architecture in patients with type 1 diabetes
    Kamila Jauch-Chara
    Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, Germany
    Diabetes Care 31:1183-8. 2008
    ..Disturbances of sleep may arise from and contribute to the disease process in chronically ill patients with type 1 diabetes...
  13. pmc Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Diabetes 59:1101-7. 2010
    ....
  14. doi request reprint Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders?
    M Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Diabetologia 52:2264-9. 2009
    ....
  15. ncbi request reprint Intranasal insulin improves memory in humans: superiority of insulin aspart
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuropsychopharmacology 32:239-43. 2007
    ..This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease...
  16. ncbi request reprint Brief sleep after learning keeps emotional memories alive for years
    Ullrich Wagner
    Department of Neuroendocrinology, Medical University of Lubeck, Lubeck, Germany
    Biol Psychiatry 60:788-90. 2006
    ....
  17. doi request reprint Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 93:1339-44. 2008
    ..Long-term administration of intranasal insulin reduces body weight in men, but not in women, while improving hippocampus-dependent memory processing in both genders...
  18. ncbi request reprint Modulation of food intake by glucose in patients with type 2 diabetes
    Bernd Schultes
    Department of Internal Medicine I, Medical University Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Diabetes Care 28:2884-9. 2005
    ..On this background, we hypothesized that a short-term reduction of blood glucose concentration to normal values acutely increases food intake in type 2 diabetic patients...
  19. ncbi request reprint Signs of REM sleep dependent enhancement of implicit face memory: a repetition priming study
    Ullrich Wagner
    Department of Physiological Psychology, University of Bamberg, Markusplatz 3, D 96045 Bamberg, Germany
    Biol Psychol 62:197-210. 2003
    ..Together, these findings indicate that implicit face memories particularly benefit from REM sleep associated brain mechanisms...
  20. doi request reprint Blocking NMDA receptor signaling does not decrease hormonal counterregulation to hypoglycemia in humans
    Isabel Pais
    Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Psychoneuroendocrinology 33:1069-76. 2008
    ..Our data do not support the view that in humans, enhanced glutamate signaling during hypoglycemia supports the satisfaction of increased central nervous energy demands by enforcing hormonal counterregulation...
  21. doi request reprint NMDA receptor blockade by memantine does not prevent adaptation to recurrent hypoglycaemia in healthy men
    J Klement
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Diabetes Obes Metab 15:310-5. 2013
    ..If so, attenuation should be prevented by blocking glutamatergic N-methyl-d-aspartate (NMDA) receptors...
  22. doi request reprint High-calorie glucose-rich food attenuates neuroglycopenic symptoms in patients with Addison's disease
    Johanna Klement
    University of Lubeck, Department of Internal Medicine I, Ratzeburger Allee 160, House 32, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 95:522-8. 2010
    ..It will be important to investigate whether additional oral glucose supply may be helpful in improving patients' well-being...
  23. ncbi request reprint Overweight humans are resistant to the weight-reducing effects of melanocortin4-10
    Manfred Hallschmid
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 91:522-5. 2006
    ....
  24. ncbi request reprint Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    Metabolism 54:1356-61. 2005
    ..However, the effect is not observed with prolonged administration of the hormone, suggesting the emergence of counterregulatory processes...
  25. ncbi request reprint Intranasal insulin improves memory in humans
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 29:1326-34. 2004
    ..These findings could be of relevance for the treatment of patients with memory disorders like in Alzheimer's disease...
  26. ncbi request reprint Intranasal insulin to improve memory function in humans
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuroendocrinology 86:136-42. 2007
    ..e., declarative) memory. Intranasal administration of insulin provides an effective way of delivering the compound to the central nervous system, bypassing the blood-brain barrier and avoiding systemic side effects...
  27. ncbi request reprint Post-dural puncture headache in young adults: comparison of two small-gauge spinal catheters with different needle design
    U W Gosch
    Department of Anaesthesiology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Br J Anaesth 94:657-61. 2005
    ..To reduce the risk of post-dural puncture headache (PDPH) in continuous spinal anaesthesia, small-gauge spinal catheter systems with different techniques of dural perforation have been developed...
  28. ncbi request reprint Mood and cognitive functions during acute euglycaemia and mild hyperglycaemia in type 2 diabetic patients
    I Pais
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Exp Clin Endocrinol Diabetes 115:42-6. 2007
    ..We examined mood and cognitive functions in patients with T2DM during acute euglycaemia in comparison with moderate hyperglycaemia...
  29. ncbi request reprint Sleep-dependent surges in growth hormone do not contribute to sleep-dependent memory consolidation
    Steffen Gais
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Hs 23a, 23538 Lubeck, Germany
    Psychoneuroendocrinology 31:786-91. 2006
    ....
  30. ncbi request reprint Transcranial direct current stimulation during sleep improves declarative memory
    Lisa Marshall
    Institute of Neuroendocrinology H23a, University of Lubeck, 23538 Lubeck, Germany
    J Neurosci 24:9985-92. 2004
    ..Shifts in extracellular ionic concentration in frontocortical tissue (expressed as negative DC potentials during SWS) may facilitate sleep-dependent consolidation of declarative memories...
  31. ncbi request reprint Gut protein uptake and mechanisms of meal-induced cortisol release
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    J Clin Endocrinol Metab 90:1692-6. 2005
    ..We conclude that the meal-related hypothalamo-pituitary-adrenal axis response to amino acids results from a signal that rather acts at the gastrointestinal mucosa than directly via the circulating blood...
  32. pmc Sleep forms memory for finger skills
    Stefan Fischer
    Department of Neuroendocrinology, University of Lubeck, D 23538 Lubeck, Germany
    Proc Natl Acad Sci U S A 99:11987-91. 2002
    ..Retention periods of wakefulness improved performance only moderately and only if placed during daytime. The observations demonstrate a critical role of sleep for storing and optimizing motor skills...
  33. ncbi request reprint Sleep loss alters basal metabolic hormone secretion and modulates the dynamic counterregulatory response to hypoglycemia
    Sebastian M Schmid
    Department of Internal Medicine, University of Luebeck, Germany
    J Clin Endocrinol Metab 92:3044-51. 2007
    ..Sleep loss has immediate effects on metabolic function that in the long run may contribute to the development of obesity and type 2 diabetes...
  34. ncbi request reprint Preserved circadian rhythm of serum insulin concentration at low plasma glucose during fasting in lean and overweight humans
    Volker Merl
    Department of Internal Medicine I, University of Luebeck, 23538 Luebeck, Germany
    Metabolism 53:1449-53. 2004
    ..This finding suggests a central nervous system contribution to the regulation of insulin secretion independent of plasma glucose levels...
  35. ncbi request reprint Targeting metabolic and cognitive pathways of the CNS by intranasal insulin administration
    Manfred Hallschmid
    Expert Opin Drug Deliv 4:319-22. 2007
    ..These results may fuel the future development of therapeutic strategies in disorders such as obesity and Alzheimer's disease that are promoted by dysfunctions of central nervous neuropeptidergic pathways...
  36. ncbi request reprint Hypoglycemia during sleep impairs consolidation of declarative memory in type 1 diabetic and healthy humans
    Kamila Jauch-Chara
    Internal Medicine I, University of Luebeck, Luebeck, Germany
    Diabetes Care 30:2040-5. 2007
    ..Patients with type 1 diabetes frequently experience hypoglycemic episodes during sleep. We investigated whether short-lasting hypoglycemia during early nocturnal sleep affects the sleep-associated consolidation of declarative memories...
  37. ncbi request reprint Awakening and counterregulatory response to hypoglycemia during early and late sleep
    Kamila Jauch-Chara
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Diabetes 56:1938-42. 2007
    ..Here, we investigated whether awakening and counterregulatory responses differ between early and late sleep...
  38. pmc Defective awakening response to nocturnal hypoglycemia in patients with type 1 diabetes mellitus
    Bernd Schultes
    Department of Internal Medicine, University of Luebeck, Luebeck, Germany
    PLoS Med 4:e69. 2007
    ..Whether hypoglycemia normally provokes awakening from sleep in individuals who do not have diabetes, and whether this awakening response is impaired in T1DM patients, is unknown...