- Local anaesthetics inhibit signalling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase CK Hahnenkamp
Department of Anaesthesiology and Intensive Care, University Hospital, Munster, Germany
Br J Anaesth 96:77-87. 2006..One potential explanation for this beneficial effect is the inhibition of NMDA receptor activation. Therefore, we studied the effects of LA on NMDA receptor function...
- Regional anaesthesia, local anaesthetics and the surgical stress responseKlaus Hahnenkamp
Department of Anaesthesiology and Intensive Care, University Hospital Muenster, 48129 Munster, Germany
Best Pract Res Clin Anaesthesiol 18:509-27. 2004....
- Bupivacaine inhibits thromboxane A2-induced vasoconstriction in rat thoracic aortaKlaus Hahnenkamp
Department of Anesthesiology and Intensive Care, University Hospital, Munster, Germany
Anesth Analg 99:97-102. 2004..Bupivacaine inhibited carbachol-induced vascular relaxation. This study provides experimental evidence that bupivacaine is an endothelium-independent inhibitor of TXA2-induced vasoconstriction of rat thoracic aorta...
- Modulation of Xenopus laevis Ca-activated Cl currents by protein kinase C and protein phosphatases: implications for studies of anesthetic mechanismsKlaus Hahnenkamp
Department of Anesthesiology and Intensive Care, University Hospital, Muenster, Germany
Anesth Analg 99:416-22, table of contents. 2004..Our data indicate that the Xenopus I(Cl(Ca)) is modulated by phosphorylation. This may complicate design and interpretation of studies of G protein-coupled receptors using this model...
- Remifentanil directly activates human N-methyl-D-aspartate receptors expressed in Xenopus laevis oocytesKlaus Hahnenkamp
Department of Anesthesiology and Critical Care, University Hospital Muenster, Germany
Anesthesiology 100:1531-7. 2004..N-methyl-D-aspartate (NMDA) receptors are thought to play a major role in development of postoperative pain and opiate tolerance. The authors hypothesized that Ultiva directly stimulates human NMDA receptors...
- The inhibitory potency of local anesthetics on NMDA receptor signalling depends on their structural featuresCarsten Gronwald
Dept of Anesthesiology and Intensive Care, University Hospital, Muenster, Germany
Eur J Pharmacol 674:13-9. 2012..The development of novel drugs based on local anesthetic like structures may be a new approach for the protection or treatment of NMDA receptor mediated hyperalgesia and may be associated with a low side effect profile...
- Effects of antidepressants on G protein-coupled receptor signaling and viability in Xenopus laevis oocytesDanja Strumper
Department of Anesthesiology and Intensive Care Medicine, University Hospital Munster, Munster, Germany
Anesthesiology 99:911-7. 2003..Because local anesthetics block G protein-coupled receptor signaling (which explains, in part, their inflammatory modulating properties), the authors studied whether antidepressants have similar effects...
- The effects of local anesthetics on perioperative coagulation, inflammation, and microcirculationKlaus Hahnenkamp
Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster, Albert Schweitzer Strasse 33, 48129 Muenster, Germany
Anesth Analg 94:1441-7. 2002
- Time-dependent inhibition of G protein-coupled receptor signaling by local anestheticsMarkus W Hollmann
Department of Anesthesiology and Intensive Care Medicine, University Hospital Heidelberg, Germany
Anesthesiology 100:852-60. 2004..Using Xenopus oocytes and human neutrophils, the authors studied time-dependent effects of LAs on G protein-coupled receptor signaling and characterized possible mechanisms and sites of action...
- Local anesthetics inhibit thromboxane A2 signaling in Xenopus oocytes and human k562 cellsChristian W Hönemann
Department of Anesthesiology, University of Virginia, PO Box 800710, Charlottesville, VA 22908 0710, USA
Anesth Analg 99:930-7, table of contents. 2004..7 +/- 1.8 x 10(-4) M. This suggests that some of the beneficial effects of regional anesthesia techniques might be due to direct interaction of local anesthetics with the functioning of membrane proteins...
- The effects of S(-)-, R(+)-, and racemic bupivacaine on lysophosphatidate-induced priming of human neutrophilsMarkus W Hollmann
Department of Anesthesiology, University of Heidelberg, Germany
Anesth Analg 97:1053-8, table of contents. 2003..Compared with racemic bupivacaine and other anesthetics, S(-)-bupivacaine appears particularly effective in suppressing neutrophil priming, a process responsible in part for the overactive neutrophil response...
- Is there a place for local anesthetics structurally different from classical amid or ester local anesthetics?Vladimir Vegh
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia
Curr Opin Anaesthesiol 19:509-15. 2006..The aim of this review is to describe the pharmacology, toxicology and chemistry of the new group of local anesthetics of phenylcarbamic acid type...
- Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trialSusanne Herroeder
Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
Ann Surg 246:192-200. 2007..To characterize the beneficial effects of perioperative systemic lidocaine on length of hospital stay, gastrointestinal motility, and the inflammatory response after colorectal surgery...