J Hagenah

Summary

Country: Germany

Publications

  1. doi request reprint Transcranial sonography findings in a large family with homozygous and heterozygous PINK1 mutations
    J M Hagenah
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Neurol Neurosurg Psychiatry 79:1071-4. 2008
  2. doi request reprint Life-long increase of substantia nigra hyperechogenicity in transcranial sonography
    Johann Hagenah
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neuroimage 51:28-32. 2010
  3. doi request reprint [Sonography of the parenchyma in Parkinson's disease]
    J Hagenah
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Deutschland
    Nervenarzt 81:1189-95. 2010
  4. ncbi request reprint Distinguishing early-onset PD from dopa-responsive dystonia with transcranial sonography
    J M Hagenah
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160 D 23538 Lübeck, Germany
    Neurology 66:1951-2. 2006
  5. doi request reprint Basal ganglia hyperechogenicity does not distinguish between patients with primary dystonia and healthy individuals
    Johann Hagenah
    Section of Clinical and Molecular Neurogenetics, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Neurol 258:590-5. 2011
  6. pmc Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
    B F L van Nuenen
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neurology 72:1041-7. 2009
  7. ncbi request reprint High mutation rate in dopa-responsive dystonia: detection with comprehensive GCHI screening
    J Hagenah
    Department of Neurology, University of Lubeck, Lubeck, Germany
    Neurology 64:908-11. 2005
  8. doi request reprint Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit
    C Eggers
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neurology 74:1798-805. 2010
  9. ncbi request reprint Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia
    F Binkofski
    Department of Neurology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Neurology 69:842-50. 2007
  10. doi request reprint Autosomal dominant Parkinson's disease in a large German pedigree
    N Bruggemann
    Division of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lubeck, Lubeck, Germany
    Acta Neurol Scand 126:129-37. 2012

Collaborators

Detail Information

Publications23

  1. doi request reprint Transcranial sonography findings in a large family with homozygous and heterozygous PINK1 mutations
    J M Hagenah
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Neurol Neurosurg Psychiatry 79:1071-4. 2008
    ..To investigate substantia nigra (SN) echogenicity in members of a family with homozygous and heterozygous PTEN induced kinase (PINK1) mutations with or without signs of Parkinson's disease (PD)...
  2. doi request reprint Life-long increase of substantia nigra hyperechogenicity in transcranial sonography
    Johann Hagenah
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neuroimage 51:28-32. 2010
    ..The increase of SN hyperechogenicity over time suggests that the biological process underlying this ultrasound finding may be more dynamic and possibly progressive than previously thought...
  3. doi request reprint [Sonography of the parenchyma in Parkinson's disease]
    J Hagenah
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Deutschland
    Nervenarzt 81:1189-95. 2010
    ..Longitudinal studies of asymptomatic subjects with abnormal echogenicity of the SN are still ongoing to evaluate the risk for developing Parkinson's disease in the future in these subjects...
  4. ncbi request reprint Distinguishing early-onset PD from dopa-responsive dystonia with transcranial sonography
    J M Hagenah
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160 D 23538 Lübeck, Germany
    Neurology 66:1951-2. 2006
  5. doi request reprint Basal ganglia hyperechogenicity does not distinguish between patients with primary dystonia and healthy individuals
    Johann Hagenah
    Section of Clinical and Molecular Neurogenetics, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Neurol 258:590-5. 2011
    ..It remains to be explored whether this is due to a true absence of signal alterations in the basal ganglia of dystonia patients or to limitations of the current technology used...
  6. pmc Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
    B F L van Nuenen
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neurology 72:1041-7. 2009
    ..Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease alters the cortical control of sequential finger movements...
  7. ncbi request reprint High mutation rate in dopa-responsive dystonia: detection with comprehensive GCHI screening
    J Hagenah
    Department of Neurology, University of Lubeck, Lubeck, Germany
    Neurology 64:908-11. 2005
    ..The authors attribute this high mutation rate to rigorous inclusion criteria and comprehensive mutational analysis...
  8. doi request reprint Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit
    C Eggers
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neurology 74:1798-805. 2010
    ..While homozygous mutations in the PINK1 gene cause recessively inherited early-onset Parkinson disease (PD), heterozygous mutations have been suggested as a susceptibility factor...
  9. ncbi request reprint Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia
    F Binkofski
    Department of Neurology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Neurology 69:842-50. 2007
    ..We hypothesized that subclinical nigrostriatal neurodegeneration caused by these mutations would induce morphologic changes in the dysfunctional striatal gray matter...
  10. doi request reprint Autosomal dominant Parkinson's disease in a large German pedigree
    N Bruggemann
    Division of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lubeck, Lubeck, Germany
    Acta Neurol Scand 126:129-37. 2012
    ..While several genes have been identified to cause Parkinson's disease (PD), monogenic forms explain only a small proportion of cases. We report clinical and genetic results in a large family with late-onset autosomal dominant PD...
  11. ncbi request reprint Mutations in DYT1: extension of the phenotypic and mutational spectrum
    K Kabakci
    Department of Neurology, University of Lubeck, Germany
    Neurology 62:395-400. 2004
    ..Exon rearrangements are a common mutation type in other genes and have not yet been tested for in DYT1. Several lines of evidence suggest a relationship of the DYT1 gene with Parkinson disease (PD)...
  12. doi request reprint [The presymptomatic stage of neurodegenerative disorders]
    C Klein
    Sektion für Klinische und Molekulare Neurogenetik, Klinik fur Neurologie, Universitat zu Lubeck, Lubeck, Deutschland
    Nervenarzt 82:994-1001. 2011
    ..Furthermore, studies of presymptomatic disease stages are important because they may help to unravel compensatory mechanisms responsible for apparently normal brain function despite ongoing neurodegeneration...
  13. ncbi request reprint Focal and segmental primary dystonia in north-western Germany--a clinico-genetic study
    S Maniak
    Department of Neurology, Medical University of Lubeck, Lubeck, Germany
    Acta Neurol Scand 107:228-32. 2003
    ..To determine the frequency of familial focal and segmental dystonias in a large patient cohort with primary dystonia from north-western Germany...
  14. ncbi request reprint alpha-Synuclein and Parkinson disease susceptibility
    S Winkler
    Department of Neurology, University of Lübeck Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neurology 69:1745-50. 2007
    ..Furthermore, polymorphic variants in multiple regions of the gene have been associated with susceptibility to idiopathic PD in different populations...
  15. doi request reprint Myoclonus-dystonia: significance of large SGCE deletions
    A Grunewald
    Department of Neurology, Lübeck University, Lubeck, Germany
    Hum Mutat 29:331-2. 2008
    ..In conclusion, a rigorous clinical preselection of patients and careful accounting for non-motor signs should precede mutational tests. Gene dosage studies should be included in routine SGCE genetic testing...
  16. ncbi request reprint Eye movement abnormalities in spinocerebellar ataxia type 17 (SCA17)
    J Hübner
    Department of Neurology, University of Luebeck, Luebeck, Germany
    Neurology 69:1160-8. 2007
    ..In this quantitative characterization of eye movements in SCA17 mutation carriers, we investigated whether eye movement abnormalities originate from multiple lesion sites as suggested by their phenotypic heterogeneity...
  17. doi request reprint [Dystonia]
    A Schmidt
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Nervenarzt 79:53-63; quiz 64-5. 2008
    ..A trial of levodopa is recommended in young-onset cases. In focal forms, botulinum toxin injections are helpful. Anticholinergics may be beneficial. In severe cases deep brain stimulation may be considered...
  18. ncbi request reprint Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS study
    T Baumer
    Department of Neurology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Neurology 69:1976-81. 2007
    ....
  19. pmc Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease
    K Reetz
    Department of Neurology, University of Luebeck, 23538 Luebeck, Germany
    Open Neuroimag J 2:102-5. 2008
    ..The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies...
  20. ncbi request reprint Exon deletions in the GCHI gene in two of four Turkish families with dopa-responsive dystonia
    C Klein
    Department of Neurology, Medical University of Lubeck, Germany
    Neurology 59:1783-6. 2002
    ..These deletions were detected by quantitative duplex PCR that is amenable to DNA diagnostics...
  21. ncbi request reprint [Pharmacological strategies for clozapine-induced hypersalivation: treatment with botulinum toxin B in one patient and review of the literature]
    K G Kahl
    Klinik fur Psychiatrie und Psychotherapie, Universitat Lubeck, 23538 Lubeck
    Nervenarzt 76:205-8. 2005
    ..We here present an overview on current treatment strategies for sialorrhea and describe a patient who received botulinum toxin B for clozapine-induced hypersalivation...
  22. ncbi request reprint [CDG (congenital disorders of glycosylation). Differential hereditary ataxia in adulthood diagnosis]
    S Bubel
    Klinik fur Neurologie, Universitatsklinikum Lubeck, Ratzeburger Allee 160, 23538 Lubeck
    Nervenarzt 73:754-60. 2002
    ..The CDG should be included in the differential diagnostic workup of hereditary cerebellar ataxia in adults...
  23. doi request reprint [Central sleep apnea in multiple sclerosis]
    A Steffen
    Klinik fur Hals, Nasen und Ohrenheilkunde, Kopf und Halschirurgie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Deutschland
    HNO 58:405-8. 2010
    ....