J Hacker

Summary

Country: Germany

Publications

  1. pmc Ecological fitness, genomic islands and bacterial pathogenicity. A Darwinian view of the evolution of microbes
    J Hacker
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    EMBO Rep 2:376-81. 2001
  2. ncbi request reprint Pathogenicity islands of uropathogenic E. coli and the evolution of virulence
    T A Oelschlaeger
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Roentgenring 11, 97070 Wurzburg, Germany
    Int J Antimicrob Agents 19:517-21. 2002
  3. ncbi request reprint Whole genome plasticity in pathogenic bacteria
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Opin Microbiol 4:550-7. 2001
  4. pmc A genomic island, termed high-pathogenicity island, is present in certain non-O157 Shiga toxin-producing Escherichia coli clonal lineages
    H Karch
    Institut für Hygiene und Mikrobiologie, D 97080 Wurzburg, 97070 Wurzburg, Germany
    Infect Immun 67:5994-6001. 1999
  5. ncbi request reprint Microbial diversity of marine sponges
    U Hentschel
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Prog Mol Subcell Biol 37:59-88. 2003
  6. ncbi request reprint Efficient expression of the alpha-haemolysin determinant in the uropathogenic Escherichia coli strain 536 requires the leuX-encoded tRNA(5)(Leu)
    U Dobrindt
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Mol Genet Genomics 267:370-9. 2002
  7. pmc Receptor structure for F1C fimbriae of uropathogenic Escherichia coli
    A S Khan
    Institut für Molekulare Infektionsbiologie, University of Wurzburg, 97070 Wurzburg, Germany
    Infect Immun 68:3541-7. 2000
  8. ncbi request reprint Genomic structure and evolution of Legionella species
    K Heuner
    Institut für Molekulare Infektionsbiologie, Julius Maximilians Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Top Microbiol Immunol 264:61-78. 2002
  9. ncbi request reprint Genome plasticity in pathogenic and nonpathogenic enterobacteria
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Top Microbiol Immunol 264:157-75. 2002
  10. pmc Identification and characterization of a novel genomic island integrated at selC in locus of enterocyte effacement-negative, Shiga toxin-producing Escherichia coli
    H Schmidt
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Wurzburg, Germany
    Infect Immun 69:6863-73. 2001

Collaborators

Detail Information

Publications43

  1. pmc Ecological fitness, genomic islands and bacterial pathogenicity. A Darwinian view of the evolution of microbes
    J Hacker
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    EMBO Rep 2:376-81. 2001
    ..Here we discuss ways in which PAIs contribute to the pathogenic potency of bacteria, and the idea that genetic entities similar to genomic islands may also be present in the genomes of eukaryotes...
  2. ncbi request reprint Pathogenicity islands of uropathogenic E. coli and the evolution of virulence
    T A Oelschlaeger
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Roentgenring 11, 97070 Wurzburg, Germany
    Int J Antimicrob Agents 19:517-21. 2002
    ..In addition, assumptions can be made on the evolution of these important pathogens...
  3. ncbi request reprint Whole genome plasticity in pathogenic bacteria
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Opin Microbiol 4:550-7. 2001
    ....
  4. pmc A genomic island, termed high-pathogenicity island, is present in certain non-O157 Shiga toxin-producing Escherichia coli clonal lineages
    H Karch
    Institut für Hygiene und Mikrobiologie, D 97080 Wurzburg, 97070 Wurzburg, Germany
    Infect Immun 67:5994-6001. 1999
    ..The hypothesis that the HPI in STEC contributes to the fitness of the strains in certain ecological niches rather than to their pathogenic potential is discussed...
  5. ncbi request reprint Microbial diversity of marine sponges
    U Hentschel
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Prog Mol Subcell Biol 37:59-88. 2003
    ..Finally, a 'sponge-microbe interaction model' is presented that summarizes our current understanding of the processes that might have shaped the community structure of the microbial assemblages within sponges...
  6. ncbi request reprint Efficient expression of the alpha-haemolysin determinant in the uropathogenic Escherichia coli strain 536 requires the leuX-encoded tRNA(5)(Leu)
    U Dobrindt
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Mol Genet Genomics 267:370-9. 2002
    ..coli strain 536...
  7. pmc Receptor structure for F1C fimbriae of uropathogenic Escherichia coli
    A S Khan
    Institut für Molekulare Infektionsbiologie, University of Wurzburg, 97070 Wurzburg, Germany
    Infect Immun 68:3541-7. 2000
    ..coli...
  8. ncbi request reprint Genomic structure and evolution of Legionella species
    K Heuner
    Institut für Molekulare Infektionsbiologie, Julius Maximilians Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Top Microbiol Immunol 264:61-78. 2002
  9. ncbi request reprint Genome plasticity in pathogenic and nonpathogenic enterobacteria
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Top Microbiol Immunol 264:157-75. 2002
  10. pmc Identification and characterization of a novel genomic island integrated at selC in locus of enterocyte effacement-negative, Shiga toxin-producing Escherichia coli
    H Schmidt
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Wurzburg, Germany
    Infect Immun 69:6863-73. 2001
    ..We conclude that the newly described island occurs exclusively in a subgroup of STEC strains that are eae negative and contain the variant stx(2d )gene...
  11. ncbi request reprint The molecular basis of infectious diseases: pathogenicity islands and other mobile genetic elements. A review
    J Hacker
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Deutschland
    Acta Microbiol Immunol Hung 50:321-30. 2003
    ..This review summarises the current knowledge on bacterial genomic islands and their general features, and discusses their putative role in the evolution of microbes in the light of genomics of pathogenic bacteria...
  12. pmc Characterization of the sigma(B) regulon in Staphylococcus aureus
    S Gertz
    Institut fur Mikrobiologie und Molekularbiologie, D 17487 Greifswald, Germany
    J Bacteriol 182:6983-91. 2000
    ..aureus sequence solely transcribed by sigma(B). In contrast, a second clpC-homologous gene in S. aureus forming an operon with ctsR, yacH, and yacI was sigma(B) independently expressed...
  13. pmc Expression of hemin receptor molecule ChuA is influenced by RfaH in uropathogenic Escherichia coli strain 536
    G Nagy
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, 97070 Wurzburg, Germany
    Infect Immun 69:1924-8. 2001
    ..Furthermore, the presence of two different subclasses of the chuA determinant and their distribution in E. coli pathogroups are described...
  14. pmc Curli fibers mediate internalization of Escherichia coli by eukaryotic cells
    U Gophna
    Department of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel
    Infect Immun 69:2659-65. 2001
    ..coli isolate mediated a higher level of internalization. The finding that curli fibers promote bacterial internalization indicates a new role for curli fibers in pathogenesis...
  15. ncbi request reprint Yersinia HPI in septicemic Escherichia coli strains isolated from diverse hosts
    U Gophna
    Department of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Israel
    FEMS Microbiol Lett 196:57-60. 2001
    ..We have also observed two types of HPI deletions, suggesting genetic instability of this element. Notable exceptions are several strains isolated from septicemia in sheep that lacked both iron acquisition systems...
  16. ncbi request reprint A subtractive hybridisation analysis of genomic differences between the uropathogenic E. coli strain 536 and the E. coli K-12 strain MG1655
    B Janke
    , , , D-97070, , Germany
    FEMS Microbiol Lett 199:61-6. 2001
    ..Whereas two fragments were highly specific for uropathogenic E. coli (UPEC), the other fragments could also be detected among the other tested wild-type strains...
  17. ncbi request reprint Complete genetic organization and functional aspects of the Escherichia coli S fimbrial adhesion determinant: nucleotide sequence of the genes sfa B, C, D, E, F
    T Schmoll
    Institut fur Genetik und Mikrobiologie, University of Wurzburg, Germany
    Microb Pathog 9:331-43. 1990
    ..The evolutionary relationship of fimbrial adhesion determinants is discussed...
  18. pmc S-Fimbria-encoding determinant sfa(I) is located on pathogenicity island III(536) of uropathogenic Escherichia coli strain 536
    U Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, 97070 Wurzburg, Klinikum der Universität Jena, 07740 Jena, Germany
    Infect Immun 69:4248-56. 2001
    ..coli strain 536, replaces a 40-kb DNA region which represents an E. coli K-12-specific genomic island...
  19. ncbi request reprint Pathogenicity islands: the tip of the iceberg
    U Hentschel
    , , , , Germany
    Microbes Infect 3:545-8. 2001
    ..In recent years many different genomic islands have been discovered in a variety of pathogenic as well as non-pathogenic bacteria. Because they promote genetic variability, genomic islands play an important role in microbial evolution...
  20. ncbi request reprint Crystal structure of Mip, a prolylisomerase from Legionella pneumophila
    A Riboldi-Tunnicliffe
    Institute of Molecular Biotechnology, Beutenbergstr 11, D 07745 Jena, Germany
    Nat Struct Biol 8:779-83. 2001
    ....
  21. ncbi request reprint Regulation of tRNA5Leu-encoding gene leuX that is associated with a pathogenicity island in the uropathogenic Escherichia coli strain 536
    U Dobrindt
    , , Germany
    Mol Genet Genomics 265:895-904. 2001
    ..Our finding expands our knowledge of the regulation of tRNA gene transcription and represents an additional mode of regulation of gene expression that can also affect bacterial virulence...
  22. ncbi request reprint Cloning and characterization of a Legionella pneumophila-specific gene encoding a member of the LysR family of transcriptional regulators
    K Heuner
    Institut für Molekulaire Infektionsbiologie, Universitat Wurzburg, Germany
    Mol Gen Genet 264:204-11. 2000
    ..Southern analysis with a L. pneumophila Corby-specific flaR probe revealed homologous genes in various L. pneumophila strains, but not in the 12 nonpneumophila strains tested so far...
  23. ncbi request reprint Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity
    G Fischer
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle, Germany
    Mol Microbiol 6:1375-83. 1992
    ..In view of the activity of PPIases in protein-folding reactions, such prokaryotic FKBP analogues may represent a new class of bacterial pathogenicity factors...
  24. pmc Cloning, genetic analysis, and nucleotide sequence of a determinant coding for a 19-kilodalton peptidoglycan-associated protein (Ppl) of Legionella pneumophila
    B Ludwig
    Lehrstuhl fur Mikrobiologie, Universitat Wurzburg, Germany
    Infect Immun 59:2515-21. 1991
    ..pneumophila. The amino acid sequence of PplA exhibits a high degree of homology to the sequences of the Pal lipoproteins of E. coli K-12 and Haemophilus influenzae...
  25. pmc F1C fimbriae of a uropathogenic Escherichia coli strain: genetic and functional organization of the foc gene cluster and identification of minor subunits
    N Riegman
    Department of Molecular Cell Biology, University of Utrecht, The Netherlands
    J Bacteriol 172:1114-20. 1990
    ..Minor proteins of similar size were observed in purified S fimbriae. Remarkably, some mutations in the foc gene cluster result in an altered fimbrial morphology, i.e., rigid stubs or long, curly fimbriae...
  26. ncbi request reprint Characterization of Mip proteins of Legionella pneumophila
    B Ludwig
    Institut für Molekulare Infektionsbiologie, Univ Würzburg, FRG
    FEMS Microbiol Lett 118:23-30. 1994
    ..The mature Mip proteins exist in an oligomeric form. Site-directed mutagenesis demonstrated that a substitution of an Asp residue at position 142 by a Leu residue affects PPIase activity of Mip...
  27. pmc Cloning and genetic characterization of the flagellum subunit gene (flaA) of Legionella pneumophila serogroup 1
    K Heuner
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Germany
    Infect Immun 63:2499-507. 1995
    ..pneumophila Legionella strains. Two L. pneumophila strains and isolates of Legionella bozemanii and Legionella feeleii (serogroup 1) carry flaA-specific sequences but were not able to produce flagella...
  28. ncbi request reprint Confirmation of the existence of a third family among peptidyl-prolyl cis/trans isomerases. Amino acid sequence and recombinant production of parvulin
    J U Rahfeld
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle Saale, Germany
    FEBS Lett 352:180-4. 1994
    ....
  29. pmc Cloning and characterization of the S fimbrial adhesin II complex of an Escherichia coli O18:K1 meningitis isolate
    J Hacker
    Lehrstuhl für Mikrobiologie im Theodor Boveri Institut, Universitat Wurzburg, Germany
    Infect Immun 61:544-50. 1993
    ....
  30. ncbi request reprint A cyclophilin-like peptidyl-prolyl cis/trans isomerase from Legionella pneumophila--characterization, molecular cloning and overexpression
    B Schmidt
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle Saale, Germany
    Mol Microbiol 21:1147-60. 1996
    ..Like human cyclophilin, the L. p. Cyp18 exhibits nuclease activity, but this enzymatic activity does not appear to be linked with the native structure of the protein...
  31. pmc The alternative sigma factor sigma28 of Legionella pneumophila restores flagellation and motility to an Escherichia coli fliA mutant
    K Heuner
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Germany
    J Bacteriol 179:17-23. 1997
    ..coli fliA mutant. This result suggests that the L. pneumophila sigma28 protein can bind to the E. coli core RNA polymerase to direct transcription initiation from the flaA-specific promoter...
  32. pmc Sequence determination and mutational analysis of the lly locus of Legionella pneumophila
    E Wintermeyer
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Germany
    Infect Immun 62:1109-17. 1994
    ..Intracellular survival of L. pneumophila in U937 macrophage-like cells and in Acanthamoeba castellanii was not affected by mutagenization of the lly locus...
  33. ncbi request reprint Cloning and sequencing of a Shiga-like toxin II-related gene from Escherichia coli O157:H7 strain 7279
    T Meyer
    Institut für Hygiene und Mikrobiologie, Universitat, Wurzburg
    Zentralbl Bakteriol 276:176-88. 1992
    ..Immunological differences of SLT-IIvhc and SLT-II as well as their different toxicity to HeLa cells presumably resulted from the small deviations within the primary structure of the B subunit...
  34. pmc The high-pathogenicity island is absent in human pathogens of Salmonella enterica subspecies I but present in isolates of subspecies III and VI
    T A Oelschlaeger
    Institut für Molekulare Infektionsbiologie, University of Wurzburg, Roentgenring 11, D 97070 Wurzburg, Germany
    J Bacteriol 185:1107-11. 2003
    ..Most high-pathogenicity island-positive isolates produced yersiniabactin under iron-limited conditions and were positive for the high-molecular-weight proteins HMWP1 and HMWP2...
  35. ncbi request reprint Nucleotide sequence of the genes coding for minor fimbrial subunits of the F1C fimbriae of Escherichia coli
    I Van Die
    Dept of Molecular Cell Biology, University of Utrecht, The Netherlands
    Res Microbiol 142:653-8. 1991
    ..The data show that the Foc minor subunits are highly homologous to the corresponding Sfa proteins, whereas homology to the minor subunits of type 1 and P fimbriae is much lower...
  36. ncbi request reprint An oxaloacetate decarboxylase homologue protein influences the intracellular survival of Legionella pneumophila
    B Jain
    Institut für Molekulare Infektionsbiologie, Wurzburg, Germany
    FEMS Microbiol Lett 145:273-9. 1996
    ..pneumophila...
  37. pmc Functional analysis of the sialic acid-binding adhesin SfaS of pathogenic Escherichia coli by site-specific mutagenesis
    J Morschhäuser
    Institut fur Genetik und Mikrobiologie, Wurzburg, Federal Republic of Germany
    Infect Immun 58:2133-8. 1990
    ..Substitution of arginine 118 by serine also had a negative effect on the amount of SfaS adhesin proteins isolated from the S fimbrial adhesin complex...
  38. ncbi request reprint Isolation and characterization of coliphage omega 18A specific for Escherichia coli O18ac strains
    E Ulmer
    Forschungsinstitut Borstel,
    Zentralbl Bakteriol Mikrobiol Hyg A 266:403-11. 1987
    ..coli O18ac strains could be divided into two serologically distinct subgroups called O18A and O18A1. E. coli strains belonging to the subgroup O18A are sensitive to phage omega 18A whereas bacteria of subgroup A1 are resistant...
  39. ncbi request reprint Analysis of genes coding for the sialic acid-binding adhesin and two other minor fimbrial subunits of the S-fimbrial adhesin determinant of Escherichia coli
    T Schmoll
    Institut fur Genetik und Mikrobiologie, Wurzburg, FRG
    Mol Microbiol 3:1735-44. 1989
    ..It was further shown that the amino-terminal protein sequence of the isolated SfaS protein was identical to the protein sequence calculated from the DNA sequence of the sfaS gene locus...
  40. ncbi request reprint Structure, function, and regulation of the plasmid-encoded hemolysin determinant of Escherichia coli
    W Goebel
    Basic Life Sci 30:791-805. 1985
  41. pmc Flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells
    C Dietrich
    , , , Germany
    Infect Immun 69:2116-22. 2001
    ..Taking these results together, we have demonstrated that the flagellum of L. pneumophila positively affects the establishment of infection by facilitating the encounter of the host cell as well as by enhancing the invasion capacity...
  42. ncbi request reprint Adhesin regulatory genes within large, unstable DNA regions of pathogenic Escherichia coli: cross-talk between different adhesin gene clusters
    J Morschhäuser
    Institut für Molekulare Infektionsbiologie, Wurzburg, Germany
    Mol Microbiol 11:555-66. 1994
    ..The results demonstrate that cross-regulation of two unlinked virulence gene clusters together with the co-ordinate loss of large DNA regions significantly influences the virulence of an extraintestinal E. coli wild-type isolate...
  43. ncbi request reprint Human antibody response during sepsis against targets expressed by methicillin resistant Staphylococcus aureus
    U Lorenz
    Department of Surgery, The University of Würzburg, Germany
    FEMS Immunol Med Microbiol 29:145-53. 2000
    ..aureus and the other protein was identified as the phosphocarrier protein Hpr of S. aureus. The identified immunodominant proteins may serve as potential targets for the development of antibody based therapy against MRSA...