Christian P R Hackenberger

Summary

Country: Germany

Publications

  1. doi request reprint Acidic and basic deprotection strategies of borane-protected phosphinothioesters for the traceless Staudinger ligation
    Michaela Mühlberg
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Bioorg Med Chem 18:3679-86. 2010
  2. ncbi request reprint The reduction of oxidized methionine residues in peptide thioesters with NH4I-Me2S
    Christian P R Hackenberger
    Freie Universitat Berlin, Institute of Chemistry and Biochemistry, Takustr 3, 14195 Berlin, Germany
    Org Biomol Chem 4:2291-5. 2006
  3. ncbi request reprint A synthetic kiss of death: expressed protein ligation of a ubiquitin-peptide conjugate
    Christian P R Hackenberger
    Institute for Chemistry and Biochemistry, FU Berlin, Takustrasse 3, 14195 Berlin, Germany
    Chembiochem 8:1221-3. 2007
  4. ncbi request reprint Chemoselective labeling of engineered fucosylated glycoproteins
    Christian P R Hackenberger
    Institut fur Chemie und Biochemie, FU Berlin, Takustrasse 3, 14195 Berlin, Germany
    Chembiochem 8:1763-5. 2007
  5. doi request reprint Chemoselective ligation and modification strategies for peptides and proteins
    Christian P R Hackenberger
    Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin, Germany
    Angew Chem Int Ed Engl 47:10030-74. 2008
  6. doi request reprint Chemoselective Staudinger-phosphite reaction of symmetrical glycosyl-phosphites with azido-peptides and polygycerols
    Verena Böhrsch
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Org Biomol Chem 10:6211-6. 2012
  7. doi request reprint Staudinger-phosphonite reactions for the chemoselective transformation of azido-containing peptides and proteins
    M Robert J Vallée
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Org Lett 13:5440-3. 2011
  8. doi request reprint Alkyne phosphonites for sequential azide-azide couplings
    M Robert J Vallée
    Leibniz Institut fur Molekulare Pharmakologie FMP, Robert Roessle Strasse 10, 13125 Berlin Germany Humboldt Universität zu Berlin, Department Chemie, Brook Taylor Strasse 2, 12489, Berlin Germany Freie Universität Berlin, Institut fur Chemie und Biochemie, Takustrasse 3, 14195 Berlin Germany
    Angew Chem Int Ed Engl 52:9504-8. 2013
  9. doi request reprint Site-specific modification of proteins by the staudinger-phosphite reaction
    Paul Majkut
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Berlin, Germany
    Methods Mol Biol 794:241-9. 2012
  10. ncbi request reprint The Alzheimer's disease related tau protein as a new target for chemical protein engineering
    Malgorzata Broncel
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin Germany, Fax 49 30 838 52551
    Chemistry 18:2488-92. 2012

Collaborators

  • Dirk Schwarzer
  • Beate Koksch
  • C Bolm
  • Malgorzata Broncel
  • M Robert J Vallée
  • Verena Böhrsch
  • Lukas M Artner
  • Paul Majkut
  • Jens Dernedde
  • Ina Wilkening
  • Rolf Kleineweischede
  • Christoph Weise
  • Eberhard Krause
  • Remigiusz Serwa
  • Remigiusz A Serwa
  • Sara C Wagner
  • Michaela Mühlberg
  • Maximilian Zieringer
  • Michael Gerrits
  • Figen Beceren-Braun
  • Rainer Haag
  • Thresen Mathew
  • Nediljko Budisa
  • Lars Merkel
  • Nina Bohlke
  • Gregor Muller
  • Giuseppe Del Signore
  • Kerstin Paul
  • Jean Marie Swiecicki
  • Silvia Muth
  • Da san M M Jaradat
  • Decha Dechtrirat
  • Denise Homann
  • Ilona Papp

Detail Information

Publications19

  1. doi request reprint Acidic and basic deprotection strategies of borane-protected phosphinothioesters for the traceless Staudinger ligation
    Michaela Mühlberg
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Bioorg Med Chem 18:3679-86. 2010
    ..In combination with acidic and basic deprotection strategies for the borane-protected phosphinothioesters, amide bonds can be formed in the presence of azides in moderate to good overall yields...
  2. ncbi request reprint The reduction of oxidized methionine residues in peptide thioesters with NH4I-Me2S
    Christian P R Hackenberger
    Freie Universitat Berlin, Institute of Chemistry and Biochemistry, Takustr 3, 14195 Berlin, Germany
    Org Biomol Chem 4:2291-5. 2006
    ....
  3. ncbi request reprint A synthetic kiss of death: expressed protein ligation of a ubiquitin-peptide conjugate
    Christian P R Hackenberger
    Institute for Chemistry and Biochemistry, FU Berlin, Takustrasse 3, 14195 Berlin, Germany
    Chembiochem 8:1221-3. 2007
  4. ncbi request reprint Chemoselective labeling of engineered fucosylated glycoproteins
    Christian P R Hackenberger
    Institut fur Chemie und Biochemie, FU Berlin, Takustrasse 3, 14195 Berlin, Germany
    Chembiochem 8:1763-5. 2007
  5. doi request reprint Chemoselective ligation and modification strategies for peptides and proteins
    Christian P R Hackenberger
    Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin, Germany
    Angew Chem Int Ed Engl 47:10030-74. 2008
    ....
  6. doi request reprint Chemoselective Staudinger-phosphite reaction of symmetrical glycosyl-phosphites with azido-peptides and polygycerols
    Verena Böhrsch
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Org Biomol Chem 10:6211-6. 2012
    ..The phosphites were finally applied for the chemoselective reaction with azido-peptides and polyazido(poly)glycerols...
  7. doi request reprint Staudinger-phosphonite reactions for the chemoselective transformation of azido-containing peptides and proteins
    M Robert J Vallée
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Org Lett 13:5440-3. 2011
    ..Finally, the Staudinger-phosphonite reaction was successfully applied to the site-specific modification of the protein calmodulin...
  8. doi request reprint Alkyne phosphonites for sequential azide-azide couplings
    M Robert J Vallée
    Leibniz Institut fur Molekulare Pharmakologie FMP, Robert Roessle Strasse 10, 13125 Berlin Germany Humboldt Universität zu Berlin, Department Chemie, Brook Taylor Strasse 2, 12489, Berlin Germany Freie Universität Berlin, Institut fur Chemie und Biochemie, Takustrasse 3, 14195 Berlin Germany
    Angew Chem Int Ed Engl 52:9504-8. 2013
    ..This modular procedure enables a final metal-free conjugation of functional building blocks to azides. ..
  9. doi request reprint Site-specific modification of proteins by the staudinger-phosphite reaction
    Paul Majkut
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Berlin, Germany
    Methods Mol Biol 794:241-9. 2012
    ..A selective introduction of branched polyethylene scaffolds can be achieved with the application of the methodology reported herein...
  10. ncbi request reprint The Alzheimer's disease related tau protein as a new target for chemical protein engineering
    Malgorzata Broncel
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin Germany, Fax 49 30 838 52551
    Chemistry 18:2488-92. 2012
    ..The presented methodology allows for an unambiguous verification of individual phosphorylation sites on tau and significantly improves its purification...
  11. doi request reprint Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds
    Lukas M Artner
    Freie Universitat Berlin, Institut fur Chemie und Biochemie, Takustr 3, 14195 Berlin, Germany
    Chem Commun (Camb) 48:522-4. 2012
    ..These protein conjugates were employed in multivalent binding studies, which support the use of proteins as structurally defined scaffolds for the presentation of multivalent ligands...
  12. doi request reprint Phosphoramidate-peptide synthesis by solution- and solid-phase Staudinger-phosphite reactions
    Remigiusz A Serwa
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Berlin, Germany
    J Pept Sci 16:563-7. 2010
    ..The corresponding Staudinger reactions proceed in high conversion rates and deliver phosphoramidate peptides, in which the modification site is located in the middle of the peptide sequence...
  13. doi request reprint Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites
    Verena Böhrsch
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Chem Commun (Camb) 46:3176-8. 2010
    ....
  14. doi request reprint Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters
    Ina Wilkening
    Freie Universitat Berlin, Institut fur Chemie und Biochemie, Takustr 3, 14195 Berlin, Germany
    Chem Commun (Camb) 47:349-51. 2011
    ....
  15. doi request reprint Chemoselective peptide cyclization by traceless Staudinger ligation
    Rolf Kleineweischede
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin, Germany
    Angew Chem Int Ed Engl 47:5984-8. 2008
  16. doi request reprint Towards understanding secondary structure transitions: phosphorylation and metal coordination in model peptides
    Malgorzata Broncel
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Org Biomol Chem 8:2575-9. 2010
    ..This study demonstrates how small peptide models can aid in the evaluation and a better understanding of protein secondary structure transitions...
  17. doi request reprint Enzymatically triggered amyloid formation: an approach for studying peptide aggregation
    Malgorzata Broncel
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustr 3, 14195 Berlin, Germany
    Chem Commun (Camb) 46:3080-2. 2010
    ..A strategy has been demonstrated that utilizes a phosphatase as a natural tool for the triggering and control of amyloid formation in a coiled coil peptide model under conditions that closely approximate a physiological environment...
  18. ncbi request reprint Improving glycopeptide synthesis: a convenient protocol for the preparation of beta-glycosylamines and the synthesis of glycopeptides
    Christian P R Hackenberger
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 70:3574-8. 2005
    ..The new amination protocol leads to an improved synthesis of the key chitobiosyl-asparagine building block for the SPPS of glycopeptides. The utility of the method is demonstrated with the synthesis of a 39-amino acid glycoprotein...
  19. ncbi request reprint The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K
    Carsten Bolm
    Institut fur Organische Chemie, RWTH Aachen, Prof Pirlet Strasse 1, D 52056 Aachen, Germany
    Bioorg Med Chem Lett 13:3207-11. 2003
    ..Incorporation of sulfoximines as backbone modifying element results in two new pseudopeptide bonds which display enhanced (bond A) and strongly reduced reactivity (bond B) towards hydrolysis by Proteinase K...