Detlef Haase

Summary

Country: Germany

Publications

  1. ncbi request reprint New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients
    Detlef Haase
    Department of Hematology and Oncology, University of Gottingen, Gottingen, Germany
    Blood 110:4385-95. 2007
  2. pmc Cytogenetic features in myelodysplastic syndromes
    Detlef Haase
    Department of Hematology and Oncology, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Ann Hematol 87:515-26. 2008
  3. ncbi request reprint [Therapy-related hematologic neoplasias after breast cancer. Epidemiologic, etiologic and cytogenetic aspects and new risk factors according to published data and own results]
    Detlef Haase
    Abteilung Hämatologie und Onkologie, Georg August Universitat, Gottingen
    Med Klin (Munich) 99:506-17. 2004
  4. doi request reprint FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: verification of the method and application to 27 MDS patients
    Friederike Braulke
    Department of Hematology and Oncology, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
    Leuk Res 34:1296-301. 2010
  5. doi request reprint Coalesced multicentric analysis of 2,351 patients with myelodysplastic syndromes indicates an underestimation of poor-risk cytogenetics of myelodysplastic syndromes in the international prognostic scoring system
    Julie Schanz
    Department of Hematology and Oncology, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
    J Clin Oncol 29:1963-70. 2011
  6. ncbi request reprint Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1
    Detlef Haase
    Department of Hematology and Oncology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Leuk Res 26:249-54. 2002
  7. ncbi request reprint Secondary leukaemia after cure for locally advanced NSCLC: alkylating type secondary leukaemia after induction therapy with docetaxel and carboplatin for NSCLC IIIB
    Frank Griesinger
    Department of Hematology and Oncology, University of Goettingen, Robert Koch Street 40, D 37075 Goettingen, Germany
    Lung Cancer 44:261-5. 2004
  8. doi request reprint Solitary cutaneous nodule of blastic plasmacytoid dendritic cell neoplasm progressing to overt leukemia cutis after chemotherapy: immunohistology and FISH analysis confirmed the diagnosis
    Kjell Matthias Kaune
    Departments of Dermatology and Venereology, Georg August University Gottingen, Gottingen, Germany
    Am J Dermatopathol 31:695-701. 2009
  9. ncbi request reprint Adequate cytogenetic examination in myelodysplastic syndromes: analysis of 529 patients
    Christian Steidl
    Department of Hematology and Oncology, Georg August University, Goettingen, D 37099 Göttingen, Germany
    Leuk Res 29:987-93. 2005
  10. ncbi request reprint Hexadecylphosphocholine does not influence phospholipase D and sphingomyelinase activity in human leukemia cells
    Dinko Berkovic
    University Clinic of Göttingen, Department of Internal Medicine, Gottingen, Germany
    J Exp Ther Oncol 2:213-8. 2002

Detail Information

Publications29

  1. ncbi request reprint New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients
    Detlef Haase
    Department of Hematology and Oncology, University of Gottingen, Gottingen, Germany
    Blood 110:4385-95. 2007
    ..Our analyses offer new insights into the prognostic significance of rare chromosomal abnormalities and specific karyotypic combinations in MDS...
  2. pmc Cytogenetic features in myelodysplastic syndromes
    Detlef Haase
    Department of Hematology and Oncology, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Ann Hematol 87:515-26. 2008
    ..This article thus focuses on the clinical and prognostic relevance, the molecular background, and therapeutic perspectives in these three cytogenetic subgroups...
  3. ncbi request reprint [Therapy-related hematologic neoplasias after breast cancer. Epidemiologic, etiologic and cytogenetic aspects and new risk factors according to published data and own results]
    Detlef Haase
    Abteilung Hämatologie und Onkologie, Georg August Universitat, Gottingen
    Med Klin (Munich) 99:506-17. 2004
    ..Due to intensified treatment schedules remission rates and overall survival could be significantly improved. On the other hand, the long-term toxicity of this antineoplastic therapy is an increasing problem...
  4. doi request reprint FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: verification of the method and application to 27 MDS patients
    Friederike Braulke
    Department of Hematology and Oncology, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
    Leuk Res 34:1296-301. 2010
    ..This method is practicable, non-invasive, representative for the clonal situation in the bm, and has a predictive value. Its feasibility was proven in a cohort of 27 MDS patients...
  5. doi request reprint Coalesced multicentric analysis of 2,351 patients with myelodysplastic syndromes indicates an underestimation of poor-risk cytogenetics of myelodysplastic syndromes in the international prognostic scoring system
    Julie Schanz
    Department of Hematology and Oncology, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
    J Clin Oncol 29:1963-70. 2011
    ..Here we investigate the prognostic impact of cytogenetic subgroups compared with that of bone marrow blast count in a large, multicentric, international patient cohort...
  6. ncbi request reprint Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1
    Detlef Haase
    Department of Hematology and Oncology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Leuk Res 26:249-54. 2002
    ..An insufficient detoxification of cytostatic drugs such as cyclophosphamide is suggested to represent the underlying pathomechanism...
  7. ncbi request reprint Secondary leukaemia after cure for locally advanced NSCLC: alkylating type secondary leukaemia after induction therapy with docetaxel and carboplatin for NSCLC IIIB
    Frank Griesinger
    Department of Hematology and Oncology, University of Goettingen, Robert Koch Street 40, D 37075 Goettingen, Germany
    Lung Cancer 44:261-5. 2004
    ..The case will be discussed in the context of a review of the current literature...
  8. doi request reprint Solitary cutaneous nodule of blastic plasmacytoid dendritic cell neoplasm progressing to overt leukemia cutis after chemotherapy: immunohistology and FISH analysis confirmed the diagnosis
    Kjell Matthias Kaune
    Departments of Dermatology and Venereology, Georg August University Gottingen, Gottingen, Germany
    Am J Dermatopathol 31:695-701. 2009
    ..Phenotypic and karyotypic characteristics distinguishing this tumor from myelomonocytic leukemia with skin involvement are presented...
  9. ncbi request reprint Adequate cytogenetic examination in myelodysplastic syndromes: analysis of 529 patients
    Christian Steidl
    Department of Hematology and Oncology, Georg August University, Goettingen, D 37099 Göttingen, Germany
    Leuk Res 29:987-93. 2005
    ..In summary, our data suggest the examination of at least 20 metaphases in MDS...
  10. ncbi request reprint Hexadecylphosphocholine does not influence phospholipase D and sphingomyelinase activity in human leukemia cells
    Dinko Berkovic
    University Clinic of Göttingen, Department of Internal Medicine, Gottingen, Germany
    J Exp Ther Oncol 2:213-8. 2002
    ..Furthermore HePC does not seem to disturbed the activity of sphingomyelinase, another enzyme of phospholipid metabolism which has been shown to play an important role in cellular signalling as well...
  11. ncbi request reprint A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia
    Frank Griesinger
    Department of Hematology and Oncology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Genes Chromosomes Cancer 44:329-33. 2005
    ..The patient's disease did not respond to Imatinib, and this unresponsiveness was most likely a result of the BCR-JAK2 fusion protein...
  12. doi request reprint Amifostine has the potential to induce haematologic responses and decelerate disease progression in individual patients with low- and intermediate-1-risk myelodysplastic syndromes
    Julie Schanz
    Georg August University, Department of Haematology and Oncology, Robert Koch Str 40, 37075 Goettingen, Germany
    Leuk Res 33:1183-8. 2009
    ..Haematologic progression rate was 46% in the treatment group and 64% in the control group. We conclude that amifostine has the potential to induce haematologic response in individual patients suffering from MDS...
  13. doi request reprint Iron overload impairs proliferation of erythroid progenitors cells (BFU-E) from patients with myelodysplastic syndromes
    Julia Hartmann
    Department of Hematology and Oncology, Georg August University, Gottingen, Germany
    Leuk Res 37:327-32. 2013
    ..Furthermore, we show that this negative impact is reversible by sufficient iron chelation therapy...
  14. doi request reprint New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge
    Julie Schanz
    University of Gottingen, Gottingen, Germany
    J Clin Oncol 30:820-9. 2012
    ..The present study proposes a new and comprehensive cytogenetic scoring system based on an international data collection of 2,902 patients...
  15. doi request reprint Bullous sweet syndrome in a patient with t(9;22)(q34;q11)-positive chronic myeloid leukemia treated with the tyrosine kinase inhibitor nilotinib: interphase cytogenetic detection of BCR-ABL- positive lesional cells
    Kjell Matthias Kaune
    Department of Dermatology, Georg August University Goettingen, von Siebold Strasse 3, 37075 Goettingen, Germany
    Arch Dermatol 144:361-4. 2008
    ..An association of Sweet syndrome with chronic myeloid leukemia (CML) has been recently observed in patients treated with tyrosine kinase inhibitors...
  16. ncbi request reprint B-cell chronic lymphocytic leukemia with aberrant CD8 expression: genetic and immunophenotypic analysis of prognostic factors
    Roland Schroers
    Department of Hematology and Oncology, Georg August University Goettingen, Germany
    Leuk Lymphoma 45:1677-81. 2004
    ..In summary, the determined profile of prognostic markers together with the highly stable and indolent disease in the described patient suggest a good prognosis of B-CLL with aberrant CD8 expression...
  17. doi request reprint Use of total and unbound imatinib and metabolite LC-MS/MS assay to understand individual responses in CML and GIST patients
    Frank Streit
    Central Laboratory, Department of Clinical Chemistry, University Medical Center, George August University, Goettingen, Germany
    Ther Drug Monit 33:632-43. 2011
    ..In part, this is because of the lack of a single, validated, well-described clinically useful assay for these measurements. The authors report the development and application of such an assay...
  18. doi request reprint Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes: first results from a prospective multicenter German diagnostic study
    Friederike Braulke
    Department of Hematology and Oncology, University of Goettingen, Germany
    Leuk Res 37:900-6. 2013
    ..We demonstrate that CD34+ PB FISH correlates significantly with CCB analysis and represents a feasible method for a reliable non-invasive cytogenetic monitoring from PB. ..
  19. ncbi request reprint Immunophenotypic and genetic characterization of a CD8 positive mantle cell lymphoma in a patient with concomitant Mycosis fungoides
    Roland Schroers
    Department of Hematology and Oncology, Georg August University, Gottingen, Germany
    Eur J Haematol 75:78-84. 2005
    ..Hence, systematic studies addressing the incidence, biology and clinical behavior of this form of MCL seem to be justified in future...
  20. pmc ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug
    Bjoern Chapuy
    Department Hematology and Oncology, Georg August University, Goettingen Robert Koch Str 40, 37075 Goettingen, Germany
    Haematologica 94:1528-36. 2009
    ..However, a fraction of leukemic cells persists under targeted therapy and can lead to disease progression on cessation of treatment...
  21. ncbi request reprint Effects of hexadecylphosphocholine on phosphatidylcholine and phosphatidylserine metabolism in human lymphoma cells
    Dinko Berkovic
    Department of Internal Medicine, University Clinic of Göttingen, Gottingen, Germany
    J Exp Ther Oncol 2:85-92. 2002
    ..Resistant Raji cells do not seem to use the alternative pathway of PC synthesis via PS nor can this be induced by HePC. The resistance mechanism may therefore be independent of cell membrane metabolism...
  22. ncbi request reprint Mesengenic progenitor cells derived from human placenta
    Gerald G Wulf
    Department of Hematology and Oncology, Georg August University Goettingen, 37075 Goettingen, Germany
    Tissue Eng 10:1136-47. 2004
    ..In conclusion, we propose human term placenta as an easily accessible, ample source of multipotent mesengenic progenitor cells...
  23. ncbi request reprint Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML
    Torsten Haferlach
    Department of Medicine III, Ludwig Maximilians University, Grosshadern, Munich, Germany
    J Clin Oncol 21:256-65. 2003
    ..We also assessed the clinical significance of the recently introduced World Health Organization (WHO) classification for AML, which proposed dysplasia as a new parameter for classification...
  24. ncbi request reprint Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations
    Stefan Fröhling
    Department of Internal Medicine III, University Hospital of Ulm, Robert Koch Strasse 8, 89081 Ulm, Germany
    Genes Chromosomes Cancer 42:427-32. 2005
    ..Loss of a critical segment of 9q, most likely in 9q22, and disruption of CEBPA function possibly cooperate in the pathogenesis of del(9q) AML...
  25. doi request reprint Therapy-associated genetic aberrations in patients treated for non-Hodgkin lymphoma
    Jorg Basecke
    Department of Haematology and Oncology, University of Goettingen, Goettingen, Germany
    Br J Haematol 141:52-9. 2008
    ..We concluded that the high incidence of genetic aberrations reflected a dose-dependent, transient therapy-induced genetic damage which is not predictive of a t-AML/MDS...
  26. ncbi request reprint Novel cryptic chromosomal rearrangements detected in acute lymphoblastic leukemia detected by application of new multicolor fluorescent in situ hybridization approaches
    Constanze Karst
    Institut fur Humangenetik und Anthropologie, D 07743 Jena, Germany
    Int J Oncol 28:891-7. 2006
    ..In summary, mMCB and subCTM were proven to be powerful methods in the screening for new cryptic chromosomal aberrations, which considerably increased the accuracy of cytogenetic diagnosis...
  27. ncbi request reprint Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference
    Peter Valent
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Leuk Res 31:727-36. 2007
    ..Respective algorithms and recommendations should facilitate diagnostic and prognostic evaluations in MDS, selection of patients for therapies, and the conduct of clinical trials...
  28. pmc A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia
    Ulrich Steidl
    Harvard Institutes of Medicine, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    J Clin Invest 117:2611-20. 2007
    ..Thus we have identified a SNP within a distal enhancer that is associated with a subtype of leukemia and exerts a deleterious effect through remote transcriptional dysregulation in specific progenitor subtypes...
  29. ncbi request reprint Increased plasma concentrations of soluble CD40 ligand in acute coronary syndrome depend on in vitro platelet activation
    Boris T Ivandic
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Clin Chem 53:1231-4. 2007
    ..Soluble CD40 ligand (sCD40L) was suggested as a novel biomarker of cardiovascular risk. We examined the effect of preanalytical variation on the measurement of sCD40L concentration...