Affiliation: GSF-National Research Center for Environment and Health
- Nicotine and apoptosisReinhard Zeidler
ENT Department, University of Munich, c o GSF Forschungszentrum, Marchioninistr 25, 81377 Munich, Germany
Apoptosis 12:1927-43. 2007..This review provides an overlook how nicotine influences apoptotic processes and is thus directly involved in the etiology of pathological conditions like cancer and obstructive diseases...
- Identification of Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) target proteins by proteome analysis: activation of EBNA2 in conditionally immortalized B cells reflects early events after infection of primary B cells by EBVMartin Schlee
Institute of Clinical Molecular Biology and Tumor Genetics, GSF National Research Center for EnvironmentHealth, Munich, Germany
J Virol 78:3941-52. 2004..These findings underscore the value of EREB2-5 cells as an appropriate model system for the analysis of early events in the process of EBV-mediated B-cell immortalization...
- The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABPMarkus Munz
Head and Neck Research Department, Clinical Cooperation Group Molecular Oncology, GSF, National Research Center for Environment and Health, Marchioninistr 15, 81377 Munich, Germany
Cancer Lett 225:151-7. 2005..Taken together, these results provide further evidence for the direct involvement of EpCAM in signalling processes, gene regulation, and cellular metabolism supporting its important role in tumour biology...
- B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cellsAndreas Moosmann
Department of Otorhinolaryngology, Ludwig Maximilians Universitat, Munich, Germany
Blood 100:1755-64. 2002..We conclude that the pp65 mini-EBV is an attractive tool for CMV-specific adoptive immunotherapy. Mini-EBVs could also facilitate the generation of T cells specific for various other antigens of interest...
- Selection of CMV-specific CD8+ and CD4+ T cells by mini-EBV-transformed B cell linesMartina Wiesner
Department of Gene Vectors, GSF National Research Center for Environment and Health, Munich, Germany
Eur J Immunol 35:2110-21. 2005..Using a peptide library covering the pp65 sequence for further analysis of T cell clones, we identified new pp65 CD8(+) and CD4(+) T cell epitopes...
- Carcinoma-associated eIF3i overexpression facilitates mTOR-dependent growth transformationMartin Ahlemann
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Schleswig Holstein, Campus Luebeck, Luebeck, Germany
Mol Carcinog 45:957-67. 2006..Thus, eIF3i overexpression fosters the integration of growth signals by mTOR into the mRNA translation process, promoting protein synthesis and tumor growth...
- Activated B cells mediate efficient expansion of rare antigen-specific T cellsCaroline Zentz
Clinical Cooperative Group Molecular Oncology, GSF National Research Center for Environment and Health, Munich, Germany
Hum Immunol 68:75-85. 2007..These results strongly encourage the use of CD40-stimulated B cells as APCs in immunotherapy...
- Molecular profiling for the identification of new biomarkers in smokers and cancer patientsKaj Albermann
Biomax Informatics AG, D 82152 Martinsried, Germany
Cancer Genomics Proteomics 4:349-58. 2007..This review is a short survey of these investigations and how they have contributed to the detection of new biomarkers and to a better understanding of smoking-induced harm...
- Conditional immortalization of human B cells by CD40 ligationMartina Wiesner
Clinical Cooperative Group Molecular Oncology, GSF National Research Center, Ludwig Maximilians Universitat, Munich, Germany
PLoS ONE 3:e1464. 2008..Conditionally immortalized human B cells are a new tool for immunotherapy and studies of B cell oncogenesis, activation, and function...