W Wurst

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. ncbi Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids
    M B Müller
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 141:4262-9. 2000
  2. ncbi Development of dopaminergic neurons in the mammalian brain
    N Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstr 1, 85764 Munich Neuherberg, Germany
    Cell Mol Life Sci 63:187-206. 2006
  3. ncbi The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability
    M Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Munich, Germany
    Mol Cell Biol 25:7637-44. 2005
  4. ncbi Coregulation of anterior and posterior mesendodermal development by a hairy-related transcriptional repressor
    L Bally-Cuif
    Centre National de la Recherche Scientifique URA 1414, Ecole Normale Superieure, Paris, France
    Genes Dev 14:1664-77. 2000
  5. ncbi RNA interference in mice
    R Kuhn
    Institute for Developmental Genetics, GSF, National Research Center for Environment and Health, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Handb Exp Pharmacol . 2007
  6. ncbi DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments
    T T Pham
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter, Neuherberg, Germany
    Genes Brain Behav 9:305-17. 2010
  7. ncbi Genetic mouse models for behavioral analysis through transgenic RNAi technology
    S Delic
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
    Genes Brain Behav 7:821-30. 2008
  8. ncbi The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney
    J Favor
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Oberschleissheim, Germany
    Proc Natl Acad Sci U S A 93:13870-5. 1996
  9. ncbi Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain
    T Fischer
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Munich, Neuherberg, Germany
    Neuroscience 147:693-711. 2007
  10. ncbi Fate of midbrain dopaminergic neurons controlled by the engrailed genes
    H H Simon
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:3126-34. 2001

Collaborators

Detail Information

Publications25

  1. ncbi Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids
    M B Müller
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 141:4262-9. 2000
    ..Taken together, our data reveal a selective compensatory activation of the hypothalamic vasopressinergic, but not the oxytocinergic system, to maintain basal ACTH secretion and HPA system activity in Crhr1-/- mutants...
  2. ncbi Development of dopaminergic neurons in the mammalian brain
    N Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstr 1, 85764 Munich Neuherberg, Germany
    Cell Mol Life Sci 63:187-206. 2006
    ..In the present review, we provide an overview of the mechanisms and factors involved in the development of dopaminergic neurons in the mammalian brain, with a special emphasis on the midbrain dopaminergic population...
  3. ncbi The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability
    M Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Munich, Germany
    Mol Cell Biol 25:7637-44. 2005
    ..We conclude that nPHGPx, by acting as a protein thiol peroxidase in vivo, contributes to the structural stability of sperm chromatin...
  4. ncbi Coregulation of anterior and posterior mesendodermal development by a hairy-related transcriptional repressor
    L Bally-Cuif
    Centre National de la Recherche Scientifique URA 1414, Ecole Normale Superieure, Paris, France
    Genes Dev 14:1664-77. 2000
    ..Our results provide the first model for vertebrate endoderm patterning where an early regulatory step at gastrulation, mediated by her5 controls cell contribution jointly to the anterior- and posteriormost mesendodermal regions...
  5. ncbi RNA interference in mice
    R Kuhn
    Institute for Developmental Genetics, GSF, National Research Center for Environment and Health, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Handb Exp Pharmacol . 2007
    ..Taken together, the data from 80 in vivo studies show that RNAi is a useful tool that offers new opportunities for functional genomics in mice...
  6. ncbi DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments
    T T Pham
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter, Neuherberg, Germany
    Genes Brain Behav 9:305-17. 2010
    ....
  7. ncbi Genetic mouse models for behavioral analysis through transgenic RNAi technology
    S Delic
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
    Genes Brain Behav 7:821-30. 2008
    ..Our results show the feasibility of gene silencing in the adult brain and validate knockdown mice as new genetic models suitable for behavioral analysis...
  8. ncbi The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney
    J Favor
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Oberschleissheim, Germany
    Proc Natl Acad Sci U S A 93:13870-5. 1996
    ..The mid-hindbrain phenotype is similar to Wnt1 and En1 mutant phenotypes, suggesting the conservation of gene regulatory networks between vertebrates and Drosophila...
  9. ncbi Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain
    T Fischer
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Munich, Neuherberg, Germany
    Neuroscience 147:693-711. 2007
    ..This redundancy has to be taken into consideration for future analyses of Frizzled receptor function at these signaling centers in the mouse...
  10. ncbi Fate of midbrain dopaminergic neurons controlled by the engrailed genes
    H H Simon
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:3126-34. 2001
    ..However, the engrailed genes control the survival of midbrain dopaminergic neurons in a gene dose-dependent manner. Our findings also suggest a link between engrailed and Parkinson's disease...
  11. ncbi A role for the EphA family in the topographic targeting of vomeronasal axons
    B Knoll
    Department of Physical Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35 I, 72076 Tubingen, Germany
    Development 128:895-906. 2001
    ..In summary, these data, which are derived from in vitro and in vivo experiments, indicate an important role of the EphA family in setting up the vomeronasal projection...
  12. ncbi The caudal limit of Otx2 expression positions the isthmic organizer
    V Broccoli
    GSF Research Centre for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Nature 401:164-8. 1999
    ..These findings show that the caudal limit of Otx2 expression is sufficient for positioning the isthmic organizer and encoding caudal midbrain fate within the mid/hindbrain domain...
  13. ncbi An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro
    L M Forrester
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Proc Natl Acad Sci U S A 93:1677-82. 1996
    ..These studies demonstrate the potential of this induction gene trap approach for identifying and mutating genes downstream of signal transduction pathways...
  14. ncbi Disruption of feeding behavior in CRH receptor 1-deficient mice is dependent on glucocorticoids
    M B Müller
    Max Planck Institute of Psychiatry, Molecular Neurogenetics, Munich, Germany
    Neuroreport 11:1963-6. 2000
    ....
  15. ncbi Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
    R Klein
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Cell 75:113-22. 1993
    ..These findings illustrate the role of the gp145trkB protein-tyrosine kinase receptor in the ontogeny of the mammalian nervous system...
  16. ncbi Deletion of glucose transporter GLUT8 in mice increases locomotor activity
    S Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    Behav Genet 38:396-406. 2008
    ..Our data suggest that behavioral alterations of Slc2a8 -/- mice are due to dysfunctions in neuronal processes presumably as a consequence of defects in the glucose metabolism...
  17. ncbi Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
    P Timpl
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Genet 19:162-6. 1998
    ..Our results demonstrate a key role of the Crhr1 receptor in mediating the stress response and anxiety-related behaviour...
  18. ncbi Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice
    M V Schmidt
    Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 24:2291-8. 2006
    ....
  19. ncbi Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif
    M Sam
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Dev Dyn 212:304-17. 1998
    ..Aqr was mapped to mouse chromosome 2 between regions E5 through F2 by using fluorescence in situ hybridization analysis...
  20. ncbi The winged helix transcription factor Fkh10 is required for normal development of the inner ear
    M Hulander
    Department of Molecular Biology, The Lundberg Laboratory, Goteborg University, Sweden
    Nat Genet 20:374-6. 1998
    ..These findings implicate Fkh10 as an early regulator necessary for development of both cochlea and vestibulum and identify its human homologue FKHL10 as a previously unknown candidate deafness gene at 5q34...
  21. ncbi Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice
    M V Schmidt
    Leiden Amsterdam Center for Drug Research, and Leiden University Medical Center, Division of Medical Pharmacology, PO Box 9502, 2300 RA Leiden, The Netherlands
    Neuroscience 119:589-95. 2003
    ..Furthermore, we could show that the CRHr1 is regulating the expression of CRH and MRs. In contrast, effects of maternal deprivation during postnatal development on GRs are not mediated by this receptor...
  22. ncbi Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2
    J Preil
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Endocrinology 142:4946-55. 2001
    ..Within the intraadrenal CRH/ACTH system, our data suggest different roles for CRHR1 and CRHR2 in fine-tuning of adrenocortical corticosterone release...
  23. ncbi Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation
    M B Müller
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Endocrinology 142:4150-3. 2001
    ..The existence of an intra-adrenal CRH/CRHR1 regulatory system which contributes to the corticosteroid secretory activity adds to the complexity of HPA system regulation and stress hormone homeostasis...
  24. ncbi Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation
    R A Kimmel
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016 USA
    Genes Dev 14:1377-89. 2000
    ..Finally, fate mapping of AER domains in these mutants showed that En1 plays a part in positioning and maintaining the two lineage borders...
  25. ncbi Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2
    M Hanks
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Canada
    Science 269:679-82. 1995
    ..This rescued all En-1 mutant defects, demonstrating that the difference between En-1 and En-2 stems from their divergent expression patterns...