H Erich Wichmann

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. pmc Long-term air pollution exposure and living close to busy roads are associated with COPD in women
    Tamara Schikowski
    Institut fur Umweltmedizinische Forschung, Heinrich Heine University of Dusseldorf, Auf m Hennekamp50, 40225 Dusseldorf, Germany
    Respir Res 6:152. 2005
  2. pmc Does respiratory health contribute to the effects of long-term air pollution exposure on cardiovascular mortality?
    Tamara Schikowski
    Institut fur Umweltmedizinische Forschung, Heinrich Heine University Dusseldorf, Auf m Hennekamp50, 40225 Dusseldorf, Germany
    Respir Res 8:20. 2007
  3. pmc Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways
    Anne B Knol
    Dutch National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Part Fibre Toxicol 6:19. 2009
  4. pmc Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:2. 2010
  5. ncbi request reprint What can we learn today from the Central European smog episode of 1985 (and earlier episodes)?
    H Erich Wichmann
    GSF Institute of Epidemiology, Neuherberg, LMU Chair of Epidemiology, Munich, Germany
    Int J Hyg Environ Health 207:505-20. 2004
  6. ncbi request reprint Genetic epidemiology in Germany--from biobanking to genetic statistics
    H E Wichmann
    GSF Institute for Epidemiology, Neuherberg, Germany
    Methods Inf Med 44:584-9. 2005
  7. ncbi request reprint [Biobanks]
    H E Wichmann
    GSF Institut für Epidemiologie, Neuherberg, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:192-9. 2007
  8. ncbi request reprint Increased lung cancer risk due to residential radon in a pooled and extended analysis of studies in Germany
    H Erich Wichmann
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Health Phys 88:71-9. 2005
  9. ncbi request reprint KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes
    H E Wichmann
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Gesundheitswesen 67:S26-30. 2005
  10. ncbi request reprint Diesel exhaust particles
    H E Wichmann
    GSF Institute of Epidemiology, Neuherberg, Germany
    Inhal Toxicol 19:241-4. 2007

Detail Information

Publications134 found, 100 shown here

  1. pmc Long-term air pollution exposure and living close to busy roads are associated with COPD in women
    Tamara Schikowski
    Institut fur Umweltmedizinische Forschung, Heinrich Heine University of Dusseldorf, Auf m Hennekamp50, 40225 Dusseldorf, Germany
    Respir Res 6:152. 2005
    ..We especially focused on COPD as defined by GOLD criteria and additionally compared the effects of air pollution on respiratory symptoms by questionnaire data and by lung function measurements...
  2. pmc Does respiratory health contribute to the effects of long-term air pollution exposure on cardiovascular mortality?
    Tamara Schikowski
    Institut fur Umweltmedizinische Forschung, Heinrich Heine University Dusseldorf, Auf m Hennekamp50, 40225 Dusseldorf, Germany
    Respir Res 8:20. 2007
    ..The aim of this study was to investigate whether respiratory health at baseline contributes to the effects of long-term exposure to high levels of air pollution on cardiovascular mortality in a cohort of elderly women...
  3. pmc Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways
    Anne B Knol
    Dutch National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Part Fibre Toxicol 6:19. 2009
    ..abstract:..
  4. pmc Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:2. 2010
    ..The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity...
  5. ncbi request reprint What can we learn today from the Central European smog episode of 1985 (and earlier episodes)?
    H Erich Wichmann
    GSF Institute of Epidemiology, Neuherberg, LMU Chair of Epidemiology, Munich, Germany
    Int J Hyg Environ Health 207:505-20. 2004
    ..Patients with cardiovascular diseases were more severely affected than patients with respiratory diseases. Health effects were more strongly correlated with TSP than with SO2...
  6. ncbi request reprint Genetic epidemiology in Germany--from biobanking to genetic statistics
    H E Wichmann
    GSF Institute for Epidemiology, Neuherberg, Germany
    Methods Inf Med 44:584-9. 2005
    ..Its aim is to undestand the influence of genetics on the development of diseases, their course and the clinical implications, with the final goal to improve prevention, diagnostics and therapy...
  7. ncbi request reprint [Biobanks]
    H E Wichmann
    GSF Institut für Epidemiologie, Neuherberg, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:192-9. 2007
    ....
  8. ncbi request reprint Increased lung cancer risk due to residential radon in a pooled and extended analysis of studies in Germany
    H Erich Wichmann
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Health Phys 88:71-9. 2005
    ..With respect to histopathology, the risk for small cell carcinoma was higher than for other subtypes. This analysis strengthens the evidence that residential radon is a relevant risk factor for lung cancer...
  9. ncbi request reprint KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes
    H E Wichmann
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Gesundheitswesen 67:S26-30. 2005
    ..KORA-gen can be used by external partners. Interested parties can inform themselves interactively via internet about the available data and the rules of access. The genotypic data base is a common resource of all partners...
  10. ncbi request reprint Diesel exhaust particles
    H E Wichmann
    GSF Institute of Epidemiology, Neuherberg, Germany
    Inhal Toxicol 19:241-4. 2007
    ..One effective way to effectively reduce emission of DPM is the use of particle traps...
  11. doi request reprint Estimated personal soot exposure is associated with acute myocardial infarction onset in a case-crossover study
    Stephanie von Klot
    Institute of Epidemiology II, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Prog Cardiovasc Dis 53:361-8. 2011
    ..Health effects of traffic-related air pollution may need to be updated, taking into account individual time spent in traffic and outdoors, to adequately protect the public...
  12. ncbi request reprint Daily mortality and particulate matter in different size classes in Erfurt, Germany
    Matthias Stölzel
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    J Expo Sci Environ Epidemiol 17:458-67. 2007
    ..003-1.060. No association between fine particle MC and mortality was found. This study shows that UFP, representing fresh combustion particles, may be an important component of urban air pollution associated with health effects...
  13. ncbi request reprint Long-term exposure to ambient air pollution and cardiopulmonary mortality in women
    Ulrike Gehring
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Epidemiology 17:545-51. 2006
    ..We assessed whether long-term exposure to air pollution originating from motorized traffic and industrial sources is associated with total and cause-specific mortality in a cohort of women living in North Rhine-Westphalia, Germany...
  14. doi request reprint Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA
    Anne Zutavern
    GSF National Research Center for Environment and Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Pediatrics 121:e44-52. 2008
    ..This study investigates whether a delayed introduction of solids (past 4 or 6 months) is protective against the development of eczema, asthma, allergic rhinitis, and food or inhalant sensitization at the age of 6 years...
  15. ncbi request reprint Longitudinal study on cat allergen exposure and the development of allergy in young children
    Chih Mei Chen
    GSF National Research Centre for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    J Allergy Clin Immunol 119:1148-55. 2007
    ..The influence of cat allergen exposure in early childhood on the development of sensitization and allergic diseases is complex. Little is known about the natural course of the sensitization development within individuals...
  16. ncbi request reprint Exposure to pets and allergies in children
    Bernd Hölscher
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Pediatr Allergy Immunol 13:334-41. 2002
    ..In conclusion, this study supports the hypothesis of a potential protective mechanism related to dog exposure in early life, especially for children of atopic parents. However, this association was found only for dogs and not for cats...
  17. pmc Long-term exposure to NO2 and PM10 and all-cause and cause-specific mortality in a prospective cohort of women
    Joachim Heinrich
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Epidemiology I, Neuherberg, Germany
    Occup Environ Med 70:179-86. 2013
    ..These associations were temporally stable. Long-term exposure to ambient PM(10) and NO(2) was associated with increased mortality rates...
  18. doi request reprint Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years
    Peter Rzehak
    Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Obes Facts 3:173-80. 2010
    ..However, little is known about the longitudinal dynamics of these polymorphisms on body mass index (BMI), overweight, and obesity...
  19. ncbi request reprint Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study
    Arne Pfeufer
    Institute of Human Genetics, Technical University Munich, Munich, Germany
    Circ Res 96:693-701. 2005
    ....
  20. ncbi request reprint Lung cancer risk among former uranium miners of the WISMUT Company in Germany
    Irene Bruske-Hohlfeld
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Health Phys 90:208-16. 2006
    ..After 1946, the WISMUT Company developed the third-largest uranium-mining province in the world in the German Democratic Republic...
  21. ncbi request reprint Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg
    Eva Maria Sedlmeier
    Institute of Epidemiology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Eur J Endocrinol 156:377-85. 2007
    ..The present study investigated the association of nine MCP-1 single nucleotide polymorphisms (SNPs) with MetS, type 2 diabetes mellitus and metabolic risk factors...
  22. ncbi request reprint Exposure to pets and atopic dermatitis during the first two years of life. A cohort study
    Angelika Zirngibl
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Pediatr Allergy Immunol 13:394-401. 2002
    ..We assume an association between keeping pets and undefined environmental factor(s) that contribute protectively to the development of atopic dermatitis in early life, presumably by effects on the maturation of the immune system...
  23. doi request reprint Sub-micrometer particulate air pollution and cardiovascular mortality in Beijing, China
    Susanne Breitner
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany
    Sci Total Environ 409:5196-204. 2011
    ....
  24. ncbi request reprint IL-6 promoter polymorphisms and quantitative traits related to the metabolic syndrome in KORA S4
    Harald Grallert
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Germany
    Exp Gerontol 41:737-45. 2006
    ..The association with height seems to be the central factor indicating an influence of IL-6 on growth through impaired bone metabolism. However, the complex relationships need further investigation...
  25. pmc Association of lung function with declining ambient air pollution
    Christian Frye
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Epidemiologie, Neuherberg, Germany
    Environ Health Perspect 111:383-7. 2003
    ..9% for a decrement of 100 micro g/m(3) SO(2) (p = 0.029). Effects on FEV(1) were smaller and not statistically significant. Our study indicates that a reduction of air pollution in a short time period may improve children's lung function...
  26. doi request reprint Size-fractioned particulate air pollution and cardiovascular emergency room visits in Beijing, China
    Liqun Liu
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany
    Environ Res 121:52-63. 2013
    ..This study aimed at investigating whether daily changes in number or mass concentrations of accurately size-segregated particles in the range of 3nm-10μm are associated with daily cardiovascular emergency room visits in Beijing, China...
  27. doi request reprint Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season
    Regina Hampel
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Occup Environ Med 67:408-16. 2010
    ..We investigated the associations between temperature and several blood markers in patients with coronary heart disease (CHD) and pulmonary disease (PD)...
  28. pmc Impact of ambient air pollution on the differential white blood cell count in patients with chronic pulmonary disease
    Irene Brüske
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environment and Health, Neuherberg, Germany
    Inhal Toxicol 22:245-52. 2010
    ..The increase of particulate and gaseous air pollution was associated with multiple changes in the differential white blood cell count in patients with chronic pulmonary diseases...
  29. pmc High blood pressure, antihypertensive medication and lung function in a general adult population
    Eva Schnabel
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Respir Res 12:50. 2011
    ..Thus, aim of this analysis is to determine whether hypertension and antihypertensive medication have an adverse effect on lung function in a general adult population...
  30. ncbi request reprint The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome
    Thomas Illig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 52:2861-4. 2003
  31. doi request reprint Long-term effects of hydrolyzed protein infant formulas on growth--extended follow-up to 10 y of age: results from the German Infant Nutritional Intervention (GINI) study
    Peter Rzehak
    From Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Clin Nutr 94:1803S-1807S. 2011
    ..No studies have been conducted in children up to the age of 10 y...
  32. ncbi request reprint Solid food introduction in relation to eczema: results from a four-year prospective birth cohort study
    Birgit Filipiak
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    J Pediatr 151:352-8. 2007
    ..To assess the association between the introduction of solid foods in the first 12 months and the occurrence of eczema during the first 4 years of life in a prospective study of newborns...
  33. pmc Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
    Regina Hampel
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany
    Environ Health Perspect 118:1755-61. 2010
    ..Epidemiological studies have shown that ambient particulate matter (PM) and changes in air temperature are associated with increased cardiopulmonary events...
  34. pmc Gene-gene interaction between APOA5 and USF1: two candidate genes for the metabolic syndrome
    Paula Singmann
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Neuherberg, Germany
    Obes Facts 2:235-42. 2009
    ..USF1 is a transcription factor for APOA5...
  35. doi request reprint Prenatal and postnatal tobacco smoke exposure and development of insulin resistance in 10 year old children
    Elisabeth Thiering
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Int J Hyg Environ Health 214:361-8. 2011
    ..Positive dose-dependent associations and independent effects of postnatal exposure suggest involvement of environmental tobacco smoke in the risk for development of insulin resistance in children...
  36. doi request reprint SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
    Angela Doring
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Nat Genet 40:430-6. 2008
    ..The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women...
  37. ncbi request reprint Timing of solid food introduction in relation to atopic dermatitis and atopic sensitization: results from a prospective birth cohort study
    Anne Zutavern
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Pediatrics 117:401-11. 2006
    ..This study investigates whether a delayed introduction of solids (past 4 months or 6 months) is protective against the development of atopic dermatitis (AD) and atopic sensitization when considering reverse causality...
  38. ncbi request reprint Reproducibility of allergen, endotoxin and fungi measurements in the indoor environment
    Joachim Heinrich
    GSF Institute of Epidemiology, POB 1129, D 85758 Neuherberg, Germany
    J Expo Anal Environ Epidemiol 13:152-60. 2003
    ..However, repeated measurements of fungi levels were only weakly correlated and thus repeated observations for assessment of annual means of total spore counts are needed...
  39. ncbi request reprint Relationship between electrocardiographic and biochemical variables in coronary artery disease
    Wei Yue
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Int J Cardiol 119:185-91. 2007
    ..In this study, we aimed to explore the relationship between ECG and biochemical markers in a longitudinal study of coronary patients...
  40. ncbi request reprint Effect of exclusive breast-feeding and early solid food avoidance on the incidence of atopic dermatitis in high-risk infants at 1 year of age
    Angela Schoetzau
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Pediatr Allergy Immunol 13:234-42. 2002
    ..We conclude that in infants at atopic risk, exclusive breast-feeding for at least 4 months is effective in preventing AD in the first year of life...
  41. doi request reprint Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children
    Verena Morgenstern
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Am J Respir Crit Care Med 177:1331-7. 2008
    ..In vitro studies, animal experiments, and human exposure studies have shown how ambient air pollution increases the risk of atopic diseases. However, results derived from observational studies are inconsistent...
  42. ncbi request reprint Impact of measurement error in exposures in german radon studies
    Iris M Heid
    GSF Research Center, Institute of Epidemiology, Neuherberg, Germany
    J Toxicol Environ Health A 69:701-21. 2006
    ....
  43. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012
    ..Its flexible design enables both the use of prior knowledge and the generation of new knowledge on connection of multiple phenotypes. A software program for PSEA based on GWAS results is available upon request...
  44. doi request reprint Acute air pollution effects on heart rate variability are modified by SNPs involved in cardiac rhythm in individuals with diabetes or impaired glucose tolerance
    Regina Hampel
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Environ Res 112:177-85. 2012
    ..Epidemiological studies have shown associations between particulate matter (PM) and heart rate variability (HRV)...
  45. doi request reprint Growth of infants fed formula rich in canola oil (low erucic acid rapeseed oil)
    Peter Rzehak
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Clin Nutr 30:339-45. 2011
    ..The aim of this study is to investigate whether infant formulas containing canola oil support normal growth in infants as assessed by weight and length gain...
  46. ncbi request reprint Runs of ventricular and supraventricular tachycardia triggered by air pollution in patients with coronary heart disease
    Annette Berger
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    J Occup Environ Med 48:1149-58. 2006
    ..The authors conducted an investigation of the association between air pollution and arrhythmia...
  47. ncbi request reprint Epidemiological evidence on health effects of ultrafine particles
    Angela Ibald-Mulli
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    J Aerosol Med 15:189-201. 2002
    ..If these effects are confirmed by ongoing research, monitoring and regulation of particulate air pollution may need to be revised...
  48. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  49. pmc Repolarization changes induced by air pollution in ischemic heart disease patients
    Alexandra Henneberger
    Ludwig Maximilians University of Munich, Munich, Germany
    Environ Health Perspect 113:440-6. 2005
    ..This study provides evidence suggesting an immediate effect of air pollution on repolarization duration, morphology, and variability representing myocardial substrate and vulnerability, key factors in the mechanisms of cardiac death...
  50. pmc Dilution of candidates: the case of iron-related genes in restless legs syndrome
    Konrad Oexle
    Institute of Human Genetics, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Eur J Hum Genet 21:410-4. 2013
    ..Moreover, in a general power analysis, we show that genetic effects are diluted if they are transmitted via an intermediate trait to an end-phenotype. Sample size formulas are provided for small effect sizes...
  51. ncbi request reprint Seasonal and diurnal variation of PM2.5 apparent particle density in urban air in Augsburg, Germany
    Mike Pitz
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Environ Sci Technol 42:5087-93. 2008
    ..rho2.5 has the potential to serve as a crude tracer for chemical composition and atmospheric processing and might play an important role when considering the associations between health effects and ambient particles...
  52. doi request reprint Particle-associated organic compounds and symptoms in myocardial infarction survivors
    Ute Kraus
    Institute of Epidemiology II, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Inhal Toxicol 23:431-47. 2011
    ..The organic compounds may be causally related with cardiovascular health or act rather as indicators for traffic- and combustion-related particles...
  53. ncbi request reprint Effect of breast-feeding on the development of atopic dermatitis during the first 3 years of life--results from the GINI-birth cohort study
    Birgit Laubereau
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    J Pediatr 144:602-7. 2004
    ..To investigate if exclusive breast-feeding for 4 months is associated with atopic dermatitis during the first 3 years of life...
  54. pmc Short-term mortality rates during a decade of improved air quality in Erfurt, Germany
    Susanne Breitner
    Institute of Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Environ Health Perspect 117:448-54. 2009
    ..Numerous studies have shown associations between ambient air pollution and daily mortality...
  55. doi request reprint Regional and socio-economic differences in food, nutrient and supplement intake in school-age children in Germany: results from the GINIplus and the LISAplus studies
    Stefanie Sausenthaler
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Public Health Nutr 14:1724-35. 2011
    ..To describe regional differences between eastern and western Germany with regard to food, nutrient and supplement intake in 9-12-year-old children, and analyse its association with parental education and equivalent income...
  56. pmc Acute-phase serum amyloid A protein and its implication in the development of type 2 diabetes in the KORA S4/F4 study
    Carola Marzi
    Department of Molecular Epidemiology, German Research Centerfor Environmental Health, Neuherberg, Germany
    Diabetes Care 36:1321-6. 2013
    ..We sought to investigate whether elevated levels of acute-phase serum amyloid A (A-SAA) protein precede the onset of type 2 diabetes independently of other risk factors, including parameters of glucose metabolism...
  57. ncbi request reprint Mode of delivery and development of atopic disease during the first 2 years of life
    Kathrin Negele
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Pediatr Allergy Immunol 15:48-54. 2004
    ..This should be considered when cesarean section is done for other than medical reasons...
  58. pmc First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study
    Christina Holzapfel
    Else Kröner Fresenius Centre for Nutritional Medicine, Technische Universitat Munchen, Munich, Germany
    J Epidemiol Community Health 65:174-6. 2011
    ....
  59. ncbi request reprint Indoor and outdoor air concentrations of BTEX and NO2: correlation of repeated measurements
    Rebekka Topp
    GSF National Research Center for Environment Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    J Environ Monit 6:807-12. 2004
    ....
  60. pmc Novel biomarkers for pre-diabetes identified by metabolomics
    Rui Wang-Sattler
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Syst Biol 8:615. 2012
    ..The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D...
  61. pmc A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes
    Stefan Kaab
    Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig Maximilians University, Munich, Germany
    Circ Cardiovasc Genet 5:91-9. 2012
    ..We tested the hypothesis that common variants in key genes controlling cardiac electric properties modify the risk of diLQTS...
  62. ncbi request reprint Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age
    Stefanie Sausenthaler
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Am J Clin Nutr 85:530-7. 2007
    ..Maternal diet during pregnancy might be one of the factors that influences fetal immune responses associated with childhood allergy...
  63. doi request reprint Hospital admission in children up to the age of 2 years
    Eva Schnabel
    Helmholtz Zentrum Munich, Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Eur J Pediatr 168:925-31. 2009
    ..Additionally, multiple admissions play only a minor role concerning hospital admission in children up to the age of 2 years...
  64. ncbi request reprint Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients
    Wei Yue
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Mutat Res 621:50-60. 2007
    ..These results suggest that traffic-related and combustion-generated particles show stronger adverse health impact with regard to cardiac effects, and that particles from different sources induce an acute phase response in these patients...
  65. pmc Prenatal and postnatal tobacco exposure and behavioral problems in 10-year-old children: results from the GINI-plus prospective birth cohort study
    Simon Rückinger
    Ludwig Maximilians University Munich, Institute of Social Pediatrics and Adolescent Medicine, Division of Epidemiology, Munich, Germany
    Environ Health Perspect 118:150-4. 2010
    ..Prenatal and postnatal tobacco exposure have been reported to be associated with behavioral problems. However, the magnitude of the association with tobacco exposure at specific periods of exposure is unclear...
  66. pmc Association of early repolarization pattern on ECG with risk of cardiac and all-cause mortality: a population-based prospective cohort study (MONICA/KORA)
    Moritz F Sinner
    University Hospital Munich, Campus Grosshadern, Medical Department I, Ludwig Maximilians University Munich, Munich, Germany
    PLoS Med 7:e1000314. 2010
    ....
  67. ncbi request reprint A prospective study on the association between hay fever among children and incidence of asthma in East Germany
    Peter Rzehak
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, Neuherberg, Germany
    Eur J Epidemiol 23:17-22. 2008
    ....
  68. doi request reprint Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions
    Iris M Heid
    Institute of Epidemiology, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Circ Cardiovasc Genet 1:10-20. 2008
    ..We aimed to identify gene regions that influence HDLC levels by a genome-wide association analysis in the population-based KORA (Cooperative Health Research in the Region of Augsburg) study...
  69. ncbi request reprint Radon epidemiology: continuous and categorical trend estimators when the exposure distribution is skewed and outliers may be present
    Angelika Schaffrath Rosario
    GSF Research Center, Institute of Epidemiology, Neuherberg, Germany
    J Toxicol Environ Health A 69:681-700. 2006
    ..In the West German case-control study on indoor radon and lung cancer, these sensitivity analyses lead to increased risk estimates...
  70. pmc Source apportionment of ambient fine particle size distribution using positive matrix factorization in Erfurt, Germany
    Wei Yue
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Sci Total Environ 398:133-44. 2008
    ....
  71. ncbi request reprint Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
    Juliane Winkelmann
    Institute of Human Genetics, GSF National Research Center of Environment and Health, D 85764 Neuherberg, Munich, Germany
    Nat Genet 39:1000-6. 2007
    ..MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder...
  72. ncbi request reprint APOA5 variants and metabolic syndrome in Caucasians
    Harald Grallert
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    J Lipid Res 48:2614-21. 2007
    ..Furthermore, the data suggest a different mechanism of APOA5 impact on MetS in Caucasians, as variant c.56C>G (not analyzed in the Japanese study) and not -1131T>C, as in the Japanese subjects, was associated with MetS...
  73. doi request reprint Peak growth velocity in infancy is positively associated with blood pressure in school-aged children
    Elisabeth Thiering
    Helmholtz Zentrum Munich, Center for Environment and Health, Institute of Epidemiology I, Neuherberg, Germany
    J Hypertens 30:1114-21. 2012
    ..We analysed the association between peak growth velocity during the first 2 years of life and blood pressure, fasting glucose and insulin at 10 years of age...
  74. doi request reprint Fibrinogen genes modify the fibrinogen response to ambient particulate matter
    Annette Peters
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstaedter Landstrasse, Neuherberg 85764, Germany
    Am J Respir Crit Care Med 179:484-91. 2009
    ..Ambient particulate matter has been associated with systemic inflammation indicated by blood markers such as fibrinogen, implicated in promoting atherothrombosis...
  75. doi request reprint Intensity of physical exertion and triggering of myocardial infarction: a case-crossover study
    Stephanie von Klot
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Eur Heart J 29:1881-8. 2008
    ..We evaluated whether the risk of having an AMI triggered by physical exertion exhibits an exposure-response relationship, and whether it varies by ambient temperature or by taking place indoors or outdoors...
  76. doi request reprint Effect of hydrolysed formula feeding on taste preferences at 10 years. Data from the German Infant Nutritional Intervention Program Plus Study
    Stefanie Sausenthaler
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Epidemiology, Germany
    Clin Nutr 29:304-6. 2010
    ..Therefore, the aim of present study was to investigate whether feeding with different kinds of infant formula is associated with the acceptance of infant formula at 10 years of age...
  77. doi request reprint Exhaled nitric oxide and influencing factors in a random population sample
    Stefan Karrasch
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, Munich, Germany
    Respir Med 105:713-8. 2011
    ..In current smokers, however, effects were heterogeneous and information on smoking intensity seems to be useful for better adjustment...
  78. ncbi request reprint Comparison between different traffic-related particle indicators: elemental carbon (EC), PM2.5 mass, and absorbance
    Josef Cyrys
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    J Expo Anal Environ Epidemiol 13:134-43. 2003
    ..While the ratio between PM(2.5) and PM(10) mass ranged from 0.54 to 0.68, the ratio of PM(2.5) absorbance and PM(10) absorbance was 0.96-0.97, indicating that PM(2.5) absorbance captures nearly all of the particle absorbance...
  79. ncbi request reprint Day care in relation to respiratory-tract and gastrointestinal infections in a German birth cohort study
    Anne Zutavern
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Acta Paediatr 96:1494-9. 2007
    ..To investigate longitudinally whether children attending day care centres have an increased risk of acquiring common cold, bronchitis, pneumonia, otitis media or diarrhea...
  80. pmc Regional differences in prediction models of lung function in Germany
    Eva Schnabel
    Helmholtz Zentrum Munchen, Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Respir Res 11:40. 2010
    ..The aim of this analysis was to determine whether lung function determinants differ between subpopulations within Germany and whether prediction equations developed for one subpopulation are also adequate for another subpopulation...
  81. pmc Changes in deceleration capacity of heart rate and heart rate variability induced by ambient air pollution in individuals with coronary artery disease
    Alexandra Schneider
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Part Fibre Toxicol 7:29. 2010
    ..The study assessed the association between deceleration capacity (DC) as well as heart rate variability (HRV) and ambient particulate matter (PM) in patients with coronary artery disease (CAD)...
  82. ncbi request reprint Early-life otitis media and incident atopic disease at school age in a birth cohort
    Elaina A MacIntyre
    Institute of Epidemiology, German Research Centre for Environmental Health, Neuherberg, Germany
    Pediatr Infect Dis J 29:e96-9. 2010
    ..Otitis media is a common and costly disease that peaks in early childhood. Recent reviews concluded that the relationship between otitis media and atopy is not well understood, and that further research is warranted...
  83. ncbi request reprint Relationship between indoor and outdoor levels of fine particle mass, particle number concentrations and black smoke under different ventilation conditions
    Josef Cyrys
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    J Expo Anal Environ Epidemiol 14:275-83. 2004
    ..This effect was not observed for PM(2.5) or BS. This study shows the importance of the indoor air aerosol measurements for health effects studies and the need for more research on I/O transport mechanisms for NC...
  84. pmc Estimating the single nucleotide polymorphism genotype misclassification from routine double measurements in a large epidemiologic sample
    Iris M Heid
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Am J Epidemiol 168:878-89. 2008
    ..In situations with more substantial error, the presented approach using duplicate genotyping and the MC-SIMEX method is practical and helpful for quantifying the genotyping error and its impact...
  85. doi request reprint Burden of otitis media and pneumonia in children up to 6 years of age: results of the LISA birth cohort
    Eva Schnabel
    Institute of Epidemiology, Helmholtz Zentrum Munich, Center for Environment and Health, 85764 Neuherberg, Germany
    Eur J Pediatr 168:1251-7. 2009
    ..Thus, parents and physicians should not per se worry about a high frequency of otitis media during early childhood...
  86. pmc Associations between air temperature and cardio-respiratory mortality in the urban area of Beijing, China: a time-series analysis
    Liqun Liu
    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany
    Environ Health 10:51. 2011
    ..Our study investigated the association between air temperature and cardio-respiratory mortality in the urban area of Beijing, China...
  87. doi request reprint Haplotype misclassification resulting from statistical reconstruction and genotype error, and its impact on association estimates
    Claudia Lamina
    Institute of Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Ann Hum Genet 74:452-62. 2010
    ..Our findings give a sense of the impact of haplotype error under realistic scenarios and underscore the importance of high-quality genotyping, in which case the bias in haplotype association estimates is negligible...
  88. doi request reprint Sensitization to contact allergens and bronchial hyper-responsiveness
    Eva Schnabel
    Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Contact Dermatitis 63:157-63. 2010
    ..Exposure to contact allergens and specific allergic sensitization to them are common, but possible related health effects have been rarely studied...
  89. doi request reprint Air temperature and the occurrence of myocardial infarction in Augsburg, Germany
    Kathrin Wolf
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Circulation 120:735-42. 2009
    ..The objective of this study was to examine in detail the registry-based myocardial infarction (MI) rates and coronary deaths in relation to air temperature in the area of Augsburg, Germany...
  90. pmc Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
    Cornelia Huth
    Institute of Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Ann Med 41:128-38. 2009
    ..Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results...
  91. pmc Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
    Katharina Hildebrandt
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany
    Part Fibre Toxicol 6:25. 2009
    ..abstract:..
  92. ncbi request reprint Individuals with very low alcohol consumption: a heterogeneous group
    Cornelia Huth
    Institute of Epidemiology, GSF Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    J Stud Alcohol Drugs 68:6-10. 2007
    ..This study investigated differences regarding degree, duration, and motivation of abstinence within a group of individuals with very low alcohol consumption. Reliability of self-reported alcohol abstinence was examined...
  93. pmc Albuminuria, cardiovascular risk factors and disease management in subjects with type 2 diabetes: a cross sectional study
    Christa Meisinger
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Epidemiology, Neuherberg, Germany
    BMC Health Serv Res 8:226. 2008
    ....
  94. pmc Genome-wide association study of PR interval
    Arne Pfeufer
    Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Nat Genet 42:153-9. 2010
    ..0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation...
  95. ncbi request reprint Elemental composition and sources of fine and ultrafine ambient particles in Erfurt, Germany
    J Cyrys
    GSF, National Research Center for Environment and Health, Institute of Epidemiology, Geb 56, O 85764, Neuherberg, Germany
    Sci Total Environ 305:143-56. 2003
    ..Sulfur could be a tracer for coal combustion, however, it was not correlated with any of the quoted elements. Highly correlated elements V and Ni have similar enrichment factors and are considered as tracers for oil combustion...
  96. doi request reprint Short- and long-term effects of feeding hydrolyzed protein infant formulas on growth at < or = 6 y of age: results from the German Infant Nutritional Intervention Study
    Peter Rzehak
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Am J Clin Nutr 89:1846-56. 2009
    ..The short- and long-term effects of feeding with hydrolyzed formulas on growth are uncertain...
  97. ncbi request reprint Domestic cat allergen and allergic sensitisation in young children
    Chih Mei Chen
    GSF National Research Centre for Environment and Health, Institute of Epidemiology, D 85764 Neuherberg, Germany
    Int J Hyg Environ Health 211:337-44. 2008
    ..The mixed results may be explained by differences in age and avoidance patterns...
  98. doi request reprint Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene
    Matthias Elstner
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Ann Neurol 66:792-8. 2009
    ..Monogenic forms have provided molecular clues to disease mechanisms but genetic modifiers of idiopathic PD are still to be determined...
  99. ncbi request reprint Characteristics of the German uranium miners cohort study
    Michaela Kreuzer
    Federal Office for Radiation Protection, Institute of Radiation Hygiene, Neuherberg, Germany
    Health Phys 83:26-34. 2002
    ..The main strengths of the study are its size and the large group of workers having received low exposures over relatively long periods of time...
  100. ncbi request reprint Temporal changes in blood lead levels of children in east Germany
    Ines Meyer
    Ludwig Maximilians University of Munich, Chair of Epidemiology, GSF National Research Centre for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Int J Hyg Environ Health 206:181-92. 2003
    ..It seems that the decline in ambient lead fall had an impact on the body burden of lead, but the overall decrease in BLL in these two regions is caused by the overall decrease of lead in gasoline and thus in food...
  101. doi request reprint Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 122:560-8.e4. 2008
    ..These genes encode proteins thought to be involved in the regulation of posttranslation processing of filaggrin (FLG), the strongest identified genetic risk factor for eczema to date...