T Werner

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. ncbi request reprint Identification and functional modelling of DNA sequence elements of transcription
    T Werner
    Institute of Experimental Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Brief Bioinform 1:372-80. 2000
  2. ncbi request reprint Cluster analysis and promoter modelling as bioinformatics tools for the identification of target genes from expression array data
    T Werner
    Genomatix Software GmbH, Karlstrasse 55, D 80333 Munich, Germany
    Pharmacogenomics 2:25-36. 2001
  3. ncbi request reprint Target gene identification from expression array data by promoter analysis
    T Werner
    Genomatix Software GmbH, Karlstrasse 55, 80333, Munich, Germany
    Biomol Eng 17:87-94. 2001
  4. ncbi request reprint Identification of endogenous retroviral sequences based on modular organization: proviral structure at the SSAV1 locus
    J H Blusch
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Genomics 43:52-61. 1997
  5. ncbi request reprint Muscle actin genes: a first step towards computational classification of tissue specific promoters
    K Frech
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    In Silico Biol 1:29-38. 1998
  6. ncbi request reprint Experimental data of a single promoter can be used for in silico detection of genes with related regulation in the absence of sequence similarity
    V Gailus-Durner
    Institute of Experimental Genetics, GSF-National Research Center for Environment and Health, Neuherberg, Germany
    Mamm Genome 12:67-72. 2001
  7. pmc First pass annotation of promoters on human chromosome 22
    M Scherf
    Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Genome Res 11:333-40. 2001
  8. pmc Linking disease-associated genes to regulatory networks via promoter organization
    S Döhr
    Institute of Experimental Genetics, GSF National Research Center for Environment and Health Ingolstädter Landstrasse 1, D 85764 Neuherberg, Germany
    Nucleic Acids Res 33:864-72. 2005
  9. ncbi request reprint Sequence analysis of the beta B2-crystallin cDNA of hamster containing a domain conserved among vertebrates
    K Zarbalis
    Institut fur Saugetiergenetik, GSF Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany
    Gene 174:181-4. 1996
  10. ncbi request reprint GenomeInspector: a new approach to detect correlation patterns of elements on genomic sequences
    K Quandt
    Institut fur Saugetiergenetik, GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Oberschleissheim, Germany or
    Comput Appl Biosci 12:405-13. 1996

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Identification and functional modelling of DNA sequence elements of transcription
    T Werner
    Institute of Experimental Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Brief Bioinform 1:372-80. 2000
    ..Comparative genomics in non-coding regions (eg phylogenetic footprinting) is a very promising approach that allows identification of potential new regulatory elements which may be used in modelling approaches...
  2. ncbi request reprint Cluster analysis and promoter modelling as bioinformatics tools for the identification of target genes from expression array data
    T Werner
    Genomatix Software GmbH, Karlstrasse 55, D 80333 Munich, Germany
    Pharmacogenomics 2:25-36. 2001
    ..This approach also provides a powerful alternative for elucidating the functional features of genes with no detectable sequence similarity, by linking them to other genes on the basis of their common promoter structures...
  3. ncbi request reprint Target gene identification from expression array data by promoter analysis
    T Werner
    Genomatix Software GmbH, Karlstrasse 55, 80333, Munich, Germany
    Biomol Eng 17:87-94. 2001
    ....
  4. ncbi request reprint Identification of endogenous retroviral sequences based on modular organization: proviral structure at the SSAV1 locus
    J H Blusch
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Genomics 43:52-61. 1997
    ....
  5. ncbi request reprint Muscle actin genes: a first step towards computational classification of tissue specific promoters
    K Frech
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    In Silico Biol 1:29-38. 1998
    ..We believe this pilot study demonstrates the general applicability of our approach as well as the concept of modular promoter organization...
  6. ncbi request reprint Experimental data of a single promoter can be used for in silico detection of genes with related regulation in the absence of sequence similarity
    V Gailus-Durner
    Institute of Experimental Genetics, GSF-National Research Center for Environment and Health, Neuherberg, Germany
    Mamm Genome 12:67-72. 2001
    ..We believe that this new approach is a substanial extension to database analysis by BLAST or FASTA, which are restricted to sequence similarity...
  7. pmc First pass annotation of promoters on human chromosome 22
    M Scherf
    Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Genome Res 11:333-40. 2001
    ..Results are available on-line at http://genomatix.gsf.de/chr22/...
  8. pmc Linking disease-associated genes to regulatory networks via promoter organization
    S Döhr
    Institute of Experimental Genetics, GSF National Research Center for Environment and Health Ingolstädter Landstrasse 1, D 85764 Neuherberg, Germany
    Nucleic Acids Res 33:864-72. 2005
    ..Thus, data-driven in silico promoter analysis allowed integrating molecular mechanisms with biological functions of the cell...
  9. ncbi request reprint Sequence analysis of the beta B2-crystallin cDNA of hamster containing a domain conserved among vertebrates
    K Zarbalis
    Institut fur Saugetiergenetik, GSF Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany
    Gene 174:181-4. 1996
    ..This 36-aa domain contains a putative phosphorylation site for protein kinase C and is highly conserved among all known basic beta B-Cry; however, it can neither be detected in the acidic beta A-nor in the gamma-Cry...
  10. ncbi request reprint GenomeInspector: a new approach to detect correlation patterns of elements on genomic sequences
    K Quandt
    Institut fur Saugetiergenetik, GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Oberschleissheim, Germany or
    Comput Appl Biosci 12:405-13. 1996
    ..However, the functionality of biological units like promoters depends on the correct spatial organization of multiple individual elements...
  11. ncbi request reprint Regulatory modules shared within gene classes as well as across gene classes can be detected by the same in silico approach
    A Klingenhoff
    Genoma Software GmbH, Munchen, Germany
    In Silico Biol 2:S17-26. 2002
    ..All models exhibited high selectivity, e.g. the mammalian muscle actin promoter model produced no false negatives in a database search...
  12. ncbi request reprint Report on the twelfth international workshop on the identification of transcribed sequences: functional, expression and evolutionary analysis
    T Werner
    Institute for Säugertiergenetik, Oberschleissheim, Germany
    Cytogenet Genome Res 98:109-17. 2002
  13. ncbi request reprint Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein
    F Wopfner
    Genecenter, Department of Virology, Max von Pettenkofer Institute for Medical Microbiology, Ludwig Maximilians University of Munich, Feodor Lynen Str 25, Munich, 81377, Germany
    J Mol Biol 289:1163-78. 1999
    ..g. the N-terminal region from amino acid residue 23-90 and the regions located upstream of alpha-helices 1 and 3...
  14. ncbi request reprint Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes
    F Santagati
    GSF Research Center for Health and Environment, Institute of Mammalian Genetics, Neuherberg, Germany
    Mamm Genome 12:232-7. 2001
    ..Our results suggest that transcription of Pax9 may be initiated at two alternative start sites and driven by TATA-less promoters...
  15. pmc Proviral structure, chromosomal location, and expression of HERV-K-T47D, a novel human endogenous retrovirus derived from T47D particles
    W Seifarth
    Medical Clinic III, Faculty of Clinical Medicine Mannheim, University of Heidelberg, D 68305 Mannheim, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    J Virol 72:8384-91. 1998
    ..High HERV-K-T47D transcription levels were observed in human placenta tissue, whereas transcription in T47D cells was strictly steroid dependent...
  16. ncbi request reprint Genomic sequences of murine gamma B- and gamma C-crystallin-encoding genes: promoter analysis and complete evolutionary pattern of mouse, rat and human gamma-crystallins
    J Graw
    GSF Institut für Säugetiergenetik, Neuherberg, Germany
    Gene 136:145-56. 1993
    ....
  17. ncbi request reprint Alpha-crystallins are involved in specific interactions with the murine gamma D/E/F-crystallin-encoding gene
    D Pietrowski
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Saugetiergenetik, Neuherberg, Germany
    Gene 144:171-8. 1994
    ..The results reported here point to a novel function of alpha-Cry besides the structural properties in the lens...
  18. ncbi request reprint MatInspector and beyond: promoter analysis based on transcription factor binding sites
    K Cartharius
    Genomatix Software GmbH Landsberger Strasse 6, 80339 München, Germany
    Bioinformatics 21:2933-42. 2005
    ..The next steps in promoter analysis can be tackled only with reliable predictions, e.g. finding phylogenetically conserved patterns or identifying higher order combinations of sites in promoters of co-regulated genes...
  19. ncbi request reprint [Teleteaching in otorhinolaryngology (part 1). Real-time transmission of a congress in picture and tone into the Internet]
    M Fuchs
    Universitatsklinikum Leipzig AoR, Klinik und Poliklinik Fur Hals, Nasen, Ohrenheilkunde Plastische Operationen, Universitat Leipzig
    HNO 51:16-24. 2003
    ..The transmission of scientific meetings into the Internet can increase, with a justifiable technical expenditure, their efficiency by the ubiquitous availability of the information and the extension of the audience...
  20. ncbi request reprint [Teleteaching in otorhinolaryngology. Part 2: the European database "medicstream"]
    M Fuchs
    Klinik und Poliklinik Fur Hals, Nasen, Ohrenheilkunde Plastische Operationen, Universitatsklinikum Leipzig
    HNO 51:104-12. 2003
    ..The telemedicine data base "medicstream" can optimize quality and extend medical education by live-streaming as well as by archiving scientific presentations as audiovisual data...
  21. ncbi request reprint Cloning, sequencing and functional studies of the gene encoding human GTP cyclohydrolase I
    K Witter
    GSF Institut für Klinische Molekularbiologie, Munchen, Germany
    Gene 171:285-90. 1996
    ..Interferon-gamma treatment of B-cells transfected with reporter constructs had no influence on the expression activity...
  22. ncbi request reprint The Helmholtz Network for Bioinformatics: an integrative web portal for bioinformatics resources
    T Crass
    Department of Bioinformatics, Medical Faculty, Georg August University Gottingen, Goldschmidtstrasse 1, 37077 Gottingen, Germany
    Bioinformatics 20:268-70. 2004
    ..Currently, automated cascades for the analysis of regulatory DNA segments as well as for the prediction of protein functional properties are provided...
  23. ncbi request reprint Report on the thirteenth international workshop on the identification and functional, evolutionary and expression analysis of transcribed sequences: comparative and functional genomics workshop
    A Brazma
    European Bioinformatics Institute, The Wellcome Trust Genome Campus, Hinxton, UK
    Cytogenet Genome Res 105:11-7. 2004
  24. ncbi request reprint Detection of a novel sepiapterin reductase mRNA: assay of mRNA in various cells and tissues of various species
    J Maier
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut für Klinische Molekularbiologie und Tumorgenetik, Munchen, Federal Republic of Germany
    Exp Cell Res 204:217-22. 1993
    ..Moreover, the relative mRNA expression correlates with the enzymatic activities of different cell lines within the same species. This indicates that SR activity is regulated by its steady state mRNA levels...
  25. ncbi request reprint Murine gamma E-crystallin is distinct from murine gamma 2-crystallin
    J Graw
    GSF Institut für Säugetiergenetik, Neuherberg, F R G
    Gene 104:265-70. 1991
    ..There is no similar repeat structure in any other gamma-cry gene. No binding site for a common transcription factor could be detected among the 1100 bp of the 5'-region...