H Peters

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. ncbi Pax genes and organogenesis: Pax9 meets tooth development
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Eur J Oral Sci 106:38-43. 1998
  2. ncbi Teeth. Where and how to make them
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Trends Genet 15:59-65. 1999
  3. pmc Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Neuherberg D 85764, Germany
    Genetics 159:1689-700. 2001
  4. ncbi Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes
    F Santagati
    GSF Research Center for Health and Environment, Institute of Mammalian Genetics, Neuherberg, Germany
    Mamm Genome 12:232-7. 2001
  5. ncbi Pax1 and Pax9 synergistically regulate vertebral column development
    H Peters
    GSF Research Center for Environment and Health, Institute of Mammalian Genetics, Germany
    Development 126:5399-408. 1999
  6. pmc Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, 85764 Neuherberg, Germany
    Genes Dev 12:2735-47. 1998
  7. ncbi Clinical findings and biochemical and molecular analysis of four patients with holocarboxylase synthetase deficiency
    A Morrone
    Neurometabolic Unit, Department of Pediatrics, University of Florence, Italy
    Am J Med Genet 111:10-8. 2002
  8. ncbi Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    I Satokata
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 24:391-5. 2000
  9. ncbi Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
    P X Xu
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 23:113-7. 1999
  10. pmc Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain
    R Fahsold
    Gemeinschaftspraxis B Prager and A Junge, Dresden, Germany
    Am J Hum Genet 66:790-818. 2000

Collaborators

  • R Balling
  • K Imai
  • T Hermann
  • R Maas
  • J Favor
  • T Werner
  • H Wada
  • T Maeda
  • R L Strausberg
  • Chirstoph Gille
  • M Ogasawara
  • S Cho
  • E Reichenberger
  • D Kaufmann
  • Franco Laccone
  • A Boneh
  • M Łastowska
  • M Brix
  • V Tiziani
  • P Bauer
  • A Dimmler
  • A Morrone
  • Y Ueki
  • A Lal
  • F Santagati
  • R Fahsold
  • I Satokata
  • N Fukai
  • B R Olsen
  • S Heaney
  • K Kapelari
  • P X Xu
  • A G Hall
  • A D J Pearson
  • C Cullinane
  • I Lewis
  • M Santibanez-Koref
  • S A Burchill
  • D A Tweddle
  • P Roberts
  • M S Jackson
  • V Viprey
  • I Wappler
  • B Wilm
  • B Ricbourg
  • E Ranfaing
  • M Hayman
  • M Baumgartner
  • S Bosch
  • B H F Weber
  • J Andrich
  • H Weirich-Schwaiger
  • A Rolfs
  • S Liebscher
  • O Riess
  • D J Morris-Rosendahl
  • U Wullner
  • J T Epplen
  • E Holinski-Feder
  • A Neubüser
  • M Scheible
  • H O Schöcklmann
  • C Forster
  • M Hattler
  • K Amann
  • C S Haas
  • M A Donati
  • F Ciani
  • E Zammarchi
  • S Funghini
  • S Malvagia
  • E Pasquini
  • I Pela
  • C doAmaral
  • G J Riggins
  • A J van der Kogel
  • J H Kaanders
  • J Garfinkle
  • J H Blusch
  • C Santanna
  • L Rhee-Morris
  • B St Croix
  • M Habal
  • Z A Haroon
  • C Ninomiya
  • J K Gerber
  • J Adamski
  • S Kreiborg
  • C Maulik
  • J B Doss

Detail Information

Publications24

  1. ncbi Pax genes and organogenesis: Pax9 meets tooth development
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Eur J Oral Sci 106:38-43. 1998
    ..Here, we briefly summarize our current knowledge about Pax genes and introduce Pax9 to the growing family of factors which are involved in tooth development...
  2. ncbi Teeth. Where and how to make them
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Trends Genet 15:59-65. 1999
    ..This cascade provides a molecular model by which reciprocal tissue interactions are controlled...
  3. pmc Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Neuherberg D 85764, Germany
    Genetics 159:1689-700. 2001
    ..Pax6(7Neu) is a base pair substitution in the Kozak sequence and results in a reduced level of Pax6 translation product. The Pax6(4Neu) and Pax6(7Neu) alleles may be very useful for gene-dosage studies...
  4. ncbi Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes
    F Santagati
    GSF Research Center for Health and Environment, Institute of Mammalian Genetics, Neuherberg, Germany
    Mamm Genome 12:232-7. 2001
    ..Our results suggest that transcription of Pax9 may be initiated at two alternative start sites and driven by TATA-less promoters...
  5. ncbi Pax1 and Pax9 synergistically regulate vertebral column development
    H Peters
    GSF Research Center for Environment and Health, Institute of Mammalian Genetics, Germany
    Development 126:5399-408. 1999
    ..In addition, our data indicate that the development of medial and lateral elements of vertebrae is regulated by distinct genetic pathways...
  6. pmc Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, 85764 Neuherberg, Germany
    Genes Dev 12:2735-47. 1998
    ..In summary, our analysis shows that Pax9 is a key regulator during the development of a wide range of organ primordia...
  7. ncbi Clinical findings and biochemical and molecular analysis of four patients with holocarboxylase synthetase deficiency
    A Morrone
    Neurometabolic Unit, Department of Pediatrics, University of Florence, Italy
    Am J Med Genet 111:10-8. 2002
    ....
  8. ncbi Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    I Satokata
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 24:391-5. 2000
    ..Our results provide a developmental basis for PFM and demonstrate that Msx2 is essential at multiple sites during organogenesis...
  9. ncbi Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
    P X Xu
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 23:113-7. 1999
    ..In addition, our results suggest that an evolutionarily conserved Pax-Eya-Six regulatory hierarchy is used in mammalian ear and kidney development...
  10. pmc Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain
    R Fahsold
    Gemeinschaftspraxis B Prager and A Junge, Dresden, Germany
    Am J Hum Genet 66:790-818. 2000
    ..Coincidence of mutated amino acids and those conserved between human and Drosophila strongly suggest significant functional relevance of this region, with major roles played by exons 12a and 15 and part of exon 16...
  11. ncbi Developmental expression of Pax1/9 genes in urochordate and hemichordate gills: insight into function and evolution of the pharyngeal epithelium
    M Ogasawara
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 126:2539-50. 1999
    ..The Pax1/9 genes therefore might provide the first developmental genetic corroboration of hypotheses of organ-level homology that unifies hemichordates, urochordates and cephalochordates...
  12. pmc Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency
    B Wilm
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 95:8692-7. 1998
    ..Furthermore, the phenotype of mice heterozygous for the null allele demonstrates that Pax1 is haploinsufficient in some though not all skeletal elements which express Pax1 during embryonic development...
  13. ncbi Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation
    A Neubüser
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco 94143 0452, USA
    Cell 90:247-55. 1997
    ..We suggest that a similar mechanism may be used for specifying the sites of development of other organs...
  14. ncbi Isolation of the Pax9 cDNA from adult human esophagus
    H Peters
    Institut fur Saugetiergenetik, GSF Forschungszentrum Neuherberg, Oberschleissheim, Germany
    Mamm Genome 8:62-4. 1997
  15. ncbi [Genetic aspects of cherubism]
    M Brix
    Service de Chirurgie Plastique et Maxillo Faciale, CHU de Grenoble
    Rev Stomatol Chir Maxillofac 107:105-8. 2006
    ..The diagnosis is often established in children presented swelling of the jaws. The familial determinism of cherubism is well-known, and recently autosomal dominant cases have been described with detection of the exon 9 - SH3BP2 mutation...
  16. pmc Trinucleotide repeat expansion in SCA17/TBP in white patients with Huntington's disease-like phenotype
    P Bauer
    J Med Genet 41:230-2. 2004
  17. ncbi Laser capture microdissection and real-time PCR for analysis of glomerular endothelin-1 gene expression in mesangiolysis of rat anti-Thy 1.1 and murine Habu Snake Venom glomerulonephritis
    A Dimmler
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Diagn Mol Pathol 12:108-17. 2003
    ..The above data argue for an important role of ET-1 in pathogenesis and/or repair of mesangiolysis in experimental mesangioproliferative GN...
  18. ncbi Methylcrotonyl-CoA carboxylase (MCC) deficiency associated with severe muscle pain and physical disability in an adult
    A Boneh
    Metabolic Service, Genetic Health Services Victoria, Murdoch Children s Research Institute, Royal Children s Hospital, Department of Paediatrics, Melbourne University, Melbourne, Australia
    J Inherit Metab Dis 28:1139-40. 2005
    ....
  19. ncbi Transcriptional response to hypoxia in human tumors
    A Lal
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Natl Cancer Inst 93:1337-43. 2001
    ..Within our catalogue of hypoxia-responsive genes are novel candidates for hypoxia-driven angiogenesis...
  20. ncbi Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism
    Y Ueki
    Harvard Forsyth Department of Oral Biology, Harvard School of Dental Medicine and The Forsyth Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 28:125-6. 2001
    ..Here we describe seven mutations in the SH3-binding protein SH3BP2 (MIM 602104) on chromosome 4p16.3 that cause cherubism...
  21. ncbi Differential expression of the chicken Pax-1 and Pax-9 gene: in situ hybridization and immunohistochemical analysis
    H Peters
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat, Marburg, Federal Republic of Germany
    Dev Dyn 203:1-16. 1995
    ..Furthermore, chPax-9 gene products are detected in circumscribed areas of mesenchyme in the metatarsus and in entodermal derivatives, i.e., in the lining epithelium of the developing pharynx and of the embryonic and adult esophagus...
  22. ncbi A rapid screening for steroid 21-hydroxylase mutations in patients with congenital adrenal hyperplasia. Mutations in brief no. 247. Online
    K Kapelari
    Institute for General and Experimental Pathology, Department of Molecular Pathophysiology, University of Innsbruck Medical School, Austria
    Hum Mutat 13:505. 1999
    ..Our study supports the case for using this rapid technique for CAH-family screening as long as alleles from both affected patients and parents are screened in parallel...
  23. pmc The gene for cherubism maps to chromosome 4p16
    V Tiziani
    Department of Cell Biology, Harvard Medical School and Harvard Forsyth Boston, MA, USA
    Am J Hum Genet 65:158-66. 1999
    ..Three other families affected with cherubism were also genotyped and were mapped to the same locus. The combined LOD score is 4.21 at a recombination fraction of 0, and the locus spans an interval of approximately 22 cM...
  24. ncbi Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data
    M Łastowska
    Institute of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Oncogene 26:7432-44. 2007
    ..They also suggest that integration of discriminators, such as survival and comparative gene expression, with microarray data may be useful in the identification of critical genes within regions of loss or gain in many human cancers...