Elfriede Noessner

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. ncbi request reprint Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling
    Henriette Bendz
    Institute of Molecular Immunology, GSF National Research Center for Environment and Health Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 25, 81377 Munich, Germany
    J Biol Chem 282:31688-702. 2007
  2. ncbi request reprint Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells
    Elfriede Noessner
    Clinical Cooperation Group Hyperthermie, Institute of Molecular Immunology, GSF National Research Center for Environment and Health, 81377 Munich, Germany
    J Immunol 169:5424-32. 2002
  3. ncbi request reprint Thermal stress-related modulation of tumor cell physiology and immune responses
    Elfriede Noessner
    GSF National Research Center for Environment and Health, Institute of Molecular Immunology, Marchioninistrasse 25, 81377, Munich, Germany
    Cancer Immunol Immunother 55:289-91. 2006
  4. ncbi request reprint Inhibitory effect of RNA pool complexity on stimulatory capacity of RNA-pulsed dendritic cells
    Miran Javorovic
    Institute of Molecular Immunology, Clinical Cooperation Group Immune Monitoring, GSF National Research Center for Environment and Health, Munich, Germany
    J Immunother 31:52-62. 2008
  5. doi request reprint Prostate cancer lesions are surrounded by FOXP3+, PD-1+ and B7-H1+ lymphocyte clusters
    Kathleen Ebelt
    Institute of Molecular Immunology, Clinical Cooperation Group Immune Monitoring, Helmholtz Center Munich, German Research Center for Environmental Health, Marchioninistr 25, Munich 81377, Germany
    Eur J Cancer 45:1664-72. 2009
  6. ncbi request reprint Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens
    Elke Bleifuss
    Clinical Cooperation Group Hyperthermia, Helmholtz Zentrum Munchen German Research Center for Environmental Health, 81377 Munich, Germany
    Int J Hyperthermia 24:623-37. 2008
  7. ncbi request reprint High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention
    Petra U Prinz
    German Research Center for Environmental Health, Institute of Molecular Immunology, 81377 Munich, Germany
    J Immunol 188:5990-6000. 2012
  8. pmc Calcium signaling in dendritic cells by human or mycobacterial Hsp70 is caused by contamination and is not required for Hsp70-mediated enhancement of cross-presentation
    Henriette Bendz
    Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 81377 Munchen, Germany
    J Biol Chem 283:26477-83. 2008
  9. pmc A novel CXCL10-based GPI-anchored fusion protein as adjuvant in NK-based tumor therapy
    Niklas Muenchmeier
    AG Klinische Biochemie, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Munich, Germany
    PLoS ONE 8:e72749. 2013
  10. doi request reprint Transcript signature predicts tissue NK cell content and defines renal cell carcinoma subgroups independent of TNM staging
    Judith Eckl
    Clinical Cooperation Group Immune Monitoring, Institute of Molecular Immunology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany
    J Mol Med (Berl) 90:55-66. 2012

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling
    Henriette Bendz
    Institute of Molecular Immunology, GSF National Research Center for Environment and Health Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 25, 81377 Munich, Germany
    J Biol Chem 282:31688-702. 2007
    ..As Hsp70 supports the cross-presentation of different antigens and APCs and is inert to APC function, it may show efficacy in various settings of immune modulation, including induction of antigen-specific immunity or tolerance...
  2. ncbi request reprint Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells
    Elfriede Noessner
    Clinical Cooperation Group Hyperthermie, Institute of Molecular Immunology, GSF National Research Center for Environment and Health, 81377 Munich, Germany
    J Immunol 169:5424-32. 2002
    ....
  3. ncbi request reprint Thermal stress-related modulation of tumor cell physiology and immune responses
    Elfriede Noessner
    GSF National Research Center for Environment and Health, Institute of Molecular Immunology, Marchioninistrasse 25, 81377, Munich, Germany
    Cancer Immunol Immunother 55:289-91. 2006
  4. ncbi request reprint Inhibitory effect of RNA pool complexity on stimulatory capacity of RNA-pulsed dendritic cells
    Miran Javorovic
    Institute of Molecular Immunology, Clinical Cooperation Group Immune Monitoring, GSF National Research Center for Environment and Health, Munich, Germany
    J Immunother 31:52-62. 2008
    ..We conclude that larger RNA pools result in diminished presentation of individual epitopes and suggest that smaller pools of RNA be transfected into separate DC populations which are then pooled to create multiplex vaccines...
  5. doi request reprint Prostate cancer lesions are surrounded by FOXP3+, PD-1+ and B7-H1+ lymphocyte clusters
    Kathleen Ebelt
    Institute of Molecular Immunology, Clinical Cooperation Group Immune Monitoring, Helmholtz Center Munich, German Research Center for Environmental Health, Marchioninistr 25, Munich 81377, Germany
    Eur J Cancer 45:1664-72. 2009
    ..Expression of molecules associated with inhibition and exhaustion of lymphocytes may reflect events contributing to ineffective immune responses against cancer cells...
  6. ncbi request reprint Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens
    Elke Bleifuss
    Clinical Cooperation Group Hyperthermia, Helmholtz Zentrum Munchen German Research Center for Environmental Health, 81377 Munich, Germany
    Int J Hyperthermia 24:623-37. 2008
    ..Yet, CRCL may be utilized as vehicles to enhance the delivery of exogenous antigens for DC-mediated cross-presentation and T cell stimulation...
  7. ncbi request reprint High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention
    Petra U Prinz
    German Research Center for Environmental Health, Institute of Molecular Immunology, 81377 Munich, Germany
    J Immunol 188:5990-6000. 2012
    ....
  8. pmc Calcium signaling in dendritic cells by human or mycobacterial Hsp70 is caused by contamination and is not required for Hsp70-mediated enhancement of cross-presentation
    Henriette Bendz
    Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 81377 Munchen, Germany
    J Biol Chem 283:26477-83. 2008
    ..These results refute the hypothesis that mycHsp70 proteins require CCR5 expression and calcium signaling by APCs for enhanced antigen cross-presentation for T cell stimulation...
  9. pmc A novel CXCL10-based GPI-anchored fusion protein as adjuvant in NK-based tumor therapy
    Niklas Muenchmeier
    AG Klinische Biochemie, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Munich, Germany
    PLoS ONE 8:e72749. 2013
    ..The mucin domain in conjunction with the chemokine head acts to specifically recruit leukocytes expressing the corresponding chemokine receptor...
  10. doi request reprint Transcript signature predicts tissue NK cell content and defines renal cell carcinoma subgroups independent of TNM staging
    Judith Eckl
    Clinical Cooperation Group Immune Monitoring, Institute of Molecular Immunology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany
    J Mol Med (Berl) 90:55-66. 2012
    ..This now allows the analysis of large patient cohorts to substantiate a role of NK cells in cancer progression or response to immunotherapy...
  11. pmc Human renal cell carcinoma induces a dendritic cell subset that uses T-cell crosstalk for tumor-permissive milieu alterations
    Ainhoa M Figel
    Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany
    Am J Pathol 179:436-51. 2011
    ..Pharmacologic targeting of the deviated DC differentiation could improve the efficacy of immunotherapy against RCC...
  12. doi request reprint Hsp70, a messenger from hyperthermia for the immune system
    Anna Jolesch
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Molecular Immunology, Marchioninistrasse 25, Munich, Germany
    Eur J Cell Biol 91:48-52. 2012
    ..Further, we discuss that clinical hyperthermia could be a way to initiate the immunologic activity of Hsp70 by upregulating its expression and facilitating release through local necrosis...
  13. doi request reprint TIMP-1-GPI in combination with hyperthermic treatment of melanoma increases sensitivity to FAS-mediated apoptosis
    Roghieh Djafarzadeh
    Medizinische Poliklinik, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Cancer Immunol Immunother 58:361-71. 2009
    ..The targeted delivery of TIMP-1-GPI to tumor environments in the context of regional hyperthermic therapy could be optimized through the use of thermosensitive liposomes...
  14. ncbi request reprint Cell-based vaccines for renal cell carcinoma: genetically-engineered tumor cells and monocyte-derived dendritic cells
    Bernhard Frankenberger
    Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Marchioninistrasse 25, 81377 Munich, Germany
    World J Urol 23:166-74. 2005
    ....
  15. doi request reprint Treatment of dermal fibroblasts with GPI-anchored human TIMP-1 protein moderates processes linked to scar formation
    Roghieh Djafarzadeh
    Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Ludwig Maximilians Universität München, Munich, Germany
    J Invest Dermatol 133:803-11. 2013
    ..GPI-anchored TIMP-1 may represent a more effective version of the protein for use in therapeutic approaches to help control fibrosis and scar formation...
  16. pmc Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells
    Roghieh Djafarzadeh
    Arbeitsgruppe Klinische Biochemie, Medizinische Klinik und Poliklinik IV, Universitat Munchen, Munich, Germany
    PLoS ONE 7:e33963. 2012
    ..Matrix metalloproteinase (MMP) biology underlies aspects of mesothelial homeostasis as well as wound repair. The endogenous tissue inhibitors of metalloproteinases (TIMPs) moderate MMP activity...
  17. doi request reprint Modified vaccinia virus Ankara delivers a robust surrogate marker for immune monitoring to sarcoma cells even if cells are being exposed to chemotherapy and heat treatment
    Katharina Tschoep-Lechner
    Department of Internal Medicine III, Klinikum Grosshadern Medical Centre, Ludwig Maximilians University, Marchioninistrasse 25, Munich, Germany
    Int J Hyperthermia 28:33-42. 2012
    ..We examined its robustness against standard sarcoma treatment modalities, such as ifosfamide and hyperthermia...
  18. ncbi request reprint Melanoma-associated antigen tyrosinase but not Melan-A/MART-1 expression and presentation dissociate during the heat shock response
    Valeria Milani
    Clinical Cooperation Group of Hyperthermia, Internal Medicine Department III, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Int Immunol 17:257-68. 2005
    ..Moreover, these results document the maintenance of immunological homeostasis during recovery from heat treatment, thus challenging the view that tumor cells subjected to heat shock become resistant to CTL recognition...
  19. ncbi request reprint Immune suppression in renal cell carcinoma
    Bernhard Frankenberger
    Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Marchioninistrasse 25, 81377 Munich, Germany
    Semin Cancer Biol 17:330-43. 2007
    ..Understanding these complex host-tumor interactions has broad implications for successful application of cytokine therapy and other forms of immunotherapy for RCC...
  20. ncbi request reprint NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention
    Petra U Prinz
    Helmholtz Zentrum Munchen, Germany Research Center for Environmental Health, Institute of Molecular Immunology, Munich, Germany
    Int J Cancer 135:1832-41. 2014
    ..DGK and the ERK pathway thus emerge as promising therapeutic targets to restore suppressed NK-cell activity for the improvement of antitumor immunity. ..
  21. ncbi request reprint Dominance of CD4+ lymphocytic infiltrates with disturbed effector cell characteristics in the tumor microenvironment of prostate carcinoma
    Kathleen Ebelt
    Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Munich, Germany
    Prostate 68:1-10. 2008
    ..The goal of this investigation was to assess in situ characteristics of prostate cancer-infiltrating lymphocytes and to determine their activation status and effector function...
  22. ncbi request reprint Retaliation against tumor cells showing aberrant HLA expression using lymphokine activated killer-derived T cells
    Christine S Falk
    Institute of Molecular Immunology, GSF National Research Center for the Environment and Health, 81377 Munich, Germany
    Cancer Res 62:480-7. 2002
    ..Apparently, LAK-derived T cells are negatively regulated by as yet undefined inhibitory receptors...
  23. ncbi request reprint Alterations of costimulatory molecules and instructive cytokines expressed by dendritic cells in the microenvironment of an endogenous mouse lymphoma
    Marcella Naujoks
    Institut für Molekulare Immunologie, Helmholtz Zentrum Munchen, Marchioninistr 25, 81377, Munich, Germany
    Cancer Immunol Immunother 63:491-9. 2014
    ..These data are relevant for establishing novel immunotherapeutic approaches against B cell lymphoma. ..
  24. ncbi request reprint Influence of CD80, interleukin-2, and interleukin-7 expression in human renal cell carcinoma on the expansion, function, and survival of tumor-specific CTLs
    Bernhard Frankenberger
    Institute of Molecular Immunology, Forschungszentrum für Umwelt und Gesundheit National Research Center for Environment and Health, Marchioninistrasse 25, 81377 Munich, Germany
    Clin Cancer Res 11:1733-42. 2005
    ..The effect of these modifications on proliferation, function, and survival of autologous and allogeneic tumor-specific CTLs was assessed...
  25. ncbi request reprint Effects of thermal stress on tumor antigenicity and recognition by immune effector cells
    Valeria Milani
    Clinical Cooperation Group on Hyperthermia, Internal Medicine Department III, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany
    Cancer Immunol Immunother 55:312-9. 2006
    ..Consideration of these aspects might help to explain some of the conflicting results that are reported in the field of thermal stress response...
  26. doi request reprint Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation
    Anna N Mendler
    Helmholtz Zentrum München Germany Research Center for Environmental Health, Institute of Molecular Immunology, Munich, Germany
    Int J Cancer 131:633-40. 2012
    ....
  27. doi request reprint Dendritic cells in human renal inflammation--Part II
    Elfriede Noessner
    Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany
    Nephron Exp Nephrol 119:e91-8. 2011
    ..However, these studies are clearly required to define the role of DCs and DC subsets in the pathophysiology of renal disease...
  28. ncbi request reprint Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma
    Julia S Schleypen
    Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Munich, Germany
    Clin Cancer Res 12:718-25. 2006
    ..Renal cell carcinoma harbors high numbers of infiltrating lymphocytes with apparent limited efficacy in tumor control. This study focused on the natural killer (NK) cells infiltrating renal cell carcinoma...
  29. ncbi request reprint JNK MAPK pathway regulates constitutive transcription of CCL5 by human NK cells through SP1
    Dilip Kumar
    Medizinische Poliklinik, Ludwig Maximilians University of Munich, Munich, Germany
    J Immunol 182:1011-20. 2009
    ..Specificity protein 1 expression, and in turn the constitutive expression of CCL5, was found to be controlled through constitutive activation of the JNK/MAPK pathway in peripheral blood NK cells...
  30. ncbi request reprint Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes
    Boris Engels
    Institute of Biology, Humboldt University Berlin, 10115 Berlin, Germany
    Hum Gene Ther 16:799-810. 2005
    ..The results demonstrate that use of an optimized retroviral vector yielded a high TCR transduction efficiency and stable and high TCR expression in primary human T lymphocytes and redirected their specificity toward RCC cells...
  31. ncbi request reprint Adoptive transfer of cytotoxic T-cells for treatment of residual disease after irradiation
    Mechthild Krause
    Department of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Germany
    Int J Radiat Biol 83:827-36. 2007
    ..To evaluate whether immunotherapy based on adoptively transferred cytotoxic T-cells (CTL) can improve the antitumour efficacy of irradiation...
  32. ncbi request reprint Designer T cells by T cell receptor replacement
    Daniel Sommermeyer
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Eur J Immunol 36:3052-9. 2006
    ....