Research Topics
| Wolfgang G KreylingSummaryAffiliation: GSF-National Research Center for Environment and Health Country: Germany Publications
| Collaborators
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Detail Information
Publications
Expert elicitation on ultrafine particles: likelihood of health effects and causal pathwaysAnne B Knol
Dutch National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
Part Fibre Toxicol 6:19. 2009..abstract:..
Dosimetry and toxicology of ultrafine particlesWolfgang G Kreyling
Institute of Inhalation Biology, GSF National Research Center for Environment and Health, Munich, Germany
J Aerosol Med 17:140-52. 2004..Yet, based on a conservative estimate results available begin to show an adverse health risk for susceptible individuals and support the epidemiological evidence...- Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very lowW G Kreyling
GSF National Research Center for Environment and Health, Institute for Inhalation Biology, Neuherberg Munich, Germany
J Toxicol Environ Health A 65:1513-30. 2002.... - Ultrafine particle-lung interactions: does size matter?Wolfgang G Kreyling
Institute of Inhalation Biology, GSF Focus Aerosols and Health, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
J Aerosol Med 19:74-83. 2006..This paper reviews the current concept of interactions between insoluble ultrafine particles and biological systems... - Anatomic localization of 24- and 96-h particle retention in canine airwaysW G Kreyling
Institutes for, GSF National Research Center for Environment and Health, D 85758 Neuherberg Munich
J Appl Physiol 87:269-84. 1999..After 96 h, a similar pattern was found. These findings suggest that long-term retention in airways is at the bronchiolar level... - Health effects of sulfur-related environmental air pollution. III. Nonspecific respiratory defense capacitiesW G Kreyling
GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
Inhal Toxicol 11:391-422. 1999..The observed alterations in alveolar macrophage-mediated clearance mechanisms during chronic exposure of these air pollutants indicate an increased risk of health... 
Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organsWolfgang G Kreyling
Helmholtz Center Munich, Neuherberg Munich, Germany
Inhal Toxicol 21:55-60. 2009..These studies show that both NP characteristics--the material and the size of the chain-type aggregates--determine translocation and accumulation in STOs, skeleton, and soft tissue...- Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administrationStephanie Hirn
Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Munich, Germany
Eur J Pharm Biopharm 77:407-16. 2011..A better understanding of these mechanisms will improve drug delivery and dose estimates used in risk assessment... - Postnatal lung function in the developing ratInes Bolle
Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute for Inhalation Biology, Neuherberg Munich, Germany
J Appl Physiol 104:1167-76. 2008..The pivotal step for improvement of gas exchange occurs with the transition from bulk alveolarization to the phase of expansion of air spaces with septal reconstruction and microvascular maturation... - Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs)Swapna Upadhyay
Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
Part Fibre Toxicol 7:27. 2010.... - Binding of polystyrene and carbon black nanoparticles to blood serum proteinsStefanie Fertsch-Gapp
Comprehensive Pneumology Center, Institute of Lung Biology and Disease and Focus Network Nanoparticles and Health, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg Munich, Germany
Inhal Toxicol 23:468-75. 2011..Once inhaled, nanoparticles (NP) deposit on the lung surface and have first contact with the epithelial lung lining fluid (ELF) rich in proteins, which may bind to NP... - Long-term responses of canine lungs to acidic particlesJ Heyder
Institute for Inhalation Biology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg Munich, Germany
Inhal Toxicol 21:920-32. 2009..The acidic exposure had thus no pathophysiological consequences. It is therefore unlikely that long-term inhalation of acidic particles is associated with a health risk... - Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epitheliumManuela Semmler-Behnke
GSF National Research Center for Environment and Health, Institute of Inhalation Biology, Neuherberg Munich, Germany
Environ Health Perspect 115:728-33. 2007..There is ongoing discussion that inhaled nanoparticles (NPs, < 100 nm) may translocate from epithelial deposition sites of the lungs to systemic circulation... - The influence of pulmonary surfactant on nanoparticulate drug delivery systemsCarsten Schleh
Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Neuherberg Munich, Germany
Eur J Pharm Biopharm 77:350-2. 2011..In the present comment, we discuss the potential interactions of nanoparticulate drug delivery systems with pulmonary surfactant as well as the potential consequences of this interaction... - Effects of particulate air pollution on blood pressure and heart rate in subjects with cardiovascular disease: a multicenter approachAngela Ibald-Mulli
Institute of Epidemiology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
Environ Health Perspect 112:369-77. 2004..However, particle effects might differ in cardiac patients because of medication intake and disease status, both affecting the autonomic control of the heart... - Deposition, retention, and translocation of ultrafine particles from the central airways and lung peripheryWinfried Möller
GSF National Research Center for Environment and Health Institute for Inhalation Biology, Robert Koch Allee 29, D 82131 Gauting, Germany
Am J Respir Crit Care Med 177:426-32. 2008..Little is known about clearance of ultrafine carbon particles from the different regions of the human lung. These particles may accumulate and present a health hazard because of their high surface area... - Distribution pattern of inhaled ultrafine gold particles in the rat lungS Takenaka
GSF Institute for Inhalation Biology, Neuherberg Munich, Germany
Inhal Toxicol 18:733-40. 2006..To a low degree, systemic particle translocation took place... - Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organsM Semmler
GSF National Research Center, Institute for Inhalation Biology, Neuherberg Munich, Germany
Inhal Toxicol 16:453-9. 2004..1983) and Bailey et al. (1985)... - Health effects of sulfur-related environmental air pollution. II. Cellular and molecular parameters of injuryK L Maier
GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
Inhal Toxicol 11:361-89. 1999..The results emphasize the complexity of health effects on lung functions in response to the complex mixture of air pollutants and disclose the precariousness in the risk assessment of air pollutants for humans... - Health effects of sulfur-related environmental air pollution. I. Executive summaryJ Heyder
GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
Inhal Toxicol 11:343-59. 1999..It is thus also very unlikely that respiratory diseases can be initiated by the inhalation of these pollutants... - Health effects of sulfur-related environmental air pollution. V. Lung structureS Takenaka
GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
Inhal Toxicol 11:439-54. 1999..These findings suggest that sulfur aerosols have the potential to induce epithelial alterations in the proximal alveolar region, which is a primary target for air pollutants... - Increased asthma medication use in association with ambient fine and ultrafine particlesS von Klot
GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
Eur Respir J 20:691-702. 2002..The results suggest that reported asthma medication use and symptoms increase in association with particulate air pollution and gaseous pollutants such as nitrogen dioxide... - Fate and toxic effects of inhaled ultrafine cadmium oxide particles in the rat lungS Takenaka
GSF National Center for Environment and Health, Institute for Inhalation Biology, Neuherberg Munich, Germany
Inhal Toxicol 16:83-92. 2004..With regard to the deposition dose, adverse health effects of ultrafine CdO and fine CdO appear to be comparable. Apparent systemic translocation of Cd took place only in animals exposed to a high concentration that induced lung injury... - Elemental composition and sources of fine and ultrafine ambient particles in Erfurt, GermanyJ Cyrys
GSF, National Research Center for Environment and Health, Institute of Epidemiology, Geb 56, O 85764, Neuherberg, Germany
Sci Total Environ 305:143-56. 2003..Sulfur could be a tracer for coal combustion, however, it was not correlated with any of the quoted elements. Highly correlated elements V and Ni have similar enrichment factors and are considered as tracers for oil combustion... - Source apportionment of ambient fine particle size distribution using positive matrix factorization in Erfurt, GermanyWei Yue
Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
Sci Total Environ 398:133-44. 2008.... - Dose-controlled exposure of A549 epithelial cells at the air-liquid interface to airborne ultrafine carbonaceous particlesE Bitterle
GSF National Research Center for Environment and Health, Institute for Inhalation Biology, Ingolstaedter Landstr. 1, D-85764 Neuherberg/Munich, Germany
Chemosphere 65:1784-90. 2006..The 2.7-fold (p < or = 0.05) increased transcription of heme oxygenase-1 indicated a sensitive antioxidant and stress response, while cell viability did not reveal a toxic mechanism... - Pulmonary surfactant is indispensable in order to simulate the in vivo situationCarsten Schleh
Institute of Epidemiology II, Helmholtz Center Munich German Research Center for Environmental Health, D 85764, Neuherberg Munich, Germany
Part Fibre Toxicol 10:6. 2013..In the present commentary we discuss the most important points of the manuscript of Gasser et al. and discuss where the usage of pulmonary surfactant can be further optimized... - Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease: the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) studyJuha Pekkanen
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland
Circulation 106:933-8. 2002..We therefore assessed the associations between levels of the 3 main modes of urban aerosol distribution and the occurrence of ST-segment depressions during repeated exercise tests... - Relationship between different size classes of particulate matter and meteorology in three European citiesJeroen J de Hartog
Utrecht University, Institute for Risk Assessment Sciences, Environmental and Occupational Health Division, Jenalaan 18a, 3584 CK Utrecht, The Netherlands
J Environ Monit 7:302-10. 2005..Since the composition of these particle fractions also differs, it is of interest to test in future epidemiological studies whether they have different health effects... - No significant translocation of inhaled 35-nm carbon particles to the circulation in humansPernilla Wiebert
Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden
Inhal Toxicol 18:741-7. 2006..On gamma camera images the activity visibly translocated from lungs to thyroid and gastrointestinal tract. In conclusion, over a 24-h period there was no significant translocation of inhaled 35-nm particles to the systemic circulation... - Health effects of particles in ambient airAndreas D Kappos
Behörde für Umwelt und Gesundheit, Hamburg
Int J Hyg Environ Health 207:399-407. 2004..Because of the strong correlation of PM10 with PM2.5 at most German sites there is no specific need for limit values of PM2.5 for Germany in addition to those of PM10...