Wolfgang G Kreyling

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. pmc Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways
    Anne B Knol
    Dutch National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Part Fibre Toxicol 6:19. 2009
  2. ncbi request reprint Dosimetry and toxicology of ultrafine particles
    Wolfgang G Kreyling
    Institute of Inhalation Biology, GSF National Research Center for Environment and Health, Munich, Germany
    J Aerosol Med 17:140-52. 2004
  3. ncbi request reprint Health effects of sulfur-related environmental air pollution. III. Nonspecific respiratory defense capacities
    W G Kreyling
    GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
    Inhal Toxicol 11:391-422. 1999
  4. ncbi request reprint Ultrafine particle-lung interactions: does size matter?
    Wolfgang G Kreyling
    Institute of Inhalation Biology, GSF Focus Aerosols and Health, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
    J Aerosol Med 19:74-83. 2006
  5. ncbi request reprint Anatomic localization of 24- and 96-h particle retention in canine airways
    W G Kreyling
    Institutes for, GSF National Research Center for Environment and Health, D 85758 Neuherberg Munich
    J Appl Physiol (1985) 87:269-84. 1999
  6. ncbi request reprint Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low
    W G Kreyling
    GSF National Research Center for Environment and Health, Institute for Inhalation Biology, Neuherberg Munich, Germany
    J Toxicol Environ Health A 65:1513-30. 2002
  7. ncbi request reprint Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
    Wolfgang G Kreyling
    Helmholtz Center Munich, Neuherberg Munich, Germany
    Inhal Toxicol 21:55-60. 2009
  8. pmc Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration
    Stephanie Hirn
    Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Munich, Germany
    Eur J Pharm Biopharm 77:407-16. 2011
  9. doi request reprint Binding of polystyrene and carbon black nanoparticles to blood serum proteins
    Stefanie Fertsch-Gapp
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease and Focus Network Nanoparticles and Health, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg Munich, Germany
    Inhal Toxicol 23:468-75. 2011
  10. pmc Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs)
    Swapna Upadhyay
    Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
    Part Fibre Toxicol 7:27. 2010

Collaborators

Detail Information

Publications32

  1. pmc Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways
    Anne B Knol
    Dutch National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Part Fibre Toxicol 6:19. 2009
    ..abstract:..
  2. ncbi request reprint Dosimetry and toxicology of ultrafine particles
    Wolfgang G Kreyling
    Institute of Inhalation Biology, GSF National Research Center for Environment and Health, Munich, Germany
    J Aerosol Med 17:140-52. 2004
    ..Yet, based on a conservative estimate results available begin to show an adverse health risk for susceptible individuals and support the epidemiological evidence...
  3. ncbi request reprint Health effects of sulfur-related environmental air pollution. III. Nonspecific respiratory defense capacities
    W G Kreyling
    GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
    Inhal Toxicol 11:391-422. 1999
    ..The observed alterations in alveolar macrophage-mediated clearance mechanisms during chronic exposure of these air pollutants indicate an increased risk of health...
  4. ncbi request reprint Ultrafine particle-lung interactions: does size matter?
    Wolfgang G Kreyling
    Institute of Inhalation Biology, GSF Focus Aerosols and Health, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
    J Aerosol Med 19:74-83. 2006
    ..This paper reviews the current concept of interactions between insoluble ultrafine particles and biological systems...
  5. ncbi request reprint Anatomic localization of 24- and 96-h particle retention in canine airways
    W G Kreyling
    Institutes for, GSF National Research Center for Environment and Health, D 85758 Neuherberg Munich
    J Appl Physiol (1985) 87:269-84. 1999
    ..After 96 h, a similar pattern was found. These findings suggest that long-term retention in airways is at the bronchiolar level...
  6. ncbi request reprint Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low
    W G Kreyling
    GSF National Research Center for Environment and Health, Institute for Inhalation Biology, Neuherberg Munich, Germany
    J Toxicol Environ Health A 65:1513-30. 2002
    ....
  7. ncbi request reprint Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
    Wolfgang G Kreyling
    Helmholtz Center Munich, Neuherberg Munich, Germany
    Inhal Toxicol 21:55-60. 2009
    ..These studies show that both NP characteristics--the material and the size of the chain-type aggregates--determine translocation and accumulation in STOs, skeleton, and soft tissue...
  8. pmc Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration
    Stephanie Hirn
    Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Munich, Germany
    Eur J Pharm Biopharm 77:407-16. 2011
    ..A better understanding of these mechanisms will improve drug delivery and dose estimates used in risk assessment...
  9. doi request reprint Binding of polystyrene and carbon black nanoparticles to blood serum proteins
    Stefanie Fertsch-Gapp
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease and Focus Network Nanoparticles and Health, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg Munich, Germany
    Inhal Toxicol 23:468-75. 2011
    ..Once inhaled, nanoparticles (NP) deposit on the lung surface and have first contact with the epithelial lung lining fluid (ELF) rich in proteins, which may bind to NP...
  10. pmc Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs)
    Swapna Upadhyay
    Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
    Part Fibre Toxicol 7:27. 2010
    ....
  11. doi request reprint Postnatal lung function in the developing rat
    Ines Bolle
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute for Inhalation Biology, Neuherberg Munich, Germany
    J Appl Physiol (1985) 104:1167-76. 2008
    ..The pivotal step for improvement of gas exchange occurs with the transition from bulk alveolarization to the phase of expansion of air spaces with septal reconstruction and microvascular maturation...
  12. doi request reprint Long-term responses of canine lungs to acidic particles
    J Heyder
    Institute for Inhalation Biology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg Munich, Germany
    Inhal Toxicol 21:920-32. 2009
    ..The acidic exposure had thus no pathophysiological consequences. It is therefore unlikely that long-term inhalation of acidic particles is associated with a health risk...
  13. pmc Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium
    Manuela Semmler-Behnke
    GSF National Research Center for Environment and Health, Institute of Inhalation Biology, Neuherberg Munich, Germany
    Environ Health Perspect 115:728-33. 2007
    ..There is ongoing discussion that inhaled nanoparticles (NPs, < 100 nm) may translocate from epithelial deposition sites of the lungs to systemic circulation...
  14. doi request reprint The influence of pulmonary surfactant on nanoparticulate drug delivery systems
    Carsten Schleh
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Neuherberg Munich, Germany
    Eur J Pharm Biopharm 77:350-2. 2011
    ..In the present comment, we discuss the potential interactions of nanoparticulate drug delivery systems with pulmonary surfactant as well as the potential consequences of this interaction...
  15. ncbi request reprint Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery
    Winfried Möller
    GSF National Research Center for Environment and Health Institute for Inhalation Biology, Robert Koch Allee 29, D 82131 Gauting, Germany
    Am J Respir Crit Care Med 177:426-32. 2008
    ..Little is known about clearance of ultrafine carbon particles from the different regions of the human lung. These particles may accumulate and present a health hazard because of their high surface area...
  16. pmc Effects of particulate air pollution on blood pressure and heart rate in subjects with cardiovascular disease: a multicenter approach
    Angela Ibald-Mulli
    Institute of Epidemiology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Environ Health Perspect 112:369-77. 2004
    ..However, particle effects might differ in cardiac patients because of medication intake and disease status, both affecting the autonomic control of the heart...
  17. ncbi request reprint Health effects of sulfur-related environmental air pollution. II. Cellular and molecular parameters of injury
    K L Maier
    GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
    Inhal Toxicol 11:361-89. 1999
    ..The results emphasize the complexity of health effects on lung functions in response to the complex mixture of air pollutants and disclose the precariousness in the risk assessment of air pollutants for humans...
  18. ncbi request reprint Increased asthma medication use in association with ambient fine and ultrafine particles
    S von Klot
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Respir J 20:691-702. 2002
    ..The results suggest that reported asthma medication use and symptoms increase in association with particulate air pollution and gaseous pollutants such as nitrogen dioxide...
  19. ncbi request reprint Distribution pattern of inhaled ultrafine gold particles in the rat lung
    S Takenaka
    GSF Institute for Inhalation Biology, Neuherberg Munich, Germany
    Inhal Toxicol 18:733-40. 2006
    ..To a low degree, systemic particle translocation took place...
  20. ncbi request reprint Health effects of sulfur-related environmental air pollution. V. Lung structure
    S Takenaka
    GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
    Inhal Toxicol 11:439-54. 1999
    ..These findings suggest that sulfur aerosols have the potential to induce epithelial alterations in the proximal alveolar region, which is a primary target for air pollutants...
  21. ncbi request reprint Fate and toxic effects of inhaled ultrafine cadmium oxide particles in the rat lung
    S Takenaka
    GSF National Center for Environment and Health, Institute for Inhalation Biology, Neuherberg Munich, Germany
    Inhal Toxicol 16:83-92. 2004
    ..With regard to the deposition dose, adverse health effects of ultrafine CdO and fine CdO appear to be comparable. Apparent systemic translocation of Cd took place only in animals exposed to a high concentration that induced lung injury...
  22. ncbi request reprint Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs
    M Semmler
    GSF National Research Center, Institute for Inhalation Biology, Neuherberg Munich, Germany
    Inhal Toxicol 16:453-9. 2004
    ..1983) and Bailey et al. (1985)...
  23. ncbi request reprint Elemental composition and sources of fine and ultrafine ambient particles in Erfurt, Germany
    J Cyrys
    GSF, National Research Center for Environment and Health, Institute of Epidemiology, Geb 56, O 85764, Neuherberg, Germany
    Sci Total Environ 305:143-56. 2003
    ..Sulfur could be a tracer for coal combustion, however, it was not correlated with any of the quoted elements. Highly correlated elements V and Ni have similar enrichment factors and are considered as tracers for oil combustion...
  24. ncbi request reprint Health effects of sulfur-related environmental air pollution. I. Executive summary
    J Heyder
    GSF Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg, Germany
    Inhal Toxicol 11:343-59. 1999
    ..It is thus also very unlikely that respiratory diseases can be initiated by the inhalation of these pollutants...
  25. doi request reprint Blood protein coating of gold nanoparticles as potential tool for organ targeting
    Martin Schäffler
    Institute of Lung Biology and Disease, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Munich, Germany
    Biomaterials 35:3455-66. 2014
    ....
  26. pmc Source apportionment of ambient fine particle size distribution using positive matrix factorization in Erfurt, Germany
    Wei Yue
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Sci Total Environ 398:133-44. 2008
    ....
  27. ncbi request reprint Dose-controlled exposure of A549 epithelial cells at the air-liquid interface to airborne ultrafine carbonaceous particles
    E Bitterle
    GSF National Research Center for Environment and Health, Institute for Inhalation Biology, Ingolstaedter Landstr 1, D 85764 Neuherberg Munich, Germany
    Chemosphere 65:1784-90. 2006
    ..The 2.7-fold (p < or = 0.05) increased transcription of heme oxygenase-1 indicated a sensitive antioxidant and stress response, while cell viability did not reveal a toxic mechanism...
  28. pmc Pulmonary surfactant is indispensable in order to simulate the in vivo situation
    Carsten Schleh
    Department of in vivo Pharmacology Toxicology, BSL Bioservice Scientific Laboratories GmbH, Behringstr, 6 8, Planegg Munich 82152, Germany
    Part Fibre Toxicol 10:6. 2013
    ..In the present commentary we discuss the most important points of the manuscript of Gasser et al. and discuss where the usage of pulmonary surfactant can be further optimized...
  29. ncbi request reprint No significant translocation of inhaled 35-nm carbon particles to the circulation in humans
    Pernilla Wiebert
    Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden
    Inhal Toxicol 18:741-7. 2006
    ..On gamma camera images the activity visibly translocated from lungs to thyroid and gastrointestinal tract. In conclusion, over a 24-h period there was no significant translocation of inhaled 35-nm particles to the systemic circulation...
  30. ncbi request reprint Relationship between different size classes of particulate matter and meteorology in three European cities
    Jeroen J de Hartog
    Utrecht University, Institute for Risk Assessment Sciences, Environmental and Occupational Health Division, Jenalaan 18a, 3584 CK Utrecht, The Netherlands
    J Environ Monit 7:302-10. 2005
    ..Since the composition of these particle fractions also differs, it is of interest to test in future epidemiological studies whether they have different health effects...
  31. ncbi request reprint Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease: the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study
    Juha Pekkanen
    Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland
    Circulation 106:933-8. 2002
    ..We therefore assessed the associations between levels of the 3 main modes of urban aerosol distribution and the occurrence of ST-segment depressions during repeated exercise tests...
  32. ncbi request reprint Health effects of particles in ambient air
    Andreas D Kappos
    Behörde für Umwelt und Gesundheit, Hamburg
    Int J Hyg Environ Health 207:399-407. 2004
    ..A summary of a critical review by a working group of the German commission on Air Pollution Prevention of VDI and DIN of the actual data on exposure and health effects (excluding cancer) of fine particulate air pollution is presented...