P Jacob

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. doi request reprint Ultrasonography survey and thyroid cancer in the Fukushima Prefecture
    Peter Jacob
    Department of Radiation Sciences, Institute of Radiation Protection, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
    Radiat Environ Biophys 53:391-401. 2014
  2. ncbi request reprint Lung cancer risk of Mayak workers: modelling of carcinogenesis and bystander effect
    P Jacob
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Neuherberg, Germany
    Radiat Environ Biophys 46:383-94. 2007
  3. ncbi request reprint Thyroid cancer among Ukrainians and Belarusians who were children or adolescents at the time of the Chernobyl accident
    P Jacob
    GSF Institute of Radiation Protection, Neuherberg, Germany
    J Radiol Prot 26:51-67. 2006
  4. ncbi request reprint On an evaluation of external dose values in the Techa River Dosimetry System (TRDS) 2000
    P Jacob
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Environ Biophys 42:169-74. 2003
  5. ncbi request reprint Remediation strategies for rural territories contaminated by the Chernobyl accident
    P Jacob
    GSF Institute of Radiation Protection, D 85764 Neuherberg, Germany
    J Environ Radioact 56:51-76. 2001
  6. ncbi request reprint Biological parameters for lung cancer in mathematical models of carcinogenesis
    P Jacob
    GSF Research Center for Environment and Health, Institute of Radiation Protection, D 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 104:357-66. 2003
  7. ncbi request reprint Thyroid cancer risk in Belarus after the Chernobyl accident: comparison with external exposures
    P Jacob
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Neuherberg, Germany
    Radiat Environ Biophys 39:25-31. 2000
  8. ncbi request reprint Thyroid cancer risk in areas of Ukraine and Belarus affected by the Chernobyl accident
    P Jacob
    GSF Institute of Radiation Protection, Neuherberg, Germany
    Radiat Res 165:1-8. 2006
  9. ncbi request reprint Verification of external exposure assessment for the upper Techa riverside by luminescence measurements and Monte Carlo photon transport modeling
    V Taranenko
    Institute of Radiation Protection, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Radiat Environ Biophys 42:17-26. 2003
  10. pmc Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia
    P Jacob
    GSF Institute of Radiation Protection, Neuherberg, Germany
    Br J Cancer 80:1461-9. 1999

Detail Information

Publications53

  1. doi request reprint Ultrasonography survey and thyroid cancer in the Fukushima Prefecture
    Peter Jacob
    Department of Radiation Sciences, Institute of Radiation Protection, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
    Radiat Environ Biophys 53:391-401. 2014
    ..1-0.3 %, depending on average dose. ..
  2. ncbi request reprint Lung cancer risk of Mayak workers: modelling of carcinogenesis and bystander effect
    P Jacob
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Neuherberg, Germany
    Radiat Environ Biophys 46:383-94. 2007
    ..This reflects a model uncertainty in the results, which is not expressed by the standard statistical uncertainty bands...
  3. ncbi request reprint Thyroid cancer among Ukrainians and Belarusians who were children or adolescents at the time of the Chernobyl accident
    P Jacob
    GSF Institute of Radiation Protection, Neuherberg, Germany
    J Radiol Prot 26:51-67. 2006
    ..In conclusion, the baseline cases are found to contribute about 70% to the thyroid cancer incidence in Ukraine, and about 40% to the incidence in Belarus...
  4. ncbi request reprint On an evaluation of external dose values in the Techa River Dosimetry System (TRDS) 2000
    P Jacob
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Environ Biophys 42:169-74. 2003
    ..This study confirms the corresponding value of 26.6 Gy that is used in the Techa River Dosimetry System (TRDS) 2000...
  5. ncbi request reprint Remediation strategies for rural territories contaminated by the Chernobyl accident
    P Jacob
    GSF Institute of Radiation Protection, D 85764 Neuherberg, Germany
    J Environ Radioact 56:51-76. 2001
    ....
  6. ncbi request reprint Biological parameters for lung cancer in mathematical models of carcinogenesis
    P Jacob
    GSF Research Center for Environment and Health, Institute of Radiation Protection, D 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 104:357-66. 2003
    ..Based on representative results for these three parameters, implications for the biological parameters in the TSCE model are derived...
  7. ncbi request reprint Thyroid cancer risk in Belarus after the Chernobyl accident: comparison with external exposures
    P Jacob
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Neuherberg, Germany
    Radiat Environ Biophys 39:25-31. 2000
    ..According to our calculations, 80% of these cases exceed the baseline risk under enhanced thyroid surveillance...
  8. ncbi request reprint Thyroid cancer risk in areas of Ukraine and Belarus affected by the Chernobyl accident
    P Jacob
    GSF Institute of Radiation Protection, Neuherberg, Germany
    Radiat Res 165:1-8. 2006
    ..At the end of the observation period, excess risk estimates were found to be close to those observed in a major pooled analysis of seven studies of childhood thyroid cancer after external exposures...
  9. ncbi request reprint Verification of external exposure assessment for the upper Techa riverside by luminescence measurements and Monte Carlo photon transport modeling
    V Taranenko
    Institute of Radiation Protection, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Radiat Environ Biophys 42:17-26. 2003
    ..Assessed doses in bricks were found to be consistent with measured values within the uncertainty bounds, while their best estimates were approximately 15% lower than the luminescence measurements...
  10. pmc Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia
    P Jacob
    GSF Institute of Radiation Protection, Neuherberg, Germany
    Br J Cancer 80:1461-9. 1999
    ..05 Gy the risk was statistically significantly elevated. Dependencies of risks on age-at-exposure and on gender are consistent with findings after external exposures...
  11. doi request reprint Evaluation of external exposures of the population of Ozyorsk, Russia, with luminescence measurements of bricks
    Clemens Woda
    Institute of Radiation Protection, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764, Neuherberg, Germany
    Radiat Environ Biophys 48:405-17. 2009
    ..In addition, the study demonstrates the detection limit for anthropogenic doses in ca. 60-year-old bricks to be about 24 mGy, if luminescence methods are used...
  12. doi request reprint Rural areas affected by the Chernobyl accident: radiation exposure and remediation strategies
    P Jacob
    Helmholtz Zentrum Munchen, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Sci Total Environ 408:14-25. 2009
    ....
  13. ncbi request reprint In situ gamma-spectrometry several years after deposition of radiocesium. II. Peak-to-valley method
    F Gering
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Neuherberg, Germany
    Radiat Environ Biophys 37:283-91. 1998
    ..The new method has been applied to several post-Chernobyl measurements and the results agreed well with those of soil sampling...
  14. doi request reprint Screening effects in risk studies of thyroid cancer after the Chernobyl accident
    Jan Christian Kaiser
    Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Environ Biophys 48:169-79. 2009
    ..The results show that under these conditions ecological studies may provide risk estimates with an acceptable bias...
  15. doi request reprint Analysis of solid cancer mortality in the techa river cohort using the two-step clonal expansion model
    M Eidemüller
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Res 169:138-48. 2008
    ..Results from the TSCE models indicated that radiation received at older ages might have stronger biological effects than exposure at younger ages...
  16. pmc Is cancer risk of radiation workers larger than expected?
    P Jacob
    Hemholtz Zentrum München, Institute of Radiation Protection, D 85764 Neuherberg, Germany
    Occup Environ Med 66:789-96. 2009
    ..51 to 1.90). The present analysis does not confirm that the cancer risk per dose for LDRMD exposures is lower than for the atomic bomb survivors. This result challenges the cancer risk values currently assumed for occupational exposures...
  17. ncbi request reprint Uncertainty analysis of the external gamma-dose rate due to the variability of the vertical distribution of 137Cs in the soil
    K Bunzl
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Environ Radioact 54:243-52. 2001
    ..It is preferable to calculate the mean dose rate as a mean from the n individual dose rates rather than from an averaged 137Cs depth profile of the n plots...
  18. ncbi request reprint Comparison of EPR occupational lifetime external dose assessments for Mayak nuclear workers and film badge dose data
    A Wieser
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, 85758 Neuherberg, Germany
    Radiat Environ Biophys 44:279-88. 2006
    ..The discrepancies observed in the dose estimates are attributed to a bias in film badge evaluation...
  19. ncbi request reprint Lung cancer in Mayak workers: interaction of smoking and plutonium exposure
    V Jacob
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Environ Biophys 44:119-29. 2005
    ..This model version agrees with conventional epidemiological risk models, because it also suggests a higher risk estimate than the preferred TSCE model. However, it fits the data less well than the preferred model...
  20. ncbi request reprint Age- and sex-specific relative thyroid radiation exposure to 131I in Ukraine after the Chernobyl accident
    W F Heidenreich
    GSF Institut für Strahlenschutz, Neuherberg, Germany
    Health Phys 80:242-50. 2001
    ..The dose of young children is a factor of about 6.5 higher than that of adults. Uncertainties are estimated throughout...
  21. doi request reprint ReSCA: decision support tool for remediation planning after the Chernobyl accident
    A Ulanovsky
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Radiation Protection, Ingolstadter Landstrasse 1, 85764, Neuherberg, Germany
    Radiat Environ Biophys 50:67-83. 2011
    ..The paper provides in-depth description of the program, its algorithm, and structure...
  22. doi request reprint Comparison of mortality and incidence solid cancer risk after radiation exposure in the Techa River Cohort
    M Eidemüller
    Helmholtz Zentrum Munchen, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Environ Biophys 49:477-90. 2010
    ..Direct comparison of the mortality and incidence cohorts showed that the excess relative risk estimates agreed very well in both cohorts, as did the excess absolute risk and the hazard after correction for the different background rates...
  23. ncbi request reprint Simulation of DNA fragment distributions after irradiation with photons
    W Friedland
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Neuherberg, Germany
    Radiat Environ Biophys 38:39-47. 1999
    ..The excess of DNA fragments detected experimentally in the 8-300 kbp region after x-ray irradiation is not seen in our simulation results...
  24. pmc Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors
    H Schöllnberger
    Helmholtz Zentrum Munchen, Department of Radiation Sciences, Institute of Radiation Protection, Neuherberg, Germany
    Radiat Environ Biophys 51:165-78. 2012
    ..2 Gy based on 90% confidence intervals. The MMI approach described here resolves a dilemma in practical radiation protection when one is forced to select between models with profoundly different dose-responses for risk estimates...
  25. doi request reprint Breast cancer risk in atomic bomb survivors from multi-model inference with incidence data 1958-1998
    J C Kaiser
    Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Institute of Radiation Protection, 85764, Neuherberg, Germany
    Radiat Environ Biophys 51:1-14. 2012
    ..It produces more reliable point estimates and improves the characterization of uncertainties. The method is recommended for risk assessment in practical radiation protection...
  26. doi request reprint Mechanistic simulation of radiation damage to DNA and its repair: on the track towards systems radiation biology modelling
    W Friedland
    German Research Center for Environmental Health, Institute of Radiation Protection, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 143:542-8. 2011
    ..Nevertheless, already the present model represents a promising step towards systems modelling of cellular response to radiation...
  27. ncbi request reprint Simulation of DNA damage after proton and low LET irradiation
    W Friedland
    GSF National Research Centre for Environment and Health, Institute of Radiation Protection, D 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 99:99-102. 2002
    ..2 at 5 keV.micron-1 to about 2.5 at 70 keV.micron-1. About half of this growth resulted from an increased production of DSB clusters associated with small (< 10 kbp) fragments...
  28. doi request reprint Radiation risk modeling of thyroid cancer with special emphasis on the Chernobyl epidemiological data
    L Walsh
    BfS Federal Office for Radiation Protection, Neuherberg, Germany
    Radiat Res 172:509-18. 2009
    ..Based on the results of the study, it is recommended to test parametric and categorical baseline models in risk analyses...
  29. ncbi request reprint Track structures and dose distributions from decays of (131)I and (125)I in and around water spheres simulating micrometastases of differentiated thyroid cancer
    W B Li
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Res 156:419-29. 2001
    ..1 mm; however, in this medical context, many other factors also have to be considered...
  30. ncbi request reprint Photon dose conversion coefficients for human teeth in standard irradiation geometries
    A Ulanovsky
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Health Phys 89:645-59. 2005
    ..The integral conversion factors are strongly affected by the energy and angular distributions of photon fluence, which are important characteristics of an exposure scenario for reconstruction of individual occupational doses...
  31. ncbi request reprint Possible implications of non-linear radiobiological effects for the estimation of radiation risk at low doses
    V Prokic
    GSF National Research Center for Environment and Health Institute of Radiation Protection, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 99:279-81. 2002
    ..As a first step, the Radiation Effects Research Foundation (RERF) data on the lung cancer incidence are fitted to study how such a model would influence the assessment of the cancer risk at low doses...
  32. doi request reprint Track structure calculations on hypothetical subcellular targets for the release of cell-killing signals in bystander experiments with medium transfer
    W Friedland
    German Research Center for Environmental Health, Institute of Radiation Protection, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 143:325-9. 2011
    ..This has been resolved by accounting for variations in cellular characteristics among the irradiated cells...
  33. doi request reprint Modelling of intercellular induction of apoptosis in oncogenic transformed cells and radiation effects on the phenomenon
    P Kundrát
    German Research Center for Environmental Health, Institute of Radiation Protection, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 143:549-53. 2011
    ..The systems model without radiation perturbance is reviewed. First results accounting for radiation-induced modulations of the signalling schemes are presented...
  34. ncbi request reprint Mechanistic modelling in large case-control studies of lung cancer risk from smoking
    W F Heidenreich
    GSF Institute for Radiation Protection, 85758 Neuherberg, Germany
    Stat Med 21:3055-70. 2002
    ..The relative risk of male ex-smokers decreases strongly with time since end of exposure, but does not reach the risk of non-smokers, and does not decrease as much as for female ex-smokers...
  35. ncbi request reprint Simulation of 125I induced DNA strand breaks in a CAP-DNA complex
    W Li
    GSF National Research Centre for Environment and Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 99:109-12. 2002
    ....
  36. ncbi request reprint First international intercomparison of luminescence techniques using samples from the Techa River Valley
    H Y Göksu
    GSF National Research Centre for Environment and Health, Germany
    Health Phys 82:94-101. 2002
    ....
  37. ncbi request reprint Thin layer alpha-Al2O3:C beta dosemeters for the assessment of current dose rate in teeth due to 90Sr intake, and comparison with electron paramagnetic resonance dosimetry
    H Y Göksu
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Strahlenschutz, Neuherberg, Germany
    Radiat Prot Dosimetry 101:507-13. 2002
    ..The retention of 90Sr in various parts of the teeth is discussed...
  38. ncbi request reprint Simulation of exon deletion mutations induced by low-LET radiation at the HPRT locus
    W Friedland
    GSF-National Research Center for Environment and Health, Institute of Radiation Protection, 85764 Neuherberg, Germany
    Radiat Res 155:703-15. 2001
    ..The yields, size distributions and exon deletion patterns were grossly consistent, whereas larger deviations were found for the STS marker deletion patterns in this comparison...
  39. ncbi request reprint Monte Carlo simulation of DNA damage by low LET radiation using inhomogeneous higher order DNA targets
    Ph Bernhardt
    GSF National Research Center for Environment and Health, Institute of Radiation Protection, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Radiat Prot Dosimetry 99:203-6. 2002
    ..28-0.53 keV), cross sections of DNA are larger than those of water, leading to an increased yield of strand breaks per average absorbed dose in the cell nucleus...
  40. ncbi request reprint Important factors governing exposure of the population and countermeasure application in rural settlements of the Russian Federation in the long-term after the Chernobyl accident
    S Fesenko
    Russian Institute of Agricultural Radiology and Agroecology, Kievskoe Shosse, 249020 Obninsk, Kaluga Region, Russia
    J Environ Radioact 56:77-98. 2001
    ....
  41. ncbi request reprint Studies on the Mayak nuclear workers: dosimetry
    S A Romanov
    Southern Urals Biophysics Institute, Ozyorsk, Russian Federation
    Radiat Environ Biophys 41:23-8. 2002
  42. ncbi request reprint External exposure of the population living in areas of Russia contaminated due to the Chernobyl accident
    V Yu Golikov
    Institute of Radiation Hygiene, Mira Street 8, 197101 St Petersburg, Russia
    Radiat Environ Biophys 41:185-93. 2002
    ..Both the measurements and model show that the geometric mean of individual external doses is about 10% lower than the arithmetic mean and the upper bound of the 95% confidence range is larger by a factor of about 2...
  43. ncbi request reprint Investigations of thermoluminescence dosimetry in the Techa river flood plain: analysis of the new results
    N G Bougrov
    Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
    Radiat Prot Dosimetry 101:225-8. 2002
    ..In particular, the results can be applied for a more correct description of the source geometry in the settlement...
  44. ncbi request reprint Modelling study on the protective role of OH radical scavengers and DNA higher-order structures in induction of single- and double-strand break by gamma-radiation
    A Valota
    Universita degli Studi di Milano, Dipartimento di Fisica, Via Celoria 16, I 20133 Milan Italy
    Int J Radiat Biol 79:643-53. 2003
    ..To quantify the protective effects of (non-histonic) OH-radical scavengers and DNA higher-order structures in induction of single- (ssbs) and double-strand breaks (dsbs) by gamma-rays...
  45. ncbi request reprint Post-Chornobyl thyroid cancers in Ukraine. Report 1: estimation of thyroid doses
    I Likhtarov
    Radiation Protection Institute, Scientific Center for Radiation Medicine, Academy of Medical Sciences of Ukraine, Melnikova 53, 04050 Kyiv, Ukraine
    Radiat Res 163:125-36. 2005
    ....
  46. pmc Bupropion in breast milk: an exposure assessment for potential treatment to prevent post-partum tobacco use
    J S Haas
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Tob Control 13:52-6. 2004
    ....
  47. ncbi request reprint [Clinical pathways -- first results of a systematic IT-supported application at a surgical department of a university hospital]
    M K Schilling
    Klinik für Allgemeine, Viszeral, GefaSS und Kinderchirurgie, Universitatsklinikum des Saarlandes, Homburg Saar
    Dtsch Med Wochenschr 131:962-7. 2006
    ..Within this study, introduction and continuous, systematic application of clinical pathways at a surgical department of a university hospital was investigated...
  48. doi request reprint [Influence of IT-supported clinical pathways on patient satisfaction at a surgical department of a university hospital]
    J Schuld
    Klinik für Allgemeine Chirurgie, Viszeral, GefaSS und Kinderchirurgie, Universitatsklinikum des Saarlandes, Homburg Saar
    Dtsch Med Wochenschr 133:1235-9. 2008
    ..s.h.med) and used by routine. The aim of the study was to investigate the influence of IT-supported CPs on patient satisfaction...
  49. doi request reprint Surgical management of an esophagotracheal fistula as a severe, late complication of repeated endoscopic stenting treatment
    R Ladurner
    Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Tubingen, Germany
    Endoscopy 39:E341-2. 2007
  50. ncbi request reprint Evaluation of urinary trans-3'-hydroxycotinine as a biomarker of children's environmental tobacco smoke exposure
    G E Matt
    Department of Psychology, Graduate School of Public Health, San Diego, CA, USA
    Biomarkers 11:507-23. 2006
    ..Moreover, 3HC/COT may provide a useful indicator to investigate age- and race-related differences in the metabolism of COT and 3HC...
  51. ncbi request reprint Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxide
    S B Park
    Department of Pharmaceutical Chemistry and Liver Center, School of Pharmacy, University of California, San Francisco 94143 0446
    Chem Res Toxicol 6:880-8. 1993
    ..That the trans-(S)-nicotine N-1'-oxide metabolite was not appreciably reduced or oxidized further was investigated with infusion studies of (S)-nicotine-d2N-1'-oxide.(ABSTRACT TRUNCATED AT 250 WORDS)..
  52. ncbi request reprint Cardiovascular effects of carbon monoxide and cigarette smoking
    S Zevin
    Department of Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
    J Am Coll Cardiol 38:1633-8. 2001
    ..The short-term chronotropic effect, adrenergic-activating, platelet-activating and CRP-increasing effects of smoking in healthy smokers are probably due to components of cigarette smoke other than CO...
  53. ncbi request reprint [Public service strike. Effects on operating room management and training at a surgical university clinic]
    J Schuld
    Klinik für Allgemeine Chirurgie, Viszeral, GefaSS und Kinderchirurgie, Universitätsklinik des Saarlandes, 66421 Homburg Saar, Deutschland
    Chirurg 78:945-9. 2007
    ..Contrary to most hospitals in public authorities, the medical doctors of the University Hospital of Homburg/Saar did not participate in the strike, leading to pronounced tensions between patients, strikers and medical staff...